平阳霉素局部注射治疗睑黄疣的临床疗效观察

目的观察平阳霉素局部注射治疗睑黄疣的临床疗效。方法对87例睑黄疣患者在常规消毒后以平阳霉素8mg加2％利多卡因2mL溶解后行皮损内局部注射治疗作为治疗组，并设立二氧化碳激光治疗45例作为对照组。结果治疗组痊愈74例，显效9例，总有效率95．4％；对照组痊愈16例，显效14例，总有效率66．7％；两组比较差异有统计学意义（U=4．02，P〈0．01）。结论平阳霉素治疗睑黄疣疗效较常规治疗方法好。     

电针刺激督脉穴为主治疗肌筋膜炎疗效观察

目的:观察电针刺激督脉穴位治疗肌筋膜炎的疗效.方法:将78例肌筋膜炎患者随机分为两组,治疗组39例采用电针刺激督脉穴位;对照组采用传统针刺治疗.结果:治疗组痊愈24例,显效10例,有效5例,无效0例,总有效率100%;对照组痊愈8例,显效11例,有效17例,无效3例,总有效率92.3%.治疗组在改善疼痛方面与对照组比较...     

消疣液治疗扁平疣120例

目的　探讨消疣液治疗扁平疣的临床疗效。方法　将 12 0例扁平疣患者随机分为两组 ,治疗组 ( 60例 )采用消疣液外擦 ;对照组 ( 60例 )采用阿昔洛韦软膏外擦 ,疗程均为 2 0天。结果　治疗组痊愈 42例 ( 70 .0 % ) ,有效 12例 ( 2 0 .0 % ) ,无效 6例( 10 .0 % ) ,总有效率 90 .0 %。对照组痊愈 3 0例 ( 5 0 .0 % ) ,有效 14例 ( 2 3 .3 % ) ,无效 16例 ( 2 6.7% ) ,总有效率 73 .3 %。两组疗效比较 ,治疗组的痊愈率和总有效率均显著高于对照组 (P <0 .0 5 )。结论　消疣液治疗扁平疣疗效肯定、方法简便、安全实用     

高频电针配合中药倒模治疗囊肿型痤疮的疗效观察

目的:观察囊肿型痤疮治疗效果。方法:对照组(78例)常规用自制痤疮中药面膜倒模治疗,治疗组(120例)囊肿行高频电针打孔引流,囊腔内注入庆大霉素,再用痤疮中药面膜倒模治疗。结果:高频电针组痊愈79例,显效31例,总有效率为91.7%:对照组痊愈36例,显效22例,总有效率为74.4%:两组比较差异有统计学意义(χ2=11.01,P<0.01)。结论:高频电针配合中药倒模治疗重度囊肿型痤疮效果良好。     

电针配合牵引治疗神经根型颈椎病疗效观察

目的:观察电针配合牵引治疗神经根型颈椎病治疗效果,进一步探讨其作用机理。方法:将56例患者作为研究对象,随机分成两组。治疗组:电针配合牵引治疗;对照组:普通针刺配合牵引治疗。经治疗2个疗程(4周)后分别对两组患者进行疗效对比分析。结果:治疗组临床痊愈8例,显效12例,有效8例,无效0例,临床痊愈率为28.57%,显效率为42.86%。对照组临床痊愈5例,显效6,有效17例,无效0例,临床痊愈率为17.86%,总有效率为21.43%。治疗组明显优于对照组。结论:电针配合牵引治疗神经根型颈椎病疗效显著,且无不良反应。     

高频电针和阿达帕林凝胶治疗老年疣临床观察

目的观察高频电针与阿达帕林凝胶联合应用对老年疣的临床疗效。方法将患者随机分为治疗组和对照组,治疗组采用高频电针清除皮损,创面愈合即外用阿达帕林凝胶;对照组直接外用阿达帕林凝胶,两组疗程均为6个月,观察皮疹情况并统计。结果治疗组总有效率98．2％;对照组总有效率55．8％。两组总有效率比较,差异有统计学意义（P〈0．01）。结论高频电针联合阿达帕林凝胶治疗老年疣疗效好,无副作用。     

电针联合推拿治疗神经根型颈椎病60例疗效观察

目的:观察电针联合推拿治疗神经根型颈椎病的临床疗效,为神经根型颈椎病的临床治疗提供参考。方法:120例神经根型颈椎病患者按就诊顺序随机分为2组,对照组60例用电针治疗,治疗组60例用电针联合推拿治疗,1次/d,5次/w,连续治疗3 w。治疗结束后进行疗效评定。结果:对照组痊愈10例,显效25例,有效17例,无效8例,总有效率86.7%;治疗组痊愈17例,显效28例,有效13例,无效2例,总有效率96.7%。治疗组总有效率显著高于对照组(P0.05)。结论:电针联合推拿治疗神经根型颈椎病疗效较好,适宜临床推广。     

丽科韦治疗小儿病毒性呼吸道感染120例疗效观察

将病毒性呼吸道感染 2 4 0例随机分为丽科韦治疗组 1 2 0例及干扰素对照组1 2 0例 ,对其疗效及副作用进行比较 ,结果 :治疗组 1 2 0例中 ,痊愈 60例 ,显效 2 4例 ,有效 36例 ,无效 0例 ,疗效评价 83% ,总有效率 1 0 0 %。对照组 1 2 0例中 ,痊愈 60例 ,显效 2 0例 ,有效 40例 ,无效 0例 ,疗效评价 85 % ,总有效率 1 0 0 %。治疗组和对照组无明显差异 ( P>0 .0 5 )。提示应用丽科韦治疗病毒性呼吸道感染是目前安全有效广谱的抗病毒药     

针刀治疗膝关节骨性关节炎60例

目的:;观察针刀治疗膝关节骨性关节炎的临床疗效。方法:;采用完全随机抽样法将观察病例分为针刀治疗组60例,电针对照组60例。对2组临床疗效、止痛起效时间及镇痛效果进行评定。结果:;针刀组痊愈25例（41.7%）,显效17例（28.3%）,有效16例（26.7%）,总有效率96.7%;电针组痊愈19例（31.7%）,显效13例（21.6%）,有效22例（36.7%）,总有效率90.0%;2组愈显率比较有显著性差异(P<0.05),治疗组止痛起效时间、镇痛效果优于对照组。结论:;针刀治疗膝关节骨性关节炎疗效显著,其愈显率、止痛起效时间及镇痛效果均优于电针法。      

解毒祛疣方局部温热浸泡治疗多发性跖疣30例疗效观察

目的 探讨解毒祛疣方温热浸泡治疗多发性跖疣的临床疗效。方法 选择皮肤科门诊确诊的多发性跖疣病例60例,随机分为2组,治疗组30例,采用解毒祛疣方煎液温热浸泡,每日1次;对照组30例,采用温水浸泡联合维A酸乳膏外用,每日1次,连续4周为1个疗程。治疗1~3个疗程评估病情变化及治疗效果。结果 治疗组痊愈7例,显效9例,有效10例,无效4例,总有效率为86.67%;对照组痊愈0例,显效2例,有效9例,无效19例,总有效率为36.67%,2组比较,P<0.01,2组各项指标积分及总体疗效差异均有统计学意义,P<0.01。结论 解毒祛疣方局部温热浸泡可以有效治疗多发性跖疣,具有简便价廉、无创伤的优势,值得临床推广应用。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Electro-Acupuncture Combined with the Trigger Point Needle-Embedding for Treatment of Primary Trigeminal Neuralgia in 31 Cases

In recent years, the author of this essay has applied electro-acupuncture combined with the trigger point needle-embedding for treatment of primary trigeminal neuralgia in 31 cases, yielding satis- factory results as reported in the following.     

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.endometria from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.     

Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

Prof. SHI Da-zhuo, Ph.D., male, was born on March 20, 1960. Prof. SHI entered the Ph.D. program in 1990 at the China Academy of Chinese Medical Sciences under the supervision of Prof. CHEN Ke-ji, majoring in the treatment of cardiovascular diseases. After receiving his Ph.D. degree in 1993, Prof. SHI started working at the Cardiovascular Center in Xiyuan Hospital affiliated to China Academy of Chinese Medical sciences.     

Persist in and Carry Forward the Integrative Medical Research——Speech at the 6th National General Congress of Chinese Association of Integrative Medicine by Academician CHEN Zhu,Minister of Ministry of Health

The 6th National General Congress of Chinese Association of Integrative Medicine （CALM） was convened at 19-20, April 2008 in Beijing. Academician CHEN Zhu, the minister of Ministry of Health indicated at the congress that the integration of Chinese and Western medicine is very well in keeping with the situation of our country and the general rule of development in medical science; and as a good integration of Chinese medicine and Western medicine, it is mutually beneficial and advantageous to both of them. Seeing the creativity shown in integrative medical investigation in theoretic and methodological sides, we should and must persist in and develop it.