影响突发性聋患者耳鸣疗效的相关因素分析

目的探讨影响突发性聋患者耳鸣疗效的相关因素,为突发性聋伴耳鸣患者的临床诊治及预后判断提供依据。方法前瞻性分析比较117例突发性聋患者中符合入组条件的70例(74耳)突发性聋伴耳鸣患者的耳鸣疗效与性别、耳别、年龄、听力损失程度、听力曲线类型、耳鸣严重程度、听力损失疗效的关系。结果本组117例突发性聋患者中102例伴耳鸣(87.18%,102/117),其中,70例(74耳)入组对象中治疗后听力损失(耳)的总有效率为66.22%(49/74),耳鸣的总有效率为74.32%(55/74)。耳鸣疗效在不同性别、耳别、年龄、耳鸣程度患者之间的差异均无统计学意义(P>0.05);极重度聋、全聋型者的耳鸣总有效率明显低于其他各程度听力损失及各听力曲线类型者(P<0.01),听力损失疗效为无效者的耳鸣总有效率明显低于听力损失疗效为痊愈、显效、有效者(P<0.01)。结论伴耳鸣的突发性聋患者耳鸣疗效略好于其听力损失疗效,耳鸣疗效与性别、耳别、年龄、耳鸣程度无关;极重度听力损失、全聋型患者、听力损失治疗无效者的耳鸣疗效较差。     

突发性聋患者耳鸣程度及耳鸣疗效的相关因素分析

目的 研究影响突发性聋伴耳鸣患者耳鸣严重程度及远期疗效的相关因素.方法 回顾性分析2017年3月～2019年5月荆州市中心医院收治的106例单侧突发性聋伴耳鸣患者随访半年临床资料.观察耳鸣严重程度及耳鸣疗效与性别、年龄、侧别、初始听力损失程度、听力曲线类型、初诊时间、耳聋疗效的关系.结果 耳鸣严重程度与不同性别、年龄、...     

耳鸣对突发性聋疗效的影响

目的探讨耳鸣对突发性聋疗效的影响.方法根据首发症状的不同将133例突发性聋分为2组,I组90例,无耳鸣;Ⅱ组 43例,以耳鸣为首发症状 .两组均用药物结合高压氧综合治疗.结果2组总有效率分别为91.1%, 7 9.1%.总无效率分别为11.2%, 20.9% .2组差异无显著性(P>0.05).结论耳鸣对突发性聋的疗效无明显影响.     

突发性聋伴耳鸣患者耳鸣特征

目的 分析研究突发性聋伴耳鸣患者的耳鸣特点、耳鸣与听力损失的关系、耳鸣对患者的影响程度, 探讨突聋患者耳鸣的产生机制。 方法 突发性聋伴有耳鸣患者231例常规采集病史, 填写耳鸣致残量表(THI)及视觉模拟得分表(VAS), 同时进行纯音听阈测试、耳声发射、耳鸣检测及掩蔽试验等检查。分析患者的耳鸣特点、耳鸣与听力的关系、耳鸣的THI及VAS得分以及它们特点。 结果 ①听力损失特点：低中频下降型20例(占8.7%), 中高频下降型60例(占26.0%), 平坦型44例(占19.0%), 全聋型79例(占34.2%), 不规则型28例(占12.1%);②耳鸣频率:低频耳鸣(≤500 Hz)49例(占21.2%), 中频耳鸣(51～2 000 Hz)54例(23.4%), 高频耳鸣(>2 000 Hz)122例(52.8%), 未匹配6例(占2.6%)。其中听力损失类型为低中频下降型的患者中, 低频、中频、高频耳鸣的比例分别为75%、15%、10%;中高频下降型患者中, 低频、中频、高频耳鸣的比例分别为13.3%、26.7%、60.0%;全聋型患者中, 低频、中频、高频耳鸣的比例分别为17.1%、19.0%、63.3%。听力下降最明显的频率对数与耳鸣频率对数呈线性关系, r=0.592, P<0.01;③耳鸣响度:0～30 dB HL 45例(占19.5%), 31～60 dB HL 60例(占26.0%), 60～90 dB HL 102例(占44.2%), 大于90 dB HL 18例(占27.8%), 未匹配6例(占2.6%)。耳鸣响度与听力损失程度(250～4 000 Hz平均听阈)有相关性, 相关系数r=0.216, P=0.001<0.05。④耳鸣致残级别:按照Newman等依据THI得分将耳鸣残疾分级, 其中1级27例(占11.7%), 2级耳鸣44例(占19.0%), 3级66例(占28.6%), 4级94例(占40.7%)。⑤THI及VAS得分特点:THI得分与听力损失程度无相关性r=0.087, P=0.287>0.05。VAS得分与听力损失程度无相关性r=0.002, P=0.982>0.05。THI得分与耳鸣频率对数无相关性, 相关系数r=-0.056, P=0.402>0.05。VAS得分与耳鸣频率对数无相关性, 相关系数r=-0.003, P=0.970>0.05。THI得分与耳鸣响度无相关性, 相关系数r=0.039, P=0.563>0.05。VAS得分与耳鸣响度无相关性, 相关系数r=0.136, P=0.110>0.05。结论 ①突发性聋伴耳鸣患者中高频耳鸣最常见;②耳鸣频率与听力损失类型显著相关, 低中频下降型以低频耳鸣多见, 而中高频下降型及全聋型以高频耳鸣多见;③听力损失最大的频率与耳鸣的频率有较高的一致性;④突发性聋伴耳鸣患者急性期的耳鸣致残程度以3～4级为多;⑤THI及VAS得分与听力损失的程度、耳鸣的频率、耳鸣的响度均无相关性。     

突发性聋患者纯音听阈曲线与临床疗效关系的分析

目的分析突发性聋患者纯音听阈曲线与临床疗效的关系。方法选择突发性聋患者144例(151耳),根据纯音听阈曲线分为5组:下降型31耳,上升型28耳,平坦型24耳,凹槽型27耳及全聋型41耳。均住院给予扩血管药物、能量合剂、激素治疗和高压氧等综合治疗。治疗后复查纯音测听,观察患者听力改善程度。结果144例患者各型听阈曲线患者有效率分别为:上升型89.3%,下降型61.3%,平坦型75.0%,凹槽型85.2%,全聋型48.8%。结论不同听阈曲线类型突聋患者中,上升型和凹槽型疗效较好,其次为下降型和平坦型,全聋型疗效最差。     

不同年龄段突发性聋患者听力损失特征及疗效分析

目的分析不同年龄段突发性聋患者的听力学特征及疗效,为突发性聋的诊治提供参考。方法回顾性分析1 023例突发性聋患者的临床资料,按发病年龄将患者分为4～岁、15～岁、30～岁、40～岁、50～岁、≥60岁六个组,比较其性别、耳别、听力曲线类型、听力损失程度以及疗效在各年龄段的分布特点。结果 1 023例突聋患者中以15～岁、30～岁和40～岁组年龄段居多(共占68.23%),4～岁组最少(占3.91%);15～岁组男性较40～岁、≥60岁组少(P≤0.001);4～岁组与15～岁、30～岁、50～岁组年龄段患者比较,前者双耳发病居多(P<0.001);≥60岁与40～岁相比,前者左耳发病较少,双耳发病居多(P<0.001)。4～岁组与其他各年龄组相比较,重度与极重度听力损失比例较高(P<0.003);4～岁与30～岁、40～岁组比较,前者上升型、下降型较后者少,而平坦型、全聋型较后者多(P<0.001)。1 023例患者治疗后的总有效率为51.01%,15～岁组最高(63.90%),4～岁组总有效率最低(28.85%)。结论不同年龄段突发性聋患者听力损失特征及疗效各不相同,儿童患者双耳发病者较多,且听力损失程度重,疗效差,老年患者双耳发病较多;15～30岁患者疗效最好。     

性别、年龄和听力损害程度与突发性聋患者耳鸣症状相关性分析

目的 分析突发性聋患者耳鸣症状与其性别、年龄和听力损害程度等因素的相关性.方法 采用列联表x^2检验和Logistic回归分析方法,对242例住院治疗的突发性聋病例进行统计分析,探讨影响耳鸣症状的相关因素.结果 不同性别间耳鸣发生率差异不明显.Logistic回归分析表明,不同年龄患者的耳鸣发生差异P=0.024,优势比^↑OR=0.956（95%置信区间为0.919-0.994）,上限、下限均小于1,而不同听力损害水平的耳鸣发生差异x^2=6.060,P=0.109.本组患者耳鸣发生率为93.80%.结论 突发性聋患者听力损害程度和性别对耳鸣的发生率无明显影响.随着年龄的增长,患者的耳鸣发生率下降.     

突发性聋伴耳鸣患者治疗前耳鸣性状分析

目的 分析突发性聋伴耳鸣患者的耳鸣性状及其与听力损失之间的关系,探讨耳鸣对患者影响的评估方法.方法 对56例(56耳)突发性聋伴耳鸣患者行听力检测和耳鸣主观分级(评估)及耳鸣匹配检查.结果 ①耳鸣匹配的频率集中于听力损失的频率范围,耳鸣匹配的类型主要为窄带噪声,匹配响度分布较为广泛;②耳鸣主观分级与匹配类型,响度、听力...     

突发性聋预后因素分析

目的:探讨突发性聋预后的相关因素,指导其预后判断.方法:回顾性分析256例(280耳)突发性聋患者应用有序Logistic回归分析,筛选与突发性聋预后相关的因素,同一影响因素采用χ2检验,进一步量化指标,以指导预后分析.结果:年龄、病程、伴发症状、治疗前耳聋程度、听力曲线类型均与疗效有相关性;性别、耳聋侧别与疗效无相关...     

声治疗在突发性聋伴耳鸣患者中的应用

声治疗是近年来逐渐兴起的通过一种或多种声音刺激,包括白噪声、窄带噪声、自然噪声、音乐声等的用以治疗耳鸣的手段。其治疗效果已在多项临床研究中获得证实。突发性聋是临床常见的耳部疾病之一,大部分患者伴有耳鸣发作,二者的病因、发病机制以及相互作用原理目前均不明确,突发性聋伴耳鸣发病可对患者的心理健康及生活质量造成严重影响。本文就声治疗的定义和作用机制、声治疗的临床应用、声治疗对突发性聋伴耳鸣作用的国内外研究进展等方面进行综述,探究声治疗在突发性聋伴发耳鸣患者治疗中的应用及意义,并展望其未来发展方向。     

Cochlear implant in patients with sudden unilateral sensorineural hearing loss and associated tinnitus

Introduction and objectivesTo assess the efficacy of cochlear implantation in patients with unilateral sudden sensorineural hearing loss and associated disabling tinnitus.MethodsTen patients suffering from severe-to-profound sudden hearing loss and tinnitus in the affected ear received implants. The sample was comprised of 4 men and 6 women, with a mean age of 42.7 years (range 34-62) at implantation. The severity of the tinnitus was evaluated with the Spanish validated version of the Tinnitus Handicap Inventory (THI) and a visual analogue scale. These assessments were obtained before and after implantation.ResultsTinnitus suppression was observed in 2 patients. In 7 cases, we observed an improvement in the THI, in different degrees, and 1 patient remained without changes. Tinnitus worsening was not found in the series studied.ConclusionsTinnitus reduction following cochlear implantation can be explained by several mechanisms, such as habituation, acoustic masking, direct stimulation of the cochlear nerve and reorganisation of cortical areas. Even though further research is required, cochlear implantation is an effective method for the treatment of disabling tinnitus in patients with severe-to-profound unilateral sudden sensorineural hearing loss.     

突发性聋临床分析

目的探讨突发性聋的治疗方法及预后因素。方法96例突发性聋病例采用川芎嗪、皮质类固醇激素、抗病毒药物为主的综合治疗,其中43例辅以高压氧治疗,分析患者年龄、初诊听力损失程度、听力曲线类型、治疗早晚、有无眩晕与预后的关系。结果痊愈25例,显效46例,痊愈率为26.04%,痊愈、显效率为73.96%;重度听力损失组,高压氧治疗组痊愈、显效率高于非高压氧治疗组(P<0.05);年龄18～40岁组,发病后10天内就诊组,轻、中度听力损失组,初诊听力曲线为平坦型和上升型组,无眩晕组疗效分别好于对照组(P<0.05)。结论年龄18～40岁,发病后10天内就诊,轻、中度听力损失组,初诊听力曲线为平坦型和上升型,无眩晕者预后好。     

Idiopathic sudden sensorineural hearing loss

Idiopathic sudden sensorineural hearing loss remains one of the major unsolved otologic emergencies. In this paper the most important recent clinical literature is reviewed, a new method of clinical staging is presented, and unexplored potential treatments are presented. The method of clinical staging presented here is based on four elements represented by the acronym HEAR. The individual elements of the staging are hearing threshold (H), elapsed time from onset (E), audiogram shape (A), and related vestibular symptoms (R). Insufficiently explored potential treatments of sudden hearing loss include antiviral drugs, rheologic agents, and free radical scavengers.     

Sodium enoxaparin and venovenous hemofiltration in treating sudden sensorineural hearing loss and tinnitus

Sudden sensorineural hearing loss (SSNHL) constitutes a considerable diagnostic challenge because it may be caused by many diverse conditions that may be difficult to recognize. No definitive treatment for SSNHL is universally accepted; the goal of this study was to evaluate the efficacy of sodium enoxaparin associated with venovenous hemofiltration in a therapeutic regimen. We treated 20 patients divided randomly into two numerically equal groups (A and B). Group A patients underwent this therapeutic protocol: Hemofiltration was performed at the first and last day of the protocol while, beginning on the second day of the protocol, sodium enoxaparin was administered subcutaneously at a dose of 4,000 IU once a day for 10 days. After the first hemofiltration, all the patients with complete auditory recovery were discharged without receiving the treatment with sodium enoxaparin. Group B patients received conventional therapy (cortisone, vasoactive agents, and vitamin complexes) administered in physiological solution intravenously twice daily for 10 days. In our randomized, controlled trial, treated patients in group A showed more improvement than did those in group B.     

Atresia and sudden sensorineural hearing loss

This case study summarizes findings in an adult male, aged 57, who presented to the Adult Audiology Clinic with aural atresia in the right ear resulting in a conductive hearing loss and a sudden sensorineural hearing loss in the left ear. Treatment options included reconstruction surgery in the right ear, bone anchored hearing aid in the right ear to overcome the conductive hearing loss, bone anchored hearing aid in the left ear for single sided deafness, and intratympanic steroid injections in the left ear to salvage hearing. This case study highlights that when a patient is educated on all available options the patient is then able to make a decision comfortable to him and to help improve his hearing.     

Migraine and sudden sensorineural hearing loss

A 62-year-old woman developed recurrent episodes of sudden sensorineural hearing loss, occurring with migraine headaches. This is an unusual complication of migraine, which probably arises from a reversible vasoconstriction of the cochlear blood vessels. Pathogenesis of migraine and its variants are reviewed herein, along with the rationale of the modalities in its treatment. In this case, the patient's hearing improved after administration of ergot alkaloids, carbon dioxide/oxygen inhalations, and stellate ganglion blocks; it is not known whether this improvement represented therapeutic effect or spontaneous recovery.