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1.
原发性肝癌血清性激素及组织性激素受体的研究   总被引:2,自引:2,他引:2  
目的研究人体性激素水平变化与原发性肝细胞癌的关系.方法应用放免法测定肝癌组(20例),肝硬变组(16例)及正常对照组(20例)血清雌二醇(E2)及睾酮(TTT)含量,并用放免组化法(PAP法)检测肝癌组织及肝硬变组织的雌二醇受体(ER)及睾酮受体(AR)含量.结果肝癌组血清E2含量(4455±931ng/L)明显高于正常对照组(766ng/L±170ng/L)而低于肝硬变组(6496ng/L±176ng/L)(P<001);前者TTT含量(253300ng/L±56560ng/L)明显低于后二者(458580ng/L±34960ng/L)(P<001).肝癌组织ER(80%)较肝硬变时(44%)明显增加(P<0025),且与血清E2含量有明显负相关关系(r=-08473,P<0001).AR阳性百分率在两者无明显差别(r=-03135,P>005).结论血清TTT含量改变及肝组织AR浓度改变与肝癌无明显关系,而血清E2含量改变及肝组织ER浓度改变与肝癌的发生、发展有密切关系.提示原发性肝细胞癌是一雌激素依赖性肿瘤.  相似文献   

2.
肝硬变血浆内毒素与一氧化氮水平的改变及关系的研究   总被引:2,自引:0,他引:2  
目的研究肝硬变患者血浆内毒素与一氧化氮水平改变及关系.方法应用鲎试剂定量法和高效液相色谱分析法分别检测肝硬变患者44例(男32例,女12例;年龄25岁~73岁,平均504岁±110岁);ChildPughA级9例,B级20例,C级15例;其中有腹水者27例及健康对照25例(男18例,女7例,年龄24岁~63岁,平均468岁±124岁)血浆内毒素和一氧化氮水平.结果肝硬变血浆内毒素及一氧化氮水平(2371EU/L±823EU/L,38717ng/ml±10641ng/ml)明显高于对照组(1567EU/L±246EU/L,29230ng/ml±5449ng/ml,P<001).腹水患者内毒素与一氧化氮水平(2369EU/L±536EU/L,41467ng/ml±10705ng/ml)明显高于无腹水者(1969EU/L±452EU/L,32717ng/ml±7020ng/ml,P<005,P<001).一氧化氮与内毒素呈直线正相关(P<001,r=0782).结论肝硬变患者血浆内毒素及一氧化氮水平皆升高,且两者呈直线正相关.  相似文献   

3.
溃疡性结肠炎患者血清TNFα和IL-8的临床研究   总被引:2,自引:1,他引:2  
目的研究血清TNFα和IL8在溃疡性结肠炎(UC)发生发展中的作用和意义.方法利用双抗体夹心ELISA法测定33例UC患者(男17例,女16例;年龄25岁~67岁;病程2个月~15a;轻型7例,中型20例,重型6例)及正常对照者40例,血清TNFα和IL8水平.结果活动性UC患者血清TNFα(2622ng/L±20ng/Lvs1462ng/L±25ng/L,P<005)和IL8(1118ng/L±26ng/Lvs575ng/L±40ng/L,P<005)水平明显增高,并与病情的轻重和病变的范围有关(P<005).结论UC患者血清TNFα和IL8水平增高可能与UC的发生发展有关,它可作为UC病情判断的指标.  相似文献   

4.
内皮素与一氧化氮在肝硬变血流动力学紊乱中的作用   总被引:4,自引:9,他引:4  
目的研究内皮素、一氧化氮在肝硬变血流动力学紊乱中的作用及关系.方法应用放免法和高效液相色谱法分别检测肝硬变患者44例,(男32例,女12例;年龄504岁±110岁),其中腹水患者27例及健康对照25例(男18例,女7例;年龄468岁±124岁)血浆内皮素(ET)、一氧化氮(NO)及部分血管活性物质水平.结果肝硬变组血浆ET及NO水平(570ng/L±254ng/L,3872μg/L±1064μg/L)明显高于对照组(330ng/L±109ng/L,2923μg/L±545μg/L,P<001).腹水患者血浆ET及NO水平(675ng/L±247ng/L,4147μg/L±1071μg/L),显著高于无腹水患者(459ng/L±183ng/L,3272μg/L±702μg/L,P<001).NO与ET呈直线正相关(r=0772,P<001).结论肝硬变患者ET与NO水平升高,且腹水患者较无腹水者更升高;两者呈直线正相关  相似文献   

5.
结直肠癌浸润转移与癌胚抗原的关系   总被引:1,自引:0,他引:1  
目的研究结直肠癌浸润转移患者与癌胚抗原(CEA)的关系.方法结直肠癌患者60例,男36例,女24例;年龄27岁~80岁,平均549岁±132岁,皆经手术及病理证实.DukesA16例,B20例,C14例,D10例.用RIA测定血清CEA水平,并用免疫组织化学方法检测肿瘤组织CEA的表达.结果血清CEA水平及肿瘤组织CEA表达均与肿瘤浸润及转移有关.有转移的患者血清CEA水平(1146μg/L±791μg/L)明显高于无转移的患者(453μg/L±323μg/L,P<001),肿瘤组织CEA表达强度在有转移与无转移患者中亦有明显差异(强阳性率875vs389%,P<001).肿瘤组织CEA表达类型也与肿瘤转移有关,呈胞浆型表达者发生淋巴结转移(541%)及远处转移(270%)明显高于呈顶端型表达者(190%,0%,P<001).结论CEA与结直肠癌浸润转移呈正相关,肿瘤组织CEA表达类型亦可作为一项预后指标  相似文献   

6.
肝气郁结证患者血浆抗利尿激素的变化   总被引:9,自引:0,他引:9  
目的研究肝气郁结证的病理生理基础,检验血浆抗利尿激素含量变化与肝气郁结证的相关性.方法用RIA法测定辨证属于肝气郁结的神经衰弱、乳痛症、慢性胃炎和慢性胆囊炎患者血浆抗利尿激素含量.第一批测定30例,第二批测定28例,设健康对照组进行比较.结果两批患者血浆抗利尿激素含量分别为528ng/L±191ng/L和485ng/L±162ng/L显著高于健康人对照组的299ng/L±104ng/L和283ng/L±98ng/L(t=579和494,P<001).异病同证比较无显著性差异(P>005).结论血浆抗利尿激素水平升高是肝气郁结证相关性较强的指标之一.肝气郁结证与中枢神经对精神情绪调节功能异常密切相关.  相似文献   

7.
本文报告我院1990年4月~1992年10月期间经胃镜确诊的264例十二指肠球部溃疡患者胃窦部幽门螺杆菌检测和血清胃泌素测定结果。结果显示HP检出率球溃组高达80.3%(212/264),与对照组29.63%(16/54)有显著差异(P<0.005)。HP阳性球溃组血清胃泌素水平103.03±72.43(ng/L),较对照组63.33±39.04(ng/L)和HP阴性球溃组74.32±49.72(ng/L)明显增高(P均<0.005)。随访38例治疗后HP阳性球溃患者,26例溃疡愈合且HP转阴者血清胃泌素为78.32±4256(ng/L),较前明显下降(P<0.01)。表明球溃患者高胃泌素血症与HP感染有一定相关性。  相似文献   

8.
重型肝炎患者外周血内皮素及一氧化氮水平变化的意义   总被引:10,自引:4,他引:6  
目的探讨内皮素(ET)和一氧化氮(NO)在重型肝炎(SH)发病中的作用.方法检测30例SH,32例慢性肝炎(CH)患者外周血ET和NO代谢物NO-2的水平,并用NO合成酶底物左旋精氨酸(LArg)进行治疗前后对比.结果SH患者外周血ET和NO-2水平(139ng/L±14ng/L,127μmol/L±40μmol/L)明显高于CH组(85ng/L±15ng/L,63μmol/L±25μmol/L,P<001).合并有Ⅲ,Ⅳ期肝性脑病与肝肾综合征患者外周血ET和NO-2水平(149ng/L±13ng/L,162μmol/L±34μmol/L)明显高于非肝性脑病患者(115ng/L±12ng/L,88μmol/L±24μmol/L,P<001)和Ⅱ期肝性脑病患者(136ng/L±10ng/L,122μmol/L±26μmol/L,P<001);LArg静脉滴注后血浆ET水平和平均动脉压(MAP)显著下降,而肌酐清除率(cCr)和尿钠含量明显增加.结论ET和NO水平升高是引起SH多脏器功能障碍的重要因素.LArg长期治疗可能促进SH患者脑水肿形成和肝肾综合征发生.  相似文献   

9.
血清CA125诊断肝癌的价值   总被引:18,自引:5,他引:13  
目的研究血清CA125对肝癌的诊断价值.方法肝癌患者32例,男20例,女12例,平均年龄46岁±25岁;肝硬变36例,男27例,女9例,平均年龄42岁±23岁;正常对照组40例.全部受测对象均静脉采血,分离血清,-20℃贮存备测.采用IRMA法测定血清CA125含量.结果肝癌患者血清CA125含量218U/L±130U/L,显著高于肝硬变组和正常对照组(分别为19U/L±11U/L,10U/L±8U/L,P<001).肝硬变组高于正常对照(P<005),但显著低于肝癌组(P<001).以26U/L为界限值,肝癌阳性检出率为687%,其中AFP阳性(AFP>400μg/L)的肝癌中血清CA125的阳性检出率为760%,AFP阴性(AFP<20μg/L)的肝癌中血清CA125的阳性检出率为429%.结论血清CA125是诊断肝癌较好的肿瘤标记物  相似文献   

10.
5种标志物对癌性胸液的诊断价值   总被引:3,自引:0,他引:3  
测定48例癌性胸液和33例良性胸液中癌胚抗原(CEA)、糖链抗原50(CA50)、α-抗胰蛋白酶(α-AT)、唾液酸(SA)及铁蛋白(Fr)含量,评价其鉴别诊断价值。结果:①癌性胸液组CEA、CA50水平显著高于良性胸液组(P<001),分别以大于10μg/L和12kU/L为阳性界值,CEA和CA50对癌性胸液的诊断敏感性分别为771%和667%,特异性均为97%。②CEA、CA50在癌性胸液中分布无显著相关性(ρ<04,P>005),可以互补。两指标联合测定建立判断函数,对癌性胸液的诊断敏感性、特异性和准确率分别为75%、100%和842%。③α-AT、SA、Fr在癌性胸液和良性胸液中含量无显著性差异(P>005),无鉴别诊断价值  相似文献   

11.
上消化道出血患者血中胃泌素胰高血糖素生长抑素的变化   总被引:1,自引:2,他引:1  
目的上消化道出血患者血中胃泌素,胰高血糖素及生长抑素的变化规律.方法上消化道出血患者88例,消化性溃疡(PU)无出血患者15例,非PU非上消化道出血患者13例,健康人30例,用放免方法同期进行血中胃泌素,胰高糖素,生长抑素多项激素水平测定.结果各种上消化道出血患者及PU无出血患者血中生长抑素水平均明显高于正常对照组和非PU无出血组(P<001)。PU出血患者血中胃泌素和胰高血糖素明显高于健康对照组和PU无出血组(P<005;P<001).结论血中胃泌素,胰高血糖素及生长抑素水平与上消化道出血有关,联合检测多种胃肠激素为防治上消化道出血可能提供重要参考.  相似文献   

12.
Role of circulating gastrin in colorectal adenomas and carcinomas   总被引:2,自引:0,他引:2  
BACKGROUND/AIMS: A trophic role of gastrin has been convincingly demonstrated in the oxyntic mucosa of the stomach, but is still a matter of debate in the lower gastrointestinal tract. METHODS: In order to examine the role of circulating gastrin in colorectal adenoma and carcinoma fasting serum gastrin concentrations were determined in 351 patients undergoing complete colonoscopy. RESULTS: In comparison to controls (n = 145) more patients with either polyps (n = 125) or colorectal carcinoma (n = 81) have slightly increased serum gastrin concentrations, leading to an increased mean, but no change in median serum gastrin levels. In 3 patients preoperatively increased serum gastrin concentrations were normalized after surgical removal of the polyp and/or tumor, suggesting a local release of gastrin from the polyp/tumor. Gastrin concentrations do not correlate with the histopathological classification or malignant potential of adenomatous polyps. CONCLUSION: In view of these findings a significant role of circulating endogenous gastrin in human colorectal carcinogenesis seems to be unlikely.  相似文献   

13.
目的探讨老年人大肠癌组织中胃泌素表达的临床病理意义及其与血清胃泌素水平的关系。方法对46例老年人大肠癌、32例非老年人大肠癌组织胃泌素表达进行免疫组化观察,并用放免法测定其血清胃泌素水平。结果癌组织中胃泌素表达阳性率,老年组47.8%(22例),非老年组18.8%(6例)(P<0.01);老年组胃泌素的表达与肿瘤分化程度、TNM分期、淋巴结转移有关,非老年组未显示这些关系。老年组和非老年组血清胃泌素水平与健康对照组比较差异均无显著性(P>0.05),癌组织中胃泌素的表达不影响血清胃泌素水平(P>0.05)。结论胃泌素在癌组织中的表达可作为老年人大肠癌恶性度的一项指标,其表达对血清胃泌素水平无影响。  相似文献   

14.
目的探讨结肠癌患者手术前血清可溶性白介素2受体(solubleinterlukin2receptor,sIL2R)含量改变与疾病的诊断、分期、预后判断等的关系.方法采用ELISA法对27例结肠癌患者(DukesA,B期19例),C,D期8例)及42例对照组(正常32例及肠易激综合征10例)分别测定血清sIL2R含量.同时使用间接荧光染色法对各组进行血CD3,CD4,CD8及CD4/CD8的测定.结果结肠癌患者DukesA,B期组血清sIL2R含量(835pmol/L±218pmol/L)与对照组(692pmol/L±279pmol/L及762pmol/L±246pmol/L)无明显差异,而有淋巴结转移的DukesC,D期患者(3216pmol/L±2344pmol/L)则明显高于DukesA,B期患者,且CD4/CD8值明显下降(106±049比158±036);另外,血清sIL2R含量还与肿瘤细胞分化程度密切关联.结论结肠癌术前血清sIL2R含量与疾病分期及预后有关.  相似文献   

15.
Serum gastrin levels and colorectal neoplasia   总被引:2,自引:0,他引:2  
PURPOSE: Confirmation of an association between elevated serum gastrin concentrations and presence of colorectal tumors would have important implications with regard to screening procedures and therapeutic strategies. METHODS: We compared fasting serum gastrin concentrations of patients with colorectal cancer (n=91; mean age, 66 (range, 35–87) years), colorectal polyps (n=89; mean age, 61 (range, 38–86) years), or a normal colonoscopy (n = 101; mean age, 62 (range, 34–82) years) in the period between 1983 and 1992. RESULTS: Median serum gastrin concentrations were, respectively, 20, 20, and 21 pmol/liter (not significant). We were unable to find a relation with histology of the polyp, presence or severity of dysplasia, and extent of cancer. CONCLUSIONS: This large study fails to show any difference in serum gastrin concentrations among the three studied groups.Read at the American Gastroenterological Association meeting of the Digestive Disease Week, New Orleans, Louisiana, May, 1994.  相似文献   

16.
Siddheshwar RK  Gray JC  Kelly SB 《Gut》2001,48(1):47-52
BACKGROUND: The relationship between plasma gastrin levels and colorectal cancer is controversial. When confounding factors which increase plasma gastrin levels are taken into account, it has been shown that gastrin levels are not elevated in patients with colorectal cancer. However, these studies only measured amidated gastrin. Total gastrin (which includes unprocessed, partially processed, and mature forms of gastrin) has been shown to be elevated in patients with colorectal cancer. AIMS: The aim of this study was to determine whether fasting plasma levels of progastrin, amidated gastrin, or glycine extended gastrin are elevated in patients with colorectal cancer or colorectal polyps compared with controls. METHODS: Progastrin, amidated gastrin, and glycine extended gastrin were estimated by radioimmunoassay using the following antibodies: L289, 109-21, and L2. Blood samples were analysed for Helicobacter pylori by an enzyme linked immunosorbent assay. RESULTS: Median progastrin levels were significantly higher in the cancer group (27.5 pmol/l) than in the polyp (< or =15 pmol/l) or control (< or =15 pmol/l) group (p=0.0001 There was no difference in median levels of amidated gastrin between groups. Median levels of amidated gastrin were significantly higher in H pylori positive patients (19 pmol/l) than in H pylori negative patients (8 pmol/l) (p=0.0022). Median plasma progastrin levels were significantly higher for moderately dysplastic polyps (38 pmol/l) compared with mildly dysplastic (15 pmol/l) and severely dysplastic (15 pmol/l) polyps (p=0.05). CONCLUSIONS: Plasma levels of progastrin, but not amidated gastrin or glycine extended gastrin, are significantly elevated in patients with colorectal cancer compared with those with colorectal polyps or controls, irrespective of their H pylori status. We conclude that measuring plasma progastrin levels in patients with colorectal cancer is warranted.  相似文献   

17.
Serum gastrin levels in colorectal cancers. Evolution after treatment]   总被引:1,自引:0,他引:1  
Increased basal serum gastrin level has been described in patients presenting with colorectal cancer. The aim of this work was to study the evolution of serum gastrin levels after cancer treatment. We measured basal serum gastrin levels before and 1 to 2 months after treatment in 15 patients (7 men, 8 women; mean age: 61.6 years). There were 3 malignant polyps, 4 Dukes A, 3 Dukes B, 4 Dukes C and 1 Dukes D colonic cancers. Treatment included 3 endoscopic polypectomies, 2 laser photodestructions, and 10 surgical resections, Mean basal gastrin level after treatment (49.07 +/- 12.65 mIU/l) was significantly lower (P less than 0.002) than before treatment (104.47 +/- 26.98 mIU/l). In the 2 patients treated by laser therapy, recurrences were associated with reincreasing serum gastrin levels. These results suggest an "autocrine" secretion of gastrin.  相似文献   

18.
Serum levels of gastrin in patients with colorectal neoplasia   总被引:6,自引:4,他引:6  
Serum concentration of gastrin determined by radioimmunoassay in 90 consecutive patients who underwent colonoscopy, and serum levels of gastrin in patients with colorectal neoplasia and controls were compared. Based on clinical history, findings of colonoscopy, and pathologic examinations of biopsies, 80 patients were considered eligible for the study. Serum levels of gastrin in 36 controls were 54.1 +/- 13.1 pg/ml and did not differ from serum levels of gastrin in 44 patients with colorectal neoplasia. There was also no significant difference in serum levels of gastrin among 28 patients with adenomas and 16 patients with carcinoma. The present study disclosed that carcinogenesis of the colon and rectum was not associated with hypergastrinemia.  相似文献   

19.
INTRODUCTIONLiverQistagnationsyndromeiscommoninliverdisease.Thepredominantclinicalmanifestationswerecharacterizedbyemotional...  相似文献   

20.
血清透明质酸与胃癌生物学的关系   总被引:5,自引:1,他引:5  
目的研究透明质酸测定与胃癌生物学行为的关系及其临床意义.方法采用RIA法测定胃癌(n=79)、胃良性疾病(n=37)和健康人(n=30)血清中透明质酸水平,同时观察了胃癌术后患者血清透明质酸含量的变化.结果胃癌患者术前血清透明质酸水平(1295μg/L±856μg/L)明显高于正常人(387μg/L±252μg/L)和良性胃病患者(505μg/L±254μg/L,P<001),且与肿瘤大小和临床病理分期有关。癌肿切除后则明显降低(P<001).结论血清透明质酸水平能在一定程度上反映胃癌生物学行为,并用于胃癌的诊断和治疗.  相似文献   

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