尼莫地平对原发性开角型青光眼的疗效观察

目的 观察尼莫地平对原发性开角型青光眼的治疗效果.方法 原发性开角型青光眼患者22例(36眼),分为两组,两组患者的眼压均控制在18mmHg以下,其中一组予口服尼莫地平,治疗前后分别检测视力、眼压和视野(用视网膜平均光敏感度代表),采用t检验和x2检验比较两组之间的差异.结果 治疗6、12个月时,尼莫地平组的视网膜平均光敏感度分别为(16.48±3.05)dB和(16.05±2.47)dB,对照组分别为(12.36±2.64)dB和(10.49±2.58)dB,两组比较有显著性差异(t=4.43,6.54,P<0.01).治疗12个月时,尼莫地平组有2眼出现视野进行性损害,对照组有7眼出现视野进行性损害,两组比较有显著性差异(x2=5.40,P<0.05).治疗前后各时间段两组的眼压和视力无显著性差异.应用尼莫地平的患者未出现明显的药物不良反应.结论 尼莫地平可能有利于保护或改善青光眼患者的视野.     

复方樟柳碱治疗原发性开角型青光眼疗效的临床研究

目的:评价复方樟柳碱( compound anisodine,CA)对眼压已控制的原发性开角型青光眼患者视神经的作用.方法:根据改良的HPA国际视野分期法,收集中期原发性开角型青光眼患者46例,随机分为CA组23例和对照组23例,分别接受复方樟柳碱颞浅动脉旁注射和维脑路通片口服治疗,比较治疗前后视力、眼压、眼底、视野及视乳头血流情况.结果:CA组视野平均缺损值(mean of defect,MD)明显改善;两组眼动脉收缩期峰值血流速度(pSV)、舒张末期血流速度(EDV),视网膜中央动脉PSV、EDV、阻力指数(RI)较治疗前均有显著改善(P＜0.05),且CA组改善程度优于对照组.结论:复方樟柳碱能有效改善原发性开角型青光眼患者的视功能和视乳头血流,保护视神经.     

分离格栅模式视觉诱发电位对开角型青光眼早期诊断的临床观察

目的 探讨分离格栅模式视觉诱发电位( ic-VEP)定性模式检查在开角型青光眼早期诊断中的应用价值,为临床青光眼早期诊断提供客观敏感而有效依据.方法 随机选择原发性开角型青光眼患者68例(82眼)和正常对照者47例(76眼),分别进行ic-VEP与视野、视网膜神经纤维层厚度(RNFLT)进行多元相关分析,分析ic-VEP在开角型青光眼诊断中的敏感度及特异度.结果 青光眼组和正常对照组年龄、屈光度和中央角膜厚度差异均无统计学意义,而青光眼组患者的眼压、视野、RNFLT和ic-VEP与正常组相比差异具有统计学意义(P＜0.01).在青光眼组患者中,ic-VEP信号噪音比(SNR)与屈光度、眼压、视野和RNFLT的相关性分析表明,ic-VEP SNR与眼压、视野和RNFLT损伤显著相关(P＜0.01). ic-VEP检测开角型青光眼的敏感度为90. 2% ,特异度为88. 2% . ic-VEP与视野检查及 RNFLT损伤的一致性较好.结论 ic-VEP对原发性开角型青光眼的诊断具有较高的敏感度和特异度,视野、RNFLT 的损伤和 ic-VEP SNR相关.     

早期原发性开角性青光眼视网膜光阈值研究

目的观察早期原发性开角性青光眼视网膜光阈值改变.方法采用美国眼力健公司Humphrey740自动静态视分析仪对早期原发性开角性青光眼患者进行C-30-2程序视网膜光阈值测定.结果视网膜光阈值随离心度增加而减少,以上方视网膜光阈值降低为显著,视野改变以旁中心暗点、弓形暗点及鼻侧阶梯为主.结论视网膜光阈值定量检测可以做为原发性开角性青光眼早期诊断中视功能检测方法.     

早期原发性开角性青光眼视网膜光阈值研究

目的：观察早期原发性开角性青光眼视网膜光阈值改变,方法：采用美国眼力健公司Humphrey740自动静态视分析仪对早期原发性开角性青光眼患者进行C－30－2程序视网膜光阈值测定。结果：视网膜光阈值随离度增加而减少,以上方视网膜光阈值降低为显著,视野改变以旁中心暗点,弓形暗点及鼻侧阶梯为主。结论：视网膜光阈值定量检测可以做为原发性开角性青光眼早期诊断中视功能检测方法。     

益气活血利水法治疗原发性开角型青光眼临床观察

目的:探讨益气活血利水法治疗原发性开角型青光眼的临床疗效。方法:将44例原发性开角型青光眼患者随机分为治疗组23例和对照组21例。对照组滴用0.5%噻吗心安眼液治疗,治疗组在对照组基础上配合益气活血利水方治疗,疗程均为12周。观察并比较两组患者的视力、眼压、视野及临床主要症状的改善情况。结果:治疗后,两组患者的视力改善情况比较,差异无统计学意义(P>0.05);两组患者的平均眼压、临床主要症状积分较治疗前均明显下降(P<0.05),且治疗组较对照组降低更加明显(P<0.05);治疗组患者的视野平均缺损和模式标准差较治疗前均明显改善(P<0.05),而对照组患者较治疗前则无显著差异(P>0.05)。结论:益气活血利水法能降低原发性开角型青光眼患者的眼压、促进视功能恢复、改善患者临床症状。     

拉坦前列腺素对原发性开角型青光眼患者的疗效

目的:研究拉坦前列腺素对原发性开角型青光眼(POAG)患者的治疗效果.方法:POAG患者135例,随机分为观察组(n=70)和对照组(n=65),观察组给予拉坦前列腺素治疗,对照组给予噻吗心安治疗;记录2组患者治疗前后的眼压及波动值、视野缺损及视网膜纤维层(RNFL)厚度及不良反应.结果:两组患者治疗后昼夜平均眼压、眼压波动值及视野缺损范围均较治疗前明显降低,差异有统计学意义(P＜0.05);治疗后观察组昼夜平均眼压、眼压波动值较对照组降低更明显,下方视野、颞侧视野及鼻侧视野缺损范围较对照组明显缩小,上方视盘、下方视盘、颞侧视盘及鼻侧视盘较对照组明显增厚,差异均有统计学意义(P＜0.05);治疗后观察组9例(12.86％)、对照组11例(16.92％)出现不良反应,差异无统计学意义(P＞0.05).结论:拉坦前列腺素治疗原发性开角型青光眼效果优于噻吗心安.     

原发性青光眼患者屈光状态的研究

目的:探讨原发性青光眼患者的屈光状态对其发病机制的影响.方法:对原发性青光眼患者50例(100眼),分别进行裸眼视力、矫正视力、主觉和他觉验光检查,以及眼轴的测量.结果:原发性青光眼患者50例(100眼)中,屈光不正患病率为71.00%.原发性开角型青光眼患者的近视率为76.09%,平均屈光度为-3.61D;原发性闭角型青光眼患者的远视率为50.00%,平均屈光度为 0.57D(P＜0.01).原发性开角型和闭角型青光眼平均眼轴长度为24.81 mm和22.30 mm(P＜0.01).结论:原发性青光眼的发病与患者的屈光状态存在一定内在联系,原发性开角型青光眼以近视性屈光不正为主,原发性闭角型青光眼以远视性屈光不正为主.     

消心痛对开角型青光眼患者视网膜血管管径的影响

２１例原发性开角型青光眼患者给予口服直接血管扩张剂－消心痛治疗,测定治疗前、后视网膜血管的管径改变,结果显示：治疗后视网膜血管明显扩张,以静脉扩张明显,揭示消心痛在治疗原发性开角型青光眼有一定的临床价值。     

针刺配合滴眼液治疗原发性开角型青光眼降眼压的疗效观察

目的观察针刺配合滴眼液治疗原发性开角型青光眼对患者眼压的影响与单纯滴眼液治疗的疗效差异。方法将49例（86眼）原发性开角型青光眼患者,随机分为治疗组与对照组,治疗组采用针刺配合滴眼液治疗,对照组采用单纯滴眼液治疗,治疗前后分别检测2组患者眼压指标,并进行对比研究。结果2组患者治疗后眼压与治疗前相比均有显著性差异（P〈0．05）。治疗组半年后患者眼压与治疗前比较仍具有显著性差异（P〈0．05）。结论针刺配合滴眼液治疗原发性开角型青光眼可降低患者眼压。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.