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1.
本文观察了阿司匹林(B组)和维生素A、C、E、叶酸(A组)以及二者合用(C组)对孕鼠血清Zn、Fe、Mn、Cu及其胎鼠头部组织Zn、Fe、Mn、Cu、Ca、Co、Pb、Ni、Cr含量的影响.结果:B、C组孕鼠血清Fe、Mn、Cu含量较正常对照组(N组)高(P分别<0.05,<0.001,<0.01),而Zn有降低趋势.A、B、C组胎鼠头部组织Zn、Fe、Cu含量均较N组降低(P<0.01),仅Mn含量较N组增高(P<0.01);但Fe、Mn含量B、C组仍高于A组(P<0.01).而Pb、Ni含量A、B组则明显高于N、C组(P<0.05.<0.001),A组又低于B组(P<0.05,<0.01).提示阿司匹林和维生素可促进孕鼠Fe、Mn、Cu的吸收,但抑制Zn吸收;孕鼠血清Fe、Cu含量与胎鼠头部组织Fe、Cu含量为负相关.B组胎鼠头部组织Pb、Ni含量高和Zn含量低可能是阿司匹林致畸原因之一,也是其毒性表现. 相似文献
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Graves病患者~(131)I治疗前后头发6种元素含量变化及临床意义的研究 总被引:1,自引:0,他引:1
目的探讨Graves病患者经131I治疗后头发6种元素含量变化。方法:检测并比较64例患者131I治疗前和131I治疗后头发中微量元素Zn,Cu,Fe,Mn和常量元素Ca,Mg含量。结果:治疗前Graves病患者Zn,Fe,Cu,Mg,Ca明显低于对照组(P<0.01),而Mn高于对照组(P<0.01);治疗后6个月,Zn,Ca含量升高与对照组无显著差异,Mg,Cu,Fe含量升高(0.01<P<0.05),Mn含量较治疗前下降。结论:Graves病人某些临床表现可能与体内元素异常有关,经131I治愈后(甲状腺激素T3、T4正常),部分指标可恢复正常。 相似文献
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为探讨胃癌患者发中微量元素的变化信息,发样经洗涤、称重、消化、定容处理后,用WFX─型原子吸收分光光度计进行测定,结果:胃癌患者较正常人Zn、Zn/Cu、Mg、Ga显著降低(P<0.05),胃癌与胃溃疡相比,Zn、Zn/Ca、Mg均呈显著降低(P<0.05)。提示发中微量元素化学信息的变化,可为胃癌的诊断和鉴别诊断提供参考。 相似文献
4.
由内镜和病理确诊的胃和十二指肠球溃疡患者共240名,给予甘草锌治疗6周。治疗前后以AH-630-01型原子吸收分光光度计和RF-540型荧光分光光度计,测定其病变组织中Fe、Zn、Cu、Mn、Se的含量。结果:①胃和十二指肠球溃疡者的Fe、Zn、Se水平,治疗后较治疗前有明显提高,有显著性差异,P〈0.05或P〈0.01。②胃和十二指肠球溃疡者的Zn/Fe、Zn/Cu、Zn/Mn、Zn/Se比值治 相似文献
5.
阿斯匹林与维生素对孕鼠血清和胎鼠头部组织微量元素含量… 总被引:1,自引:0,他引:1
本文观察了阿司匹林(B组)和维生素A、C、E、叶酸(A组)以及二者合用(C组)对孕鼠血清Zn,Fe,Mn,Cu及其胎鼠头部组织Zn,Fe,M,Cu,Ca,Co,Pb,Ni,Cr含量的影响,结果:B、C组孕鼠血清Fe,Mn,Cu含量较正常对照组(N组)高(P分别〈0.05〈0.001〈0.01),而Zn有降低趋势。A、B、C组胎鼠头部组织Zn,Fe,Cu含量均较N组降低(P〈0.01),仅Mn含量较 相似文献
6.
本实验将24只昆明雄性大白鼠随机均分为三组,即正常对照组,发热高峰组及发热恢复组,给发热组动物腹腔注射大肠杆菌内毒素(ET)。结果发现:发热高峰组动物与正常对照组比较血清Cu含量明显)曾加(P<0.05),血清Fe含量明显减少(P<0.001),Zn、Mg含量虽也有减少,但无显著性差异,恢复组动物与对照组比较血清Cu、Zn、Fe、Mg含量均无明显变化。丘脑下部组织Cu、Zn、Fe和Mg在发热高峰组与对照组比较无明显变化,发热恢复组动物与对照组比较,丘及下部Cu、Zn含量明显增加(P<0.01)。作者认为:大鼠ET发热时血清微量元素Cu、zn、Fe、Mg含量与丘脑下部的含量变化无关,血清Cu含量增加,Fe含量减少可能参与动物发热时的急性期反应,与机体发热时的防御反应有关。 相似文献
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8.
本文采用微分电位溶出法测定213例脑梗塞患者血清中Cu、Pb、Cd、Zn、Fe、Mn等微量元素的含量,并与69例正常人对照。结果表明,各患者组血清中Fe、Mn与正常组无明显差别,Pb、Cd含量均显著高于正常组(P〈0.01);急性脑梗塞患者(5天内)组Cu/Zn比值明显高于对照组(P〈0.01),但随时间延长Cu/Zn比值逐渐降低;恢复期(31 ̄60天)及脑梗塞后遗症两组患者血清Cu低于对照组(P 相似文献
9.
用电分析化学方法系统地测定了50例肺癌病人和30例肺心病人血清Cu、Zn、Pb、Ca、Ni、Co、Se、Mo、Mn等9种微量元素,并同21例健康组进行对照,结果是肺癌组血清Cu、Pb、Cd高于对照组(P<0.01),血清Zn、Se、Mo、Mn低于对照组(P<0.01),Ni和Co无明显变化。肺心病组血清Cu、Co、Mn高于对照组(P<0.01),Cd略高于对照组P>0.1),ZnMo低于对照组(P<0.01)。Se、Ni、Pb无明显变化。再以肺癌组和肺心病组进行比较,结果肺癌组Cu、Pb、Cd、Ni均高于肺心病组(P<0.01),而Zn、Co、Mo、Mn、Se均低于肺心病组(P<0.01)。 相似文献
10.
应用原子吸收法测定了急性视力降低(实验组)和正常人(对照组)各30例枕发中锌(Zn)、铁(Fe)、铜(Cu)、钙(Ca)、镁(Mg)、镉(Cd)含量的变化。结果表明:实验组Zn、Fe、Ca、Mg含量明显低于对照组,差异非常显著(P〈0.01);而Cd含量明显高于对照组,差异非常显著(P〈0.01);实验组Cu含量虽然低于对照组,但无显著性差异(P〉0.05),而Cu/Zn比值明显高于对照组,差异显 相似文献
11.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD. 相似文献
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Jiageng Zhu Jun Li Ruipeng Ji Jianghao Su Mingshun Shen Zhigang Cao 《南京医科大学学报(自然科学版)》2007,21(2):125-128
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment. 相似文献
13.
Tao Ye * Zhi-quan Liu Jian-jun Mu Xi-han Fu Jun Yang Bao-lin Gao and Xiao-hong Zhang Department of Cardiology First Hospital of Xi'an Jiaotong University Xi'an Hanzhong Cardiovascular Institute Hanzhong 《中国医学科学杂志(英文版)》2004,19(4):248-251
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure. 相似文献
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目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险. 相似文献
15.
Jingming Zhu Ningning Hui Xiuhong Jiang Huaxing Zhang Chengzhang Fu 《南京医科大学学报(自然科学版)》2007,21(6):386-389
Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P<0.01);the MAP decreased(P<0.01)and the HR increased drastically(P<0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients. 相似文献
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Objective:To investigate the gene expression of osteoprotegerin(OPG) and osteoclast differentiation factor(ODF) in the bone tissue of patients with hip fracture due to osteoporosis. Methods:OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers(over 50 years old) with hip fracture(Observer Group) and 30 cases of hip facture sufferers with no osteoporosis(Control group) were analyzed with the Semi-Quantitative RT-PCR method. Results:The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion:Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption. 相似文献
17.
The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas: report of 9 cases 总被引:1,自引:0,他引:1
Shaoqin Chen Shengquan Zou Qibao Dai Peisheng Huang Weihua Cai Hong Li 《南京医科大学学报(自然科学版)》2007,21(6):398-401
Objective:To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas(SPTP). Methods:Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin(HE) staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results:Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin(9/9 cases), AAT(9/9 cases), NSE(9/9 cases), ACT(7/9 cases), CK20(2/9 cases), CgA(1/9 cases), S-100(3/gcases), PR(4/gcases), Syn(3/9 cases) and CD56(5/9cases), negative in CEA and ER. Conclusion:SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype. 相似文献
18.
Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine
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A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes. 相似文献
19.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P. 相似文献
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Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine. 相似文献