针灸治疗原发性痛经的取穴现状分析

目的:总结原发性痛经针灸腧穴的运用规律,为临床针灸治疗原发性痛经取穴方案的优化和制订提供依据。方法:查阅1989～2008年中国医用信息资源系统(维普)数据库中所有针灸治疗原发性痛经的文献,对穴位选取进行统计分析。结果:针灸治疗原发性痛经取穴主要分布于任脉与足太阴脾经,部位主要集中在腹部、下肢及腰背部;交会穴占很大优势;对于单穴的使用,次髎、三阴交、神阙、十七椎、地机具有初步的研究意义。结论:应用任脉与足三阴经的交会穴配伍组方对原发性痛经取穴方案的优化和制订具有重要参考意义。     

针灸治疗单纯性肥胖取穴规律的临床研究*

[目的]探讨针灸治疗单纯性肥胖的取穴规律。[方法]建立Excel数据库,对中国期刊全文数据库(CNKI)近20年来发表的针灸治疗单纯性肥胖的文献进行整理分析。[结果]纳入分析的文献共158篇,统计得出使用频次最多的腧穴为三阴交、足三里、天枢、丰隆、中脘等,在所选用经脉中以胃经、脾经、任脉、膀胱经为主;选用腧穴多集中在胸腹部,募穴、合穴、下合穴为使用频次最多的特定穴。[结论]针灸治疗单纯性肥胖病安全、有效,以胃经、脾经、任脉、膀胱经腧穴为主。     

基于数据挖掘探讨针刺治疗小儿遗尿的选穴规律

目的 基于数据挖掘探讨针刺治疗小儿遗尿的选穴规律。方法 检索建库至2022年9月中国知网、万方数据库、维普网收录的针刺治疗小儿遗尿的临床研究文献,统计纳入文献处方中的腧穴及其使用频次、频率、归经、分布部位、特定穴情况,并分别采用IBM SPSS Modeler 18.0、IBM SPSS Statistics 19.0对腧穴处方进行关联规则及聚类分析。结果 共纳入75篇文献,包含75则针刺处方、62个腧穴,腧穴总频次为464次。高频腧穴依次为关元、三阴交、中极、肾俞、足三里;任脉和足太阳膀胱经为使用频次较多的经脉,所用腧穴多分布于胸腹、腰骶背部,募穴为使用频次最高的特定穴。关元-中极-三阴交为针刺治疗小儿遗尿的常用穴组。聚类分析得到5个聚类作为常用腧穴组。结论 针刺治疗小儿遗尿选穴注重小儿生理病理,以补为主,在辨病基础上辨证增穴以加强效果。     

针刺治疗排卵障碍性不孕症取穴规律

目的:探讨现代文献针刺治疗排卵障碍性不孕症的取穴规律。方法:检索中国知网(CNKI)、维普、万方数据库1998年12月—2016年6月国内有关针刺治疗排卵障碍性不孕症的临床文献。在检索结果中筛选并记录各腧穴的应用频次,对腧穴的十四经分布、所属部位、特定穴应用情况等进行统计描述。探讨针刺治疗排卵障碍性不孕症的临床常用、少用腧穴及其归经、分部规律。结果:纳入文献91篇,涉及的穴位共有59个,腧穴涉及11条经脉,使用穴位数较多的经脉主要有足太阳膀胱经、任脉等。其中特定穴42个,占71.19%;分部选穴是以下肢部远端选穴和下腹部、腰背部的局部选穴为主。结论:现代针刺治疗排卵障碍性不孕症的常用穴位主要有三阴交、关元、中极、子宫等,选穴部位主要集中在下腹部、腰背部和下肢部。     

基于数据挖掘的针灸治疗急迫性尿失禁临床取穴规律*

目的对针灸治疗急迫性尿失禁临床文献的取穴规律进行归纳分析。方法 参考中国知网（China National Knowledge Infrastructure，CNKI）、万方（WanFang Data，WF）、维普（China Secience and Technology Journal，VIP）、PubMed、Ovid、Cochrane Library等数据库并从中摘取2000年1月-2019年6月以来针灸治疗急迫性尿失禁的临床研究类文献，通过数据挖掘技术分析针灸临床取穴规律特点。结果 共纳入32篇文献，涉及腧穴25个：①腧穴使用频次最高的为会阳、次髎、中髎、中极；②腧穴关联度：会阳-中膂俞、次髎-三阴交（会阳）、大赫-委中；③涉及到的经脉以足太阳膀胱经、任脉、足太阴脾经为主，占总频次的81.2%；④腰骶部选穴部位频次最高，占选穴部位总频次的53.4%。结论 以数据挖掘技术的方式总结出针灸治疗急迫性尿失禁的腧穴和经脉的内在规律，以会阳、次髎、中髎、中极最为常用，电针为主，采用局部（病位）（腰骶部）与“经脉所过，主治所及”原则相结合的取穴方式，为针灸治疗急迫性尿失禁的临床选穴依据提供循证依据。     

穴位埋线与艾灸治疗原发性痛经的取穴规律

目的:比较分析穴位埋线及艾灸治疗原发性痛经的临床取穴规律,为临床选穴提供参考和理论依据。方法:电子检索CNKI、万方、维普三大中文数据库,收集符合标准的穴位埋线及艾灸治疗原发性痛经的文献,从处方腧穴的频次、归经、分布、特定穴等方面进行统计分析对比,探讨两者的临床用穴规律。结果:共纳入78篇相关文献,其中穴位埋线治疗原发性痛经的相关文献28篇,艾灸治疗原发性痛经的相关文献50篇。穴位埋线治疗原发性痛经主要取穴为三阴交、关元、次髎、肾俞、肝俞、脾俞、气海、子宫;艾灸治疗原发性痛经主要取穴为关元、三阴交、中极、气海。结论:穴位埋线与艾灸治疗原发性痛经选穴大体不同,穴位埋线选穴以背腰部、足太阳膀胱经、背俞穴为主;艾灸选穴以胸腹部、任脉、募穴为主。     

针灸治疗溃疡性结肠炎类似病症的古代文献研究

目的:通过文献查阅,了解古代针灸医家采用针灸治疗溃疡性结肠炎类似病症的一般规律,从而确定其基本穴位配方。方法:借助《中华大典·医学分典·针灸推拿总部》,检索相关条文,从经脉、穴位的选用等方面进行整理分析,并总结古人的配方规律。结果:检索出条文314条,通过规范化处理,整理出经穴97个,经外奇穴15个,选用频次最多的经脉包括任脉、膀胱经、胃经和脾经,所用腧穴主要集中在腹部、下肢和腰背部,以募穴、背俞穴、下合穴三类特定穴选用频次最多。结论:以穴位使用频次为参考,结合针灸学理论,分析认为天枢、中脘、足三里、上巨虚可以作为针灸治疗溃疡性结肠炎基本配方。     

近10年针灸治疗痛经的同功穴选用规律的文献分析

目的运用数据挖掘技术,总结分析近10年现代文献中针灸治疗痛经的同功穴选用规律。方法采用计算机检索的方式,对2006—2016年中国期刊全文数据库(CNKI)、万方数据知识服务平台(WF)和维普数据库中针灸治疗痛经的相关文献进行检索及整理。结果得到相关文献128篇。治疗痛经的同功穴有49个,其中十四经腧穴47个,经外奇穴2个;主要穴位为三阴交、关元、中极,所属经脉主要为足太阳膀胱经和任脉,所在部位主要是胸腹部和腰背部。按照使用频率将腧穴分为3级:一级谱腧穴9个、二级谱腧穴13个、三级谱腧穴27个。结论同功穴的概念进一步诠释了腧穴配伍的协同增效作用,可对针灸处方的选择以及临床疗效的提高起到指导作用。     

针灸治疗2型糖尿病选穴规律现代文献研究

目的:通过对近10年针灸治疗2型糖尿病现代文献的研究,分析针灸治疗2型糖尿病的选穴规律。方法:检索分析2006至2016年中国知识资源总库(CNKI)中针灸治疗为主或者针灸联合其他疗法治疗2型糖尿病的临床文献,得到相关文献83篇,分析其选穴规律。结果:针灸治疗2型糖尿病最常用的腧穴是足三里、三阴交、肾俞、太溪和脾俞;腧穴所属经脉主要集中于足太阳膀胱经、足阳明胃经、任脉和足太阴脾经;腧穴主要分布位置在下肢及背腰部;特定穴类型广泛,以五输穴、交会穴及背俞穴为多。结论:针灸治疗2型糖尿病疗效肯定,有循经选穴、分部选穴、辨证选穴和特定穴选穴的特点。     

基于数据挖掘探讨针灸治疗胃下垂文献的选穴规律

目的通过对针灸治疗胃下垂的文献进行归纳整理,对其选穴规律进行分析,总结针灸治疗胃下垂的选穴规律和治疗思路。方法检索建库起至2020年10月期间中国知网、万方、维普、PubMed等数据库中针灸治疗胃下垂的文献,将筛选出文献的治疗方法、所选穴位、穴位归经、分布及特定穴的应用归纳总结,用Excel表格整理归纳,形成针灸治疗及处方数据库,采用SPSS 23.0统计学软件进行统计分析。结果共筛选出60篇文献,经统计分析,针灸治疗胃下垂所选经穴50个穴位和经外奇穴13个,其中足三里和中脘使用频次最高,达到总频次的10%以上;腧穴的选择以远部与近部配合取穴为主;任脉、胃经穴位使用频次最高;经外奇穴分布部位以腹部为主。结论针灸治疗胃下垂经脉多选取任脉、胃经腧穴,配伍以局部与远端要穴相配为主。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.     

Possible Spread of adenovirus type 3 from poultry to humans ：indirect evidence from an outbreak in China

Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.