甲钻胺对64例突发性耳聋患者耳鸣症状的疗效观察

目的观察甲钴胺对改善突发性耳聋患者耳鸣症状的疗效。方法运用前瞻分组对照研究的方法,取发病7d内就诊且伴有耳鸣的突发性耳聋患者64例,按就诊先后顺序分为治疗组及对照组,两组均应用东菱克栓酶（DF-521）、丹参、地塞米松、辅酶A等常规药物治疗,治疗组加用甲钴胺注射液500μg肌注1次／d;对照组加用生理盐水注射液10ml肌注1次／d。10d为1个疗程,治疗2个疗程。疗程结束1个月后观察患耳耳鸣恢复情况。结果治疗组耳呜恢复有效率为52．9％;对照组有效率为26．7％,差异有统计学意义（P＜0．05）。结论甲钴胺对改善突发性耳聋患者的耳鸣症状有明显效果。     

甲钴胺对64例突发性耳聋患者耳鸣症状的疗效观察

目的观察甲钴胺对改善突发性耳聋患者耳鸣症状的疗效。方法运用前瞻分组对照研究的方法,取发病7 d内就诊且伴有耳鸣的突发性耳聋患者64例,按就诊先后顺序分为治疗组及对照组,两组均应用东菱克栓酶(DF-521)、丹参、地塞米松、辅酶A等常规药物治疗,治疗组加用甲钴胺注射液500μg肌注1次/d;对照组加用生理盐水注射液10 ml肌注1次/d。10 d为1个疗程,治疗2个疗程。疗程结束1个月后观察患耳耳鸣恢复情况。结果治疗组耳鸣恢复有效率为52.9%;对照组有效率为26.7%,差异有统计学意义(P<0.05)。结论甲钴胺对改善突发性耳聋患者的耳鸣症状有明显效果。     

鼓膜鼓室内穿刺注射地塞米松治疗突发性耳聋

目的：对在鼓膜鼓室内注射地塞米松治疗突发性耳聋疗效的探讨研究。方法对收住院的50名突发性耳聋患者，随机分为观察组，对照组，观察组采取在鼓室内注射地塞米松治疗突发性耳聋，对照组采取常规静脉注射地塞米松治疗突发性耳聋，对观察组与对照组治疗效果给予对比研究。结果比较差异有统计学意义（P＜0．05）。结论在鼓室内注射地塞米松治疗突发性耳聋的效果明显优于常规静脉注射地塞米松治疗突发性耳聋，并且副作用少，临床值得推广。     

半植入式微管跨膜控释给药治疗梅尼埃病的研究

目的探讨半植入式微管跨膜控释给药对梅尼埃病的治疗效果。方法经临床确诊的6例梅尼埃病患者接受微管给药治疗(美国耳鼻喉学会标准)。患者年龄34～72岁,男性5例、女性1例;病程为9个月到20年,患耳的听力均为4级(听阈70 dB以上),术前6个月内平均每个月发作眩晕1～2次。在耳显微镜下向患者鼓室植入IntraEAR微管(美国Durect公司),微管的一端位于圆窗龛,另一端与体外控释泵连接,以50μl/h的速度释放庆大霉素工作液(2 mg/ml)。每天给药3 h,7～10 d后拨管结束治疗。结果治疗期间6例均未出现眩晕,但其中1例出现耳鸣增强。随访1～14个月,除1例失访外,其余5例在眩晕、听力及耳鸣方面都有不同程度的改善。5例中,3例发作性眩晕的程度较术前明显减轻;2例术后未发作眩晕。1例治疗期间耳鸣增强的至随访14个月时,耳鸣程度较术前明显减轻。1例复查前庭功能有改善。结论应用半植入式微管小剂量低流速跨圆窗膜控释给药能够有效控制或减轻梅尼埃病的眩晕,是治疗顽固性梅尼埃病的一种安全、有效的手段。     

银杏叶提取物治疗突发性耳聋效果观察

目的:观察银杏叶提取物(金纳多)治疗突发性耳聋的临床疗效。方法:将突发性耳聋66例(67耳),随机分为观察组30例(30耳),采用金纳多静脉滴注;对照组36例(37耳)采用盐酸丁咯地尔静脉滴注,10天为一疗程。比较2组听力、耳鸣、眩晕的疗效。结果:2组纯音测听检查气、骨导均有明显提高,与治疗前比较,差异显著(P<0.05);观察组有效率86.7%,对照组有效率77.8%,差异不显著(P>0.05);观察组耳鸣改善有效率88.8%,对照组60.0%,差异显著(P<0.05);观察组改善眩晕程度明显优于对照组(P<0.05)。结论:金纳多治疗突发性耳聋疗效好,且无明显不良反应。     

免疫球蛋白治疗EB病毒感染的临床疗效观察

目的考察人免疫球蛋白联合阿糖腺苷和甲强龙治疗EB病毒感染的临床疗效。方法将100例EB病毒感染患者随机分为研究组和对照组,每组各50例。对照组给予阿糖腺苷和甲强龙治疗,研究组给予人免疫球蛋白联合单磷酸阿糖腺苷和甲强龙治疗。比较两组的病毒转阴率和治疗前后的症状总积分。结果研究组病毒转阴率为82.0%,对照组为50.0%,两组存在统计学差异（P〈0.01）;治疗前研究组和对照组的症状总积分分别为（12.3±9.4）和（10.9±7.0）分,两组无统计学差异（P〉0.05）,治疗后研究组和对照组的症状总积分分别为（3.9±3.3）和（6.1±4.8）分,两组存在统计学差异（P〈0.05）。结论人免疫球蛋白联合阿糖腺苷和甲强龙治疗EB病毒感染安全、有效,具有临床应用价值。     

甲强龙与氢化可的松琥珀酸钠治疗支气管哮喘急性发作期的早期疗效观察

目的比较甲强龙与氢化可的松琥珀酸钠治疗支气管哮喘急性发作期的早期疗效。方法将40例重度支气管哮喘患者分为两组,甲强龙组与氢化可的松组,各20例。甲强龙组给予静脉滴注甲强龙40mgq12h,氢化可的松组给予氢化可的松琥珀酸钠200mgq12h治疗,观察3天,并比较疗效。结果甲强龙组总有效率为95％,氢化可的松琥珀酸钠（氢考）组总有效率为80％,两组比较无显著差异,P〉0．05。结论甲强龙与氢化可的松琥珀酸钠早期疗效无显著差异。     

高压氧联合常规药物治疗突性耳聋的疗效观察

目的：探讨提高突发性耳聋疗效的方法。方法：将突发性耳聋病例分为两组,高压氧联合常规药物治疗组３０例,常规药物对照组２８例,结果：临床总有效率分别为９０％、４６．４％,两组差异显（Ｐ〈０．００５）,治疗中未发生并发症,结论：高压氧联合常规药物治疗突发性聋可明显提高疗效,且具有较高的安全性。     

氯己定贴膜治疗中耳炎、外耳道炎50例

近年来，我们采用氯己定口腔溃疡膜（西安康华制药厂生产）治疗急、慢性中耳炎、外耳道炎、外耳道疖50例，获得较好疗效。1临床资料1．1一般情况本组50例（58耳），男38例，女12例；年龄5～67岁，平均25．6岁。右侧18耳，左侧40耳。急性化脓性中耳炎36耳，慢性化脓性中耳炎12耳，急性外耳道炎7耳，外耳道疖3耳。1．2治疗方法（1）将外耳道用过氧化氢清洗干净，将溃疡膜用过氧化氢湿润后置入炎性区域或疖部位；（2）对外耳道炎则将膜贴敷于耳道壁充血最明显处；（3）对中耳炎尽可能将药膜贴敷于鼓膜缘，有鼓膜穿孔则靠近穿孔线贴敷。通常情况…     

舒血宁治疗突发性耳聋的疗效观察

突发性耳聋是耳鼻咽喉科的常见急症之一，常有耳鸣，部分患者且有眩晕、恶心、呕吐及耳闷胀感。突发性耳聋的病因至今不明，发病机制不清。因此，临床治疗方法较多，但疗效不确定。从2003年8月-2004年8月，应用舒血宁治疗突发性耳聋患者40例(44耳)，取得了较好疗效。现报道如下。     

Knee injury and Osteoarthritis Outcome Score (KOOS) - validation of a Swedish version

The Knee injury and Osteoarthritis Outcome Score (KOOS) is a self-administered instrument measuring outcome after knee injury at impairment, disability, and handicap level in five subscales. Reliability, validity, and responsiveness of a Swedish version was assessed in 142 patients who underwent arthroscopy because of injury to the menisci, anterior cruciate ligament, or cartilage of the knee. The clinimetric properties were found to be good and comparable to the American version of the KOOS. Comparison to the Short Form-36 and the Lysholm knee scoring scale revealed expected correlations and construct validity. Item by item, symptoms and functional limitations were compared between diagnostic groups. High responsiveness was found three months after arthroscopic partial meniscectomy for all subscales but Activities of Daily Living.     

The acutely limping child

Acute limping may be the result of multiple pathologies in children. The differential diagnosis varies based on the age of the child. Irrespective of age, the initial imaging work-up includes AP and frog leg radiographs of the pelvis and ultrasound; MRI may sometimes be helpful. In children less than 3 years, infections and trauma are most frequent. MRI is the imaging modality of choice when osteomyelitis is clinically suspected. Between the ages of 3 and 10 years, transient synovitis of the hip and Legg-Calvé-Perthes disease are main considerations but infection, inflammation and focal bony lesions are also considered. In children over 10 years, slipped capital femoral epiphysis also is considered.     

Do Balance Board Training Programs Reduce the Risk of Ankle Sprains in Athletes?

Introduction Ankle sprains are the most common musculo-skeletal injury that occurs in athletes,particularly in sports that require jumping and landing on one foot such as soccer,and basketball(1-4).These injuries often result in significant time loss from participation,long-term disability,and have a major impact on health care costs and resources(5-8).     

High Intensity Interval Training:New Insights

KEY POINTS ·High-intensity interval training(HIT)is characterized by repeated sessions of relatively brief，intermittent exercise.often performed with an“a11 out”effort or at an intensity close to that which elicits peak oxygen uptake(i.e.，≥90%of VO2 peak).     

Endovascular management of carotid-cavernous fistulas

Objective To investigate endovascular treatment of traumatic direct carotid-cavernous fistulas （CCF） and their complications such as pseudoaneurysms. Methods： Over a five-year period, 22 patients with traumatic direct CCFs were treated endovascularly in our institution. Thirteen patients were treated once with the result of CCF occluded, 8 twice and 1 three times. Treatment modalities included balloon occlusion of the CCF, sacrifice of the ipsilateral internal carotid artery with detachable balloon, coll embolization of the cavernous sinus and secondary pseudoaneurysms, and covered-stem management of the pseudoaneurysms. Results All the direct CCFs were successfully managed endovascularly. Four patients developed a pseudoaneurysm after the occlusion of the CCF with an incidence of pseudoaneurysm formation of 18.2% （4/22）. A total number of 8 patients experienced permanent occlusion of the ICA with a rate of ICA occlusion reaching 36.4% （8/22）. Followed up through telephone consultation from 6 months to 5 years, all did well with no recurrence of CCF symptoms and signs. Conclusion Traumatic direct CCFs can be successfully managed with endovascular means. The pseudoaneurysms secondary to the occlusion of the CCFs can be occluded with stent-assisted coiling and implantation of covered stents.     

Developmental validation of the PowerPlex(®) ESI 16 and PowerPlex(®) ESI 17 Systems: STR multiplexes for the new European standard

In response to the ENFSI and EDNAP groups’ call for new STR multiplexes for Europe, Promega^® developed a suite of four new DNA profiling kits. This paper describes the developmental validation study performed on the PowerPlex^® ESI 16 (European Standard Investigator 16) and the PowerPlex^® ESI 17 Systems. The PowerPlex^® ESI 16 System combines the 11 loci compatible with the UK National DNA Database^®, contained within the AmpFlSTR^® SGM Plus^® PCR Amplification Kit, with five additional loci: D2S441, D10S1248, D22S1045, D1S1656 and D12S391. The multiplex was designed to reduce the amplicon size of the loci found in the AmpFlSTR^® SGM Plus^® kit. This design facilitates increased robustness and amplification success for the loci used in the national DNA databases created in many countries, when analyzing degraded DNA samples. The PowerPlex^® ESI 17 System amplifies the same loci as the PowerPlex^® ESI 16 System, but with the addition of a primer pair for the SE33 locus. Tests were designed to address the developmental validation guidelines issued by the Scientific Working Group on DNA Analysis Methods (SWGDAM), and those of the DNA Advisory Board (DAB). Samples processed include DNA mixtures, PCR reactions spiked with inhibitors, a sensitivity series, and 306 United Kingdom donor samples to determine concordance with data generated with the AmpFlSTR^® SGM Plus^® kit. Allele frequencies from 242 white Caucasian samples collected in the United Kingdom are also presented. The PowerPlex^® ESI 16 and ESI 17 Systems are robust and sensitive tools, suitable for the analysis of forensic DNA samples. Full profiles were routinely observed with 62.5 pg of a fully heterozygous single source DNA template. This high level of sensitivity was found to impact on mixture analyses, where 54–86% of unique minor contributor alleles were routinely observed in a 1:19 mixture ratio. Improved sensitivity combined with the robustness afforded by smaller amplicons has substantially improved the quantity of data obtained from degraded samples, and the improved chemistry confers exceptional tolerance to high levels of laboratory prepared inhibitors.     

Bronchial stump fistula :treatment with covered retrievable hinged metallic stents-preliminary clinical experience

Objective To evaluate the preliminaily clinical efficacy and retrievability of a retrievable hinged covered metallic stent in the treatment of the bronchial stump fistula （BSF）. Methods Between April 2003 and March 2005, 8 patients with bronchial stump fistula after pneumonectomy or lobectomy were treated with two types （A and B） of retrievable hinged covered metallic stents. Type A stent was placed in 6 patients and type B in 2 under fluoroscopic guidance. The stent was removed with a retrieval set when BSF was healed or complications occurred. Results Stent placement in the bronchial tree was technically successful in all patients, without procedure-related complications. Immediate closure of the BSF was achieved in all patients after the procedure. Stents were removed from all patients but one. Removal of the stents was difficult in two patients due to tissue hyperplasia. Patients were followed up for 6 - 21 months. Placement of the stents remained stable in all patients except one due to severe cough. Permanent closure of BSF was achieved in 7 （87.5%） of 8 patients. Conclusion Use of a retrievable hinged covered expandable metallic stent is a simple, safe, and effective procedure for closure of the BSF. Retrieval of the stent seems to be feasible. （J Intervent Radiol, 2007, 16： 253-257）     

Prevalence and severity of hip and groin pain in sub‐elite male football: a cross‐sectional cohort study of 695 players

The purpose of this study was twofold: (a) to investigate the prevalence of hip and groin pain in sub‐elite male adult football in Denmark and (b) to explore the association between prevalence and duration of hip and groin pain in the previous season with the Copenhagen Hip and Groin Outcome Score (HAGOS) in the beginning of the new season. In total 695 respondents from 40 teams (Division 1–4) were included. Players completed in the beginning of the new season (July–Sept 2011) a self‐reported paper questionnaire on hip and/or groin pain during the previous season and HAGOS. In total 49% (95% CI: 45–52%) reported hip and/or groin pain during the previous season. Of these, 31% (95% CI: 26–36%) reported pain for >6 weeks. Players with the longest duration of pain during the previous season had the lowest HAGOS scores, when assessed at the beginning of the new season, P < 0.001. This study documents that half of sub‐elite male adult football players report pain in the hip and/or groin during a football season. The football players with the longest duration of pain in previous season displayed the lowest HAGOS scores in the beginning of the new season.