胃食管反流病

引言在西方国家,胃食管反流病(gastroesophageal reflux disease,GERD)不仅发病率高,而且因该病的食管外临床表现(如哮喘、喉痉挛、顽固性咳嗽咳痰,以致鼻窦炎、咽炎等耳鼻喉科症状)有较广泛的认识和报道[1],且相比之下,该病在亚洲地区及我国的发病率和人们对本病的认识都显得较低。本文报道1例被诊断为哮喘并经正规治疗1年以上、基本无效、最终接受腹腔镜下胃底折叠术的患者,治疗后其严重的致命性呼吸道表现立即完全消失,并停止所有治疗GERD和哮喘的药物,患者康复。此病例因最终诊断为简单的GERD而不是哮喘,预示着在哮喘患者群中应该…     

胃食管反流病诊疗新进展

胃食管反流病(gastroesophageal reflux disease,GERD)是由胃内容物反流入食管或以上部位,进入口腔(包括咽部)或肺引起的症状或并发症~[1]。GERD患者在全球分布较为广泛,近年来随着我国人民生活水平的提高,GERD发病率也呈迅速上升趋势,同时对GERD的认识也在不断深入,发现越来越多的疾病与之相关。若GERD得不到有效的控制,轻则对患者生活质量产生不良影响,重则导致严重的并发症甚至致命,因此,对GERD合理诊治具有重要意义。笔者现对GERD的症状、诊断方法和治疗做一总结。     

胃食管反流病如何选择抗反流术式

胃食管反流病(gastroesophageal reflux disease,GERD)引起的严重食管和食管外并发症越来越多,国内发病率呈上升趋势,自1936年Nissen开始第1例抗反流手术(antireflux surgery,ARS)以来,经过80年来上百种术式的演变,已基本固定为全包绕胃底折叠术和半包绕胃底折叠术两大类。关于ARS术式的争议从未停止,国内研究相对较少,且尚无     

腹腔镜抗反流手术治疗胃食管反流病对慢性阻塞性肺部疾病的影响

目的观察腹腔镜抗反流手术治疗胃食管反流病(GERD)对慢性阻塞性肺部疾病(COPD)的影响。方法收集2016年1月至2017年12月期间在郑州大学第一附属医院住院且采用腹腔镜抗反流手术治疗的20例GERD合并COPD患者,对所有患者采用反流诊断量表、肺功能、肺功能评估测试量表、24 h食管pH-阻抗监测和食管压力测定并对其结果作相关性分析。所有患者经保守治疗无效后选择腹腔镜下抗反流手术,12个月后完成随访,并再次对治疗前、后COPD和GERD相关参数结果进行对比,评价治疗效果。结果本组20例GERD患者均成功实施腹腔镜手术,无疝补片修补患者,无死亡病例,所有患者未发生食管破裂、出血、感染等术后严重并发症。术后8例患者出现不同程度的吞咽困难和10例出现不同程度的腹胀,均自行缓解。对20例GERD合并COPD患者在术后随访1年,无一例失访。与治疗前比较,治疗后患者的GERD症状评分、反流次数、DeMeester评分、COPD评估测试量表评分均明显降低(P<0.05),下食管括约肌压力、第1秒用力呼气容积(FEV1)占预计值百分率和FEV1/用力肺活量(FVC)均明显升高(P<0.05)。按照全球创议慢性阻塞性肺病分级标准,8例痊愈患者中5例Ⅰ级、2例Ⅱ级、1例Ⅲ级,9例改善患者中1例Ⅰ级、4例Ⅱ级、4例Ⅲ级,3例无效患者中1例Ⅰ级、1例Ⅱ级、1例Ⅳ级,总有效率85%(17/20)。结论 COPD与GERD密切相关,腹腔镜抗反流术的治疗不仅能治疗GERD,还可以明显改善COPD。     

腹腔镜胃底折叠术治疗胃食管反流病

目的探讨腹腔镜胃底折叠术治疗胃食管反流病的临床效果。方法2008年1月-2011年11月对40例胃食管反流病行腹腔镜胃底折叠术。腹腔镜单纯胃底折叠术7例（Toupt式）,腹腔镜食管裂孔疝修补加胃底折叠术33例（Nissen式5例,Toupet式28例）。结果手术均获成功,无中转开腹及死亡病例,无术后严重并发症。手术时间75～215min,平均112min;术中出血量10-350ml,平均52ml;术后住院5—10d,平均7d。40例术后随访1—24个月,平均16个月,34例临床症状完全消失,6例症状明显好转。结论腹腔镜胃底折叠术治疗胃食管反流病疗效满意。     

Pathophysiological Measurement and Results After Laparoscopic Fundoplication for Gastroesophageal Reflux Disease

Purpose: Both surgical and conservative treatments for gastroesophageal reflux disorder (GERD) are controversial. The aim of this prosepective study was to examine outcomes after laparoscopic antireflux surgery. Methods: The subjects were 143 patients who underwent laparoscopic antireflux surgery. Following diagnostic procedures 126 patients were allocated to a total fundoplication group (360°C, Nissen-DeMeester) and 17, to a posterior semifundoplication group (250–270°, Toupet). All complications were registered, and pathophysiological and outcome data were examined 3, 6, and 9 months after surgery. Results: By 6 months after surgery the mean lower esophageal sphincter (LES) pressure had improved significantly, to 14.8 mmHg in the Nissen-DeMeester group, and to 12.1 mmHg in the Toupet group, corresponding to successful prevention of esophageal reflux in both groups. Dysphagia was more common in the early postoperative period after total fundic wrap (17% vs 12%), but this difference disappeared in time. All patients reported complete relief of reflux symptoms, although two of those who underwent the Nissen-DeMeester fundoplication experienced relapse of GERD and required open reconstruction (1.4%). The laparoscopic procedure was converted to open surgery in three patients (2%). There were no associated deaths and the perioperative complication rate was 4.2%. Conclusion: Laparoscopic antireflux surgery is an effective treatment for GERD. More than 93% of the patients in this series rated their outcome as good to excellent following the operation. Received: December 10, 2001 / Accepted: May 7, 2002 Reprint requests to: K. Ludwig     

The Effect of Helicobacter Pylori on Gastroesophageal Reflux Disease

Background and Objectives:

Helicobacter pylori infection represents one of the most common and medically prominent infections worldwide. Gastroesophageal reflux disease (GERD) has a multifactorial etiology. The nature of the relationship between Helicobacter pylori infection (HP) and reflux esophagitis is still not clear. This study is designed to find the influence of HP on GERD.

Patients and Methods:

The study was conducted retrospectively at Sakarya Newcity Hospital between January 2006 and January 2009. Data were collected on patient''s age, sex, weight, the grade of GERD and the severity of HP.

Results:

There were 1,307 women and 1,135 men in this review with a mean age of 39,54 (range, 17 to 70) years. Helicobacter pylori positive (1 to 3 severity) was frequently seen in patients with GERD. A statistically significant relationship was found between HP positivity and the grade of GERD. The Helicobacter pylori infection (1 to 3 severity) was found in 1,437 (82.5%) of patients with GERD in our series.

Conclusions:

Controversy still exists about the association between GERD and HP infection. Based on our findings, significant evidence suggests the potential role of HP infection in the development of GERD. Also, the current data provide sufficient evidence to define the relationship between GERD and HP infection.     

超重患者胃食管反流病的腹腔镜治疗

目的 探讨腹腔镜手术治疗超重患者胃食管反流病（gastroesophageal reflux disease,GERD）的临床效果.方法 2008年1月~2013年1月,对23例体重指数（BMI）26.1~29.7的超重GERD患者行腹腔镜治疗.单纯胃底折叠术5例（Toupet式）,18例合并食管裂孔疝者行食管裂孔疝修补加胃底折叠术（Nissen式4例,Toupet式14例）.结果 全组手术均获成功,手术时间85~225 min,平均117 min;术中出血量30~200 ml,平均70 ml;术后住院时间4~8 d,平均7 d.无中转开腹及死亡,无术后严重并发症.术后随访1~24个月,平均14个月,其中15例〉12个月,21例治愈,2例缓解.结论 腹腔镜食管裂孔疝修补和胃底折叠术治疗超重GERD患者效果满意.     

Laparoscopic Nissen Fundoplication for Gastroesophageal Reflux Disease in Japan

Purpose Laparoscopic antireflux surgery is the standard treatment for gastroesophageal reflux disease (GERD) in Western countries where this disorder is common; however, it has only recently been introduced in Japan. We examined the effectiveness of laparoscopic antireflux surgery in a small series of Japanese patients.Methods Between 1998 and 2001 we performed laparoscopic Nissen fundoplication in 23 patients to evaluate the efficiency of this technique. We examined the following four parameters pre- and postoperatively: symptoms, endoscopic findings, gastroesophagogram findings, and the results of intraesophageal 24-h pH monitoring. We also examined the operation time, blood loss, intraoperative complications, and postoperative complications.Results The operation was safely performed in all patients, regardless of age, and there were no intraoperative complications. Postoperatively, more than three parameters were effectively normalized in 17 (89.5%) of 19 patients. The only postoperative complications were delayed gastric emptying in three patients and persistent dysphagia in five patients. During follow-up, esophagitis recurred in two patients, one of whom underwent laparoscopic refundoplication, which normalized the condition.Conclusion Laparoscopic Nissen fundoplication is highly effective for GERD and could become the standard surgical treatment in Japan.     

Impact of Changing Epidemiology of Gastroesophageal Reflux Disease on its Diagnosis and Treatment

Gastroesophageal reflux disease (GERD) has emerged as one of the most common diseases in modern civilization. This article reviews selected changes in epidemiology of GERD during the past decade and provides information on treatment options with a focus on the impact of GERD and potential role of laparoscopic antireflux surgery in patients with diabetes mellitus, obesity, liver cirrhosis, at the extremes of life age and in immunocompromised individuals such as liver and lung transplant recipients.     

腹腔镜Nissen胃底折叠术治疗胃食管反流病110例报告

目的探讨胃食管反流病（gastroesophageal reflux disease,GERD）的临床表现、腹腔镜Nissen胃底折叠术的治疗效果。方法回顾性分析2007年1月～2008年12月共110例行腹腔镜Nissen胃底折叠术的GERD临床资料。18例以反酸、烧心、嗳气、反食、胸痛等食管内症状为主,92例表现为咳嗽、咳痰、喘息等呼吸道症状为主（6例无反酸、烧心等消化道症状）。结果中转开腹1例,余均成功实施腹腔镜Nissen胃底折叠术。手术时间30～245min,平均67.8min;术中出血量5～450ml,平均28.8ml;术后住院时间2～8d,平均4.1d。术后102例获得6～24个月随访,平均13个月,8例失访。其中66例仅接受电话随访。102例按照症状频次、程度问卷表对其症状进行评分,参考反流性疾病问卷（reflux diagnostic questionnaire,RDQ）评分标准症状评分,术后6个月反酸、烧心、胸痛、咳嗽、喘息、憋气、咽异物感、喉部发紧、声音嘶哑的评分均明显下降（P〈0.05）。87例手术有效,15例手术无效。术后62例（60.8%）出现进食困难,经饮食训练2～6周后60例消失,2例症状严重,经胃镜扩张后缓解。1例术后2个月食管裂孔疝复发,再次腹腔镜手术修补。36例术后3个月选择性地进行了胃镜、24h食管pH监测和食管压力监测复查。28例食管炎患者复查胃镜,25例恢复正常,1例从Ⅲ级转为Ⅰ级,1例从Ⅱ级转为Ⅰ级,1例无变化;31例复查24h食管pH值监测,DeMeester评分恢复正常30例,1例从中度降至轻度;18例复查食管测压,下食管括约肌（LES）静息压从术前的1.2～34.1（中位数14.3）mmHg升至14.3～33.0（中位数20.0）mmHg（Z=3.72,P=0.000）。结论腹腔镜Nissen胃底折叠术是治疗GERD的有效方法,具有微创、损伤小、病人恢复快和操作安全的优点,对诊断明确的以食管外症状为主要表现的GERD特别值得提倡。