原发性肝癌血清性激素及组织性激素受体的研究

目的研究人体性激素水平变化与原发性肝细胞癌的关系．方法应用放免法测定肝癌组（２０例），肝硬变组（１６例）及正常对照组（２０例）血清雌二醇（Ｅ２）及睾酮（ＴＴＴ）含量，并用放免组化法（ＰＡＰ法）检测肝癌组织及肝硬变组织的雌二醇受体（ＥＲ）及睾酮受体（ＡＲ）含量．结果肝癌组血清Ｅ２含量（４４５５±９３１ｎｇ／Ｌ）明显高于正常对照组（７６６ｎｇ／Ｌ±１７０ｎｇ／Ｌ）而低于肝硬变组（６４９６ｎｇ／Ｌ±１７６ｎｇ／Ｌ）（Ｐ＜００１）；前者ＴＴＴ含量（２５３３００ｎｇ／Ｌ±５６５６０ｎｇ／Ｌ）明显低于后二者（４５８５８０ｎｇ／Ｌ±３４９６０ｎｇ／Ｌ）（Ｐ＜００１）．肝癌组织ＥＲ（８０％）较肝硬变时（４４％）明显增加（Ｐ＜００２５），且与血清Ｅ２含量有明显负相关关系（ｒ＝－０８４７３，Ｐ＜０００１）．ＡＲ阳性百分率在两者无明显差别（ｒ＝－０３１３５，Ｐ＞００５）．结论血清ＴＴＴ含量改变及肝组织ＡＲ浓度改变与肝癌无明显关系，而血清Ｅ２含量改变及肝组织ＥＲ浓度改变与肝癌的发生、发展有密切关系．提示原发性肝细胞癌是一雌激素依赖性肿瘤．     

肝硬变血浆内毒素与一氧化氮水平的改变及关系的研究

目的研究肝硬变患者血浆内毒素与一氧化氮水平改变及关系．方法应用鲎试剂定量法和高效液相色谱分析法分别检测肝硬变患者４４例（男３２例，女１２例；年龄２５岁～７３岁，平均５０４岁±１１０岁）；ＣｈｉｌｄＰｕｇｈＡ级９例，Ｂ级２０例，Ｃ级１５例；其中有腹水者２７例及健康对照２５例（男１８例，女７例，年龄２４岁～６３岁，平均４６８岁±１２４岁）血浆内毒素和一氧化氮水平．结果肝硬变血浆内毒素及一氧化氮水平（２３７１ＥＵ／Ｌ±８２３ＥＵ／Ｌ，３８７１７ｎｇ／ｍｌ±１０６４１ｎｇ／ｍｌ）明显高于对照组（１５６７ＥＵ／Ｌ±２４６ＥＵ／Ｌ，２９２３０ｎｇ／ｍｌ±５４４９ｎｇ／ｍｌ，Ｐ＜００１）．腹水患者内毒素与一氧化氮水平（２３６９ＥＵ／Ｌ±５３６ＥＵ／Ｌ，４１４６７ｎｇ／ｍｌ±１０７０５ｎｇ／ｍｌ）明显高于无腹水者（１９６９ＥＵ／Ｌ±４５２ＥＵ／Ｌ，３２７１７ｎｇ／ｍｌ±７０２０ｎｇ／ｍｌ，Ｐ＜００５，Ｐ＜００１）．一氧化氮与内毒素呈直线正相关（Ｐ＜００１，ｒ＝０７８２）．结论肝硬变患者血浆内毒素及一氧化氮水平皆升高，且两者呈直线正相关．     

溃疡性结肠炎患者血清TNFα和IL-8的临床研究

目的研究血清ＴＮＦα和ＩＬ８在溃疡性结肠炎（ＵＣ）发生发展中的作用和意义．方法利用双抗体夹心ＥＬＩＳＡ法测定３３例ＵＣ患者（男１７例，女１６例；年龄２５岁～６７岁；病程２个月～１５ａ；轻型７例，中型２０例，重型６例）及正常对照者４０例，血清ＴＮＦα和ＩＬ８水平．结果活动性ＵＣ患者血清ＴＮＦα（２６２２ｎｇ／Ｌ±２０ｎｇ／Ｌｖｓ１４６２ｎｇ／Ｌ±２５ｎｇ／Ｌ，Ｐ＜００５）和ＩＬ８（１１１８ｎｇ／Ｌ±２６ｎｇ／Ｌｖｓ５７５ｎｇ／Ｌ±４０ｎｇ／Ｌ，Ｐ＜００５）水平明显增高，并与病情的轻重和病变的范围有关（Ｐ＜００５）．结论ＵＣ患者血清ＴＮＦα和ＩＬ８水平增高可能与ＵＣ的发生发展有关，它可作为ＵＣ病情判断的指标．     

内皮素与一氧化氮在肝硬变血流动力学紊乱中的作用

目的研究内皮素、一氧化氮在肝硬变血流动力学紊乱中的作用及关系．方法应用放免法和高效液相色谱法分别检测肝硬变患者４４例，（男３２例，女１２例；年龄５０４岁±１１０岁），其中腹水患者２７例及健康对照２５例（男１８例，女７例；年龄４６８岁±１２４岁）血浆内皮素（ＥＴ）、一氧化氮（ＮＯ）及部分血管活性物质水平．结果肝硬变组血浆ＥＴ及ＮＯ水平（５７０ｎｇ／Ｌ±２５４ｎｇ／Ｌ，３８７２μｇ／Ｌ±１０６４μｇ／Ｌ）明显高于对照组（３３０ｎｇ／Ｌ±１０９ｎｇ／Ｌ，２９２３μｇ／Ｌ±５４５μｇ／Ｌ，Ｐ＜００１）．腹水患者血浆ＥＴ及ＮＯ水平（６７５ｎｇ／Ｌ±２４７ｎｇ／Ｌ，４１４７μｇ／Ｌ±１０７１μｇ／Ｌ），显著高于无腹水患者（４５９ｎｇ／Ｌ±１８３ｎｇ／Ｌ，３２７２μｇ／Ｌ±７０２μｇ／Ｌ，Ｐ＜００１）．ＮＯ与ＥＴ呈直线正相关（ｒ＝０７７２，Ｐ＜００１）．结论肝硬变患者ＥＴ与ＮＯ水平升高，且腹水患者较无腹水者更升高；两者呈直线正相关     

结直肠癌浸润转移与癌胚抗原的关系

目的研究结直肠癌浸润转移患者与癌胚抗原（ＣＥＡ）的关系．方法结直肠癌患者６０例，男３６例，女２４例；年龄２７岁～８０岁，平均５４９岁±１３２岁，皆经手术及病理证实．ＤｕｋｅｓＡ１６例，Ｂ２０例，Ｃ１４例，Ｄ１０例．用ＲＩＡ测定血清ＣＥＡ水平，并用免疫组织化学方法检测肿瘤组织ＣＥＡ的表达．结果血清ＣＥＡ水平及肿瘤组织ＣＥＡ表达均与肿瘤浸润及转移有关．有转移的患者血清ＣＥＡ水平（１１４６μｇ／Ｌ±７９１μｇ／Ｌ）明显高于无转移的患者（４５３μｇ／Ｌ±３２３μｇ／Ｌ，Ｐ＜００１），肿瘤组织ＣＥＡ表达强度在有转移与无转移患者中亦有明显差异（强阳性率８７５ｖｓ３８９％，Ｐ＜００１）．肿瘤组织ＣＥＡ表达类型也与肿瘤转移有关，呈胞浆型表达者发生淋巴结转移（５４１％）及远处转移（２７０％）明显高于呈顶端型表达者（１９０％，０％，Ｐ＜００１）．结论ＣＥＡ与结直肠癌浸润转移呈正相关，肿瘤组织ＣＥＡ表达类型亦可作为一项预后指标     

肝气郁结证患者血浆抗利尿激素的变化

目的研究肝气郁结证的病理生理基础，检验血浆抗利尿激素含量变化与肝气郁结证的相关性．方法用ＲＩＡ法测定辨证属于肝气郁结的神经衰弱、乳痛症、慢性胃炎和慢性胆囊炎患者血浆抗利尿激素含量．第一批测定３０例，第二批测定２８例，设健康对照组进行比较．结果两批患者血浆抗利尿激素含量分别为５２８ｎｇ／Ｌ±１９１ｎｇ／Ｌ和４８５ｎｇ／Ｌ±１６２ｎｇ／Ｌ显著高于健康人对照组的２９９ｎｇ／Ｌ±１０４ｎｇ／Ｌ和２８３ｎｇ／Ｌ±９８ｎｇ／Ｌ（ｔ＝５７９和４９４，Ｐ＜００１）．异病同证比较无显著性差异（Ｐ＞００５）．结论血浆抗利尿激素水平升高是肝气郁结证相关性较强的指标之一．肝气郁结证与中枢神经对精神情绪调节功能异常密切相关．     

十二指肠球部溃疡患者高胃泌素血症与幽门螺杆菌相关性的研究

本文报告我院１９９０年４月～１９９２年１０月期间经胃镜确诊的２６４例十二指肠球部溃疡患者胃窦部幽门螺杆菌检测和血清胃泌素测定结果。结果显示ＨＰ检出率球溃组高达８０．３％（２１２／２６４），与对照组２９．６３％（１６／５４）有显著差异（Ｐ＜０．００５）。ＨＰ阳性球溃组血清胃泌素水平１０３．０３±７２．４３（ｎｇ／Ｌ），较对照组６３．３３±３９．０４（ｎｇ／Ｌ）和ＨＰ阴性球溃组７４．３２±４９．７２（ｎｇ／Ｌ）明显增高（Ｐ均＜０．００５）。随访３８例治疗后ＨＰ阳性球溃患者，２６例溃疡愈合且ＨＰ转阴者血清胃泌素为７８．３２±４２５６（ｎｇ／Ｌ），较前明显下降（Ｐ＜０．０１）。表明球溃患者高胃泌素血症与ＨＰ感染有一定相关性。     

重型肝炎患者外周血内皮素及一氧化氮水平变化的意义

目的探讨内皮素（ＥＴ）和一氧化氮（ＮＯ）在重型肝炎（ＳＨ）发病中的作用．方法检测３０例ＳＨ,３２例慢性肝炎（ＣＨ）患者外周血ＥＴ和ＮＯ代谢物ＮＯ－２的水平,并用ＮＯ合成酶底物左旋精氨酸（ＬＡｒｇ）进行治疗前后对比．结果ＳＨ患者外周血ＥＴ和ＮＯ－２水平（１３９ｎｇ／Ｌ±１４ｎｇ／Ｌ,１２７μｍｏｌ／Ｌ±４０μｍｏｌ／Ｌ）明显高于ＣＨ组（８５ｎｇ／Ｌ±１５ｎｇ／Ｌ,６３μｍｏｌ／Ｌ±２５μｍｏｌ／Ｌ,Ｐ＜００１）．合并有Ⅲ,Ⅳ期肝性脑病与肝肾综合征患者外周血ＥＴ和ＮＯ－２水平（１４９ｎｇ／Ｌ±１３ｎｇ／Ｌ,１６２μｍｏｌ／Ｌ±３４μｍｏｌ／Ｌ）明显高于非肝性脑病患者（１１５ｎｇ／Ｌ±１２ｎｇ／Ｌ,８８μｍｏｌ／Ｌ±２４μｍｏｌ／Ｌ,Ｐ＜００１）和Ⅱ期肝性脑病患者（１３６ｎｇ／Ｌ±１０ｎｇ／Ｌ,１２２μｍｏｌ／Ｌ±２６μｍｏｌ／Ｌ,Ｐ＜００１）;ＬＡｒｇ静脉滴注后血浆ＥＴ水平和平均动脉压（ＭＡＰ）显著下降,而肌酐清除率（ｃＣｒ）和尿钠含量明显增加．结论ＥＴ和ＮＯ水平升高是引起ＳＨ多脏器功能障碍的重要因素．ＬＡｒｇ长期治疗可能促进ＳＨ患者脑水肿形成和肝肾综合征发生．     

血清CA125诊断肝癌的价值

目的研究血清ＣＡ１２５对肝癌的诊断价值．方法肝癌患者３２例，男２０例，女１２例，平均年龄４６岁±２５岁；肝硬变３６例，男２７例，女９例，平均年龄４２岁±２３岁；正常对照组４０例．全部受测对象均静脉采血，分离血清，－２０℃贮存备测．采用ＩＲＭＡ法测定血清ＣＡ１２５含量．结果肝癌患者血清ＣＡ１２５含量２１８Ｕ／Ｌ±１３０Ｕ／Ｌ，显著高于肝硬变组和正常对照组（分别为１９Ｕ／Ｌ±１１Ｕ／Ｌ，１０Ｕ／Ｌ±８Ｕ／Ｌ，Ｐ＜００１）．肝硬变组高于正常对照（Ｐ＜００５），但显著低于肝癌组（Ｐ＜００１）．以２６Ｕ／Ｌ为界限值，肝癌阳性检出率为６８７％，其中ＡＦＰ阳性（ＡＦＰ＞４００μｇ／Ｌ）的肝癌中血清ＣＡ１２５的阳性检出率为７６０％，ＡＦＰ阴性（ＡＦＰ＜２０μｇ／Ｌ）的肝癌中血清ＣＡ１２５的阳性检出率为４２９％．结论血清ＣＡ１２５是诊断肝癌较好的肿瘤标记物     

5种标志物对癌性胸液的诊断价值

测定４８例癌性胸液和３３例良性胸液中癌胚抗原（ＣＥＡ）、糖链抗原５０（ＣＡ５０）、α－抗胰蛋白酶（α－ＡＴ）、唾液酸（ＳＡ）及铁蛋白（Ｆｒ）含量，评价其鉴别诊断价值。结果：①癌性胸液组ＣＥＡ、ＣＡ５０水平显著高于良性胸液组（Ｐ＜００１），分别以大于１０μｇ／Ｌ和１２ｋＵ／Ｌ为阳性界值，ＣＥＡ和ＣＡ５０对癌性胸液的诊断敏感性分别为７７１％和６６７％，特异性均为９７％。②ＣＥＡ、ＣＡ５０在癌性胸液中分布无显著相关性（ρ＜０４，Ｐ＞００５），可以互补。两指标联合测定建立判断函数，对癌性胸液的诊断敏感性、特异性和准确率分别为７５％、１００％和８４２％。③α－ＡＴ、ＳＡ、Ｆｒ在癌性胸液和良性胸液中含量无显著性差异（Ｐ＞００５），无鉴别诊断价值     

上消化道出血患者血中胃泌素胰高血糖素生长抑素的变化

目的上消化道出血患者血中胃泌素，胰高血糖素及生长抑素的变化规律．方法上消化道出血患者８８例，消化性溃疡（ＰＵ）无出血患者１５例，非ＰＵ非上消化道出血患者１３例，健康人３０例，用放免方法同期进行血中胃泌素，胰高糖素，生长抑素多项激素水平测定．结果各种上消化道出血患者及ＰＵ无出血患者血中生长抑素水平均明显高于正常对照组和非ＰＵ无出血组（Ｐ＜００１）。ＰＵ出血患者血中胃泌素和胰高血糖素明显高于健康对照组和ＰＵ无出血组（Ｐ＜００５；Ｐ＜００１）．结论血中胃泌素，胰高血糖素及生长抑素水平与上消化道出血有关，联合检测多种胃肠激素为防治上消化道出血可能提供重要参考．     

Role of circulating gastrin in colorectal adenomas and carcinomas

BACKGROUND/AIMS: A trophic role of gastrin has been convincingly demonstrated in the oxyntic mucosa of the stomach, but is still a matter of debate in the lower gastrointestinal tract. METHODS: In order to examine the role of circulating gastrin in colorectal adenoma and carcinoma fasting serum gastrin concentrations were determined in 351 patients undergoing complete colonoscopy. RESULTS: In comparison to controls (n = 145) more patients with either polyps (n = 125) or colorectal carcinoma (n = 81) have slightly increased serum gastrin concentrations, leading to an increased mean, but no change in median serum gastrin levels. In 3 patients preoperatively increased serum gastrin concentrations were normalized after surgical removal of the polyp and/or tumor, suggesting a local release of gastrin from the polyp/tumor. Gastrin concentrations do not correlate with the histopathological classification or malignant potential of adenomatous polyps. CONCLUSION: In view of these findings a significant role of circulating endogenous gastrin in human colorectal carcinogenesis seems to be unlikely.     

老年人大肠癌组织胃泌素表达及其与血清胃泌素水平的关系

目的探讨老年人大肠癌组织中胃泌素表达的临床病理意义及其与血清胃泌素水平的关系。方法对４６例老年人大肠癌、３２例非老年人大肠癌组织胃泌素表达进行免疫组化观察,并用放免法测定其血清胃泌素水平。结果癌组织中胃泌素表达阳性率,老年组４７．８％（２２例）,非老年组１８．８％（６例）（Ｐ＜０．０１）;老年组胃泌素的表达与肿瘤分化程度、ＴＮＭ分期、淋巴结转移有关,非老年组未显示这些关系。老年组和非老年组血清胃泌素水平与健康对照组比较差异均无显著性（Ｐ＞０．０５）,癌组织中胃泌素的表达不影响血清胃泌素水平（Ｐ＞０．０５）。结论胃泌素在癌组织中的表达可作为老年人大肠癌恶性度的一项指标,其表达对血清胃泌素水平无影响。     

结肠癌患者血清可溶性sIL-2R含量的变化

目的探讨结肠癌患者手术前血清可溶性白介素２受体（ｓｏｌｕｂｌｅｉｎｔｅｒｌｕｋｉｎ２ｒｅｃｅｐｔｏｒ，ｓＩＬ２Ｒ）含量改变与疾病的诊断、分期、预后判断等的关系．方法采用ＥＬＩＳＡ法对２７例结肠癌患者（ＤｕｋｅｓＡ，Ｂ期１９例），Ｃ，Ｄ期８例）及４２例对照组（正常３２例及肠易激综合征１０例）分别测定血清ｓＩＬ２Ｒ含量．同时使用间接荧光染色法对各组进行血ＣＤ３，ＣＤ４，ＣＤ８及ＣＤ４／ＣＤ８的测定．结果结肠癌患者ＤｕｋｅｓＡ，Ｂ期组血清ｓＩＬ２Ｒ含量（８３５ｐｍｏｌ／Ｌ±２１８ｐｍｏｌ／Ｌ）与对照组（６９２ｐｍｏｌ／Ｌ±２７９ｐｍｏｌ／Ｌ及７６２ｐｍｏｌ／Ｌ±２４６ｐｍｏｌ／Ｌ）无明显差异，而有淋巴结转移的ＤｕｋｅｓＣ，Ｄ期患者（３２１６ｐｍｏｌ／Ｌ±２３４４ｐｍｏｌ／Ｌ）则明显高于ＤｕｋｅｓＡ，Ｂ期患者，且ＣＤ４／ＣＤ８值明显下降（１０６±０４９比１５８±０３６）；另外，血清ｓＩＬ２Ｒ含量还与肿瘤细胞分化程度密切关联．结论结肠癌术前血清ｓＩＬ２Ｒ含量与疾病分期及预后有关．     

Serum gastrin levels and colorectal neoplasia

PURPOSE: Confirmation of an association between elevated serum gastrin concentrations and presence of colorectal tumors would have important implications with regard to screening procedures and therapeutic strategies. METHODS: We compared fasting serum gastrin concentrations of patients with colorectal cancer (n=91; mean age, 66 (range, 35–87) years), colorectal polyps (n=89; mean age, 61 (range, 38–86) years), or a normal colonoscopy (n = 101; mean age, 62 (range, 34–82) years) in the period between 1983 and 1992. RESULTS: Median serum gastrin concentrations were, respectively, 20, 20, and 21 pmol/liter (not significant). We were unable to find a relation with histology of the polyp, presence or severity of dysplasia, and extent of cancer. CONCLUSIONS: This large study fails to show any difference in serum gastrin concentrations among the three studied groups.Read at the American Gastroenterological Association meeting of the Digestive Disease Week, New Orleans, Louisiana, May, 1994.     

Plasma levels of progastrin but not amidated gastrin or glycine extended gastrin are elevated in patients with colorectal carcinoma

BACKGROUND: The relationship between plasma gastrin levels and colorectal cancer is controversial. When confounding factors which increase plasma gastrin levels are taken into account, it has been shown that gastrin levels are not elevated in patients with colorectal cancer. However, these studies only measured amidated gastrin. Total gastrin (which includes unprocessed, partially processed, and mature forms of gastrin) has been shown to be elevated in patients with colorectal cancer. AIMS: The aim of this study was to determine whether fasting plasma levels of progastrin, amidated gastrin, or glycine extended gastrin are elevated in patients with colorectal cancer or colorectal polyps compared with controls. METHODS: Progastrin, amidated gastrin, and glycine extended gastrin were estimated by radioimmunoassay using the following antibodies: L289, 109-21, and L2. Blood samples were analysed for Helicobacter pylori by an enzyme linked immunosorbent assay. RESULTS: Median progastrin levels were significantly higher in the cancer group (27.5 pmol/l) than in the polyp (< or =15 pmol/l) or control (< or =15 pmol/l) group (p=0.0001 There was no difference in median levels of amidated gastrin between groups. Median levels of amidated gastrin were significantly higher in H pylori positive patients (19 pmol/l) than in H pylori negative patients (8 pmol/l) (p=0.0022). Median plasma progastrin levels were significantly higher for moderately dysplastic polyps (38 pmol/l) compared with mildly dysplastic (15 pmol/l) and severely dysplastic (15 pmol/l) polyps (p=0.05). CONCLUSIONS: Plasma levels of progastrin, but not amidated gastrin or glycine extended gastrin, are significantly elevated in patients with colorectal cancer compared with those with colorectal polyps or controls, irrespective of their H pylori status. We conclude that measuring plasma progastrin levels in patients with colorectal cancer is warranted.     

Serum gastrin levels in colorectal cancers. Evolution after treatment]

Increased basal serum gastrin level has been described in patients presenting with colorectal cancer. The aim of this work was to study the evolution of serum gastrin levels after cancer treatment. We measured basal serum gastrin levels before and 1 to 2 months after treatment in 15 patients (7 men, 8 women; mean age: 61.6 years). There were 3 malignant polyps, 4 Dukes A, 3 Dukes B, 4 Dukes C and 1 Dukes D colonic cancers. Treatment included 3 endoscopic polypectomies, 2 laser photodestructions, and 10 surgical resections, Mean basal gastrin level after treatment (49.07 +/- 12.65 mIU/l) was significantly lower (P less than 0.002) than before treatment (104.47 +/- 26.98 mIU/l). In the 2 patients treated by laser therapy, recurrences were associated with reincreasing serum gastrin levels. These results suggest an "autocrine" secretion of gastrin.     

Serum levels of gastrin in patients with colorectal neoplasia

Serum concentration of gastrin determined by radioimmunoassay in 90 consecutive patients who underwent colonoscopy, and serum levels of gastrin in patients with colorectal neoplasia and controls were compared. Based on clinical history, findings of colonoscopy, and pathologic examinations of biopsies, 80 patients were considered eligible for the study. Serum levels of gastrin in 36 controls were 54.1 +/- 13.1 pg/ml and did not differ from serum levels of gastrin in 44 patients with colorectal neoplasia. There was also no significant difference in serum levels of gastrin among 28 patients with adenomas and 16 patients with carcinoma. The present study disclosed that carcinogenesis of the colon and rectum was not associated with hypergastrinemia.     

Plasma L-ENK, AVP, ANP and serum gastrin in patients with syndrome of Liver-Qi-stagnation

ＩＮＴＲＯＤＵＣＴＩＯＮＬｉｖｅｒＱｉｓｔａｇｎａｔｉｏｎｓｙｎｄｒｏｍｅｉｓｃｏｍｍｏｎｉｎｌｉｖｅｒｄｉｓｅａｓｅ．Ｔｈｅｐｒｅｄｏｍｉｎａｎｔｃｌｉｎｉｃａｌｍａｎｉｆｅｓｔａｔｉｏｎｓｗｅｒｅｃｈａｒａｃｔｅｒｉｚｅｄｂｙｅｍｏｔｉｏｎａｌ...     

血清透明质酸与胃癌生物学的关系

目的研究透明质酸测定与胃癌生物学行为的关系及其临床意义．方法采用ＲＩＡ法测定胃癌（ｎ＝７９）、胃良性疾病（ｎ＝３７）和健康人（ｎ＝３０）血清中透明质酸水平，同时观察了胃癌术后患者血清透明质酸含量的变化．结果胃癌患者术前血清透明质酸水平（１２９５μｇ／Ｌ±８５６μｇ／Ｌ）明显高于正常人（３８７μｇ／Ｌ±２５２μｇ／Ｌ）和良性胃病患者（５０５μｇ／Ｌ±２５４μｇ／Ｌ，Ｐ＜００１），且与肿瘤大小和临床病理分期有关。癌肿切除后则明显降低（Ｐ＜００１）．结论血清透明质酸水平能在一定程度上反映胃癌生物学行为，并用于胃癌的诊断和治疗．