消风散治疗多形日光疹28例

多形日光疹亦称多形光敏疹，是由日光晒后发生的多形变态反应性皮肤病，主要由中波紫外线引起，部分有家族光过敏史。主要以有明显季节性，皮损多形性，发生于身体曝露部位为主要表现。近年来，我科用消风散加减治疗此病取得明显疗效，现报告如下。     

蒿甲醚治疗多形性日光疹、慢性光化性皮炎的临床疗效观察

目的观察蒿甲醚胶囊治疗多形性日光疹（polymorphous light eruption，PLE）和慢性光化性皮炎（chronic actinic dermatitis，CAD）的临床疗效及安全性，为光敏性皮肤病寻找更好的治疗方法．方法105例慢性光化性皮炎和63例多形性日光疹病人随机分为治疗组和对照组，治疗组（CAD63例，PLE32例）口服蒿甲醚胶囊，40mg／次，2次／d；对照组口服硫酸羟氯喹片（CAD42例，PLE31例）0．2g／次，2次／d．局部均用10％氧化锌软膏外檫2次／d，其它治疗相同，半月1疗程，治疗两疗程．结果多形性日光疹治疗组总有效率84．4％（27／32）。对照组总有效率80．6％（25／31），两组总有效率经卡方检验统计无显著性差异．慢性光化性皮炎治疗组总有效率85．7％（54／63），对照组81％（34／42），两组总有效率经卡方检验统计无显著性差异．口服蒿甲醚胶囊治疗多形性日光疹和慢性光化性皮炎均未发现副作用．结论蒿甲醚胶囊治疗多形性日光疹和慢性光化性皮炎是有效、安全、方便、经济的．     

浅谈日光与皮肤病

日光照射与很多皮肤病密切相关。最具直接关系的是日晒伤和多形性日光疹;长期过度日晒可引起皮肤皱褶、松弛、表面干燥粗糙等皮肤老化表现;癌前病变中的日光性角化、皮肤癌中的Bowen病,基底细胞癌、鳞癌、恶性黑素瘤等均与过度日晒有关。有一些皮肤病与光感物质和日光协同作用有关,如光感性药疹,植物日光性皮炎、泥螺日光性皮炎、卟啉病等。还有一些皮肤病如黄褐斑、红斑狼疮、毛囊角化病,尽管日晒不是其根本病因,但可促发或加重这些皮肤病。本文将着重介绍日光引起皮肤病的机制、日晒伤和多形性日光疹的临床表现,光感物质的种类和外源性光感性皮炎的临床表现和与日光有关皮肤病的防治。     

痘疮样水疱病(附3例报告)

痘疮样水疱病是一种少见的以水疱和疤痕为主要表现的光敏性皮肤病，常自幼年发病，反复发作，现认为有遗传倾向，其发病与暴露日光有关。治疗方法主要是外用避光剂、口服氯喹和皮质类固醇激素。并提出本病需与红细胞生成性原叶啉症，多形日光疹及盘状狼疮进行鉴别。     

痘疮样水疱病

痘疮样水疱病是一种少见的以水效疤痕为主要的光敏性皮肤病，常自幼年发病，反复发作，现认为有遗传倾向，其发病与暴露日光有关。治疗方法主要是外骼避光剂、口服氯喹和皮质类固醇激素。并提出本病需与红细胞生成性原叶啉症，多形日光疹及盘状狼进行鉴别。     

光老化性皮肤病76例临床分析

光老化性皮肤病，又称多型性日光疹是云南省的常见病、多发病，全年均有发生。是高原地区较为常见的一种光敏性皮肤病。我们收集了近年来收治的76例光老化性皮肤病患者，为进一步阐明在高原气候条件下光老化性皮肤病的发生、发展规律，进行分析。76例光老化性皮肤病中男62例，女14例。发病部位典型病例皮损好发于面、颈和手背等处的曝光区域。皮疹依据常见的形态依次为：丘疹型、斑块型、红斑水肿型等。验证了光老化性皮肤病公认的诊断标准，分析提示光老化性皮肤病好发于中年男性，患者男性多于女性，光老化性皮肤病发病与季节有关系。     

多形性日光疹的针尖状丘疹变异:临床和病理学相关性

背景:多形性日光疹(PM LE)是一种最常见的慢性特发性日光性皮肤病,通常表现为丘疹并伴随几种其他形态的变异型,包括针尖状丘疹变异。材料和方法:1998年6月至2003年8月在H enry Ford医院皮肤科就诊的10例PLM E患者,均主诉有日光暴露相关的瘙痒性针尖状丘疹。对6例患者进行了活组     

70例多形性日光疹的临床分析

本文报道70例多形性日光疹的临床分析,多形性目光疹是反复发作的慢性光感性皮肤病中的一种独特的疾病。发病与季节有明显关系,病程长,可持续几年甚至几十年。根据其临床形态特征,可分为不同的临床亚型。对氨苯甲酸是治疗该病有效的和较为理想的遮光剂。     

日光性皮炎及药物治疗

日光性皮炎(Solar Dermatitis)又称多形性日光疹(Polymor-phous light eruption),俗称晒斑,是一种由日光诱发的迟发性光变态反应性皮肤病,多数人认为主要由中波紫外线引起,但也有人认     

多形性日光疹

多形性日光疹是一种常见的、特发性、获得性,因光线照射诱发的迟发型变态反应性皮肤病。 1 病因 日光照射为直接病因,但对日光照射的敏感性个体差异较大。本病致病光谱较宽,中波(290～320nm)及长波(320～480nm)紫外线均可致病。已经证实,可见光、红外线、α粒子、X射线和短波紫外线等均可引起某些患者出现异常反应。     

香菇多糖对电离辐射所致小鼠损伤的保护作用

目的：探讨香菇多糖（PLE）对辐射损伤小鼠免疫、抗氧化及造血功能损伤的影响。方法：50只ICR小鼠随机分为正常对照组（NC）、辐射对照组（IC）和PLE低、中、高剂量给药组,剂量分别为 800、1 600 和2 400 mg?kg-1,连续7 d灌胃给药,NC组和IC组给予等量的生理盐水。第8天除NC组外,均接受2.0 Gy X线照射,检测小鼠脾指数和胸腺指数、过氧化物歧化酶（SOD）活性、肝脏丙二醛（MDA）含量和照射24 h后小鼠外周血白细胞数和骨髓嗜多染红细胞(PCE)微核数。 结果：与IC组比较,PLE高剂量组脾指数、胸腺指数、小鼠肝脏SOD活性明显升高（P< 0.05）,PLE中、高剂量组小鼠肝脏中MDA的含量明显升高（P< 0.05）,PLE各剂量组小鼠白细胞数明显升高（P< 0.05）,中、高剂量组小鼠骨髓PCE微核数明显降低（P< 0.05）。结论：PLE对电离辐射所致的小鼠损伤有明显的保护作用。     

朗格汉斯细胞在多形日光疹皮损中的表达及超微结构

目的探讨朗格汉斯细胞（Langerhans Cell,LC）在多形日光疹（polymorphic light eruption,PLE）发病中的作用及其与细胞免疫的关系。方法应用免疫组织化学技术标记健康皮肤及PLE皮肤组织中LC的CD1a,观察两组组织中LC的数量、形态及分布;用透射电镜观察2例PLE患者皮损中LC的超微结构并和2例面颈部正常皮肤作比较,结果进行统计学分析。结果PLE皮损中LC的数量较正常皮肤组织明显增多,树突变长且数量增多,而且其LC中Birbeck（BG）颗粒数量显著增多,粗面内质网扩张,部分粗面内质网核糖体颗粒脱落,高尔基复合体分泌旺盛。结论LC在PLE的发病中起重要作用,在此过程中LC自身也受到不同程度的损害。     

Naproxen-induced bullous photodermatitis

A case of naproxen-induced bullous photodermatitis ("pseudoporphyria") is presented. A 37-year-old woman with systemic lupus erythematosus developed tense bullae on her hands and lips, and was found to have a clinical and histological condition that was similar to porphyria cutanea tarda without the associated haematological abnormalities. The lesions remitted upon the cessation of naproxen therapy. Although this adverse effect of naproxen has been seen most frequently in patients from Australia and New Zealand, it has not been reported in the Australian medical literature previously.     

Paraneoplastic limbic encephalitis in an elderly patient with small cell lung carcinoma

We report a case of paraneoplastic limbic encephalitis (PLE) in an elderly lady with small-cell lung carcinoma (SCLC) and positive anti-RI neuronal auto-antibody. PLE is a relatively rare clinical entity associated with cancer patients, but is probably under-diagnosed. PLE typically presents clinically with affective changes in personality, cognitive dysfunction and seizures in a patient with malignancy, particularly SCLC. Although diagnosis does not rely upon definitive investigation results, serum paraneoplastic antibodies, abnormal CSF, and characteristic MRI and EEG findings may support the diagnosis. As PLE often presents prior to the discovery of a primary tumour, knowledge of the disease may assist in identifying underlying malignancy.     

Protein losing enteropathy caused by eosinophilic gastroenteritis: A case report

Protein losing enteropathy (PLE), a very rare disease with hypoproteinemia and edema as its characteristics, is caused by various diseases resulting in protein depletion from the gut. The diagnosis is relatively difficult due to its complex pathogeneses. The present paper reported a case whose symptom started with acute diarrhea and hypoproteinemia. Gastrointestinal endoscopies showed digestive ulcers and colon polyp. The treatments contained albumin infusion, Chinese herbal decoction and other symptomatic therapies. The hypoproteinemia become even worse and edema occurred after 4 days' treatment. A larger dose of albumin infusion (40-60 g/d) and modified herbal decoctions were prescribed. A final diagnosis of eosinophilic gastroenteritis (EG) complicated with PLE was confirmed by histopathological examination of a repeated gastroscopy. After three weeks' treatment, the serum albumin level was raised and the edema subsided gradually. In conclusion, herbs may have an effect on PLE patients, but PLE resulting from EG is very complex and easy to misdiagnose, especially in atypical conditions. Further studies are required to find the exact mechanisms.     

紫外线的不同组成部分照射对HaCaT细胞的影响

目的观察紫外线照射的不同组成部分对HaCaT细胞的影响，为下一步进行光敏性皮炎患者的体外实验提供依据，以进一步阐述光敏性皮炎的发病机制．方法以不同剂量的长波紫外线和中波紫外线照射人永生化表皮细胞HaCaT细胞，观察照射后12h细胞形态学变化，并计数细胞数．结果UV照射后细胞联接松散，折光性差，部分细胞死亡，其中以大剂量UVB为明显．结论紫外线照射对HaCaT细胞的影响因照射剂量不同而不同，为下一步进行光敏性皮炎发病机制的探讨提供实验依据．     

中药治疗多形性日光疹68例疗效观察

目的　观察中药治疗多形性日光疹的临床疗效。方法　 6 8例多形性日光疹患者 ,36例 (男 12例 ,女 2 4例 )口服中药汤剂 ,2次 /日 ;32例 (男 10例 ,女 2 2例 )作为对照组口服氯喹片 ,0 .2 5～ 0 .12 5 /次 ,2次 /日。两组局部外擦 10 %氧化锌软膏 ,2次 /日 ,连续观察 1个月。结果　中药治疗多形性日光疹的总有效率 97.2 % ,对照组 84 .4 % ,2组比较 ,差异具有显著性统计学意义 (P<0 .0 1)。结论　中药治疗多形性日光疹疗效确切。     

石榴叶提取物诱导前列腺癌细胞凋亡并抑制其增殖转移的研究

目的 研究石榴叶提取物(pomegranate leaves extract, PLE)对前列腺癌细胞增殖、凋亡及转移能力的影响。方法 采用MTT法检测不同质量浓度PLE（终质量浓度分别为12.5、25、50、100、200 μg/mL）干预作用不同时间(24、48、72 h)对前列腺癌细胞TRAMP-C1、DU145、PC3增殖的影响,克隆形成实验验证PLE对DU145、PC3细胞增殖的长期影响。PLE干预PC3细胞48 h后,Hoechst-33258染色观察细胞核内染色质变化,流式细胞术检测细胞凋亡率变化,细胞划痕实验测试细胞迁移运动能力的变化。结果 与对照组比较,PLE在12.5～200 μg/mL范围内对TRAMP-C1、DU145、PC3细胞增殖具有抑制作用(P<0.05);PLE在6.25～100 μg/mL范围内使DU145和PC3集落形成数明显减少(P<0.01)。PLE干预48 h后,PC3出现细胞核断裂、产生凋亡小体的现象,随着PLE质量浓度增大,凋亡率逐渐上升(P<0.05),同时PC3细胞向划痕区域迁移生长的能力比对照组低(P<0.01)。结论 PLE能抑制前列腺癌细胞增殖,同时促进PC3细胞凋亡,减弱其迁移能力。     

Impact of Cerebrovascular Disease Mortality on Life Expectancy in China

Objective To evaluate the impact of cerebrovascular disease mortality on life expectancy （LE） in China in 2010 compared with 2005, and to identify the high-risk population （age, sex, and region） where cerebrovascular disease mortality has had a major impact on LE. Methods LE and cause-eliminated LE were calculated by using standard life tables which used adjusted mortality data from the Death Surveillance Data Sets in 2005 and 2010 from the National Disease Surveillance System. Decomposition was used to quantitate the impact of cerebrovascular disease in different age groups. Results LE in China was 73.24 years in 2010, which was higher in women and urban residents compared with men and rural residents. The loss of LE caused by cerebrovascular disease mortality was 2.26 years, which was higher in men and rural residents compared with women and urban residents. More than 30% of the loss of LE were attributed to premature death from cerebrovascular disease in people aged 〈65 years. Compared with 2005, LE in 2010 increased by 0.92 years. The reduction of cerebrovascular disease mortality in urban residents contributed 0.45 years to the increase of LE, but the increase of cerebrovascular disease mortality caused a 0.12-year loss of LE in rural residents. Conclusion Cerebrovascular disease mortality had a major impact on LE in China, with a significant difference between urban and rural residents. LE is likely to be further increased by reducing cerebrovascular disease mortality, and special attention should be paid to reducing premature deaths in people aged 〈65 years.