Study of survival and prognostic factors in patients undergoing resection for gastric linitis plastica: a review of 86 cases

A retrospective study was conducted in a series of 86 patients (51 men and 35 women; mean age 63.4 years) treated from 1979 to 1995 for linitis plastica of the stomach (LP). The mean interval between the first manifestations and surgery was 3.5 months. The most frequent clinical sign was epigastric pain which occurred in 80.4% of cases. Biopsies were positive in 75.6% of cases. Typical features of LP were found in only 46% of esogastric barium enemas and 11.8% of upper gastrofiberscopic examinations. Seventy-four patients had surgical excision (51 total and 23 partial gastrectomies). There were 6 (7%) postoperative deaths and 10 (11.6%) surgical complications. Node involvement was found in 54 (72.9%) patients. Overall actuarial survival (n = 86) was 50% at 12 months, 40% at 18 months and 7.5% at 84 months. Survival did not depend on the delay in diagnosis, histological analysis of the extremities of the excised piece, associated tissue differentiation, node involvement or the type of surgical excision. The prognosis differed according to tumor height (P<0.01) and involvement of the deep stomach wall (P<0.001). No independent prognostic factor was found in multivariate analysis. Surgery remains the sole possibility for curative therapy in these patients.     

腹腔镜结直肠肿瘤切除术的难点及对策(附83例报告)

目的:探讨腹腔镜结直肠肿瘤切除的常见难点及对策。方法:回顾分析2005年2月至2007年6月83例腹腔镜结直肠肿瘤切除术患者的临床资料。结果:74例手术成功,9例中转开腹。手术并发症是皮下气肿5例(6.0%)、不完全性肠梗阻5例(6.0%)、术后大出血1例(1.2%)、肠管损伤3例(3.6%)、吻合口漏1例(1.2%)等。结论:腹腔镜结直肠肿瘤切除术的常见难点为血管的识别及处理、脏器损伤特别是输尿管及肠管损伤的预防及手术操作面的显露等。正确的解剖入路、开腹手术经验丰富及良好的腹腔镜培训可减少手术并发症的发生。     

胸腔镜下食管平滑肌瘤摘除术83例临床分析

目的 探讨胸腔镜下摘除食管平滑肌瘤的可行性.方法 回顾性分析2002年12月至2012年8月间在复旦大学附属中山医院胸外科接受胸腔镜下食管平滑肌瘤摘除术的83例患者的临床资料.全组患者肿瘤直径为 0.8～12.0（平均3.3）cm,其中肿瘤直径大于5 cm者22例.结果 3例患者术中发现食管黏膜破裂,其中2例于胸腔镜下行食管黏膜修补,另1例中转开胸修补.全组手术时间40～300（平均83.0）min,术中出血 20～150（平均52.4）ml,术后住院时间3～50（平均5.8）d.术后1例患者出现食管瘘,经胸腔引流保守治疗治愈.80例（96.4％）患者获2～117月的术后随访,随访期间所有患者吞咽困难症状均消失,未见肿瘤复发、食管憩室及食管狭窄等发生.结论 胸腔镜下摘除食管平滑肌瘤是安全、有效的手术方式,并具有创伤小、康复快等优势.对于大于5 cm的食管平滑肌瘤,胸腔镜下摘除也是可供选择的手术方式,但应在具有一定胸腔镜手术经验的中心开展.     

胃癌手术患者预后的多因素分析

目的探讨影响胃癌手术患者预后的相关因素。方法应用单因素和多因素的分析方法,回顾性分析1990年1月至2001年12月有完整临床资料和随访资料的887例胃癌患者的临床资料。结果胃癌患者总的1年生存率为79.63%,3年生存率为49.29%,5年生存率为43.40%。单因素分析结果显示肿瘤部位,TNM分期,病理分型,手术方式,化疗方法与患者的预后具有相关性。应用COX回归模型分析显示TNM分期,病理分型,手术方式,化疗方法是影响胃癌患者手术预后的相关因素。结论 TNM分期,病理分型,手术方式,化疗方法是影响胃癌手术患者预后的重要指标。     

手术治疗大面积脑梗死22例临床分析

目的 探讨大面积脑梗死的临床特点、手术治疗及疗效。 方法 对我院2007年7月至2010年9月的22例大面积脑梗死患者,行标准去骨瓣减压术的临床资料进行回顾性分析。 结果 本组22例患者,存活19例,存活率86. 4% 。死亡3例,死于严重肺炎并发脑水肿,脑疝和脑干功能衰竭。存活者经综合康复治疗后,神经功能均有不同程度的恢复,但大部分生活不能自理。本组无失访病例,随访时间为6个月~1年,Barthel评分：>60分11例,<60分8例。 结论 去骨瓣减压术是治疗大面积脑梗死的重要措施,早期手术以及防治并发症,能有效降低死亡率,为进一步康复治疗争取机会,改善病人预后。     

贲门癌根治术后患者预后的多因素分析

目的探讨贲门癌根治术后患者预后的影响因素。方法通过回顾性分析我院1994年7月至2003年12月间行根治性手术治疗并有完整随访资料的108例贲门癌患者的临床病理资料，探讨影响贲门癌预后的相关因素。结果108例患者中，SiewertⅡ型占68例，Ⅲ型占40例；淋巴结转移率为68．5％（74／108）。本组患者随访至2004年12月，平均生存时间为37个月（95％CI为29．3～44．7月），中位生存时间为26．6个月；1、3和5年生存率分别为77．2％、33．6％和21．8％。单因素分析结果显示，是否行脾切除术、肿瘤大小、肿瘤浸润深度及淋巴结转移情况是影响患者预后的因素。多因素分析结果显示，仅肿瘤浸润深度（P=0．009）及淋巴结转移情况（P=0．001）是影响患者预后的独立因素，OR值分别为2．373（95％CI为1．474～16．212）和2．269（95％CI为1．450～4．997）。结论贲门癌根治术后患者的预后与肿瘤浸润深度及淋巴结转移数目呈负相关。脾脏未受侵犯时应予以保留，全胃切除未能改善贲门癌根治术后患者的预后。     

癌结节对结直肠癌肝转移同期切除术预后的影响

目的探讨癌结节对初始可切除同时性结直肠癌肝转移患者同期切除术预后的影响。 方法回顾性分析2003年7月至2015年7月复旦大学附属中山医院行同期切除的212例同时性结直肠癌肝转移患者资料,分析癌结节和临床病理因素的相关性,采用Kaplan-Meier生存分析和Cox回归模型分析癌结节对预后的影响。 结果癌结节的阳性率为43.9%（93/212）,癌结节和肿瘤分化、淋巴结转移、血管浸润和神经浸润显著相关（P=0.044、0.001、0.035、<0.001）,是低DFS的独立预后因素。癌结节阳性患者的OS和DFS明显低于癌结节阴性患者,差异有统计学意义（P=0.003、<0.001）。淋巴结阳性的135例患者中,癌结节阳性和阴性患者的OS比较,差异无统计学意义（P=0.608）,癌结节阳性患者DFS更低（P=0.003）;在淋巴结阴性的77例患者中,癌结节阳性患者的OS和DFS均显著低于癌结节阴性患者（P<0.001、0.010）。 结论对于结直肠癌肝转移同期切除术后患者,癌结节和肿瘤分化、淋巴结转移以及神经浸润显著相关,且预示不良预后。     

Laparoscopic enucleation or wedge resection of benign gastric pathology: analysis of 44 consecutive cases

Laparoscopic resection of gastric submucosal tumors has been described, but the role of laparoscopy for tumors within the esophagus or near the gastroesophageal junction is not clearly defined. The aim of this study was to examine the outcomes of laparoscopic or thoracoscopic enucleation or wedge resection of benign gastric tumors. The charts of 44 patients who underwent minimally invasive resection of benign esophagogastric tumors were reviewed. Surgical approaches included thoracoscopic enucleation (n = 2), laparoscopic enucleation (n = 6), transgastric enucleation (n = 2), and laparoscopic gastric wedge resection (n = 34). There were 23 males with a mean age of 57 years. There was one conversion (2.5%) to laparotomy. Mean operative time was 97 ± 52 minutes. The mean length of hospital stay was 2.6 ± 2.0 days. One patient developed gastric outlet obstruction requiring Roux-en-Y reconstruction. There were no leaks and the 90-day mortality was zero. Pathology demonstrated gastrointestinal stromal tumor (n = 31), leiomyoma (n = 6), and other benign pathology (n = 7). There has been one tumor recurrence at a mean follow-up of 4.3 years. The laparoscopic approaches to local resection of gastric tumors are safe and feasible. The type of minimally invasive surgical approaches should be tailored based on the location and size of the lesion.     

Analysis of prognostic factors in patients undergoing resection of pulmonary metastases from soft tissue sarcomas

The selection of objective criteria that can reliably predict survival in patients undergoing resection of pulmonary metastases remains controversial. Between 1974 and 1982, 487 patients with soft tissue sarcomas presented to the National Cancer Institute. Eighty patients underwent thoracotomy for putative metastases and 67 patients had histologically proved pulmonary metastases. The 3 year tumor-free survival rate was 30% by actuarial analysis. Patients with resectable metastases had significantly prolonged post-thoracotomy survival compared to those patients with unresectable metastases. The most significant preoperative predictors of survival were the tumor doubling time, the number of metastases on preoperative linear chest tomograms, and the disease-free interval. Patients with a tumor doubling time of 20 days or more had a significantly longer post-thoracotomy survival (22 months median) than patients with a tumor doubling time of less than 20 days (6 months median). Those patients with four nodules or less on preoperative tomograms had significantly longer post-thoracotomy survival times (23 months median) than those patients with more than four nodules (6 months median). Patients with a disease-free interval of more than 12 months had a longer post-thoracotomy survival (32 months median) than patients with a disease-free interval of 12 months or less (10 months median). Combining these three prognostic factors significantly increased the predictive ability of this model. These criteria provide an accurate and rapid method to identify preoperatively those patients who will maximally benefit from resection of pulmonary metastases from soft tissue sarcomas.     

44例肾移植术后多瘤病毒相关性肾病患者的临床病理特征和预后分析

目的  探讨肾移植术后多瘤病毒相关性肾病（PyVN）的临床病理学特征及预后。 方法  回顾性分析44例肾移植术后确诊PyVN患者的临床资料,分析患者穿刺原因及病理学诊断时间。按Banff 2018标准进行组织学分级,比较各级患者临床资料及病理特征。分析患者血、尿BK病毒DNA载量及移植肾功能。比较各组患者的预后情况,分析影响预后的危险因素。 结果  患者病理诊断PyVN距肾移植手术时间为16（8,29）个月,血清肌酐升高为穿刺的主要原因。44例患者中,PyVN 1级19例、2级21例、3级4例,各组光学显微镜下病毒包涵体阳性率差异无统计学意义（P=0.148）,2级患者炎症细胞浸润、间质纤维化、肾内多瘤病毒载量均多于或高于1级患者,3级患者炎症细胞浸润及肾内多瘤病毒载量多于或高于1级患者,3级患者肾内多瘤病毒载量多于或高于2级患者,差异均有统计学意义（均为P < 0.05/3）。确诊时39例患者具有血、尿BK病毒DNA载量检测记录,其中38例尿BK病毒阳性,30例血BK病毒阳性。患者确诊PyVN时血清肌酐较术后1个月升高,末次随访时血清肌酐较确诊PyVN时升高,差异均有统计学意义（P < 0.001、P=0.049）。不同级别PyVN患者术后1个月血清肌酐差异无统计学意义（P=0.554）,确诊时2级患者血清肌酐水平高于1级患者（P=0.007）。肾移植术后1、3、5年移植肾累积存活率分别为95%、69%、62%,不同分级PyVN间移植肾存活率差异有统计学意义,分级越高,存活率越低（P=0.014）。单因素和多因素Cox回归分析提示肾内多瘤病毒载量、确诊时血清肌酐水平为移植肾失功的独立危险因素（均为P < 0.05）。 结论  PyVN多发生在肾移植术后2年内,临床表现以血清肌酐升高、BK病毒血症和BK病毒尿症为主,术后常规监测BK病毒有利于早期诊断并保护移植肾,Banff 2018分级标准可有效预测移植肾预后。     

Renal carcinoma in patients undergoing nephrectomy: analysis of survival and prognostic factors.

A series of 155 patients who underwent nephrectomy for renal carcinoma between 1965 and 1985 at Manchester Royal Infirmary were analysed for survival in relationship to presenting features, surgical staging and histopathology. Univariate and multivariate analyses were carried out. Five-year survival estimates for stage 1 disease were 81%, for stage 2 disease 65%, for stage 3 disease 39% and for stage 4 disease 6%. An erythrocyte sedimentation rate (ESR) greater than 30 mm/h was associated with worse survival and a history of hypertension was associated with better survival. Renal vein invasion alone was related to worse survival. Perinephric fat invasion was also associated with worse survival and this association in the multivariate analysis was more significant than expected, suggesting that the principles of radical surgery should be observed. The presence of granular cells as opposed to clear cells worsened survival. Patients with papillary tumours had a better survival than those with solid tumours.     

T4胃癌根治切除术患者预后的分析

目的：探讨T4胃癌根治切除术患者的生存情况及预后影响因素。 方法：对2007年1月—2011年12月收治的有完整临床及随访资料的183例T4胃癌根治切除术患者行回顾性分析。 结果：全组患者1,3,5年累积生存率分别为92%,60%,42%,单因素分析显示,淋巴结转移率、pN分期、肿瘤浸润深度、组织学类型与患者术后生存率有关（均P<0.05）;多因素分析显示,淋巴结转移率、pN分期、肿瘤浸润深度是影响患者预后的独立危险因素（均P<0.05）。 结论：淋巴结转移率、pN分期、肿瘤浸润深度是影响T4胃癌根治切除术患者生存的独立预后因素。     

肥胖患者腹腔镜全子宫切除术44例报告

目的:探讨肥胖患者行腹腔镜子宫全切术的疗效。方法:回顾分析2003年7月至2006年7月行子宫全切除术肥胖患者44例的临床资料,并与同期行开腹子宫全切除术肥胖患者44例进行比较。结果:腹腔镜组患者术中出血少,术后留置尿管时间短,进食早,排气快,下床活动早,住院时间短,与开腹组的差异有统计学意义(P<0.001);不增加手术时间(P>0.05),切口愈合良好。结论:腹腔镜子宫全切除术对肥胖患者安全、有效,充分体现了微创手术的优势。     

Mesenteric venous thrombosis with transmural intestinal infarction: a population-based study

OBJECTIVE: To determine the cause-specific mortality from and incidence of transmural intestinal infarction caused by mesenteric venous thrombosis (MVT) in a population-based study and to evaluate the findings at autopsy by evaluating autopsies and surgical procedures. METHODS: All clinical (n = 23,446) and forensic (n = 7569) autopsies performed in the city of Malm? between 1970 and 1982 (population 264,000 to 230,000) were evaluated. The autopsy rate was 87%. The surgical procedures were performed in 1970, 1976, and 1982. Autopsy protocols coded for intestinal ischemia or mesenteric vessel occlusion, or both, were identified in a database. In all, 997 of 23,446 clinical and 9 of 7,569 forensic autopsy protocols were analyzed. A 3-year sample of the surgical procedures, comprising 21.3% (11,985 of 56,251) of all operations performed during the entire study period, was chosen to capture trends of diagnostic and surgical activity. In a nested case-control study within the clinical autopsy cohort, four MVT-free controls, matched for gender, age at death, and year of death were identified for each fatal MVT case to evaluate the clinical autopsy findings. RESULTS: Four forensic and 23 clinical autopsies demonstrated MVT with intestinal infarction. Seven patients were operated on, of whom six survived. The cause-specific mortality ratio was 0.9:1000 autopsies. The incidence was 1.8/100,000 person years. At autopsy, portal vein thrombosis and systemic venous thromboembolism occurred in 2 of 3 and 1 of 2 of the cases, respectively. Obesity was an independent risk factor for fatal MVT (P =.021). CONCLUSIONS: The estimated incidence of MVT with transmural intestinal infarction was 1.8/100,000 person years. Portal vein thrombosis, systemic venous thromboembolism and obesity were associated with fatal MVT.