人工流产术后即时放置MCu IUD临床效果观察

目的探讨人工流产术后即时放置MCu宫内节育器（intrauterine contraceptive device,IUD）的临床效果。方法对要求行人工流产术后即时放置IUD的妇女360例（观察组）和人工流产术后月经复潮后要求放置IUD的妇女240例（对照组）,排除禁忌证,放置MCu IUD。术后填写统一记录,并于术后1、3、6、12个月随访,观察脱落率、因症取出率、带器妊娠率、累积续用率及月经情况和不良反应情况。结果两组带器妊娠率分别为0.28%、0.42%;脱落率分别为0.28%、0.42%;因症取出率分别为1.11%、1.25%;续用率分别为95.83%、95.00%,两组比较差异均无统计学意义（P〉0.05）。两组置器后的不良反应比较,差异无统计学意义（P〉0.05）。结论人工流产后即时放置MCu IUD,并不增加痛苦且安全可靠,是行之有效的方法,值得临床应用。     

无痛超导人工流产术后即时放置吉妮宫内节育器临床观察

目的:观察无痛超导人工流产术后即时放置吉妮宫内节育器(IUD)的临床效果。方法:对无痛超导人工流产术后即时放置吉妮IUD的生育后育龄妇女266例与同期无痛超导人工流产术后未放置IUD的生育后育龄妇女280例进行观察比较;与同期月经后放置吉妮IUD的生育后育龄妇女223例进行观察并随访12个月。结果:人工流产术后即时放置吉妮IUD组与未放置IUD组阴道流血时间、术后盆腔感染率比较差异无统计学意义(P>0.05);与经后放置吉妮IUD组比较带器妊娠率、脱落率、因症取出率、续用率比较差异无统计学意义(P>0.05)。结论:无痛超导人工流产术后即时放置吉妮IUD效果良好,值得临床推广使用。     

人工流产后即时放置宫内节育器的临床效果观察

目的 观察人工流产后即时放置宫内节育器的临床效果.方法 选择我院2015年2月-2016年2月就诊行人工流产术的患者82例,随机分为试验组和对照组,每组41例,试验组患者术后即时放置吉妮宫内节育器,对照组患者术后即时放置宫腔形宫内节育器.均随访12个月,观察带器妊娠、停用节育器、续用节育器情况,分别于术后1个月、3个月、6个月及12个月时统计不良反应发生率.结果 2组患者带器妊娠率、术后1个月不良反应发生率相近,无统计学差异(P>0.05).试验组患者术后3个月、6个月及12个月时不良反应发生率低于对照组,差异具有统计学意义(P<0.05).对照组不良反应主要表现为经量增多、经期延长、腰酸等,经药物治疗逐渐缓解.结论 人工流产术后即时放置宫内节育器是安全有效的,但吉妮宫内节育器具有良好的应用效果,不良反应较轻,更能提高患者生活质量.     

人工流产后即时放置曼月乐的临床观察

目的 观察早孕人工流产后即时放置与月经后期放置左炔诺孕酮宫内缓释系统(曼月乐)的避孕效果、不良反应比较.方法 166例自愿选择放置曼月乐的已生育女性,分人工流产术后即时放置组(观察组)86例和月经后期放置组(对照组)80例,随访12个月,对其避孕效果、续用率及不良反应进行观察比较.结果 观察组与对照组的妊娠率均为0,脱环率均为0,续用率分别为100％、95％,两组比较差异无统计学意义(P＞0.05),放置后3个月内点滴出血的发生率观察组为27.5％,对照组36.2％,两组比较差异有统计学意义(P＜0.05);1年内闭经分别为23.3％(20/86)、23.8％(18/76),两组比较差异无统计学意义(P＞0.05);其他不良反应如体重增加、痤疮、下腹胀、乳胀等的发生率低,两组相比差异无统计学意义(P＞0.05).结论 早孕人工流产后即时放置曼月乐,术后3个月点滴出血的发生率明显少于月经后期放置.曼月乐在人工流产术后即时放置与月经后放置具有相同的避孕效果,减少了点滴出血的发生,避免了2次宫腔操作.     

早孕人工流产术后即时放置曼月乐的临床研究

目的观察早孕(<10周)人工流产术后即时放置曼月乐的临床效果。方法采用非对照的开放式病例观察,研究对象为早孕(<10周)行人工流产术后即时自愿放置曼月乐的患者50例,于放器后第1、3、6、12个月随访,以观察其出血模式、出血主诉率、疼痛主诉率、感染率、因出血和/或疼痛终止率等,并调查医生的接受率及受试者的满意率,从而评价人工流产术后即时放置曼月乐的可行性。结果其出血模式为不规则出血、点滴出血、经量减少、闭经;出血主诉率、闭经主诉率相对较高,且随术后时间变化;感染率0%;终止率4%(疼痛终止1例,闭经终止1例);医生接受率100%,患者满意率90%。结论曼月乐适于人流术后即时放置。     

人工流产术后即放置宫内节育器临床分析

目的:观察分析人工流产术后即放置宫内节育器(IUD)的临床效果。方法:选择人工流产后自愿即时放置宫内节育器者的100例作为观察组,于月经干净后3~7天内放置宫内节育器者120例作为对照组。术后1、3、6、12个月定期随访,了解月经情况(月经量增多,经期延长、痛经)、带器妊娠、脱落、不良反应情况。结果:2组术后1、3、6、12个月月经异常发生率比较无统计学差异(P>0.05),带器妊娠率、脱落率、不良反应发生率均无统计学差异(P>0.05)。结论:人工流产术后即放入宫内节育器安全有效,适用于临床。     

人工流产术后即时放置宫内节育器240例观察

目的观察比较人工流产术后即时放置爱母IUD和母体乐375 IUD的临床效果。方法选择知情同意于人工流产术后放置IUD的育龄妇女240例,随机分成A、B 2组各120例,分别放置爱母IUD、母体乐375 IUD,并进行12个月的随访观察和比较。结果爱母IUD和母体乐375 IUD在腰酸腹坠、白带增多、移位脱落、带器妊娠、因症取出率等方面差异有显著性（P〈0.05）。结论爱母IUD更适合人工流产术后即时放置。     

人工流产术后与月经间期放置MCu功能性宫内节育器的临床效果观察

目的比较人工流产术后即时、月经间期放置MCu功能性宫内节育器（IUD）的临床使用效果。方法将165例自愿选择放置MCu功能性IUD作为惟一避孕方法的妇女分人工流产术后即时放置组（观察组）和月经间期放置组（对照组）,其中观察组86例,对照组79例,随访12个月,比较避孕效果、续用率和副反应发生情况。结果观察组和对照组的妊娠率均为0,续用率分别为94.19%、93.67%,因症取出率分别为3.49%、5.06%,二组比较差异无统计学意义（P〉0.05）。结论MCu功能性IUD在人工流产术后即时放置避免了二次宫腔操作及短期内再次妊娠,安全性高、避孕效果可靠,具有脱落率低、副反应小等优点,适于临床应用。     

人工流产术时和月经7天内放置曼月乐的临床效果比较

目的 比较人工流产术时即时放置曼月乐(左炔诺酮宫内缓释系统)和月经第7天内放置曼月乐的临床效果.方法 观察组2011年2~12月早孕患者自愿行人工流产术时即时放置曼月乐72例,对照组月经来潮第7天内放置曼月乐81例,随访时间为6个月,对其避孕效果及副反应进行临床观察比较.结果 观察组和对照组均带环怀孕率为0,副反应(闭经率、点滴出血率、脱落率、满意率),各项相比均无统计学意义(P>0.05).结论 曼月乐是一种安全、可靠的宫内节育系统,更适用于人工流产即时放置,值得推广.     

人工流产术后即时放置宫内节育器198例效果观察

目的:观察人工流产妇女放置TCu220C宫内节育器(IUD)的临床效果。方法:采用随机对照临床研究方法,将198例健康妇女人工流产术毕即时放置TCu220C IUD(Ⅰ组),192例经后及经间期放置TCu220C IUD(Ⅱ组),于放置后1、3、6、12和24个月随访,以生命表法统计两种IUD的终止情况。结果:两组在经期经量、带器妊娠、脱落、因症取出方面均差异无统计学意义。结论:人工流产后即刻放置TCu220C IUD不增加放置宫内节育器后副反应,续用率与经间期放置差异无统计学意义,具有其可行性及优越性,值得推广。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Electro-Acupuncture Combined with the Trigger Point Needle-Embedding for Treatment of Primary Trigeminal Neuralgia in 31 Cases

In recent years, the author of this essay has applied electro-acupuncture combined with the trigger point needle-embedding for treatment of primary trigeminal neuralgia in 31 cases, yielding satis- factory results as reported in the following.     

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.endometria from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.     

Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

Prof. SHI Da-zhuo, Ph.D., male, was born on March 20, 1960. Prof. SHI entered the Ph.D. program in 1990 at the China Academy of Chinese Medical Sciences under the supervision of Prof. CHEN Ke-ji, majoring in the treatment of cardiovascular diseases. After receiving his Ph.D. degree in 1993, Prof. SHI started working at the Cardiovascular Center in Xiyuan Hospital affiliated to China Academy of Chinese Medical sciences.     

Persist in and Carry Forward the Integrative Medical Research——Speech at the 6th National General Congress of Chinese Association of Integrative Medicine by Academician CHEN Zhu,Minister of Ministry of Health

The 6th National General Congress of Chinese Association of Integrative Medicine （CALM） was convened at 19-20, April 2008 in Beijing. Academician CHEN Zhu, the minister of Ministry of Health indicated at the congress that the integration of Chinese and Western medicine is very well in keeping with the situation of our country and the general rule of development in medical science; and as a good integration of Chinese medicine and Western medicine, it is mutually beneficial and advantageous to both of them. Seeing the creativity shown in integrative medical investigation in theoretic and methodological sides, we should and must persist in and develop it.