Deliberate self-harm in adolescents

Deliberate self-harm refers to an intentional act of causing physical injury to oneself without wanting to die. It is frequently encountered in adolescents who have mental health problems. Primary care physicians play an important role in the early detection and timely intervention of deliberate self-harm in adolescents. This article aims to outline the associated risk factors and possible aetiologies of deliberate self-harm in adolescents, as well as provide suggestions for clinical assessment and appropriate management within the primary care setting.     

Self-harm: 1. Suicide.

Although suicide rates have remained relatively stable, the risk of suicide has increased among 25- to 35-year-old men. Attempts to understand suicide fall into three major frameworks: sociologic theories, psychologic theories and the relation of suicide to psychiatric illness. The risk of suicide can be assessed by means of a relatively simple clinical interview. Since most suicide victims consult their family doctors within the month before their death, physicians are in a unique position to prevent suicide. Routine assessment of the risk of suicide among patients who appear depressed or are undergoing an emotional crisis can lead to accurate diagnosis and effective intervention. Similarly, the appropriate use of psychotropic medication can lead to effective treatment while minimizing the risk of a lethal overdose.     

Motivation in deliberate self-harm.

Fifty adult patients presenting with deliberate self-harm at the Royal Victoria Hospital were given a choice of nine reasons for their actions. Most chose more than one reason and all but two of the 24 who said that they wished to die chose at least one other motive. There were no trends with respect to sex, past history, or method of deliberate self-harm. These results illustrate the complexity of this condition and show the importance of investigating motives beyond simply the intent to die.     

Oral contraceptives and nonfatal myocardial infarction.

We obtained information on 107 women younger than 46 years who were discharged from a hospital with a diagnosis of acute myocardial infarction. In the series 26 women were otherwise apparently healthy and potentially childbearing. Among these 26 women, 20 (77%) were taking oral contraceptives just prior to admission, and one was taking conjugated estrogens. Among 59 control women, 14 (24%) were taking oral contraceptives and one was taking conjugated estrogens. The relative risk estimate, comparing oral contraceptive users with nonusers, is 14 with 90% confidence limits of 5.5 and 37. All but two of the 26 women were cigarette smokers. While this illness is rare in most healthy young women, the risk in women older than about 37 years who both smoke and take oral contraceptive appears to be high.     

Noncontraceptive estrogens and nonfatal myocardial infarction.

We obtained information on 107 women younger than 46 years discharged from a hospital with a diagnosis of acute myocardial infarction. In the series there were 17 women aged 39 to 45 years who were otherwise apparently healthy and had had a natural menopause, hysterectomy, or tubal ligation or whose spouse had had a vasectomy. Among them, nine (53%) were taking noncontraceptive estrogens just prior to admission. Among 34 control women, four (12%) were taking estrogens. The relative risk estimate, comparing estrogen users with nonusers, is 7.5, with 90% confidence limits of 2.4 and 24. All but one of the 17 ml subjects were cigarette smokers. While this illness is rare in most healthy young women, the risk in women older than about 38 years who both smoke and take estrogens appears to be substantial.     

Deliberate self-poisoning presenting at Craigavon Area Hospital: 1976 and 1986.

Deliberate self-poisoning presenting at Craigavon Area Hospital was compared in the years of 1976 and 1986. A decline in the use of benzodiazepines and increase in other agents, notably paracetamol, is reported. Alcohol is frequently associated with deliberate self-poisoning, while severe mental illness is less common. Diagnostic practice may have effects on bed occupancy in this group.     

Severe burn trauma from deliberate self-harm: the Sokoto experience

BACKGROUND: Burn injury is one of the most severe forms of trauma that can afflict mankind. Although several forms of suicide and para suicide have been reported worldwide, severe burn injuries from deliberate self-harm have been poorly documented in Africa. AIM: To evaluate the pattern of deliberate self-harm by burning in our environment. METHOD: This is a 5-year retrospective analysis of all patients who sustained burns from deliberate self-harm (DSH) seen at the Usmanu Danfodiyo University Teaching Hospital, Sokoto from June 1998 to May 2003. The patients' data and other necessary information were extracted from the case notes. RESULTS: Seven patients were seen over the study period. There were six females and one male, giving a female to male ratio of 6:1. All the injuries occurred at home from kerosene flame burns. In all cases, the intent was to take the patient's own life. The triggering factors were mainly psychosocio-economic. Six patients had up to secondary education while one patient had a degree certificate. None of the patients was gainfully employed at the time of incidence. Two patients had previously attempted suicide. Only one patient had a history of psychiatric illness. All sustained severe flame burns ranging from 45% - 98% body surface area (BSA). Compliance to treatment was generally poor. All patients were managed at the intensive care unit (ICU) of the hospital.. Five patients died, while the remaining two signed against medical advice (SAMA) during the course of management. The duration of hospital stay ranged from 2 - 10 days. CONCLUSION: Severe burn injury from DSH, although previously poorly documented in Africa, is not uncommon in our environment. The morbidity and mortality are high, not only because of the nature of injury, but probably because of poor compliance to treatment. We advocate community based studies and routine screening of adolescents to identify those at risk. The need for the establishment suicide information, intervention and prevention centre in Nigeria cannot be overemphasised.     

2型糖尿病患者中使用二甲双胍引起致死性和非致死性乳酸酸中毒的危险(摘要)

随着对糖尿病研究的深入,目前对口服降糖药的要求已不局限于降糖,还要求有诸如调脂、对抗高凝状态等降糖以外的作用,双胍类药物正适合了这种要求。但长期以来有一种观点认为双胍类药物易致乳酸酸中毒,特别是在欧美,双胍类药物曾一度被禁用。为了详细了解双胍类药物(主要是二甲双胍)和乳酸酸中毒的关系,我们摘译了《Cochrane图书馆》这篇对从1959年开始有关于二甲双胍的所有研究进行的系统评价,以供临床医生参考。     

Deliberate use of placebos in clinical practice: what we really know

Increasingly a focus of research as well as media reports and online forums, the use of placebos in clinical medicine extends beyond sugar pills and saline injections. Physician surveys conducted in various countries invariably report that placebos are routinely used clinically, impure placebos more frequently than the pure ones, and that physicians consider them to be of legitimate therapeutic value. Inconsistent study methodologies and physician conceptualisations of placebos may complicate the interpretation of survey data, but hardly negate the valuable insights these research findings provide. Because impure placebos are often not recognised as such by practitioners, they remain at the fringe of many placebo-related debates, hence quietly absent from discussions concerning policy and regulation. The apparent popularity of impure placebos used in clinical practice thus presents unresolved ethical concerns and should direct future discussion and research.     

Effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. VII. Mortality and selected nonfatal events with insulin treatment.

The University Group Diabetes Program is a long-term prospective clinical trial designed to evaluate the effects of various hypoglycemic agents on vascular complications in patients with asymptomatic adult-onset diabetes. Mortality and blood glucose levels were determined as well as certain nonfatal events for patients assigned to diet alone or to either of two insulin treatment regimens. Lower levels of blood glucose with mean values close to normoglycemia were achieved in the treatment group in which the insulin dosage was adjusted to achieve normoglycemia compared with the levels achieved in patients treated with diet alone or with a fixed dose of insulin. In spite of differences in blood glucose levels among the treatment groups, there were only minor differences in the occurrence of fatal or nonfatal events.     

Survivors of deliberate self-harm attempt in the military milieu: An exploratory study of psychiatric morbidity and psychosocial correlates

BackgroundDeliberate self-harm (DSH) is common in modern society. A million people worldwide die from suicide each year, leading to a large toll on human resources and economy. Research has revealed DSH as an important indicator of eventual suicide worldwide. The present study focused on DSH attempters among Armed Forces personnel and family members with the aim of identifying modifiable factors to provide recommendations for primary prevention in the military milieu.MethodsHundred cases of survivors of DSH were evaluated in a case–control study using psychiatry assessment instruments (the Mini-International Neuropsychiatric Interview, Pierce Suicide Intent Scale, Hamilton's Depression and Anxiety Scales and presumptive life event scale) to assess psychiatric morbidity and psychosocial correlates. The findings were compared with those of 100 healthy matched controls. The data were analysed using SPSS software.ResultThe majority of DSH survivors (98%) had concurrent psychiatric morbidity, major depressive disorder (23%) being the commonest diagnosis followed by psychotic disorder and alcohol use disorder. Presence of relationship problems (69%) and financial difficulties (19%) were significant triggering factors in our study. Many DSH attempters had voiced suicidal ideation (66%) before their act and had history of aggression or violence (76%) in the past.ConclusionOur findings are discussed in relation with findings in the literature. Recommendations regarding awareness campaign, specific skill development programs and the need for early intervention in individuals with psychiatric morbidity have been proposed to prevent such behaviours.     

Ethical practice in internet research involving vulnerable people: lessons from a self-harm discussion forum study (SharpTalk)

The internet is widely used for health information and support, often by vulnerable people. Internet-based research raises both familiar and new ethical problems for researchers and ethics committees. While guidelines for internet-based research are available, it is unclear to what extent ethics committees use these. Experience of gaining research ethics approval for a UK study (SharpTalk), involving internet-based discussion groups with young people who self-harm and health professionals is described. During ethical review, unsurprisingly, concerns were raised about the vulnerability of potential participants. These were dominated by the issue of anonymity, which also affected participant safety and consent. These ethical problems are discussed, and our solutions, which included: participant usernames specific to the study, a closed website, private messaging facilities, a direct contact email to researchers, information about forum rules displayed on the website, a 'report' button for participants, links to online support, and a discussion room for forum moderators. This experience with SharpTalk suggests that an approach to ethics, which recognises the relational aspects of research with vulnerable people, is particularly useful for internet-based health research. The solutions presented here can act as guidance for researchers developing proposals and for ethics committees reviewing them.