椎管内硬膜外血管脂肪瘤的诊治(附2例报告)

椎管内硬膜外血管脂肪瘤是一种罕见的肿瘤，占所有椎管内肿瘤的0.14%-0.8%，占硬膜外肿瘤的2%-2.2%。本院近5年收治2例患者，报告如下。     

椎管内硬膜外脂肪瘤

脂肪瘤为一种常见的良性肿瘤,但发生于椎管内硬膜外的却很少见。我院曾于１９９５年５月～１９９７年５月收治４例。１典型病例例１,女性,６１岁,双下肢渐进性麻木、无力３年,于３个月前出现双下肢运动功能丧失、感觉减退、便秘及小便失禁。入院查体：被动平卧体位,...     

椎管内血管脂肪瘤

血管脂肪瘤及血管肌肉脂肪瘤主要见于肾脏,发生在椎管内者甚少见.1990年～1997年我们收治7例,经手术彻底切除,疗效满意.     

椎管内血管脂肪瘤9例报告

[目的]探讨椎管内血管脂肪瘤的临床特性。[方法]报道9例椎管内血管脂肪瘤的临床资料并回顾文献。[结果]9例患者经外科切除肿瘤后预后良好。[结论]诊断主要以磁共振为依据。治疗以外科切除为主,不论是否浸润,预后良好。     

椎管内硬膜外血管脂肪瘤MRI表现及临床病理对照观察

目的:探讨椎管内硬膜外血管脂肪瘤的MRI特点,并观察MRI表现与病理特点之间的对应关系。方法:回顾性分析2例椎管内硬膜外血管脂肪瘤患者的临床资料、MRI信号和形态特点,并与临床病理学(含细胞组成、异型性和免疫组化结果)对照。结果:血管脂肪瘤病理学上由纤细的血管和成熟的脂肪细胞两部分组成,肿瘤位于椎管内硬膜囊后方呈哑铃型,邻近椎间孔扩大,MRI信号由血管和脂肪所含比例决定,与脂肪瘤等其他椎管内硬膜外肿瘤相比,血管脂肪瘤T1WI为等或高信号,T2WI为高信号,脂肪抑制像序列信号增高或减低,增强扫描病灶有强化。结论:MRI能清楚显示血管脂肪瘤的大小、形态、信号特征及其与椎管邻近结构的关系,脂肪抑制序列及增强扫描具有较高的诊断价值。     

椎管内血管周细胞瘤2例报告并文献复习

血管周细胞瘤（ hemangiopericytoma, HPC）,又称血管外皮细胞瘤,是一种起源于血管周细胞的中间型侵袭性肿瘤,主要发生于软组织和骨质,而发生于中枢神经系统者很少见,其中原发于椎管者更为罕见。1942年Stout和Murray^[1]首次将外膜细胞构成的肿瘤命名为血管外皮细胞瘤,即HPC。     

胸椎管内血管纤维脂肪瘤1例

椎管内血管脂肪瘤是一种少见的肿瘤。我院骨科于2001年7月遇到1例胸椎管内的血管纤维脂肪瘤,成功施行了摘除手术,报告如下。患者女,70岁。于2001年1月始背部疼痛不适,逐渐出现双下肢麻木、无力,至行走困难。于2001年7月来我院骨科就诊。检查:T4棘突压痛及扣痛,剑突以下感觉减退,双下肢肌力2级,膝腱及跟腱反射亢进,Babinski征阳性,踝阵挛阳性。X线片见胸椎有轻度退行性改变,MRI检查于T3~T5椎管内后方有条索状不规则影,T1、T2加权像均表现为高信号,长度达两个椎节,脊髓受压。于2001年7月24日在局麻下行胸椎管探查术,术中咬除T4及T3下1/2…     

儿童巨大肾血管平滑肌脂肪瘤1例报告及文献复习

目的探讨儿童肾脏血管平滑肌脂肪瘤(angiomyolipoma,AML)的临床特征、诊断及治疗方法。方法通过回顾分析1例术前误诊为肾母细胞瘤的儿童巨大肾脏AML的临床、影像学及病理资料,结合相关文献复习,讨论其临床生物学行为、诊断及治疗方法。结果 CT及MRI检查提示左肾肾母细胞瘤,由于肿瘤体积巨大,行剖腹探查及左肾切除术,术后病理诊断为肾AML,随访6个月未见复发。结论对于小体积及儿童肾AML,仅仅依靠CT影像资料做诊断可能存在一定困难,体积巨大而肿瘤脂肪成分低的患者容易被误诊,大体积的儿童肾AML可以行手术治疗以避免不必要的化疗。     

肾上皮样血管平滑肌脂肪瘤1例报告及文献复习

目的：探讨肾上皮样血管平滑肌脂肪瘤（EAML）的临床病理特征、诊断、鉴别诊断、治疗方法及预后。方法：通过观察1例肾EAML患者的临床病理学表现与免疫组化标记并复习有关文献,讨论其组织学特征及临床生物学行为。结果：CT平扫呈略高密度实性肿块,边界清楚,病灶内无明显脂肪密度;增强扫描密度相对均匀,实质期强化程度最高,排泄期密度下降较少。镜检示肿瘤细胞弥漫分布,瘤体主要成分为上皮样细胞,细胞异型性明显,大小形状不等,核大且染色明显加深,偶有多核巨细胞,核分裂像明显。免疫组化染色显示瘤细胞HMB45＋,SMA＋,CK-。结论：病史、体检结合影像学检查能够给我们提供重要的诊断线索,组织病理学特点结合免疫组化标记有助于该疾病的确诊,治疗方法以手术切除为主,对于预后较差的患者应按照肾细胞癌标准长期随访。     

椎管内脂肪瘤伴多发性囊肿1例报告

患者男，14岁。因胸腰部疼痛伴双下肢进行性截瘫加重9个月于2002年6月19日入院。自诉从2001年10月开始不明原因出现胸背部疼痛，后逐渐出现腰痛，疼痛有时缓解，双下肢乏力、麻木，行走困难。2002年2月上述症状开始加重，双下肢颤抖、僵硬，不能行走而休学。曾在外院诊断为“风湿”、“骨结核”，行多种保守治疗无效，感觉减     

Spinal angiolipoma: case report and literature review

BACKGROUND/OBJECTIVE: Spinal angiolipoma (SAL) is an uncommon clinico-pathological entity. DESIGN: Single case report. METHODS: Retrospective data analysis. FINDINGS: An obese woman with a 1-year history of progressive spastic paraparesis and acute deterioration underwent magnetic resonance imaging of the thoracic spine, the results of which suggested a tumor compressing the thoracic spinal cord. The histopathological examination of the completely resected tumor revealed an epidural angiolipoma. CONCLUSIONS: This case report offers a reminder that SAL should be considered in the differential diagnosis of long-standing, slowly progressive paraparesis. It remains unclear whether an increased body mass index might be a contributing factor to the development of SAL.     

Spinal angiolipoma: case report and review of literature.

Spinal extradural angiolipomas are distinct, benign, and rare lesions composed of mature lipocytes admixed with abnormal blood vessels. They account for 0.14% of all spinal axis tumors. The case described here was a 72-year-old patient presenting with a history of paraparesis, hypoesthesia under the T2 level, hyperreflexia, and urinary overflow incontinence that appeared within 7 days after the administration of a coronary vasodilator drug regimen. The spinal magnetic resonance scan showed a lipomatous mass with signal void lesions, suggesting a vascular component of the tumor. The patient improved rapidly after surgical resection of the epidural tumor and decompression of the cord. According to the present literature, the duration of neurological symptoms ranges from 1 to 180 months (mean 28 months). But this patient's neurological deterioration took place 4 days before hospitalization. We believe that this can be explained by the increased tumor blood volume caused by vasodilator drugs, which in turn exerted a pulsatile compressive effect on the cord.     

Spinal angiolipoma: case report and review of the literature

Summary Spinal angiolipomas are rare lesions usually found in the epidural space of the thoracic spine. This report presents a case of and reviews the literature on this rare entity. The etiology, clinical presentation, imaging, and treatment are discussed. In 92 reported cases of spinal angiolipoma 56 occurred in women (61%), and 36 in men (39%). Mean age of occurrence is 42.9 years (range 10 days–85 years) with most patients presenting with slowly progressive symptoms of spinal cord compression. Most cases occur in the extradural compartment, and are of the non-invasive subtype. This rare clinical entity must be considered in the differential diagnosis of spinal epidural lesions. In most cases complete removal is possible, however, prognosis is good even for infiltrating lesions. Thus, one must not risk neurological damage to attain complete resection.     

Spinal epidural cavernous haemangioma: a case report and review of literature

STUDY DESIGN: A case report of purely epidural cavernous haemangioma with MRI appearance and pathological features. OBJECTIVE: To present a rare case of extradural mass with differential diagnosis. SETTING: Delhi, India. METHOD: A 55-year-old man presented with progressive weakness and diminished sensation in both lower limbs. MRI demonstrated a pure extradural mass with no bony invasion. Histopathology of the lesion revealed a typical cavernous haemangioma. RESULT: The patient showed significant improvement after surgery. CONCLUSION: Radiological presentation could be confusing in a purely epidural cavernous haemangioma. Awareness of the characteristics of the lesion will facilitate diagnosis and treatment of the lesion.     

Spinal extradural angiolipoma: a case report]

This 60-year-old man had been well until four years prior to admission, when he developed slowly progressive weakness of the lower extremities. On admission he was found to have a spastic paraparesis, sensory disturbance below the level of T10 and mild sphincter dysfunction. Conventional myelography and CT myelography demonstrated an epidural mass located from T5 to T8 vertebral level. MRI revealed that the epidural mass was fusiform and markedly enhanced by the contrast medium. Laminectomy was performed and a fibrous tumor red in color was subtotally removed. Histological findings were consistent with those of angiolipoma. Angiolipoma is a rare tumor in the central nervous system and is regarded as a clinical entity different from a spinal lipoma. Occurrence of angiolipoma in the central nervous system has been reported in 40 cases in the world literature. Thirty nine cases of them occurred in the spinal canal, especially in the dorsal epidural space of the thoracic region. The fusiform shape demonstrated in this case might also be characteristic of angiolipoma in this region.     

Spinal extradural angiolipoma: a report of two cases and review of the literature

Extradural angiolipomas are rare tumors that can produce spinal cord compression. Two patients with thoracic spinal angiolipoma are presented that were treated with surgical resection and radiation. The histological and clinical features of the 18 previously reported cases of these tumors are discussed.     

Infiltrating spinal angiolipoma: a case report and review of the literature

Angiolipomas are rarely encountered in the spine. We report the case of a 47-year-old man with a thoracic angiolipoma involving the T9 vertebral body. A preoperative spinal angiogram confirmed a highly vascular neoplasm. The lesion was treated with endovascular embolization prior to a T9 corpectomy and resection of the epidural component of the tumor. At time of surgery, minimal blood loss occurred during resection of the vertebral body and the epidural mass. Pathologic examination demonstrated features consistent with spinal angiolipoma. This report emphasizes the clinical, radiographic, and pathologic features of infiltrating spinal angiolipoma and discusses therapeutic management options.     

Spinal extradural angiolipoma: report of two cases and review of the literature

Spinal angiolipomas are benign uncommon neoplasm composed of mature lipocytes admixed with abnormal blood vessels. They account for only 0.04–1.2% of all spinal tumors. We report two cases of lumbar extradural angiolipoma and review previously reported cases. We found 118 cases of spinal epidural angiolipoma (70 females and 48 males; age range 1.5–85 years, mean 44.03) spanning from 1890 to 2006. Prior to diagnosis 40.6% of the patients had weakness of the lower limbs. The interval between the initial symptoms and tumor diagnosis ranged from 1 day to 17 years (mean 20.2 months). Except for four cases diagnosed at autopsy, 109 patients underwent surgery and gross-total resection was performed in 79 cases (72.4%). Spinal angiolipomas are tumors containing angiomatous and lipomatous tissue, predominantly located in the mid-thoracic region. All angiolipomas show iso- or hyperintensity on T1-weighted images and hyperintensity on T2-weighted images and most lesions enhance with gadolinium administration. The treatment for spinal extradural angiolipomas is total surgical resection and no adjuvant therapy should be administered.     

Lumbar extradural infiltrating angiolipoma: a case report and review of 17 previously reported cases with infiltrating spinal angiolipomas

BACKGROUND CONTEXT: Spinal extradural angiolipomas are rare benign tumors, and most of them are noninfiltrating tumors located in the extradural space. However, there are 17 cases with extradural infiltrating spinal angiolipomas extending into the vertebral bodies or posterior vertebral arches in literature. These 17 tumors are mostly located at the thoracic region, and anterior or in the anterolateral extradural space, and they generally infiltrate only one vertebra. Only two of them are located at the lumbar region, four are mainly located in the posterior extradural space, and three infiltrate more than one vertebra. PURPOSE: To present an exceptional case with infiltrating extradural spinal angiolipoma involving two lumbar segments and mainly located in the posterior extradural space. STUDY DESIGN: A case report. METHODS: A 41-year-old woman with infiltrating spinal angiolipoma was treated by incomplete surgical removal of the tumor. RESULTS: There were no complaints nor recurrence after 18 months follow-up. CONCLUSIONS: Outcome after surgery for spinal angiolipomas is very good overall even in the cases with infiltrating tumors. Although complete removal is certainly preferred, outcomes remained favorable despite incomplete resections.