A histomorphometric study of alveolar bone modeling and remodeling under experimental anaemia and polycythaemia in rats

Alveolar bone is the least stable of the periodontal tissues, because it is subjected to continuous modeling and remodeling. OBJECTIVE: To perform a histological and histomorphometric evaluation of bone modeling and remodeling of periodontal alveolar bone under experimental anaemia and polycythaemia. METHODS: Thirty Wistar rats were divided into three groups: control (C), animals were i.p. injected with 0.5 mL of saline solution; anaemia (A), animals were injected with 6 mg/100 b.w. of phenylhydrazine every 48 h; polycythaemia (P), animals were transfused with 2.5 mL/100 b.w. of 80% suspension of homologous erythrocytes. All the animals were sacrificed 14 days after the onset of the experiment. The mandibles were resected, fixed in formalin, radiographed, processed and embedded in paraffin. Bucco-lingually oriented sections were obtained at the level of the mesial root of the first lower molar, and stained with hematoxylin-eosin. Histological and histomorphometric studies were performed on the buccal and lingual plates of periodontal alveolar bone. RESULTS: Histological and histomorphometric studies showed a statistically significant decrease in bone formation both in buccal and lingual plates in group A (anaemia) as compared to group C (control). An increase in active bone formation was found in the lingual plate in group P (polycythaemia) as compared to group C (control). CONCLUSION: The results obtained using this experimental model evidenced alterations in bone modeling and remodeling under conditions of anaemia and polycythaemia and/or associated factors.     

A histomorphometric study of alveolar bone modelling and remodelling in mice fed a boron-deficient diet

OBJECTIVE: Emerging evidence indicates that boron (B) plays a role in bone formation and maintenance. Thus, a study was performed to determine whether dietary B-deficiency affects periodontal alveolar bone modelling and remodelling. DESIGN: Weanling Swiss mice (n=30) were divided into three groups: control diet (GI, 3mg B/kg); B-deficient diet (GII, 0.07 mg B/kg); and pair-fed with GII (GIII). The animals were maintained on their respective diets for 9 weeks and then sacrificed. The guidelines of the NIH for the care and use of laboratory animals were observed. The mandibles were resected, fixed, decalcified in 10% EDTA and embedded in paraffin. Buccolingually oriented sections were obtained at the level of the mesial root of the first lower molar and stained with H-E. Histomorphometric studies were performed separately on the buccal and lingual sides of the periodontal alveolar bone. Percentages of osteoblast surfaces (ObSs), eroded surfaces (ESs), and quiescent surfaces (QSs) were determined. RESULTS: No statistically significant differences in food intake and body weight were observed between the groups. When compared with GI and GIII mice, GII mice (B-deficient) had 63% and 48% reductions in ObS and 58% and 73% increases in QS in buccal and lingual plates, respectively. ES were not affected by B nutriture. CONCLUSION: The results are evidence that dietary boron deprivation in mice alters periodontal alveolar bone modelling and remodelling by inhibiting bone formation.     

下颌阻生第三磨牙拔除同期植骨对第二磨牙远中牙槽骨缺损修复的影响

目的：观察下颌阻生第三磨牙拔除时,于拔牙创内同期植入自体骨混合Bio-Oss人工骨粉,对第二磨牙远中牙槽骨缺损修复的影响。方法：术前根据下颌第三磨牙与第二磨牙的位置,预估下颌阻生牙拔除后,第二磨牙发生远中骨组织缺损的风险,分为低、中、高风险3组。在中、高风险组中再根据是否在术中行同期植骨,分为植骨组与不植骨组,术后1、6个月进行复查,剔除术后感染及失访病例后,植骨组（A组）共计36例,不植骨组（B组）共计45例。术后复查指标包括患者主观感觉,第二磨牙远中探诊深度,曲面体层片观察第二磨牙远中牙槽骨高度变化。数据采用SPSS 19.0软件包进行t检验。结果：术后6个月中风险组中,植骨组第二磨牙远中主观感觉冷热刺激不适者0例,不植骨组中为6例,差异有统计学意义（P<0.05）。第二磨牙远中牙周探诊深度植骨组为（2.93±0.34）mm,不植骨组为（2.95±0.50）mm,差异无统计学意义（P=0.931）。X线片检查第二磨牙远中牙槽骨高度增量Δh植骨组为（3.31±1.02）mm,不植骨组为（3.10±1.72）mm,差异有统计学意义（P=0.749）。高风险组中,植骨组第二磨牙远中主观感觉冷热刺激不适者4例,不植骨组为10例,差异有统计学意义（P<0.05）。第二磨牙远中牙周探诊深度植骨组为（3.08±0.37）mm,不植骨组为（3.24±0.41）mm,差异无统计学意义（P=0.162）。X线片检查第二磨牙远中牙槽骨高度增量Δh植骨组为（5.21±1.79）mm,不植骨组为（2.99±2.42）mm,差异有统计学意义（P<0.001）。结论：术前对阻生牙拔除后第二磨牙远中骨组织缺损进行风险分型,有助于判断术中是否需要植骨。在牙槽骨缺损较多的情况下（高风险型）,于拔牙创内同期植入自体骨混合Bio-Oss人工骨粉,对第二磨牙远中牙槽骨高度的恢复促进作用更显著,并且能够减少第二磨牙因远中牙根暴露所致的不适。     

不同牙槽骨高度的磨牙压低时牙周膜应力分析

目的：通过建立具有不同牙槽骨高度的上颌第一磨牙三维有限元模型,在压力载荷下,计算分析其牙周膜应力的大小和分布,为正畸治疗提供力学参考。方法：采用CT对上颌第一磨牙进行扫描,建立牙槽骨发生不均衡水平吸收的上颌第一磨牙的三维有限元数字模型,计算加载垂直向的压低力时,牙周膜应力的大小和分布。结果：当牙槽骨从正常高度降低3.5 mm时,加载产生的牙周膜应力增加平缓,高应力集中部位在根分叉处;而牙槽骨降低超过6.0 mm,根分叉部分暴露时,牙周膜应力明显增加,应力集中的部位转移至根尖及根1/3处。结论：当牙槽骨高度降低未超过6 mm时(牙槽骨吸收未超过根长的48%),应根据牙槽骨的丧失程度来减小矫治力值;当牙槽骨高度降低6 mm以上时(牙槽骨吸收超过根长48%),磨牙的根分叉完全暴露,则应显著减小矫治力值。     

Histomorphometric study on the effects of age on orthodontic tooth movement and alveolar bone turnover in rats

The aim of this study was to investigate, in a rat model, the effects of age on the amount of tooth movement and concomitant changes in alveolar bone turnover activity adjacent to orthodontically treated tooth roots. Rats (n = 48) of four different age groups (10, 30, 50, and 80 wk of age) were used in the experiment. Maxillary first molars were tipped mesially with a nickel titanium alloy coil-spring for 2 wk by a continuous force of 10 cN. Forty-eight age-matched untreated rats were used as controls. The changes in alveolar bone turnover were assessed histomorphometrically. Two weeks after the start of tooth movement, the amount of tooth movement was found to decrease with age and was significantly different among the four age groups. The histomorphometric study demonstrated that, in all experimental groups, turnover of alveolar bone increased significantly compared with that of each age-matched untreated group. However, the rate of increase decreased in an age-related manner. These results suggest that the age-dependent decrease in alveolar bone turnover activity, in response to mechanical forces, may negatively affect the amount of tooth movement.     

Morphometric evaluation of changes in the alveolar bone and roots of the maxillary anterior teeth before and after en masse retraction using cone-beam computed tomography

Objective:To evaluate the morphometric changes in the alveolar bone and roots of the maxillary anterior teeth (MXAT) after en masse retraction with maximum anchorage (EMR-MA).Materials and Methods:The samples consisted of 37 female adult patients who had Class I dentoalveolar protrusion (CI-DAP) and were treated by extraction of the first premolars and EMR-MA. Using three-dimensional cone-beam computed tomography taken before treatment and after space closure, the maxillary central incisors (MXCI, N  =  66), lateral incisors (MXLI, N  =  69), and canines (MXC, N  =  69) were superimposed using individual reference planes. After alveolar bone area (ABA), vertical bone level (VBL), root length (RL), root area (RA), and prevalence of dehiscence (PD) were measured at the cervical, middle, and apical levels, statistical analyses were performed.Results:On the palatal side, ABA significantly decreased in all levels of MXAT (P < .001; middle of MXC, P < .01). MXCI and MXLI exhibited a greater decrease in the ratio of change in palatal ABA than did MXC (cervical, P < .01; middle and apical, P < .05; total, P < .001). Palatal/labial ABA ratios decreased in MXCI (cervical, middle, total, P < .001; apical, P < .05) and MXLI (cervical, P < .001; apical, P < .05). They showed greater amounts and ratios of change in VBL on the palatal side compared to the labial side (all P < .001). The palatal side showed more PD in the cervical area than did the labial side (MXCI and MXLI, P < .001; MXC, P < .01). Significant root resorption occurred in MXAT (RL and RA, all P < .001).Conclusions:During EMR-MA in cases with CI-DAP, ABA and VBL on the palatal side and RL and RA of MXCI and MXLI were significantly decreased.     

环形骨块内嵌式窦底提升与常规上颌窦外提升术式的比较研究

目的：探讨牙槽嵴顶入路环形骨块内嵌式窦底提升与常规上颌窦外提升术式的优缺点。方法将骨量严重缺失（窦嵴距离≤4 mm）患者80例共120个上颌窦,随机分为2组,每组60个上颌窦。分别通过牙槽嵴顶入路（牙槽嵴顶入路组）和上颌侧壁开窗入路（上颌侧壁开窗入路组）2种不同入路途径进行上颌窦底提升植骨。半年后植入种植体,植入种植体半年后行永久修复。比较2组上颌窦窦膜穿孔情况、手术时间、患者痛苦指数、上颌窦底提升高度。结果牙槽嵴顶入路组术后无一例出现鼻孔流血现象,窦膜穿孔率为0,上颌侧壁开窗入路组有2例术后鼻孔少量流血,窦膜穿孔率为3.33%;牙槽嵴顶入路组手术时间为（42.82±3.46） min,明显少于上颌侧壁开窗入路组的（88.38±4.37）min,差异具有统计学意义（t=35.237,P=0.001）;牙槽嵴顶入路组痛苦指数4.20±0.68,低于上颌侧壁开窗入路组6.34±0.45,2组差异具有统计学意义（t=3.056,P=0.003）;牙槽嵴顶入路组平均提升高度为（12.44±2.48）mm,上颌侧壁开窗入路组平均提升高度为（12.28±2.87）mm,2组差异无统计学意义（t=0.908,P=0.390）;牙槽嵴顶入路组种植牙成功率为100%,上颌侧壁开窗入路组为99.03%（102/103）。结论牙槽嵴顶入路环形骨块内嵌式窦底提升术式相比常规上颌窦外提升术式手术时间明显缩小,患者痛苦指数明显减少,并发症少;而在上颌窦底提升高度、种植牙成功率及窦膜穿孔率方面2组无明显差异。     

上前牙矢状面牙根位置分类及唇侧骨板厚度的CBCT研究

目的 应用锥形束CT（CBCT）对上颌前牙矢状面牙根在牙槽骨中的解剖位置进行分类,并测量其唇侧骨板厚度,为上颌前牙即刻种植修复治疗提供影像学研究数据。方法 回顾性筛选出200名患者的CBCT影像,其中男性80名,女性120名。CBCT矢状面影像中,上前牙牙根在牙槽骨中的位置分为4类,并且测量其唇侧牙槽嵴顶下1.5 mm处唇侧骨板的厚度。结果 中切牙4种分类的发生率分别为I类80.5%、Ⅱ类7.5%、Ⅲ类1%以及Ⅳ类11%,侧切牙的发生率分别为I类72%、Ⅱ类11.5%、Ⅲ类1%以及Ⅳ类15.5%,尖牙的发生率分别为I类82%、Ⅱ类9.5%、Ⅲ类0%以及Ⅳ类8.5%。中切牙唇侧骨板平均厚度男性为（1.10±0.26）mm、女性为（0.98±0.19）mm,侧切牙唇侧骨板平均厚度男性为（0.87±0.20）mm、女性为（0.83±0.20）mm,尖牙唇侧骨板平均厚度男性为（1.18±0.35）mm、女性为（1.04±0.25）mm。除侧切牙外,中切牙和尖牙唇侧骨板厚度男性均大于女性,且差异具有统计学意义。结论 上前牙矢状面牙根位置的影像学分类研究对该区域患牙即刻种植修复治疗手术有导向性意义,并且上前牙牙槽嵴顶下1.5 mm处唇侧骨板菲薄,即刻种植修复前应结合以上两点进行详细评估。     

青少年正畸上颌切牙不同内收方式对牙槽骨形态的影响

目的: 探讨青少年正畸上颌切牙不同内收方式对牙槽骨形态的影响。方法: 收集2018年6月—2019年6月福建医科大学附属协和医院收治的颌骨前突畸形82例患者的328颗上颌切牙,135颗切牙纳入倾斜内收组,193颗切牙纳入控根内收组。拍摄锥形束 CT（CBCT）,测量患者上颌切牙内收情况及牙槽骨高度、厚度、骨密度变化。采用SPSS 18.0软件包对数据进行统计学分析。结果: 倾斜内收组治疗后上颌切牙切缘至腭中垂面长度（IE-MP）、上颌切牙长轴与腭平面后下角（LAI-PP）变化值显著大于控根内收组（P<0.05）,倾斜内收组上颌切牙根尖至腭中垂面长度（RA-MP）变化值显著小于控根内收组（P<0.05）。倾斜内收组治疗后L1、L2、L3、P1、T1显著低于治疗前（P<0.05）,治疗后P2、P3、T2、T3显著高于治疗前（P<0.05）;控根内收组治疗后L1、L2、L3显著高于治疗前（P<0.05）,治疗后P1、P2、P3、T1、T2、T3显著低于治疗前（P<0.05）;倾斜内收组治疗前、治疗后的L2、L3、P3、T3变化量显著高于控根内收组（P<0.05）,倾斜内收组治疗前、治疗后的L1、P1、P2、T1、T2变化量显著低于控根内收组（P<0.05）。2组治疗前、治疗后6个月的上、下颌牙槽骨骨密度相比,差异无统计学意义（P>0.05）。结论: 青少年上颌切牙大范围内收时,倾斜内收组唇侧根尖区、腭侧牙槽嵴区及控根内收组腭侧牙根颈部均为牙槽骨吸收高风险区。     

Effect of streptozotocin-induced diabetes mellitus on alveolar bone deposition in the rat

Effects of diabetes on alveolar bone remodelling were assessed by quantitative histology and a chronological lead-labelling technique. Experimental diabetes was induced by a single dose of 40 mg/kg of streptozotocin. Remodelling of the alveolar wall surrounding the root of mandibular first molar was studied in control rats fed ad libitum, and in diabetic and insulin-treated diabetic rats 24 days after the induction of diabetes. The volumes of bone formation on the mesial side of the alveolar wall were evaluated over a 10-day period by chronological lead-labelling and computer image analysis. For a histometric measure of bone-resorption, the number of osteoclasts along the distal surface of the alveolar wall was counted. The volume of bone formed and the number of osteoclasts were significantly lower in the diabetic rats than in the controls, but insulin treatment of diabetic rats normalised these histomorphometric measures of bone turnover. These results demonstrate that streptozotocin-induced diabetes mellitus reduces the rate of bone turnover in the alveolar wall surrounding the root, which reduction is corrected by treatment with insulin.     

正畸拔牙矫治前后上颌牙槽骨改建的初步研究

目的 通过正畸拔牙治疗前后上颌骨三维重建和配准研究,确定上颌前牙区牙槽骨在正畸治疗前后的改建情况.方法 选择15例拔牙治疗病例治疗前后CBCT为研究样本,用mimics10.0进行三维重建,采用上颌骨双颧部重叠法用rapidform 2006软件对治疗前后上颌骨进行配准并进行全局偏差检测,从而研究上颌前牙区牙槽骨改建情况.结果 上颌牙槽骨大部分区域配准偏差在0-0.50mm,极少部分可见橘色或红色区域配准偏差达1.5-2.0mm;腭侧牙槽骨则大部分为蓝色,其中穿插少部分浅绿色配准偏差约0.6mm之内.配准全局偏差结果显示15名患者治疗前后上颌骨配准平均距离在0.50mm之内.结论 生长发育结束的患者正畸拔牙治疗前后上颌牙槽骨改建大多在0.50mm之内,唇侧牙槽骨改建较多,腭侧改建相对较少.     

双侧上颌磨牙区对称性多生牙2例

报道2例罕见双侧磨牙区对称性多生牙的病例,并对相关文献进行回顾.     

MTA与PRF在上颌前牙拔牙患者牙槽骨再生中的应用效果评价

目的：评价骨替代物矿物三氧化物骨料（MTA）与自体富血小板纤维蛋白（PRF）用于上颌前牙拔牙患者牙槽骨再生的效果。方法：选择2017年1月—2019年12月杭州口腔医院收治的上颌前牙拔牙患者66例,根据填塞材料分为MTA组、PRF组、联合组（MTA+PRF）,每组各22例。获取术前和术后1、3、6、12个月的锥形束CT(CBCT)图像,比较3组患者损伤组织愈合、牙槽骨密度和牙槽骨体积。采用SPSS 21.0软件包对数据进行统计学分析。结果：66例患者中,61例获得完整随访记录,随访率为92.42%,其中MTA组、PRF组、联合组分别为20例、20例、21例。3组患者术后3、6、12个月的牙槽骨密度显著高于术前（P<0.05）。联合组术后6、12个月的牙槽骨密度显著高于MTA组和PRF组（P<0.05）,MTA组术后6、12个月的牙槽骨密度显著高于PRF组（P<0.05）。3组患者术后3、6、12个月的牙槽骨体积显著低于术前（P<0.05）,联合组术后6个月、12个月的牙槽骨体积显著低于PRF组（P<0.05）。结论：MTA单独用于上颌前牙拔牙患者牙槽骨修复...     

Decreased alveolar bone turnover is related to the occurrence of root resorption during experimental tooth movement in dogs

Objective:To investigate the relationship between root resorption (RR) and bone turnover in two different types of tooth movement in dogs.Materials and Methods:A total of 16 dogs in two different groups were used. Tooth movement of dog premolars resulted from approximately 200 g of force. Histomorphometric analysis of premolar roots was assessed after 4 and 12 weeks of tooth movement by comparing nonresorptive to resorptive surfaces.Results:Histomorphometric analysis indicated a significant decrease in the bone formation rate in the root resorptive areas, which resulted in decreased bone volume after 12 weeks. The threshold to detect RR in periapical radiographs was about 1.0 mm².Conclusions:A sustained mechanical load, due to the prolonged stress and strain of continuous mechanics, induces elevated bone metabolic activity, such as the bone turnover (remodeling) and change in bone volume (modeling). Therefore, our data support the hypothesis that increased RR is related to decreased bone formation (turnover) in high stress areas exposed to prolonged orthodontic tooth movement.     

生长因子在牙槽骨组织再生中的应用与研究进展

实现牙槽骨组织再生是口腔医学领域的热门研究方向。许多国内外研究表明,生长因子在牙槽骨组织再生中起到重要作用,无论是在口腔种植,牙周治疗,还是拔牙位点保存等多个领域均有广阔的应用前景。本文对生长因子在口腔领域中促进牙槽骨组织再生的应用及研究进展进行综述。     

拔牙后牙槽骨愈合速度及骨密度变化的横向研究

目的：探讨性别差异对拔牙创牙槽骨愈合速度的影响。方法：采用双能Ｘ线吸收法测量不同年龄组的男性、女性拔牙后的牙槽骨骨密度。结果：３５～５４岁之间,男性与女性之间牙槽骨骨密度值无显著差异,而牙槽骨愈合速度有一定差异;５５～６４岁年组男性牙槽骨骨密度值高于女性。结论：年龄、性别对牙槽骨骨密度变化有显著影响,随着年龄的增长,男性牙槽骨愈合速度高于女性。     

A clinical and histomorphometric study of calcium sulfate compared with freeze-dried bone allograft for alveolar ridge preservation

Background: Many materials have been found to be effective in ridge preservation. The purpose of this study is to determine whether calcium sulfate (CS) is as effective as freeze‐dried bone allograft (FDBA) in preserving postextraction ridge dimensions and to evaluate the amount of new bone formation and graft clearance through histologic analysis. Methods: Thirty‐one extraction sites were selected. Postextraction clinical measurements were made, and sites were divided randomly into the test group (CS) or the control group (FDBA). After graft placement, all individuals received the same postoperative treatment and instructions. Participants were recalled after 3 months, measurements were made, and sites were re‐entered. Bone samples were harvested and analyzed with histologic methodology for new bone formation and remaining residual graft. Results: Thirteen test and 15 control sites were evaluated. There was no significant change in vertical ridge height before or after surgery within the test and control groups (P = 0.57, P = 0.68, respectively). There was a significant decrease in bucco‐lingual ridge width for both groups (P = 0.0003, P = 0.0075, respectively), but the difference between groups was not significant (P = 0.11). Histologic analysis revealed an average of 32% new bone formation with 2.5% graft remaining for the test group and 16.7% new bone formation with 21% graft remaining for the control. Conclusions: Results indicate that CS is as effective as FDBA in preserving postextraction ridge dimensions in non‐molar extraction sites. There is greater clearance of CS with more new bone formation after ≈3 months compared with FDBA in these sites. This paper received the Maynard K. Hine Award for Excellence in Dental Research presented by the Indiana Section of the American Association for Dental Research and supported by Procter & Gamble.     

自体骨即刻移植对阻生第三磨牙拔除术后第二磨牙远中骨质缺损的疗效分析

目的探讨阻生第三磨牙拔除术后,采用自体骨即刻移植对第二磨牙远中骨质缺损的治疗效果。方法 2016年7月至12月接受阻生下颌第三磨牙拔除术的106例(106颗牙)患者,按入院顺序随机均分为观察组和对照组,各53例。2组均采用超声骨刀进行手术,术后观察组将术中所取自体骨即刻移植到第二磨牙远中骨缺损处,对照组则不植骨。对比2组手术近期效果,术前、术后1周、6个月、12个月时锥形束CT所测第二磨牙远颊角骨缺损深度(ODD),术后6个月及12个月时标准牙周探针所测第二磨牙远颊角探诊深度(PD)和临床附着水平(CAL)。结果观察组术后开口度明显低于对照组,差异有统计学意义(P<0.05),2组术后疼痛、肿胀、术后症状严重度评分对比,差异无统计学意义(P>0.05)。术后1周、6个月、12个月时观察组ODD均明显低于对照组,差异有统计学意义(P<0.05)。术后6个月及12个月时,2组PD对比,差异无统计学意义(P>0.05),观察组CAL均明显低于对照组,差异有统计学意义(P<0.05)。结论在阻生第三磨牙拔除术后,以自体骨即刻移植治疗第二磨牙远中骨质缺损,有助于修复骨缺损,且安全性较高。     

Local biochemical markers of bone turnover: relationship to subsequent density of healing alveolar bone defects

OBJECTIVES: This pilot study was designed to test whether biochemical markers of bone turnover in washes of periosteal or trabecular alveolar bone surfaces could be correlated with increases in bone density of an adjacent healing implant socket. METHODS: Ten subjects had a canula inserted into the alveolar crest and sterile phosphate-buffered saline was washed over the periosteal and trabecular surfaces and collected. Surgical flaps were reflected, 5 mm diameter bone cores were removed from the bone wash site, and standardized radiographs were taken. The sites were allowed to heal for 12 weeks, and radiographs were repeated. Bone washes of the healing sites were also collected after 2 and 12 weeks. Washes were analysed for bone turnover markers osteocalcin (OC; radioimmunoassay) and C-terminal telopeptide of Type 1 collagen (ICTP; enzyme-linked immunosorbent assay (ELISA)), and blood component albumin (ALB; ELISA). Changes in bone density during healing were determined by radiographic absorptiometry. RESULTS: OC/ALB and ICTP/ALB ratios were higher for trabecular than periosteal washes at baseline (p相似文献   

骨碎补总黄酮对骨质疏松症患者牙槽骨的影响

目的: 研究骨碎补总黄酮对合并牙列缺损或缺失的骨质疏松症患者牙槽骨高度、厚度、骨密度及牙槽嵴顶宽度的影响。方法: 将符合纳入标准的46例患者随机分为实验组和对照组,每组23例,实验组服用强骨胶囊,对照组服用阿仑膦酸钠片;于药物治疗前及治疗后1、3、6个月时分别行锥形束CT（CBCT）检查,应用Anatomage invivo 5软件测量并观察牙槽骨高度、厚度、骨密度及牙槽嵴顶宽度的变化,采用SPSS17.0软件包进行统计学分析。结果: 对照组牙槽骨颊(唇)侧皮质骨的骨密度在药物治疗后1个月时较实验组显著升高（P<0.05）,实验组牙槽骨的颊（唇）侧皮质骨骨密度在药物治疗后3个月和6个月时均较对照组显著升高（P<0.05）。对照组牙槽嵴顶宽度和牙槽骨的颊（唇）侧皮质骨厚度在药物治疗后3个月较实验组显著升高（P<0.05）,在药物治疗后6个月时,2组间差异无统计学意义（P>0.05）。不同时点实验组和对照组在基骨的颊（唇）侧皮质骨、松质骨、腭（舌）侧皮质骨的厚度变化均无显著差异（P>0.05）。结论: 骨碎补总黄酮能显著增加骨质疏松症患者牙槽骨骨密度,在增加牙槽骨的颊（唇）侧皮质骨的骨密度上较阿仑膦酸钠存在优势;骨碎补总黄酮能增加骨质疏松症患者牙槽骨的颊（唇）侧皮质骨厚度,对牙槽嵴顶宽度、牙槽骨高度影响不大。