卵巢巨大粘液性囊腺瘤1例报告

1病案摘要患者,女性,65岁,因腹部渐进性增大包块4年余,右上腹隐痛3天于2005年3月9日入院。入院查体:一般情况良好,营养中等,腹部膨隆,下腹部可及一巨大包块,约25cm×20cm,触之质硬,无触痛,活动度差,叩诊呈浊音,不移动。右上腹压痛明显,未及反跳痛。肠鸣音位置抬高,位于脐上约8cm处,肠鸣音亢进,约7次/分,未及气过水声或金属音。外院CT检查提示:腹盆腔囊性占位(来源卵巢可能性大)。我院B超提示:盆腔巨大不均质回声团,大小约30cm×18cm,占满整个腹腔,内见密集可移动点状强回声,其中可见局限性分隔。在全麻下行剖腹探查术,术中见腹腔与盆腔完…     

巨大卵巢粘液性囊腺瘤1例

1 临床资料 韦某，女，55岁，农民，因发现腹部胀大伴阴道流血3年多入院。诉3年前无明显诱因出现腹部胀大，开始是下腹部胀大，未触及包块，无压痛、无恶心、呕吐、腹泻，也无尿频、尿急、尿痛。伴阴道流血，色暗红，每天用卫生纸1～2张．无血块，无肉样组织物及水泡样物排出，因不影响日常工作及生括而未及时诊治．无发热、咳嗽、咯血、盗汗，自觉腹部逐渐增大．     

同侧卵巢粘液性囊腺瘤与畸胎瘤并存三例

卵巢粘液性囊腺瘤及卵巢囊性畸胎瘤在临床上均常见。由于两种肿瘤来源不同 ,同侧卵巢两种肿瘤并存很少见。我院近 3年来发现 3例 ,报告如下。　　例 1　患者 53岁 ,以“下腹进行性增大 6 个月 ,加剧 10余天”于 1997年 7月 2 1日入院。伴尿频尿急 ,无尿痛、腹痛等。查体 :Ｔ、Ｐ、Ｒ、ＢＰ正常。腹膨隆 ,盆腔内触及一约孕 7个月大小包块 ,囊性感 ,无压痛及反跳痛。移动性浊音可疑阳性。Ｂ超提示 :腹腔内可见一巨大不均回声光团 ,最大深度 12 0ｃｍ。界清 ,包膜回声完整。其内液性暗区 ,散在强光带、光团 ,呈蜂窝状。入院诊断 :卵巢肿瘤。行…     

卵巢甲状腺肿同侧合并勃勒纳瘤及粘液性囊腺瘤1例

临床资料患者女,56岁.因下腹部膨隆4个月伴腹胀2个月于1999年4月15日入院.入院前6个月,发现下腹部增大、膨隆,未在意.近2月出现腹胀,下腹沉坠感,致食欲下降就诊.查体:腹部膨隆,上腹饱满.全身浅表淋巴结无肿大,肝脾未触及,甲状腺不肿大.妇科检查:子宫前位,大小正常.盆腔内可触及一巨大肿块,约孕6+月大小,囊性,表面光滑,边界清.B超示:子宫大小如常,图像未见异常,腹腔内囊性包块.临床诊断:左侧卵巢囊肿.     

原发性腹膜后粘液性囊腺瘤癌变1例

 患者女 ,36岁 ,4天前晨炼抬右腿时 ,出现右下腹牵拉痛 ,于 1999年7月 15日入院。体查 :腹平坦可触及7ｃｍ× 5ｃｍ肿块 ,边界光滑有触痛 ,质软 ,活动度好。ＣＴ示 :右中下腹部腹膜后囊性占位 ,肿块与卵巢无相连 ,Ｂ超 :子宫及附件无异常。胃镜 :慢性浅表性胃炎 ,十二指肠球炎。胸片 :心肺无异常病变 ,手术所见 :在升结肠后方腹膜后有 - 7ｃｍ× 5ｃｍ的囊性肿块 ,表面光滑 ,包膜完整 ,将肿块完整切除送病检 :囊性肿块一个 ,8ｃｍ× 7ｃｍ× 2 5ｃｍ ,包膜完整 ,光滑 ,切面囊壁厚 0 1ｃｍ ,部分区域〈附壁结节〉见有 3个 1 0ｃｍ× 1 0ｃｍ及 1 0ｃｍ× 0 6ｃｍ和 0 8ｃｍ× 0 5ｃｍ大小菜花样隆起灰白色结节 ,切面灰白色 ,囊内充满淡黄乳白色混浊液。镜检 :囊壁为纤维结缔组织 ,衬覆肠型粘液上皮 ,核位于基底部 ,胞浆丰富透亮 ,附壁结节区瘤细胞排列成腺管状细胞 ,部分呈乳头状结构 ,乳头中心索为少量纤维血管间质 ,瘤细胞柱状 ,胞核排列参差不齐 ,呈假复层 ,核大深染 ,分裂象易见 ,囊壁的瘤细胞与附壁结节的癌细胞之间无移行 ,病理诊断 :...     

1 例原发性卵巢平滑肌肉瘤伴黏液样变性诊治分析

患者女,24岁,因腹胀纳差2个月,消瘦1个月入院。月经规律,G2P2。查体：一般情况差,贫血貌,腹部膨隆,移动性浊音可疑,可触及不规则结节,质硬,活动,无压痛。盆腔检查：子宫正常大小,双附件区可触及结节状肿物,左侧直径约10 cm,右侧直径9 cm,活动欠佳,子宫直肠陷凹触及形状不规则质硬结节,直径约13 cm。B超及腹部CT提示：盆腹腔多发结节状肿物,腹水。CA125：45 U/mL。开腹探查见：腹水500 mL;大网膜和肠管表面多个实性、结节状肿物,表面较光滑,大小2～8cm不等（图1）;子宫正常大小,肿瘤表面种植;双侧卵巢肿物,左侧10 cm×6 cm×6cm,右侧8 cm×6 cm×5 cm,均为实性,表面不规则,结节状,包膜破裂（图2）;膀胱正常。遂行肿瘤细胞减灭术+子宫切除术+双侧输卵管卵巢切除术+大网膜切除术。病理检查：巨检：双侧卵巢肿瘤,浸润卵巢表面,右侧卵巢包膜破裂,左侧卵巢包膜完整,大网膜肠管肿瘤种植,切开肿瘤见切面囊实相间,以实性为主。常规病理切片示：切片见大量蜂窝状组织,由梭形细胞束组成,呈编织状态排列,伴有轻度至中度多形性,细胞密集区核分裂像≥10个/10HPF,可见黏液样变性（图3）。免疫组织化学：SMA（+）（图4）、Vimentin（+）（图5）、Myoglobin（-）、S-100（-）、广谱CK（-）。病理诊断：双侧卵巢平滑肌肉瘤,黏液样变性,大网膜肠管转移瘤。术后给予顺铂和表阿霉素辅助化疗。术后2个月B超提示复发,随访7个月后患者死亡。     

卵巢粘液性囊腺瘤伴肉瘤性附壁结节1例

患者25岁.因下腹部逐渐隆起半年,左下腹发现肿物半个月于1992年10月入院.体检左下腹肿物有压痛,边界清,可活动.11月6日开腹探查,发现右侧卵巢囊性物27cm×22.5cm,无腹水及肿大淋巴结.完整切除肿物冰冻病理报告为恶性肿瘤,又补加大网膜及阑尾切除.术后病理为右卵巢粘液性囊腺瘤伴恶性纤维组织细胞瘤型附壁结节.术后4个月内COF方案加DDP化疗3个疗程(总量CTX6g、VCR6mg、5—Fu7.5g、DDP300mg).1993年5月中旬自感腰痛,伴无痛性全程血尿.逆行性尿路造影见右肾盂积水,右输尿管受压.B超示右肾孟及输尿管上端占位性病变,腔静脉及腹主动脉周围有多个肿物,最大4.4cm×2.75cm.于1993年7月26日开始腹部放疗,放疗至DT20Gy时发现左锁上淋巴结肿大,针吸为恶性瘤细胞.1周后患者突然出现腹胀.少尿及阵发性心慌,面部及双下肢浮肿,腹围增     

Ovarian mucinous cystadenocarcinoma with sarcoma-like mural nodules

A rare case of ovarian mucinous cystadenocarcinoma with sarcoma-like mural nodules is reported. Macroscopically, nodular or granular lesions were scattered over the inner surface of a huge, multilocular tumor in the left ovary. The histopathological features were consistent with those of previously documented cases, except significant squamous metaplasia in the present case. The pleomorphic sarcoma-like cells showed a positive reaction for vimentin and α-antichymotrypsin but were negative for carcinoembryonic antigen and common epithelial membrane antigen by immunohistochemistry. Electron microscopically, the tumor cells had neither desmosomes nor secretory granules, but they possessed abundant intermediate filaments. Both immunostaining and ultrastructure suggested that the sarcoma-like nodules were derived from reactive proliferation of fibrohis-tiocytic cells. The fibrohistiocytic reaction seemed to occur in response to hemorrhage, because hemorrhage was reported to be associated with the mural nodules in most of the previous cases as well as ours. © 1995 Wiley-Liss, Inc.     

Ovarian mucinous tumors with sarcoma-like mural nodules: a report of seven cases.

Seven cases of mucinous ovarian tumors with sarcoma-like nodules in their walls are reported. The age of the patients ranged from 18--81 years. Each of them had a large abdominal mass which proved on exploration to be a Stage Ia cystic ovarian tumor. All the specimens contained one or more discrete nodules in their walls, most of which were soft, dark brown, and hemorrhagic. On microscopical examination the epithelial component of four of the tumors was of borderline malignancy and of three was well-differentiated carcinoma. Three patterns were encountered in the nodules: pleomorphic and epulis-like in four cases, pleomorphic and spindle-celled in one case, and giant cell-histiocytic in two cases. These patterns simulated those of malignant giant cell tumor of soft parts, spindle cell sarcoma, and well-differentiated rhabdomyosarcoma, respectively. Postoperative follow-up ranging from 1 to 11 1/2 years (average 7 1/2 years) revealed no evidence of recurrence. Reports of seven similar tumors were found in the literature. Although follow-up has been less complete in these cases, none of the tumors is known to have spread beyond the ovary. These data suggest that mural nodules of the types described are not sarcomatous but could represent a reactive process that has no effect on the prognosis of the patient.     

Primary retroperitoneal mucinous cystadenocarcinoma with mural nodules: a case report and literature review

A primary retroperitoneal mucinous cystadenocarcinoma (PRMC) is an extremely rare lesion. To date, only 49 cases have been reported. The presence of mural nodules in a PRMC may indicate a worse prognosis. We report the case of a 40-year-old Japanese woman with a PRMC with mural nodules. Microscopic examination revealed that the stromal cells of the nodules were spindle-shaped and varied in size. The nodules were immunoreactive for vimentin but negative for cytokeratin and EMA, and the nuclei of the stromal cells were pleomorphic and strongly Ki-67 immunoreactive. The nodules were diagnosed as true sarcoma. To the best of our knowledge, this is 11th published case report of a PRMC with mural nodules.     

Pancreatic mucinous cystadenocarcinoma with pseudosarcomatous mural nodules. A report of a case with immunohistochemical study.

A case of pancreatic mucinous cystadenocarcinoma (PMC) with two pseudosarcomatous mural nodules (PMN) is described. These nodules have not been previously described in this type of tumor. In ovarian mucinous tumors (OMT), similar nodules have been reported, the nature of which has been discussed in detail. Here the similarity between the tumor described here and ovarian tumors is stressed. The immunohistochemical study carried out disclosed in the nodules strong positive staining for vimentin and moderate positivity for keratin and epithelial membrane antigen. These findings, along with histologic details, favor the epithelial nature of the nodules. It was concluded that the nodules are foci of anaplastic carcinoma with high proliferative cell rate, which could explain the coexpression of vimentin and keratin.     

Main-duct intraductal papillary mucinous adenoma of the pancreas with a large mural nodule

Intraductal papillary mucinous neoplasm (IPMN) is an increasingly recognized entity representing a spectrum of benign and malignant neoplasms of the pancreas. Preoperative distinction between benign and malignant IPMNs remains difficult. Reported predictive factors for malignancy are size of the main pancreatic duct, cystic neoplasm, and mural nodule. We report herein the case of a 50-year-old woman in whom a large mural nodule (30 mm) in the dilated main pancreatic duct (16 mm in diameter) was detected by ultrasonography, computed tomography, and endoscopic retrograde cholangiopancreatography. Because the large mural nodule and dilatation of the main pancreatic duct were also detected by endoscopic ultrasonography (EUS) and intraductal ultrasonography (IDUS), the main-duct IPMN was considered to have malignant potential. Thus, pylorus-preserving pancreaticoduodenectomy with lymph node dissection was performed. The resected intraductal tumor appeared polypoid with a broad stalk and comprised a proliferation of mucin-containing columnar epithelial cells with papillary structures without malignant features. The final diagnosis was intraductal papillary mucinous adenoma of the pancreas. The size of the mural nodule and the final diagnosis in this case suggest that the introduction of a novel molecular-biological approach might be necessary for the precise preoperative diagnosis of main-duct IPMN and adequate surgical treatment.     

Krukenberg tumor of ovary with features of mucinous cystadenocarcinoma

An unusual case of bilateral Krukenberg tumors having a predominant multicystic mucinous component which on gross and microscopic examination resembled a mucinous cystadenocarcinoma is presented. It is important to distinguish between these two tumors as Krukenberg tumours have a significantly worse prognosis.     

Methotrexate with citrovorum factor in low-risk gestational trophoblastic tumor

From January 1976 through December 1985, methotrexate (MTX) with citrovorum factor (CF) was administered as primary treatment to 57 patients with low-risk gestational trophoblastic tumor (GTT); 51 patients were non-metastatic and 6 were metastatic GTT. The median number of courses needed to achieve biochemical remission was two (range, 1-7). Complete remission was attained in 95% of non-metastatic GTT patients with postmolar persistent trophoblastic disease, but when choriocarcinoma was histologically confirmed, this fell to 60%. The cure rate of metastatic GTT patients was only 50%. The overall remission rate with the MTX-CF combination was 84.2%. Toxicity was mild, consisting of myelosuppression and mucositis. Fifteen patients were resistant to MTX-CF, or relapsed subsequently, but they all achieved remission with chemotherapy rescue treatment (VP 16 alone, EMA/CO, CHAMOCA). Two patients required a pulmonary lobectomy. They are all still alive in biochemical remission with a median survival of 54 months. Our experience suggests that drug resistance and relapse rate seem related to a beta-HCG value higher than 10(4), an enlarged uterus with myometrial deep involvement, and a histologically confirmed diagnosis of choriocarcinoma. In conclusion, the MTX-CF combination is effective in postmolar GTT, whereas a different therapeutic approach may be considered for a "special" low-risk group of patients, on the basis of prognostic factors.     

Ovarian sex cord tumor with annular tubules

A pathologic study was done on four cases of ovarian sex cord tumor with annular tubules. All four tumors occurred in young women (11-24 years of age) and were not associated with the Peutz-Jeghers syndrome. Two patients had evidence of hyperestrinism. One patient who had metastasis to the retroperitoneum, left supraclavicular lymph node, and liver confirmed the malignant potential of this tumor. Gross examination revealed tumors that were solid, yellowish, and unilateral, with varying degrees of cystic degeneration. Microscopic examination showed simple or complex annular tubules with prominent basement membranes. Many tumor cells contained lipid in the cytoplasm. Ultrastructural study showed Charcot-Bottcher filaments in all four cases, indicating Sertoli cell differentiation. True lumens and microvilli were identified in one case. The classification of the sex cord tumor with annular tubules as a Sertoli cell tumor, annular tubular type was proposed on the basis of ultrastructural findings.     

Ovarian endodermal sinus tumor with intestinal differentiation

A 12-year-old girl was admitted to the hospital for evaluation of an abdominal mass. A preoperative computed tomography scan showed a large tumor in the pelvis. The serum alpha-fetoprotein level was 2,170,000 ng/ml. A 3000-g left ovarian neoplasm was resected. It was encapsulated and showed focal microcystic degeneration, necrosis, and hemorrhage. Microscopically, it was composed of gland-like spaces containing mucin-positive material and surrounded by scant fibrovascular tissue. The epithelial cells were low columnar with immature oval, basophilic nuclei. Immunoperoxidase staining for alpha-fetoprotein and alpha1-antitrypsin were positive. Enzyme histochemistry was negative for alkaline phosphatase and positive for alpha-naphthyl acetate esterase. Electron microscopy, including freeze-fracture analysis, showed desmosomes and tight junctions. No gap junctions were identified. Actin filaments, glycogen, and microvilli were abundant. This is the first case of an ovarian endodermal sinus tumor with exclusive enteric differentiation.     

CD10在卵巢黏液性肿瘤间质细胞中的表达与肿瘤进展的关系

目的 观察CD10在卵巢黏液性囊腺瘤(Mucinous adenoma,MA)、黏液性交界性肿瘤(Mucinous borderline tumor,MB)和黏液性腺癌(Mucinous adenocarcinoma,MC)间质细胞中的表达,探讨CD10在卵巢黏液性肿瘤(Ovarian mucinous tumor,OMT)恶性进展中的作用及意义。方法 选用明确诊断的OMT标本156例,其中包括42例MA、72例MB和42例MC,同时选取20例正常卵巢组织标本。应用免疫组织化学方法对其进行CD10抗体标记并分析其表达情况。结果 CD10在20例正常卵巢组织中呈阴性表达;CD10在42例MA中,28例阴性,14例阳性;72例MB中,18例阴性,54例阳性;42例MC间质中,全部呈阳性。CD10在MA-MB-MC间质细胞中阳性表达率逐渐升高(33.3%、75%、100%,P＜0.0001)。结论 CD10在卵巢黏液性肿瘤间质的高表达与肿瘤进展密切相关。