重复NEVA检测结合HEF-5在阴茎勃起功能障碍（ED）诊断中的意义

目的探讨重复夜间阴茎勃起测定系统（NEVA）结合国际勃起功能评分（IIEF-5）在勃起功能障碍（ED）诊断中的可行性及临床意义。方法对90例门诊ED患者用IIEF-5对其评分，再连续3晚进行NEVA检测，回收数据并分析。结果无器质性疾病52例（58％），第1次夜间勃起的次数、阴茎勃起时血容量变化值、最长持续时间等客观指标均要差于连续测定结果，差异有统计学意义（P〈0．05）。IIEF-5评分值与NEVA检测阴茎勃起时血容量变化值有正相关。结论NEVA与IIEF-5结合有互补性。重复NEVA并与IIEF-5结合分析，能减小数据误差，提高诊断ED的可靠性，能有效地区分功能性与器质性ED。尤其对怀疑夜间阴茎勃起（NPT）检查结果有误差的特殊病例更有价值。     

重复NEVA检测结合IIEF-5在阴茎勃起功能障碍(ED)诊断中的意义

目的 探讨重复夜间阴茎勃起测定系统(NEVA)结合国际勃起功能评分(IIEF-5)在勃起功能障碍(ED)诊断中的可行性及临床意义.方法 对90例门诊ED患者用IIEF-5对其评分,再连续3晚进行NEVA检测,回收数据并分析.结果 无器质性疾病52例(58%),第1次夜间勃起的次数、阴茎勃起时血容量变化值、最长持续时间等客观指标均要差于连续测定结果,差异有统计学意义(P＜0.05).IIEF-5评分值与NEVA检测阴茎勃起时血容量变化值有正相关.结论 NEVA与IIEF-5结合有互补性.重复NEVA并与IIEF-5结合分析,能减小数据误差,提高诊断ED的可靠性,能有效地区分功能性与器质性ED.尤其对怀疑夜间阴茎勃起(NPT)检查结果有误差的特殊病例更有价值.     

勃起功能国际指数5与夜间阴茎勃起实验在诊断勃起功能障碍中的应用

20 0 1年9月至2 0 0 3年6月,我们采用勃起功能国际指数5 (IIEF 5 )与NEVA夜间阴茎勃起实验检测(NPT)在勃起功能障碍(ED)诊断中的应用进行了研究。材料与方法　门诊ED患者1 5 0例。年龄2 0～70岁。ED史6～2 4个月。伴发疾病有高血压、糖尿病、前列腺术后、直肠癌术后、尿道外伤尿道吻合术后;心理性因素包括夫妻关系不和谐、性知识缺乏、工作压力大。IIEF 5评分总分为2 5分,≥2 2分无ED ,<2 2分判定为ED ;5～7分为重度ED ,8～1 1分为中度ED ,1 2～2 1分为轻度ED。统计学处理采用χ2 检验。结果　1 5 0例ED患者IIEF 5评分结果见…     

IIEF-5在血管性勃起功能障碍诊断中的应用

目的:评价国际勃起功能简化量表(IIEF-5)对血管性勃起功能障碍(ED)病因区分的意义,以指导血管性ED诊断及治疗。方法:将103例ED患者分为4组,非血管性ED组37例(37/103,35.9%)、动脉性ED组18例(18/103,17.5%)、静脉性ED组35例(35/103,34.0%)、混合性ED组13例(13/103,12.6%),其IIEF-5得分与海绵体血管活性药物注射试验结果、多普勒超声检查结果及双核素检测结果进行比较,以非参数检验的多个独立样本检验(Kruskal-WallisTEST)比较各组之间IIEF-5得分差异的显著性。结果:上述4组之间的IIEF-5得分没有统计学差异(P=0.253)。结论:IIEF-5不能作为一种诊断工具用于鉴别血管性ED的病因以及判断血管病变严重程度。     

NEVA在不同原因勃起功能障碍诊断中的应用

目的探讨NEVA在不同原因勃起功能障碍(ED)诊断中的作用。方法应用NEVA分别对15例勃起功能正常、18例心理(ED)性、16例阴茎动脉供血不足及8例阴茎静脉瘘者进行NPT监测。结果正常组夜间勃起血容量(?)分比228.5±14.0,勃起持续时间42.8±4.0min。心理性ED组分别为224.4±20.1及40.8±4.4,二项参数与正常组无显著性差异异(P>0.05)。阴茎动脉供血不足组,这两项指标分别为160.1±12.4及22.9+3.0,阴茎静脉瘘组分别为124.4±10.2及18.0±2.5,器质性ED这两项参数低于正常组与心理性ED组,呈显著性差异(P<0.01)。结论在筛选ED和诊断血管性ED中,NEVA是有效、易被病人接受的一种NPT检查工具。     

睾酮在阴茎勃起功能障碍中的应用及研究进展

阴茎勃起困难常见的因素有:年龄增加、糖尿病、心血管疾病等躯体疾病、抑郁症、性伴侣相关精神心理及社会等问题。年龄增加是阴茎勃起困难最常见的因素。随着年龄增加,激素、血管因素及神经因素在勃起过程中的生物调节作用逐渐受损;糖尿病、心血管疾病及其治疗药物的应用使老龄男性阴茎勃起困难程度加重。老龄男性抑郁症患者并不少见。性伴侣缺乏、配偶老龄化或患疾病等都阻碍老龄男子的性活     

夜间阴茎勃起试验在勃起功能障碍诊断中的应用

勃起功能障碍(erectile dysfunction,ED)常见于男性尤其是中、老年男性.根据病因将其分为器质性ED(动脉性、静脉性、神经性和内分泌性等)、心理性ED及混合性ED(器质性病因和心理因素同时存在)3种类型.ED的诊断除了详细的病史资料、体格检查和一般实验室检查之外,部分患者必须通过一种或者多种特殊检查才能最后确诊.随着对阴     

阴茎夜间勃起监测系统NEVA在勃起功能障碍诊断中的应用

目的 探讨夜间阴茎勃起监测系统对勃起功能障碍(ED)诊断的应用价值.方法 应用国产伟力NEVA夜间阴茎勃起监测系统对正常志愿者(32例)、心理性ED患者(63例),动脉性ED患者(61例)和静脉性ED患者(28例),检查阴茎血容积变化率、阴茎勃起次数、每次勃起持续时间、阴茎长度变化率及阴茎周径变化率.结果 正常志愿者组及心理性ED组的阴茎血容积变化率为231.5±112.5及221.8±96.7,每次勃起持续时间分别为(27.2±12.5)min及(25.9±11.1)min,这两项指标两组比较,差异均无统计学意义,P均＞0.05.而动脉性ED组及静脉性ED组的以上两项指标为172.8±56.8及130.6±22.1,(20.1±8.6)min及(18.1±10.5)min,这两项指标两组比较,差异均无统计学意义,P均＞0.05.NEVA对动脉性及静脉性ED诊断的准确率分别为91.8%和96.4%.结论 NEVA夜间阴茎勃起监测系统在ED筛选和血管性ED诊断中是有效的、易于接受的方法.     

老年勃起功能障碍的临床分析

目的 :分析老年勃起功能障碍 (ED)病人的临床特点。　方法 :4 8例 60岁以上ED病人 ,同期 4 0岁以下ED病人 4 0例作为对照 ,分别比较两组的病因、病程、常见危险因子、体质指数及勃起功能 (EF)积分的差异。　结果 :60岁以上组与对照组相比 ,以器质性ED为主 ( 3 1/48) ,病程为 ( 6.2 3± 0 .77)年对 ( 3 .82± 0 .4 5 )年 ,伴常见危险因子者为 3 1例对 8例 ,体质指数为 ( 2 4 .5 6± 0 .3 6)对 ( 2 4 .18± 0 .3 5 ) ,EF积分为 ( 8.98± 0 .5 8)分对 ( 12 .5 8± 0 .71)分。统计学检验表明 ,两组病因组成、病程、常见危险因子伴随者比例及EF积分有显著差异 (P <0 .0 1) ,而体质指数无显著差异 (P =0 .77)。　结论 :老年ED病人以器质性ED为主 ,伴随常见危险因子增多 ,病程延长 ,ED加重。     

血小板与阴茎勃起功能障碍

血小板是一种从骨髓成熟的巨核细胞胞质裂解脱落下来的具有生物活性的小块胞质。血小板受刺激后产生一氧化氮(NO),抑制自身活化、聚集。在病理状态下,内皮细胞的损伤使血小板活化,其功能发生改变,释放的炎症递质及细胞因子诱导并促进动脉粥样硬化的发生、发展,进而促使勃起功能障碍(ED)发生,同时血小板及其相关功能指标也可能作为ED诊疗中的一类重要指标。     

夜间生物电阻抗容积测定在血管性勃起功能障碍诊断中的应用

目的探讨夜间生物电阻抗容积测定(NEVA)在诊断血管性勃起功能障碍(ED)中的临床应用价值。方法对临床怀疑血管性ED的58例患者进行NEVA测定,其结果与阴茎海绵体造影联合彩超的诊断结果进行比较,从而了解NEVA在诊断血管性ED中的临床应用价值.结果58例患者中确诊血管性ED的患者有30人,其中18名为动脉性ED,12名为静脉性ED,非血管性ED的患者有28人。应用NEVA发现在30名血管性ED的患者中有6名NPT正常,在28名非血管性ED的患者中有4名NPT有异常。NEVA对血管性ED诊断的敏感度为80%,特异度为85.71%,准确度为82.76%。在非血管组、动脉组、静脉组中有统计学差异的NEVA参数为:每晚勃起次数、勃起持续时间、血容量改变、横截面改变。结论NEVA对临床上怀疑血管性ED的诊断有参考价值。     

夜间生物电阻抗容积测定对勃起功能障碍的诊断

目的:探讨夜间生物电阻抗容积测定(NEVA)在诊断勃起功能障碍(ED)中的应用价值。方法:对临床怀疑ED的100例患者进行NEVA测定。其中58例怀疑血管性ED,将该测定与阴茎海绵体造影联合彩超检查进行比较。结果:10例糖尿病性ED中有2例夜间阴茎勃起(NPT)正常,2例为动脉供血不足,6例无NPT。4例内分泌性ED患者中,2例NPT正常,2例无NPT。20例心理性ED的患者中,16例NPT正常,1例为动脉供血不足,3例无NPT。58例怀疑血管性ED的患者中确诊者有30例,其中18例为动脉性,12例为静脉性,非血管性ED28例。而应用NEVA发现在30例血管性ED中6例NPT正常,28例非血管性ED中4例NPT异常。8例外伤性ED中,2例腰椎骨折患者的NPT表现为轻度动脉供血不足;3例骨盆骨折患者中2例NPT正常,1例无NPT;3例骨盆骨折并发-后尿道断裂的患者,2例NPT正常,1例NPT提示动脉供血不足。结论:NE-VA对临床上怀疑心理性ED和血管性ED的诊断有较好的参考价值。     

Nocturnal electrobioimpedance volumetric assessment of patients with erectile dysfunction

Objectives. Electrobioimpedance volumetric assessment is a procedure that can measure penile length, cross-sectional area, and volume. From these variables, the number and duration of erectile events, volume change, and percentage of volume increase from baseline can be determined. This procedure was performed on patients with erectile dysfunction (ED) and findings were compared with patients with no history of ED. Examples of etiology are reported.Methods. Two groups of patients with ED were evaluated by electrobioimpedance assessment. Group 1 patients (n = 23), ranging in age from 26 to 60 years (mean 50), were involved in simultaneous electrobioimpedance assessment and duplex Doppler ultrasound penile volume measurements. A tissue correction was derived. Group 2 patients (n = 10), ranging in age from 38 to 64 years (mean 50), used nocturnal electrobioimpedance volumetric assessment (NEVA) at home for 2 consecutive nights.Results. After deriving an expression to correct for tissue volume, simultaneous measurement of penile blood volume by NEVA and duplex Doppler showed that the regression line for study participants and the identity line was not significantly different by analysis of variance. Using NEVA in comparing patients with ED to a reference population with no history of ED, and using a two-tailed Student’s t test for means, the data demonstrated a statistically significant (P ≤0.05) difference in the number of erectile events and percentage of volume change over baseline. With NEVA data, it was possible to distinguish arterial insufficiency from veno-occlusive dysfunction.Conclusions. The present study demonstrates that electrobioimpedance volumetric assessment can be used in patients with ED. Compared with a reference population with no history of ED, the group with ED had fewer nocturnal erectile events that resulted in a smaller increase in penile blood volume change over baseline. Although the time dependence of the measured variables identifies the cause of ED, the application of NEVA to a larger population will allow further analysis of the dynamic information contained in the NEVA data.     

Predicting risk of erectile dysfunction in patients with nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is one of the risk factors for erectile dysfunction (ED). We aimed to predict the risk of ED in patients with NAFLD. The study included 146 male patients complaining impotence admitted to the urology outpatient clinic aged 24–80 years without a history of alcohol use who underwent abdominal ultrasonography between February 2018 and January 2019. 106 patients with NAFLD and 40 men without NAFLD were included in the study. Clinical and laboratory parameters, ED status according to International Index of Erectile Function-5 were compared between patients with and without NAFLD. The mean age of patients was 51.47 ± 10.34 years. NAFLD was detected in 72.6% of the patients. No statistically significant difference was found regarding mean age, BMI, IIEF-5 scores, DM status, serum glucose levels (p > .05). Fasting insulin levels, hypertension (HT), insulin resistance (IR) and ED status of the patients with NAFLD were significantly higher than patients without NAFLD (p < .05). NAFLD was found to be a significantly independent associated with ED. We also found that patients with NAFLD have risk of ED 2.92 times higher than without NAFLD (OR: 2.92). For the patients presenting with erectile dysfunction, hepatic steatosis should also be considered.     

Application of nocturnal electrobioimpedance volumetric assessment: a feasibility study in men without erectile dysfunction

PURPOSE: Electrobioimpedance volumetric assessment is based on the principle of delivering a constant, nondetectable alternating current to a tissue segment. A potential difference measured between the electrodes is converted to impedance. Since impedance changes with variations in blood flow, penile volumetric change is measured noninvasively. We applied this procedure to the development of a new device to evaluate erectile activity nocturnally, and we report our findings in men with no history of erectile dysfunction. MATERIALS AND METHODS: Our study group comprised 10 men with a mean age of 44 years who had no history of erectile dysfunction. The NEVA device consists of a small recording device attached to the upper thigh, and 3 small adhesive electrode pads placed over the hip and on the penile base and glans, respectively. Each subject used the NEVA device for 2 nights. RESULTS: Overall 20 nights of electrobioimpedance volumetric assessment were recorded. Tumescence monitoring revealed 3 to 6 erections per night per subject (mean 3.45) lasting 10 to 50 minutes (mean 17). As determined from the impedance measurements, mean volume change was 14.4 ml. with a 213% mean volume change over baseline. CONCLUSIONS: The new NEVA device is small, comfortable to wear and easy to use. It determines the number and duration of erectile events and percentage increase of blood volume changes during these events in normal men in a noninvasive manner. Future directions of study include a comparison to men with erectile dysfunction and analysis of the dynamic information of the NEVA data.     

男性不育患者中勃起功能状况的初步研究

目的调查男性不育患者的勃起功能状况及相关影响因素。方法选取来协和医院泌尿外科就诊的男性不育患者278例,采用勃起功能国际问卷5(IIEF-5)调查患者的勃起功能状况,并利用自行设计的信息收集表,调查可能影响勃起功能的相关一般信息,分析勃起功能状况的相关影响因素。结果在调查的278例男性不育患者中,符合勃起功能障碍(ED)诊断标准的患者达到199例,ED的发生率为71.6%,其中轻度ED 117例(42.1%)、轻-中度ED 40例(14.4%)、中度ED34例(12.2%)、重度ED 8例(2.9%);在全部被调查的患者中,为了加强受孕概率,202例(72.7%)患者掌握并采取了易受孕期性交,但是其中46例(22.8%)存在不同程度的应激性ED,还有76例(27.3%)患者不了解易受孕期性交;在79例勃起功能正常的不育患者中,6例(7.6%)存在应激性ED,而在199例合并ED的不育患者中,40例(20.1%)存在应激性ED,显著高于勃起功能正常的患者(P0.05)。结论在男性不育患者中存在较高的ED和应激性ED的发生率,给不育诊疗带来不利影响。     

夜间电子生物阻抗测量装置对阴茎勃起功能障碍的检测

目的 :探讨夜间电子生物阻抗测量装置 (NEVA)在阴茎勃起功能障碍的诊断中的应用价值。方法 :对 4 1例主诉阴茎勃起功能障碍者 (障碍组 ) 19例主诉无勃起功能障碍但有射精障碍者 (无障碍组 )进行NEVA检测。结果 :障碍组夜间试验中的夜间勃起的次数、阴茎勃起的最大体积改变、最长持续时间等客观指标均要差于无障碍组 ,差异有统计学意义 (P <0 .0 1)。结论 :NEVA为非侵入性检测、可鉴别心理性阴茎勃起功能障碍和严重的器质性勃起功能障碍 ,且对勃起功能障碍的定性和定量具有一定的客观性。     

Smoking status and the baseline international index of erectile function score can predict satisfactory response to platelet-rich plasma in patients with erectile dysfunction: A prospective pilot study

Erectile dysfunction (ED) is a common condition with a significant impact on the quality of life. Regenerative medicine maladies are intended to repair or replace damaged tissues and organs through different therapeutic mechanisms. Our aim was to study the effect of intra-corporeal injection (ICI) of platelet-rich plasma (PRP) in ED patients. Thirty-four patients’ erectile function was evaluated by filling up an abridged form of the international index of erectile function (IIEF-5) before and after PRP therapy. ICI of PRP was done once per week for 2 months. All patients were prescribed PDE5Is for one month after PRP therapy. Penile haemodynamics was assessed using 20 µg of PGE1 before and 3 months after initiating PRP therapy. Interestingly, our study had shown that there was a statistically significant difference in the IIEF-5 score after ICI of PRP (−5.5, ±5.2, p=<0.001). Furthermore, in multiple logistic regression model for PRP responsiveness, smoking and IIEF score before PRP were the only significant independent variables (p = .040, p = .023 respectively). PRP injection for ED patients may be a promising modality as well as baseline IIEF-5, and smoking status can be used as predictors for a satisfactory response to PRP in such patients.     

NEVA夜间阴茎勃起测定系统的临床应用 (附83例报告)

目的探讨应用NEVA夜间阴茎勃起测定系统检测勃起功能障碍的可行性及其中存在的问题。方法83例门诊初诊勃起功能障碍的男性,睡前正确粘贴NEVA测定仪电极,完整检测睡眠时段,次晨把数据上传入主机回放分析。结果全部病人均对测试耐受良好,62例病人资料提示阴茎无器质性疾病,14例提示阴茎动脉轻度供血不足,7例提示阴茎动脉重度供血不足,3种勃起事件分别为(4.240.6)7次(,3.600.8)1次(,1.430.)69次;平均阴茎血容量峰/基准比值为(327.2251.6)3%,(171.3423.9)2%,(127.3414.5)8%。结论NEVA夜间阴茎勃起测定系统简便、无创,可作为勃起功能障碍病人的常规检测手段。