施他宁在术后早期炎性肠梗阻治疗中的应用

目的探讨施他宁在术后早期炎性肠梗阻中的治疗作用。方法对我院2002年10月至2005年5月期间63例术后早期炎性肠梗阻患者,双盲法应用超过2 d的施他宁治疗,随机分为施他宁 常规治疗组(治疗组,33例)和常规治疗组(对照组,30例),观察临床症状、胃肠减压量、腹部平片、明确肠梗阻后的平均住院时间等各项指标,对结果分别进行对比。结果施他宁组较常规治疗组腹胀均有不同程度的缓解,腹部平片显示液平面明显减少、变小。施他宁组患者的胃肠减压量(525.7±292.5)ml/d较常规治疗组(895.6±351.4)ml/d明显减少,且平均住院时间(13.3±8.5)d较常规治疗组(20.6±11.7)d明显缩短,差异有统计学意义(P<0.05)。结论施他宁能抑制消化道内液分泌、缓解扩张、促进肠蠕动,对治疗术后早期炎性肠梗阻有明显作用。     

术后早期炎性肠梗阻的多方位集束治疗

目的 探讨多方位集束治疗策略在术后早期炎性肠梗阻的临床应用.方法 回顾性分析吉林大学第一医院胃结直肠外科2007年7月至2011年7月间收治的31例术后早期炎性肠梗阻患者的临床资料.其中采用多方位集束治疗者13 例（治疗组）,采用其他非手术方法治疗者18例（对照组）,比较两组患者的治疗效果.结果 治疗组和对照组患者治疗后4d好转率分别为76.9％（10/13）和44.4％（8/18）,7d治愈率分别92.3％（12/13）和77.8％ （14/18）,差异均有统计学意义（均P＜0.05）.治疗组比对照组治疗后肠鸣音恢复时间[（2.3±1.5）d比（4.7±1.9）d]、肛门排气时间[（2.9±2.4）d比（5.1±3.7）d]、排粪时间[（3.5±2.7）d比（6.2±2.8）d]、腹胀消失时间[（4.6±2.3）d比 （9.1±3.4）d]、开始经口进食时间[（5.9±1.8）d比（10.2±2.7）d]、腹部CT肠管改善时间[（6.6±3.5）d比 （11.4±9.6）d]以及从治疗开始至出院时间[（7.3±2.9）d比（14.8±11.2）d]均缩短,差异均有统计学意义（P＜0.05）.结论 多方位集束治疗策略可有效缩短术后早期炎性肠梗阻治愈时间,具有良好的应用前景.     

复方大承气汤治疗术后早期炎性肠梗阻12例临床观察

为观察复方大承气汤对腹部手术术后早期炎性肠梗阻的疗效,将24例术后早期炎性肠梗阻患者随机分为两组,治疗组12例在传统治疗方法上加用复方大承气汤,并与用传统方法治疗的对照组12例进行对比观察。结果显示,治疗组肠梗阻缓解所需时间15-25d,平均10d;对照组7-34d,平均14d。治疗组肠梗阻缓解时间明显短于对照组（P〈0．05）。结果表明,复方大承气汤治疗术后早期炎性肠梗阻是有效的,可促进胃肠功能恢复,增加胃肠蠕动,明显缩短术后早期炎性肠梗阻的恢复时间。     

肠梗阻导管在腹部术后早期炎性肠梗阻治疗中的应用

目的探讨经鼻型肠梗阻导管在腹部术后早期炎性肠梗阻治疗中的作用。方法对我院2004年6月至2006年6月期间40例腹部术后早期炎性肠梗阻患者,随机分成经鼻型肠梗阻导管组和鼻胃管组。观察腹胀改善情况(腹围)、胃肠减压量、腹部X线平片、气液平面消失时间等指标,对结果进行分析比较。结果经鼻型肠梗阻导管组患者的胃肠减压量(1021.2±265.4)ml/d较鼻胃管组(642.5±325.4)ml/d明显增多,且腹围(15.2±5.5)cm减少较鼻胃管组的(5.7±3.6)cm更明显,气液平面消失时间(10.3±8.5)d较鼻胃管组的(15.6±11.7)d明显缩短,差异有统计学意义(P<0.05)。结论经鼻型肠梗阻导管能更有效胃肠减压,减轻腹胀,促进肠蠕动,治疗腹部术后早期炎性肠梗阻作用显著。     

鼻肠管减压及奥曲肽治疗术后早期炎症性肠梗阻的临床研究

目的 评价、比较鼻肠减压导管以及奥曲肽,在腹部手术后早期炎症性肠梗阻保守治疗中的作用.方法 2005年3月至2009年1月期间45例腹部手术后早期炎症性肠梗阻的患者,使用鼻胃管减压等常规保守治疗无效后,非随机分为肠减压导管治疗组(23例)以及奥曲肽治疗组(22例),比较两种治疗方法与常规保守治疗方法以及两种治疗方法之间的疗效差别.结果 经鼻胃管减压的常规保守治疗无效的45例患者,经过上述两种治疗方法的保守治疗,3-12 d所有患者的肠梗阻均得以缓解;与奥曲肽治疗组相比,肠减压导管治疗组的自主排气时间更短[(4.7±1.9)d比(6.7 ±1.6)d]、腹围恢复得更快[(90.4±2.0)%比(95.1±1.3)%],但累计胃肠减压量[(4037±1155)ml比(3316±1038)m1]及日均胃肠减压量[(890±181)ml比(492±83)ml均更多,两组差异均有统计学意义(P均＜0.05).结论 肠减压导管以及奥曲肽治疗术后早期炎症性肠梗阻安全有效,肠减压导管的治疗时间更短,奥曲肽能够降低胃肠减压量.     

术后早期炎性肠梗阻诊治体会

目的探讨术后早期炎性肠梗阻的病因、临床特点及诊断与治疗。方法对我院40例腹部手术后早期炎性肠梗阻患者的诊断和治疗情况进行回顾性分析。结果全部患者症状缓解的时间为3～7d(平均5d)、住院时间为7～20d(平均13d)。随访时间为6～12个月(平均9个月),随访中有2例再次出现肠梗阻,经保守治疗治愈。结论术后早期炎性肠梗阻好发于腹腔污染重或创伤大的腹部手术,多发生于术后1～3周,肠梗阻症状和体征典型,很少发生肠绞窄坏死,保守治疗效果好。     

隔药灸治疗术后早期炎性肠梗阻的疗效观察

目的:观察隔药灸治疗术后早期炎性肠梗阻的疗效及对血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)的影响。方法:将78例术后早期炎性肠梗阻患者分为观察组和对照组各39例。对照组接受生长抑素(0.25mg/h连续滴注)治疗,治疗组接受天枢、大肠俞穴隔药灸治疗。7 d后观察主要症状、肠功能评分、CRP、TNF-α、IL-6水平,总结疗效。结果:观察组和对照组总有效率分别为92.31%、76.92%(P0.05),观察组治疗后肛门恢复排气时间、腹部症状缓解时间、肠鸣音恢复时间分别为(3.49±1.37)d、(3.68±1.03)d、(2.14±0.55)d,均分别短于对照组的(5.05±1.50)d、(5.85±1.68)d、(4.01±0.95)d,P0.05。治疗后观察组CRP、TNF-α、IL-6水平分别为(6.04±1.10)mg/mL、(60.05±5.12)ng/mL、(28.06±4.02)pg/mL,均低于对照组的(8.13±1.65)mg/mL、(73.11±6.93)ng/mL、(56.14±5.86)pg/mL,P0.05。结论:隔药灸能够明显改善术后早期炎性肠梗阻患者的症状,有效调节血清CRP、TNF-α、IL-6水平。     

腹部手术后粘连性肠梗阻的临床护理体会

目的总结腹部手术后粘连性肠梗阻的护理体会。方法在对42例腹部术后粘连性肠梗阻患者治疗期间,给予密切病情观察、加强胃肠减压护理、积极开展健康教育等综合护理干预。结果 42例患者中,38例经非手术治疗缓解,4例经手术治疗后缓解,均康复出院。住院时间(8.24±2.65)d。术后随访3个月~1 a,未出现复发病例。结论在腹部术后粘连性肠梗阻患者的治疗期间,加强综合护理干预,可提高治愈率,促进患者早期康复。     

强筋补骨汤联合C 臂辅助下PFNA 术式对股骨粗隆间骨折PLT、D-D、IL-13 水平的影响

目的:研究强筋补骨汤联合C臂辅助下股骨近端防旋髓内钉内固定(PFNA)术式对股骨粗隆间骨折患者血小板计数(PLT)、D-二聚体(D-D)、白细胞介素-13(IL-13)水平的影响。方法:选取2016年3月—2018年3月在我院接受治疗的股骨粗隆间骨折患者120例。通过随机抽签法将其均分成研究组与对照组。对照组予以C臂辅助下PFNA术式治疗,研究组则在对照组的基础上加用强筋补骨汤治疗。分别对比两组在术后恢复情况,术后不同时间段两组髋关节与膝关节功能恢复情况,手术前后两组PLT、D-D、IL-13水平,以及术后并发症等方面的差异。结果:研究组的下床活动时间[(3.84±0.56)d]、骨折愈合时间[(113.88±14.89)d]、完全负重下地时间[(130.22±17.39)d]比对照组[(6.02±0.87)d]、[(150.82±19.85)d]、[(194.73±21.75)d]低(均P0.05)。研究组术后3、6、12个月的髋关节评分[(64.27±8.14)分]、[(71.60±9.22)分]、[(78.13±9.27)分]、膝关节评分[(88.41±11.48)分]、[(94.17±13.06)分]、[(98.27±14.32)分]比对照组[(52.09±6.23)分]、[(58.54±6.39)分]、[(64.01±7.26)分]、[(79.05±9.33)分]、[(84.07±9.33)分]、[(90.25±13.95)分]高(均P0.05)。研究组术后7天时的PLT[(225.18±14.28)×10~9/L]、D-D[(92.35±35.28)μg/mL]、IL-13水平[(13.58±2.03)pg/mL]比对照组[(234.75±15.06)×10~9/L]、[(109.66±36.83)μg/mL]、[(19.24±3.48)pg/mL]低(均P0.05)。研究组与对照组在感染、压疮、深静脉血栓形成、骨折不愈合发生率方面无明显差异(均P0.05)。结论:强筋补骨汤联合C臂辅助下PFNA术式治疗股骨粗隆间骨折的效果显著,有利于促进患者膝关节以及髋关节功能恢复,改善PLT、D-D、IL-13水平,值得临床推广应用。     

生长抑素(施他宁)在结直肠术后早期炎性肠梗阻治疗中的应用

目的:探讨生长抑素(施他宁)在结直肠术后早期炎性肠梗阻治疗中的作用。方法:将2002年2月至2006年10月期间29例结直肠术后早期炎性肠梗阻患者,随机分为生长抑素加常规治疗组(治疗组,15例)和常规治疗组(对照组,14例),观察两组病例治疗前后临床症状、体征、胃肠减压量、腹部平片、腹部CT、实验室检查及明确肠梗阻后的平均住院时间等各项指标,对结果分别进行对比。结果:治疗组肛门排气时间、腹胀症状消失时间较对照组提前,胃肠引流量减少,红细胞比容接近正常,平均住院时间明显缩短,两组患者的影像学检查均得到改善。结论:生长抑素能抑制消化道内液分泌,减轻肠壁水肿,缓解扩张,促进肠蠕动,对治疗结直肠术后早期炎性肠梗阻有明显作用。     

Vasopressor hormone response following mesenteric traction during major abdominal surgery

Background : We investigated the vasopressor hormone response following mesenteric traction (MT) with hypotension due to prostacyclin (PGI₂) release in patients undergoing abdominal surgery with a combined general and epidural anesthesia. Methods : In a prospective, randomized, placebo-controlled study we administered 400 mg ibuprofen (i.v.) in 42 patients scheduled for abdominal surgery. General anesthesia was combined with epidural anesthesia (T4-L1). Before as well as 5, 15, 30, 45, and 90 min after MT we recorded plasma osmolality, hemodynamics and measured 6-keto-PGFlα (stabile metabolite of PGI₂), TXB₂ (stabile metabolite of thromboxane A₂) active renin, and arginine vasopressin (AVP) plasma concentrations by radioimmunoassay. Catecholamine levels were assessed by high-pressure liquid chromatography (HPLC) with electrochemical detection. Results : Following MT, arterial hypotension occurred along with a substantial PGI₂ release. This was completely abolished by ibuprofen administration. Although plasma levels of 6-keto-PGF_1α (1133 (708) vs. 60 (3) ng/L, median (median absolute deviation), P=0.0001, placebo vs. ibuprofen) remained significantly elevated, blood pressure was restored within 30 min after MT in the placebo group. At the same point in time plasma concentrations of TXB² (164 (87) vs. 58 (1) ng/L, P=0.0001), epinephrine (46 (33) vs. 14 (6) ng/L, P=0.001), AVP (41 ± (18) vs. 12 (7) ng/L, P=0.0004), and active renin (27 (12) vs. 12 (4) ng/L, P = 0.001) were significantly higher in placebo-treated patients. Conclusion : Under combined general and epidural anesthesia arterial hypotension following MT due to endogenous PGI₂ release is associated with enhanced release of AVP, active renin, epinephrine and thromboxane A₂, presumably contributing to hemodynamic stability within 30 min after MT.     

A Teaspoon Pump for Pumping Blood with High Hydraulic Efficiency and Low Hemolysis Potential

Abstract: Virtually all blood pumps contain some kind of rubbing, sliding, closely moving machinery surfaces that are exposed to the blood being pumped. These valves, internal bearings, magnetic bearing position sensors, and shaft seals cause most of the problems with blood pumps. The original teaspoon pump design prevented the rubbing, sliding machinery surfaces from contacting the blood. However, the hydraulic efficiency was low because the blood was able to "slip around" the rotating impeller so that the blood itself never rotated fast enough to develop adequate pressure. An improved teaspoon blood pump has been designed and tested and has shown acceptable hydraulic performance and low hemolysis potential. The new pump uses a nonrotating "swinging" hose as the pump impeller. The fluid enters the pump through the center of the swinging hose; therefore, there can be no fluid slip between the revolving blood and the revolving impeller. The new pump uses an impeller that is comparable to a flexible garden hose. If the free end of the hose were swung around in a circle like half of a jump rope, the fluid inside the hose would rotate and develop pressure even though the hose impeller itself did not "rotate"; therefore, no rotating shaft seal or internal bearings are required.     

Microspheres Based Detoxification System: A New Method in Convective Blood Purification

Abstract: A variety of protein-bound or hydrophobic substances, accumulating as a result of pathologic conditions such as exogenous or endogenous intoxications, are removed poorly by conventional detoxification methods because of low accessibility (hemodialysis), insufficient adsorption capabilities (hemosorption), low efficiency (peritoneal dialysis), or economic limitations (high-volume plasmapheresis). Combining advantages of existing methods with microspheric technology, a module-based system was designed. Major operating parameters of the latter can be modified to allow for adjustment to individual clinical situations. An extracorporeal blood circuit including a plasmafilter is combined with a secondary high-velocity plasma circuit driven by a centrifugal pump. Different microspheric adsorbers can be combined in one circuit or applied in sequence. Thus, a prolonged treatment can be tailored using specially designed selective adsorber materials. Comparing this system with existing methods (high-flux hemodialysis, molecular adsorbent recycling system), results from our in vitro studies and animal experiments demonstrate the superior efficiency of substance removal.     

Tissue perfusion in relation to cardiac output during continuous positive-pressure ventilation and administration of propranolol or verapamil

Background : Our objective was to determine whether administration of propranolol or verapamil modifies the hemodynamic adaptation to continuous positive-pressure ventilation (CPPV), in particular the regional distribution of cardiac output (CO).
Methods : General hemodynamics and regional blood flows assessed by microsphere technique (15 (μm) were recorded in 16 anesthetized pigs during spontaneous breathing (SB) and CPPV with 8 cm H₂O end-expiratory pressure (CPPV8) before and after intravenous administration of propranolol (0.3 mg · kg⁻¹ followed by 0.15 mg · kg⁻¹ · h⁻¹, n=8) or verapamil (0.1 mg · kg⁻¹ followed by 0.3 mg · kg⁻¹ · h⁻¹, n=8).
Results : CPPV8 depressed CO by 25% without shifts in its relative distribution with the exception of a noteworthy increase in adrenal perfusion. Propranolol increased arterial blood pressure, and due to a fall in heart rate, CO dropped by 25%. The kidneys and, to a lesser extent, the splanchic region and central nervous system received increased fractions of the remaining CO at the expense of skeletal muscle flow. Similar patterns were seen during SB and CPPV8 such that the combination of propranolol and CPPV8 depressed CO by 50%. The circulatory effects of verapamil were less evident but myocardial perfusion tended to increase.
Conclusions : The combination of propranolol or verapamil with CPPV does not result in any specific hemodynamic interaction in anesthetized pigs, except that the combined effect of propranolol and CPPV may severely reduce CO.     

Bariatric Surgery in Some "Central and East-European (former Eastern bloc)"Countries - Current Status and Prediction for the Next Millennium

Background: Obesity is increasing globallly, including in the formerly "Eastern Bloc" countries. Methods: A survey was made of obesity and bariatric surgery. Results: In the 8 East and Central European countries studied, with total population 300 million, roughly 43% of the population was overweight (BMI 25-30), 23% obese (BMI > 30), with about 15 million people morbidly obese (BMI > 40). From 0-10 morbidly obese individuals/100,000/year undergo bariatric surgery. Conclusion: Most countries were found to provide inadequate treatment for obesity.The majority of the morbidly obese are not treated effectively. However, health-care awareness of obesity and bariatric surgeons are slowly increasing.     

Volatile anaesthetics reduce adhesion of blood platelets under low-flow conditions in the coronary system of isolated guinea pig hearts

Background : Inhibitory effects of volatile anaesthetics on platelet aggregation have been demonstrated in several studies. However, the influence of volatile anaesthetics on intracoronary platelet adhesion has not been elucidated so far.
Methods : Isolated hearts of guinea pigs were perfused with buffer in the absence or presence of volatile anaesthetics (0.5 and 1 MAC) at constant coronary flow rates of 5 ml/min for 25 min, then 1 ml/min for 30 min and again 5 ml/min for 10 min. Before, during and after low-flow perfusion, a bolus of human platelets was applied into the coronary system. To simulate thrombogenic conditions, 0.3 U/ml human thrombin was infused during low-flow perfusion and reperfusion. The number of platelets sequestered to the endothelium was calculated from the difference between coronary in- and output of platelets. The myocardial production of lactate and consumption of pyruvate and coronary perfusion pressure were also determined.
Results : At a flow rate of 5 ml/min only about 3% of the applied platelets did not emerge from the coronary system, in any group. In contrast, 13.1±1.2% (mean±SEM) of infused platelets became adherent in low-flow perfusion in the control group without anaesthetic. The adherence was reduced with each 1 MAC isoflurane (to 6.2±1.2%), sevoflurane (to 4.4±0.9%) or halothane (to 3.2±1.5%) (each P <0.05 vs. control). Volatile anaesthetic, 0.5 MAC, did not inhibit platelet adhesion to a statistically significant extent in any case. Perfusion pressure and metabolic parameters were not statistically different between the control and the hearts exposed to anaesthetics.
Conclusion : Volatile anaesthetics in a concentration of 1 MAC can reduce the adhesion of platelets in the coronary system under reduced flow conditions. This action does not arise from vasodilation or inhibition of ischaemic stress.     

Synergistic interaction between the effects of propofol and midazolam with fentanyl on phrenic nerve activity in rabbits

Background: It has been shown that the depressive effects of both propofol and midazolam on consciousness are synergistic with opioids, but the nature of their interactions on other physiological systems, e. g. respiration, has not been fully investigated. The present study examined the effect of propofol and midazolam alone and in combination with fentanyl on phrenic nerve activity (PNA) and whether such interactions are additive or synergistic. Methods: PNA was recorded in 27 anaesthetised and artificially ventilated rabbits. In three groups, propofol, fentanyl and midazolam were administered intravenously in incremental doses to construct dose-response curves for the depressant effects of each one on PNA. In another two groups, the effect of pretreatment with either fentanyl 1 μg · kg^?1 i. v. or midazolam 0.05 mg · kg^?1 i. v. on the effects of propofol and fentanyl respectively on PNA were studied. Results: Propofol and fentanyl caused a dose-dependent depression of PNA with complete abolition at the highest total doses of 16 mg · kg^?1 i. v. and 32 μg · kg^?1 i. v., respectively. In contrast, midazolam in incremental doses to a total of 0.8 mg · kg^?1 reduced mean PNA by 63%, but approximately 12% of PNA remained at a total dose as high as 6.4 mg · kg^?1. The mean ED₅₀s, calculated from dose-response curves, were 5.4 mg · kg^?1, 3.9 μg · kg^?1 and 0.4 mg · kg^?1 for propofol, fentanyl and midazolam, respectively. Initial doses of either fentanyl 1 μg · kg^?1 i. v. or midazolam 0.05 mg · kg^?1 i. v. acted synergistically with subsequent doses of either propofol or fentanyl to abolish PNA at total doses of 8 mg · kg^?1 and 8 μg · kg^?1, respectively. Conclusion: Fentanyl has a synergistic interaction with both propofol and midazolam on PNA and hence potentially on respiration.     

Influence of dopexamine hydrochloride on haemodynamics and regulators of circulation in patients undergoing major abdominal surgery

Background: Catecholaminergic support is often used to improve haemodynamics in patients undergoing major abdominal surgery. Dopexamine is a synthetic vasoactive catecholamine with beneficial microcirculatory properties. Methods: The influence of perioperative administration of dopexamine on cardiorespiratory data and important regulators of macro- and microcirculation were studied in 30 patients undergoing Whipple pancreaticduodenectomy. The patients received randomized and blinded either 2 μg · kg^?1 · min^?1 of dopexamine (n=15) or placebo (n=15, control group). The infusion was started after induction of anaesthesia and continued until the morning of the first postoperative day. Endothelin-1 (ET-1), vasopressin, atrial natriuretic peptide (ANP), and catecholamine plasma levels were measured from arterial blood samples. Measurements were carried out after induction of anaesthesia, 2 h after onset of surgery, at the end of surgery, 2 h after surgery, and on the morning of the first postoperative day. Results: Cardiac index (CI) increased significantly in the dopexamine group (from 2.61±0.41 to 4.57±0.78 1 · min^?1 · m^?2) and remained elevated until the morning of the first postoperative day. Oxygen delivery index (DO₂I) and oxygen consumption index (VO₂I) were also significantly increased in the dopexamine group (DO₂I: from 416±91 to 717±110 ml/m² · m²; VO₂I: from 98±25 to 157±22 ml/m² · m²), being significantly higher than in the control group. pHi remained stable only in the dopexamine patients, indicating adequate splanchnic perfusion. Vasopressive regulators of circulation increased significantly only in the untreated control patients (vasopressin: from 4.37±1.1 to 35.9±12.1 pg/ml; ET-1: from 2.88±0.91 to 6.91±1.20 pg/ml). Conclusion: Patients undergoing major abdominal surgery may profit from prophylactic perioperative administration of dopexamine hydrochloride in the form of improved haemodynamics and oxygenation as well as beneficial influence on important regulators of organ blood flow.     

Systemic analgesia adapted to the children's condition

A concept of balanced analgesia using nonsteroidal anti-inflammatory drugs (NSAIDs), paracetamol (acetaminophen), opioids, and corticosteroids can also be used in patients with pre-existing illnesses. NSAIDs are the most effective treatment for acute pain of moderate intensity in children; however, these drugs should be avoided in patients at increased risk for serious side effects, e.g. patients with renal impairment, bleeding tendency, or extreme prematurity. NSAIDs can be given with minimal risks to the younger child with mild to moderate asthma, and, in these patients, the use of steroids can be encouraged; in addition to their antiemetic and analgesic action, a beneficial effect on asthma symptoms can be expected. In the non-intubated child with cerebral trauma, exaggerated sedation caused by opioids and increased bleeding tendency caused by NSAIDs must be avoided. In neonates and small infants, the oral administration of sucrose or glucose is helpful to minimize pain reaction during short uncomfortable interventions.     

A comparison of the inhibitory effects of four volatile anaesthetics on the metabolism of chlorzoxazone, a substrate for CYP2E1, in rabbits

Background: Halothane inhibits in vitro and in vivo activity of cytochrome P-450 (CYP) 2E1. There are several fluorinated volatile anaesthetics besides halothane, and most of them are defluorinated by CYP2E1. It is unclear whether other fluorinated anaesthetics inhibit the in vivo activity of CYP2E1.
Methods: We compared the inhibitory effects of therapeutic concentrations of four inhalational anaesthetics, halothane, enflurane, isoflurane, and sevoflurane, on chlorzoxazone metabolism in rabbits receiving artificial ventilation.
Results: All four inhalational anaesthetics decreased arterial blood pressure and increased plasma chlorzoxazone concentration. However, no significant differences in the plasma chlorzoxazone concentration were found between the four anaesthetics. The estimated chlorzoxazone clearance increased after beginning inhalation with all four agents, but no significant difference in clearance was noted between agents.
Conclusions: At therapeutic concentrations, the in vivo inhibitory effect on chlorzoxazone metabolism was similar for all four inhalational anaesthetics examined, even though their chemical characteristics and extent of hepatic metabolism differ considerably.