共查询到17条相似文献,搜索用时 187 毫秒
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由于肾癌对放化疗不敏感,以IL-2和IFN为主的免疫治疗成为主要的治疗手段,但是应用高剂量IL-2和IFN所产生的严重不良反应又限制了其应用.近年来,对肾癌的生物学和分子机制的研究发现,肾透明细胞癌发病机制与VHL(Von Hippel-Lindau)、Ras和PTEN等基因的突变有关,针对这些突变基因及其信号传导途径中的多种分子靶向治疗药物相继问世,并取得了良好的效果.2008年NCCN肿瘤治疗指南已经将靶向治疗药物,Sorafenib、Sunitinib、Temsirolimus应用到晚期.肾癌的一线治疗.在欧洲Bevacizumab联合干扰素已经批准应用在晚期肾癌的一线治疗.目前几种新的药物正在进行Ⅲ期临床试验. 相似文献
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随着对肾癌发生发展过程的分子信号通路研究的不断深入,晚期肾癌的靶向治疗取得了重大进展.曾作为标准的细胞因子治疗效果不佳且有明显毒副作用,而靶向治疗已显示出在治疗晚期肾癌方面的明显优势.本文对舒尼替尼、索拉非尼、贝伐单抗、帕唑帕尼、Temsirolimus、依维莫司六种靶向药物的临床疗效,毒副作用以及对策,在贯序治疗、联合治疗和新辅助治疗方面的进展作一综述. 相似文献
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自2005年美国FDA批准索拉非尼用于晚期肾细胞癌的治疗以来,晚期肾癌的治疗疗效发生了划时代的巨变,揭开了晚期肾癌靶向治疗的序幕。近年来,治疗肾癌的靶向药物层出不穷,在过去的1年里,不仅原有的4个靶向药物(索拉非尼、索坦、贝伐单抗、替西罗莫司)临床研究继续得到关注,而且又有2个新的靶向药物得到批准。 相似文献
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肾细胞癌被认为是最难治的恶性肿瘤之一。由于对肾细胞癌分子发病机制研究的进一步深入,在晚期肾细胞的治疗中出现了一系列成功范例。在过去20年,非特异性免疫治疗被认为是晚期肾细胞癌治疗标准。近年,随着分子靶向药物的研发和临床使用,肿瘤的分子靶向治疗已成为肿瘤治疗的研究热点,同时由于对肾细胞癌进一步了解,肾细胞癌的治疗已开始转向抗-血管内皮生长因子及其相关通路研究,大量的临床研究试验,证明了分子靶向治疗在晚期肾细胞癌的疗效,其中Sorafenib(索拉非尼)和Sunitinib(舒尼替尼)分别于2005年和2006年经美国FDA批准用于晚期肾细胞癌。本文将围绕VEGF在肾细胞癌的重要性和Bevacizumab(贝伐单抗)、Sunitinib和Sorafenib治疗晚期肾细胞癌研究进展等问题进行简要阐述。 相似文献
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晚期肾癌预后差而且对放化疗抗拒,免疫治疗仅使极少部分患者受益。血管内皮生长因子(VEGF)在肾透明细胞癌过量表达,表明它可以作为一个新的靶向治疗途径。经过临床试验证实,以VEGF为靶向通路的药物在治疗肾癌方面取得令人鼓舞的效果。 相似文献
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In the past decade, progress has been made in the development of targeted therapies for advanced renal cell carcinoma (RCC).
However, as multiple therapeutic choices become available to clinicians, we currently lack effective indicators that allow
physicians to choose the best treatment option for specific patients. For approved targeted therapies, potential molecules
that could indicate drug effectiveness in a specific tumor follow naturally from both the therapeutic mechanism and the previously
elucidated tumor biology. However, in advanced RCC, the use of these molecules as biomarkers for treatment selection has shown
equivocal results and requires further investigation. In addition to looking at specific molecular targets, subclassification
of tumors based on their molecular characteristics may also allow stratification of patients based on therapeutic benefits,
providing information for treatment selection. Furthermore, the continued development of such tumor classification schemes
will hopefully uncover other molecular targets that warrant development as future RCC therapies. The use of molecular classification
of patients’ tumors for treatment selection will provide the opportunity to increase the effectiveness of currently available
therapies for advanced RCC and to judiciously pursue promising options for future RCC therapies. 相似文献
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鼻咽癌是我国华南地区常见的的恶性肿瘤之一,初诊即为晚期的达75%以上,放疗或同步放化疗是鼻咽癌重要的治疗手段,取得了较好的疗效.在调强放射治疗时代,局部晚期鼻咽癌5年局部控制率、5年生存率明显提高,但治疗效果已达瓶颈.调强放射治疗、诱导化疗、同期放化疗、抗EGFR分子靶向治疗是局部晚期鼻咽癌治疗的主要方法,联合免疫检查... 相似文献
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肿瘤关键分子靶点的异常表达(表达水平和表达状态)与分子靶向治疗反应、治疗效果及预后密切相关。因此,精准评价肿瘤关键分子表达水平和表达状态,无论在肿瘤分子靶向治疗开展前、过程中以及治疗后均显得尤为关键。分子成像可以无创、实时而全面地对肿瘤关键靶点的表达水平及表达状态进行定性、定量研究,对筛选优势人群、指导治疗、判断预后具有重大意义。本文简述基于不同分子探针的分子成像技术在肿瘤靶向治疗过程中的应用,对比分析分子成像在靶向治疗中的价值,以期有益于新型治疗策略的开发。 相似文献
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转移性肾癌的靶向治疗 总被引:1,自引:0,他引:1
转移性肾癌是一种对于传统化、放疗较不敏感的不可治愈性疾病。虽然免疫治疗对部分患者具一定疗效,但疗效通常并不持久,且治疗可能导致严重的毒副作用。随着近年来对肾癌生物学及分子发病机制的加深理解,针对使用多种靶向治疗药物治疗肾癌的研究取得了可喜的成果。无论针对初治或以往治疗失败的患者,靶向治疗均显示出高于传统治疗的优越性。此外,治疗的耐受性非常良好,并不影响患者的生存质量。本综述将依据最新的临床证据,着重围绕目前主要的治疗进展加以分别阐述,同时简单概括相关的治疗靶点信息,力求使读者在基础和临床两方面对转移性肾癌的靶向治疗获得较为深刻的认识。 相似文献
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Renal cell carcinoma is the most common tumor of the kidney. It has an unpredictable behavior and poor response to systemic therapy. Developing newer therapy for this disease is a priority considering the high recurrence rate and the small subset of patients who benefit from the use of cytokines such as interferon-alpha or interleukin-2. Identifying molecular targets and targeting various biomarkers has revolutionized the therapeutic approach to advanced and metastatic renal cell carcinoma. Although some of the antiangiogenic agents and receptor tyrosine kinase inhibitors appear promising, further understanding of their mechanism of action and the patient population who would benefit most from such agents is still being explored. As numerous targeted agents are entering the clinical investigation arena in a relatively short period of time, newer challenges in renal cell carcinoma therapeutics are emerging. Some of the future challenges in using targeted antineoplastic agents in renal cell carcinoma will include evaluating their long-term safety and benefit, using the particular drug in the appropriate patient population after appropriate stratification and studying the combination of some of these drugs for synergy or additive effects. 相似文献
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肿瘤靶向治疗新探:多靶点Raf激酶抑制剂 总被引:2,自引:1,他引:2
随着对肿瘤分子机制的加深理解,对肿瘤分子靶向治疗的研究已获重大进展。蛋白激酶抑制剂是新近研发的靶向治疗药物之一,通过阻碍细胞内分子传导通路,影响肿瘤细胞的存活、增殖以及疾病进展。在Raf/MEK/ERK信号传导通路中,Raf激酶发挥着至关重要的作用。尽管在正常组织中Raf激酶的功能尚未明朗,但现有的基础及临床研究结果均显示,Raf基因的上调及其蛋白的过度表达存在于多种实体肿瘤之中,包括肾细胞癌、肝细胞癌、黑色素瘤以及非小细胞肺癌等。索拉非尼是全球首个口服的Raf激酶抑制剂。此外,作为一个多靶点药物,索拉非尼同时具有针对包括VEGFR与PDGFR的广泛酪氨酸激酶受体抑制功能。目前美国FDA已经批准索拉非尼用于治疗转移性肾癌。另外,该药物在针对黑色素瘤、肝癌、胰腺癌以及非小细胞肺癌的临床研究中也已经显示出一定的疗效。本综述将简要说明Raf激酶在正常与肿瘤细胞中的功能以及在不同肿瘤中的作用机制,并重点介绍索拉非尼的临床应用及研究。 相似文献
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Eric A. Singer Gennady Bratslavsky W. Marston Linehan Ramaprasad Srinivasan 《Targeted oncology》2010,5(2):119-129
The treatment of advanced and metastatic kidney cancer has been revolutionized by the development of targeted systemic therapies.
Despite the growing number of available agents approved for use against clear cell renal cell carcinoma, patients with non-clear
histologies, constituting approximately 1 in 4 cases of kidney cancer, have not received the same attention. The majority
of clinical trials testing novel targeted therapies have excluded non-clear subtypes, providing limited therapeutic options
for patients with these diagnoses and their oncologists. This review will focus on the use of targeted therapies against the
non-clear histologic subtypes of renal cell carcinoma: papillary I and II, chromophobe, and collecting duct. The unique genetic
and molecular profiles of each distinct non-clear kidney cancer subtype will be described, as these differences are integral
to the development and effectiveness of the novel agents used to treat them. Trials focusing on non-clear kidney cancer, or
those that treated clear cell tumors along with significant numbers of non-clear subtypes, will be discussed. The role of
cytoreductive nephrectomy and the use of neoadjuvant and adjuvant targeted therapy will be reviewed. Lastly, areas of future
research will be highlighted. 相似文献