多囊卵巢综合征患者血浆内脂素相关研究

多囊卵巢综合征（PCOS）是妇科常见的疾病之一，是以内分泌紊乱为主、多种代谢异常导致的异质性临床综合征，是引起女性不排卵性不孕的主要原因之一。胰岛素抵抗和肥胖是PCOS的重要表现。内脂素（visfafin）是近年来发现的一种脂肪细胞因子，主要发现在脂肪细胞的细胞核和细胞质中，能够调控腹部脂肪细胞的分化和成脂作用，并能与胰岛素受体结合，调节胰岛素敏感性。通过对PCOS患者血浆内脂素水平的研究以及内脂素基因水平的探索．寻找PCOS和内脂素的关联，并可能为进一步了解PCOS的发病机制，诊断和治疗PCOS提供一个新的方向和途径。     

血浆内脂素和多囊卵巢综合征关系的研究进展

内脂素(visfatin)是新近从内脏脂肪细胞得到的一种脂肪细胞因子,主要存在于脂肪细胞的细胞核和细胞质中,可结合并激活胰岛素受体,模拟胰岛素作用,从而降低血糖;还能促进脂肪组织的分化、合成及积聚。胰岛素抵抗和肥胖是PCOS的重要表现,PCOS患者血浆内脂素水平明显高于正常妇女,内脂素mRNA及蛋白水平在内脏脂肪组织和皮下脂肪组织中也均高于正常妇女,其原因尚不清楚,但为进一步了解PCOS的发病机制、诊断和治疗提供了一个新的方向。     

血浆内脂素与多囊卵巢综合征的相关性

目的 探讨血浆内脂素与多囊卵巢综合征(PCOS)及肥胖的关系.方法 选择2008年1～6月在徐州医学院附属医院妇产科确诊为PCOS的患者70例,将PCOS组患者根据体重指数(BMI)分为肥胖者(BMI≥25)34例和非肥胖者(BMI<25)36例;选择同期就诊的非PCOS不孕患者和健康志愿者60例为对照组(肥胖者30例,非肥胖者30例).采用酶联免疫吸附法(ELISA)检测两组空腹血浆内脂素浓度,同时测定身高、体重、腰围、臀围、空腹血糖(FBS)、空腹胰岛素(FINS),计算BMI、腰臀比(WHR)、胰岛素抵抗指数(HOMA-IR).结果 PCOS组肥胖、非肥胖患者血浆内脂素[分别为(66.31±14.93)μg/L和(45.52±18.67)μg/L]明显高于对照组肥胖、非肥胖者[分别为(41.03±17.93)μg/L和(26.94±13.38)μg/L],差异有统计学意义(P<0.05);PCOS组肥胖患者血浆内脂素浓度高于非肥胖患者,差异有统计学意义(P<0.05).相关分析显示PCOS患者血浆内脂素浓度与BMI呈正相关(r=0.402,P<0.05),而与WHR、FBS、FINS、HOMA-IR无相关性.结论 PCOS患者存在高内脂素血症,内脂素水平与BMI呈正相关,提示内脂素可能参与PCOS与肥胖的发病机制.     

内脂素与多囊卵巢综合征相关研究进展

内脂素（visfatin）是近年发现的脂肪细胞因子,主要分布在脂肪细胞的细胞核和细胞质中,能调控内脏脂肪细胞的分化和成脂作用及胰岛素的敏感性。国外研究已证实,卵泡颗粒细胞分泌内脂素,其分泌水平受某些激素的影响。多囊卵巢综合征（PCOS）是一种严重影响女性生育的内分泌代谢失调性疾病,胰岛素抵抗、肥胖及生殖内分泌失调是其主要临床特征,这使内脂素与PCOS的发病机制紧密联系。综述内脂素与PCOS的相关研究。     

内脂素与多囊卵巢综合征相关研究进展

内脂素(visfatin)是近年发现的脂肪细胞因子,主要分布在脂肪细胞的细胞核和细胞质中,能调控内脏脂肪细胞的分化和成脂作用及胰岛素的敏感性.国外研究已证实,卵泡颗粒细胞分泌内脂素,其分泌水平受某些激素的影响.多囊卵巢综合征((PCOS)是一种严重影响女性生育的内分泌代谢失调性疾病,胰岛素抵抗、肥胖及生殖内分泌失调是其...     

多囊卵巢综合征患者血清ADMA和内脂素水平测定及临床意义

多囊卵巢综合征(polycystic ovary syndrome,PCOS)是一种常见的内分泌代谢性疾病.流行病学调查证实,PCOS患者发生2型糖尿病、高血压、冠心病等疾病的危险性明显升高.近年国外很多研究证实非对称性二甲基精氨酸(asymmetric dimethylarginine,ADMA)是独立的心血管疾病危险因子,与2型糖尿病、高血压、冠心病等疾病密切相关,但ADMA与PCOS的关系国内尚未见报道.为探讨PCOS患者血清ADMA水平的变化,本研究检测了PCOS患者血清ADMA、内脂素、胰岛素及血脂水平,并探讨了其相互关系.     

脂联素与胰岛素抵抗和多囊卵巢综合征

脂联素是新近发现的脂肪特异性蛋白，具有抗炎，增加胰岛素敏感性，抗动脉硬化等效应．与多种代谢性疾病的发生、发展有关。多项研究证实，肥胖人群和2型糖尿病患者体内血浆脂联素水平降低。多囊卵巢综合征（PCOS）是常见的妇科内分泌和代谢紊乱疾病，胰岛素抵抗和高雄激素血症是其重要的病理生理变化。与正常女性相比，PCOS患者发展为2型糖尿病的风险较高。而研究PCOS患者体内脂联素水平，分析该主要决定因素．阐明脂联素与IR和PCOS的关系，可能对PCOS病因分析、诊断、治疗提供新的靶点和途径。     

多囊卵巢综合征胰岛素抵抗相关基因研究进展

多囊卵巢综合征是一种以内分泌紊乱为主,多种代谢异常导致的异质性临床综合征,胰岛素抵抗是一个重要环节,本文对多囊卵巢综合征胰岛素抵抗相关基因的研究现状进行综述。     

多囊卵巢综合征患者组织胰岛素抵抗

多囊卵巢综合征（PCOS）是一种发病多因性、临床表现呈多态性的内分泌综合征。其发病原因至今尚未阐明，近年大量研究表明胰岛素抵抗（IR）与PCOS之间关系密切，胰岛素抵抗可能是PCOS发生发展的主要因素之一。胰岛素作用的经典靶器官是肝脏、脂肪及肌肉。目前，对PCOS患者组织胰岛素抵抗的研究主要有脂肪、肌肉、卵巢及子宫内膜．对其作一综述。     

多囊卵巢综合征患者的胰岛素抵抗

多囊卵巢综合征（peOS）是女性常见的生殖功能障碍性疾病,主要表现为卵巢的雄激素过多及无排卵,其发生率占生育年龄妇女的5％－10％卜］。此外,PCOS患者也存在糖代谢异常,主要表现为胰岛素抵抗（IR）及代偿性高胰岛素血症,其糖耐量低减的发生率也占生育年龄妇女的10％［'］。现就关于poOS的IR基础及临床方面研究进展作一综述。一、胰岛素作用及IR（一）胰岛素作用的细胞机理胰岛素是人体最重要的代谢激素,也是唯一降糖激素。胰岛素的生物学作用主要是调节糖代谢和脂代谢,还通过调控基因表达和蛋白质合成等进一步影响相应器官的…     

Serum visfatin levels in women with polycystic ovary syndrome

The aim of this study is to determine the serum levels of visfatin in patients with polycystic ovary syndrome (PCOS) and to understand its correlations with other metabolic and hormonal parameters. Thirty-seven patients with PCOS and 30 women without concomitant disease were included in this study. Serum visfatin levels were similar in patients with PCOS and control group. Visfatin levels were higher in normal weight PCOS when compared with obese PCOS, but it did not reach statistical significance. Visfatin levels correlated negatively with fasting blood glucose, total cholesterol (TC), low-density lipoprotein (LDL) and lipoprotein-a levels in PCOS patients. CRP levels increased both in obese PCOS and in obese controls. Plasma visfatin levels had no correlation with homeostasis model assessment-insulin resistance and fasting insulin levels, but the negative correlation between plasma visfatin levels and lipoprotein-a, fasting plasma glucose, TC and LDL levels may indicate a role for visfatin in cardiovascular disease independent of insulin resistance.     

The correlation of plasma homocysteine with insulin resistance in polycystic ovary syndrome

AIM: This study aims to investigate the existence of any relationship between homocysteine levels and insulin resistance in Turkish women with polycystic ovary syndrome. METHODS: A case-controlled, cross-sectional, observational study was undertaken in a total of 94 infertile Turkish women who required professional help in the Department of Infertility of Dr Zekai Tahir Burak Women's Health Research and Education Hospital. The correlation between serum homocysteine with age, body mass index, hormone profile, fasting insulin and glucose concentrations and insulin resistance were examined in patients with polycystic ovary syndrome and the results were compared to those of women with normal ovaries, who served as a control group. RESULTS: The mean serum fasting glucose and insulin levels, thus insulin resistance index of women with polycystic ovary syndrome, were significantly higher than those of the control subjects. The mean serum homocysteine levels were significantly higher in women with polycystic ovary syndrome than those in the control group. A positive correlation was detected between the mean homocysteine, the insulin resistance index determined by homeostasis model assessment and the fasting insulin levels in polycystic ovary syndrome patients. CONCLUSIONS: Serum homocysteine levels are elevated in women with polycystic ovary syndrome, and this elevation is associated with the serum insulin level rather than androgen excess. The intense treatment of hyperhomocysteinemia in women with polycystic ovary syndrome might improve reproductive outcome and contribute to protection from cardiovascular risks.     

Serum visfatin in Asian women with polycystic ovary syndrome

Objective.?To determine serum visfatin levels in Asian polycystic ovary syndrome (PCOS) women and its correlations with various parameters.

Study design.?Case–control study.

Setting.?University hospital.

Subjects.?Eighty women were enrolled in this study. Of these, 40 women were PCOS and 40 age-matched subjects with regular menstrual cycles were controls.

Intervention.?Seventy-five gram oral glucose tolerance tests were performed in all women. Fasting venous blood samples for serum visfatin, insulin and androgen levels were obtained both from the PCOS and the control women.

Main outcome measures.?Serum concentrations of visfatin, fasting insulin (FI), fasting glucose, 2-h post-load glucose (2hPG), homeostasis model assessment insulin resistance, homeostasis model assessment beta cell function, total testosterone, free testosterone, androstenedione and dehydroepiandrosterone sulfate were measured in both groups.

Results.?Women with PCOS had significantly higher serum visfatin levels than the healthy controls [100.39 ± 41.90 vs. 45.09 ± 28.24 mg/ml, p < 0.01]. PCOS women also had significantly higher concentrations of all androgens (p < 0.01). Insulin resistance seemed to be greater in the PCOS than the control groups, but did not reach a statistically significant level. In the PCOS group, serum visfatin levels were positively correlated with 2hPG, and systolic blood pressure and diastolic blood pressure. Serum visfatin levels were negatively associated with FI (r = ?0.80, p = 0.03) and positively associated with systolic and diastolic blood pressure (r = 0.77, p = 0.04, r = 0.79, p = 0.03, respectively) in the sub-group of PCOS women with abnormal glucose tolerance (AGT).

Conclusions.?Asian PCOS women had significantly higher serum visfatin levels than age-matched healthy controls. Their levels were significantly correlated with 2hPG and blood pressure in PCOS women, and with FI and blood pressure in PCOS women with AGT.     

The polycystic ovary syndrome

Much is known about the pathophysiology and pathogenesis of the polycystic ovary syndrome (PCO). The key clinical features are inappropriate gonadotropin secretion, altered production rates, binding and metabolism of steroids and androgen excess, all resulting in defeminization, anovulatory infertility, obesity and endometrial hyperplasia. Management should be based on the patient's reproductive goals. Adjunct measures can control hirsutism.     

Relation between hyperprolactinemia and polycystic ovary syndrome

The authors compared 12 hyperprolactinemic patients with polycystic ovary (PCO) syndrome to 12 patients with galactorrhea-amenorrhea (GA) syndrome. Luteinizing hormone-releasing hormone (LH-RH) and thyreotropin-releasing hormone (TRH) tests were performed at the same time in every case to determine the reactivity of the pituitary gland. The distinctive features of the PCO syndrome were beyond the clinical symptoms the characteristic ovarian structure verified by ultrasound examination, as well as the elevated serum LH, testosterone levels and the estradiol concentration at the normal upper limit. The basal prolactin value was higher at the GA patients than at the PCO ones. The patients with PCO syndrome demonstrated significantly greater LH and prolactin elevation to the combined LH-RH + TRH test than the patients with GA syndrome. On the basis of basal prolactin, estradiol and stimulated prolactin values it is likely, that the hyperprolactinemia in the two groups developed through different pathomechanisms. The persistent anovulation and the abnormal hormonal milieu in PCO syndrome cause the increased secretion of the pituitary lactotrophs supported by the TRH test, whereas the central dopamine decrease is the most likely explanation in the non-tumourous GA cases.     

The plasma homocysteine levels are increased in polycystic ovary syndrome

Women with polycystic ovary syndrome (PCOS) have several cardiovascular disease risk factors. Since hyperhomocysteinemia is associated with early atherosclerosis, it was postulated that the homocysteine levels are higher in PCOS patients than in control subjects which, therefore, may explain the cardiovascular disease risk. Thirty-five women with PCOS and 20 healthy subjects were studied. Endocrine assays, lipid profile, homocysteine and insulin level determinations, and ultrasound evaluation were performed in all subjects. We found significantly higher mean plasma homocysteine concentrations in patients with PCOS as compared with controls (10.4 +/- 4.4 vs. 7.2 +/- 1.5 ng/dl; p < 0.003). These data show that in PCOS early atherosclerosis is not exclusively dependent on hyperinsulinemia and elevated lipid profile - PCOS patients are exposed to significantly higher homocysteine levels which might increase the cardiovascular disease risk.