Effect of Ruxiankang(乳腺康) on Rhythm of Pituitary Sex Hormone Secretion in Patients of Mammary Gland Hyperplasia

ＥｆｆｅｃｔｏｆＲｕｘｉａｎｋａｎｇｏｎＲｈｙｔｈｍｏｆＰｉｔｕｉｔａｒｙＳｅｘＨｏｒｍｏｎｅＳｅｃｒｅｔｉｏｎｉｎＰａｔｉｅｎｔｓｏｆＭａｍｍａｒｙＧｌａｎｄＨｙｐｅｒｐｌａｓｉａ￥ＷＯＸｉｎｇ－ｄｅ；ＬＯＵＬｉ－ｈｕａ；ＬＩＷａｎ－ｌｉ；ｅｔａｌ...     

Clinical Study on Effect of Shenlong Oral Liquid (神龙口服液)Combined with Radiotherapy in Treating Nasopharyngeal Carcinoma

Ｒａｄｉｏｔｈｅｒａｐｙｉｓｔｈｅｆｉｒｓｔｃｈｏｉｃｅｏｆｔｒｅａｔ ｍｅｎｔｏｆｎａｓｏｐｈａｒｙｎｇｅａｌｃａｒｃｉｎｏｍａ （ＮＰＣ）,ｈｏｗｅｖｅｒ,ｎｏｓａｔｉｓｆａｃｔｏｒｙｔｈｅｒａｐｅｕｔｉｃｅｆｆｅｃｔｓｏｆｒａｄｉｏｔｈｅｒａｐｙｈａｖｅｂｅｅｎｇｏｔｔｅｎｔｉｌｌｎｏｗ．Ｆｕｒ ｔｈｅｒｍｏｒｅ,ｒａｄｉｏｔｈｅｒａｐｙｏｆｔｅｎｐｒｏｄｕｃｅｓａｌｏｔｏｆｓｉｄｅｅｆｆｅｃｔｓ,ａｎｄａｌｓｏｉｍｐａｉｒｓｔｈｅｉｍｍｕｎｅｆｕｎｃ ｔｉｏｎｏｆｈｕｍａｎｂｏｄｙ．Ｉｎｏｒ…     

Clinical and Experimental Study on Effect of Yangxin Fumai Oral Liquid (养心复脉口服液) in Treating Patients with Extrasystole

Ｏｂｊｅｃｔｉｖｅ：Ｔｏｅｖａｌｕａｔｅｔｈｅｔｈｅｒａｐｅｕｔｉｃｅｆ ｆｅｃｔｏｆＹａｎｇｘｉｎＦｕｍａｉＯｒａｌＬｉｑｕｉｄ（ＹＦＯＬ,养心复脉口服液）,ａＣｈｉｎｅｓｅｈｅｒｂａｌｍｅｄｉｃｉｎｅｆｏｒｎｏｕｒｉｓｈｉｎｇＨｅａｒｔａｎｄｒｅｓｔｏｒｉｎｇｐｕｌｓｅ,ｉｎｔｒｅａｔ ｉｎｇｐａｔｉｅｎｔｓｗｉｔｈｅｘｔｒａｓｙｓｔｏｌｅ．Ｍｅｔｈｏｄｓ：ＴｈｅｅｆｆｅｃｔｏｆＹＦＯＬｗａｓｏｂｓｅｒｖｅｄｉｎｔｒｅａｔｉｎｇ 30 ｐａ ｔｉｅｎｔｓｗｉｔｈｄｉｆｆｅｒｅｎｔｋｉｎｄｓｏｆｅｘ…     

Effect of Kangquan Recipe (康泉方) on BAMBI Expression in Hypothalamic-Pituitary-Prostate in Rats with Benign Prostatic Hyperplasia

Objective: To investigate the effect of Kangquan Recipe (康泉方, KQR) on bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) expression and its mechanism in rats with benign prostatic hyperplasia (BPH). Methods: Forty-eight male Sprague-Dawley rats were divided into 6 groups using a random number table, with 8 in each group: the normal group (normal saline 10 mL/kg), the model group (normal saline 10 mL/kg), the finasteride group (0.5 mg/kg), the low-dose KQR group (3.5 g/kg), the middle-dose KQR group (7 g/kg), and the high-dose KQR group (14 g/kg). The 40 rats were subcutaneously injected with testosterone propionate after castration for 30 days to establish the BPH rat model except for those in the normal group. At the same time, the corresponding drugs were administered by gavage for 30 consecutive days. The effects of different doses of KQR on the protate wet weight, prostate volume and prostate index (PI) were observed. The changes in histopathology were monitored with hematoxylin-eosin staining. BAMBI protein and mRNA expression contents were determined by Western blot and quantitative real-time polymerase chain reaction, respectively. Results: All doses of KQR could decrease prostatic epithelial tissue proliferation. Compared to the model group, the high and middle-dose KQR significantly reduced prostate wet weight, prostate volume and PI; increased BAMBI protein expression in the hypothalamus, pituitary and prostate tissue; all doses of KQR up-regulated BAMBI mRNA expression in serum, prostatic fluid and prostate tissue (P<0.05 or P<0.01). Conclusions: KQR could inhibit the proliferation of rat prostatic tissue, promote BAMBI protein expression in the hypothalamic-pituitary-prostate of rats with BPH; and increase BAMBI mRNA expression in the blood, prostatic fluid and prostate tissue of rats with BPH, showing a dose-effect relationship. KQR can be used as a potential drug for the treatment of BPH.     

Clinical observation on treatment of hyperplasia of mammary gland by Lirukang Granule (利乳康颗粒)

Objective:To explore the effi cacy and mechanism of Lirukang Granule(利乳康颗粒,LRKG) in treating hyperplasia of mammary gland(HMG).Methods:One hundred patients with HMG were randomly assigned to two groups,50 in each group.The patients in the treated group were orally administered with LRKG thrice a day,one package each time,and those in the control group were given orally Rukuaixiao Tablet(乳块消,RKX) thrice a day,4 tablets each time.The therapeutic course for both groups was 4 months.The clinical eff icacy,pain alleviating rate,as well as changes of local sign and symptom scores were observed before and after treatment.The changes of serum estradiol(E2),progesterone(P),testosterone(T),follicle stimulating hormone(FSH),luteinizing hormone(LH) and prolactin(PRL) in some randomly selected patients(24 patients in the treated group and 24 in the control group) before and after treatment were measured with radioimmunoassay.Results:The total clinical effi cacy in the treated group was superior to that in the control group,signifi cant difference was shown between the two groups(P<0.01).The cure-effective rate and total effective rate in the treated group were 70.0%and 88.0% respectively,signif icantly higher than those in the control group(38.0% and 64.0%) respectively(P<0.01),and the pain alleviating rate in the treated group was also significantly higher in the former than that in the latter(88.0% vs 64.0%,P<0.05).Moreover,the treated group showed obvious superiority in improving the patients' symptom and sign scores(P<0.01),and abnormalities of gonadal hormone as compared with the respective items in the control group(P<0.01).Conclusion:LRKG has good effi cacy in the treatment of HMG,and its mechanism may be related to the regulation on endocrine and immune function.     

Effect of Tongmai Jiangzhi Oral Liquid (通脉降脂口服液) on Serum P-selectin,von Willebrand Factors and D-Dimer in Patients with Atherosclerosis

Objective: To explore the role of cytokines on the pathogenesis of atherosclerosis, and the effect of Tongmai Jiangzhi oral liquid (通脉降脂口服液,TMJZ) on cytokines through observing serum P-se-lectins (Ps), von Willebrand (vWF), and D-dimer (D-D) in atherosclerosis (AS) patients. Methods: Sixty-three AS patients were randomly divided into the treated group (n = 33, treated with TMJZ, 10 ml each time, three times a day) and the control group (n = 30, treated with Lovastatin, 10 mg, once daily). The levels of serum lipids (enzymatic methods), Ps, vWF, and D-D were measured before and after 8 weeks of treatment. Results: Serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), apo-protein B-100 (apoB-100) were significantly decreased (P<0.05 or P< 0.01) and high-density lipoprotein cholesterol (HDL-C) was significantly raised (P<0.05) after TMJZ treatment. Serum Ps, vWF, and D-D also declined (P<0.05) after treatment. There was no significant difference between the tre     

Effect of Compound Recipe Gengniankang (更年康) on Senile Sexual Hormone and Expression of Estrogen Receptor in Bone of Climacteric Female Rats

Estrogenis a vital hormone to women's wholelife.It is aninevitable process that thelevel of ser-umestrogen decreases when women enter the agedphase,and that the ovary function is exhausted.Accompanying this process,theincidence of osteo-porosis is increased and affects the quality of lifeseverely.Using hormone replacement treat ment toprevent and treat osteoporosis is very effective.Itis proved that osteoporosis is related to the lack ofestrogen,which plays a veryi mportant role duringthe proc…     

Clinical Study on Effect of Kang'aibao Oral Liquid(抗癌宝口服液) in Treating 103 Patients of Malignant Tumor

Ｋａｎｇ＇ａｉｂａｏｏｒａｌｌｉｑｕｉｄ（ＫＡＢＬ）ｉｓａｎｅｍｐｉｒｉｃａｌｒｅｃｉｐｅｏｆｔｅｎｕｓｅｄｔｏｔｒｅａｔｍａｌｉｇｎａｎｔｔｕｍｏｒｏｆｍｉｄｄｌｅｏｒａｄｖａｎｃｅｄｓｔａｇｅｉｎｔｈｅｉｎｔｅｒｎａｌｍｅｄｉｃｉｎｅｄｅｐａｒｔｍｅｎｔｏｆｔｈｅａｕｔｈｏｒｓ＇ｈｏｓｐｉｔａｌ．ＦｒｏｍＭａｒｃｈ1993ｔｏＭａｒｃｈ1996，103ｃａｓｅｓｏｆｃａｎｃｅｒｐａｔｉｅｎｔｓｔｒｅａｔｅｄｗｉｔｈＫＡＢＬｗｅｒｅｏｂｓｅｒｖｅｄａｎｄｃｏｍｐａｒｅｄｗｉｔｈ90ｃａｓｅｓｗｈｏｒｅｃｅ…     

Effect of Huanshuai Recipe Oral Liquid (缓衰口服液) on Renal Dysfunction Progression in Patients with Atherosclerotic Renal Artery Stenosis

Objective:To investigate the effect of Huanshuai Recipe Oral Liquid(缓衰口服液,HSR) on retarding the progression of renal dysfunction in patients with atherosclerotic renal artery stenosis(ARAS).Methods:A total of 52 ARAS patients with the Chinese medicine(CM) syndrome of qi deficiency and blood stasis,phlegm and dampness retention were recruited and randomly assigned into the treatment group(36 cases) and the control group(16 cases).Both groups received a basic treatment(high-quality low-protein diet,blood pressure control,lipid-lowering,correcting the acidosis,etc.).In addition,the treatment group received 20 mL HSR and the control group received placebo,3 times a day for 6 months.Renal function(serum creatinine,blood urea nitrogen and uric acid) and blood lipids(cholesterol,triglycerides and low density lipoprotein) were examined monthly.The estimated glomerular filtration rate(eGFR) and CM syndrome score were compared between groups.Results:After treatment,compared with the control group,the serum creatinine level,uric acid level and CM syndrome score of the treatment group were significantly decreased(P0.05 or P0.01),and the eGFR in the treatment group were significantly increased(P0.05).Conclusion:HSR can effectively improve the renal function and clinical symptoms of ARAS patients.     

Clinical and Experimental Study on Treatment of Childhood Cough with Zhenkeling Oral Liquid(镇咳灵口服液)

Ｃｌｉｎｉｃａｌ　ａｎｄ　Ｅｘｐｅｒｉｍｅｎｔａｌ　Ｓｔｕｄｙ　ｏｎ　Ｔｒｅａｔｍｅｎｔ　ｏｆ　Ｃｈｉｌｄｈｏｏｄ　Ｃｏｕｇｈ　ｗｉｔｈ　Ｚｈｅｎｋｅｌｉｎｇ　Ｏｒａｌ　Ｌｉｑｕｉｄ（镇咳灵口服液）ＳＨＩＹｕ－ｍｉｎ（时毓民），ＺＨＡＮＧＹｉ－ｑｕｎ...     

Clinical Observation on Treatment of Mammary Gland Hyperplasia by Acupoint Injection Combined with Ion-Introduction of Chinese Herbal Medicine

BasedonthetheoryoftraditionalChinesemedicine(TCM),combinedtherapyofacupointinjectionandion--introductionofChineseherbalmedicines(CHM)wasusedtotreatS6casesofmammaryglandhyperplasia(MGH)andcomparedwiththecontrolgroupstreatedwithotherChineseorwesterndrugs.METHODClinicalMaterialsPatientswerediagnosedaccordingtothefollowingstandard;(1)Breastpainwasaggravatedbeforemenstruation;(2)Somecordshapedordiffusepatchytenaciousnodlllesdifferentinsizeandwithapparenttendernesswerefoundinthemammarygland;…     

Effect of Prevention and Treatment of Murine Acute Viral Myocarditisand Protection of Lymphoid Organ Atrophy withXinkang Oral Liquid (心康口服液)

Ｉｔｈａｓｂｅｅｎｅｓｔａｂｌｉｓｈｅｄｔｈａｔｃｏｘｓａｃｋｉｅｖｉｒｕｓｉｓｔｈｅｐｒｅｄｏｍｉｎａｎｔｃａｕｓｅｏｆｖｉｒａｌｍｙｏｃａｒｄｉｔｉｓｉｎｈｕｍａｎ(1) ,ｗｈｉｃｈｉｓａｃｏｍｍｏｎｄｉｓｅａｓｅｓｅｒｉｏｕｓｌｙｅｎｄａｎｇｅｒｈｅａ     

Effect of Compound 962 Capsule on Liver Lipid Peroxidation and Indexes of Thymus Gland and Spleen in Rats

Objective: To investigate the effect of compound 962 capsule (abbre. as 962) on liver lipid peroxidation and indexes of thymus and spleen in aged rats.Methods: Rats were divided into young control, aged model, Piracetam, 962 middle dose (0.9 g/kg) and high dose (1.8 g/kg) groups. All test drugs were administrated for 1 month by gastrogavage. The liver lipid peroxidation was determined by thiobarbituric (TBA) method. The thymus index and spleen index were determined by weighing method.Results: 962 (middle and high dose) attenuated liver lipid peroxidation, increased the thymus index of aged rats. There was no effect on spleen index in all drug-treated groups.Conclusion: 962 could decrease liver lipid peroxidation and increase thymus index. It suggested that 962 might be beneficial in retarding aging process. This study was funded by Scientific Committee of Beijing (No. 951890600) and State Ministry of Personnel(No.l998)     

A Randomized Trial of Chinese Medicine Lirukang Granule (利乳康颗粒) Combined with Psychological Intervention for Cyclomastopathy and Menoxenia

Objective:To observe the influence of therapy with Chinese medicine Lirukang Granule（利乳康颗粒）,LRKG) combined with psychological intervention on anxiety states and sex hormones in patients with cyclomastopathy and menoxenia.Methods:A total of 470 subjects were randomly assigned to three groups by the net-central randomization system,the treatment group（161 patients,treated with LRKG and psychological intervention）,the Chinese medicine group（157 patients,treated with LRKG）,and the psychological intervention group（152 patients,treated with psychological intervention）.The dose of LRKG was 12 g three times per day; psychological intervention included establishing relations,cognitive intervention and psychological persuasion, 30-40 min per session,once a week.The therapy duration for all groups was three months.The efficacy was compared and anxiety state/State-Trait Anxiety Invertory（STAI） scoring was measured before and after treatment.The serum estradiol（E₂）,progesterone（P）,prolactin（PRL） and follicle stimulating hormone（FSH） levels of 60 patients selected randomly from each group during the luteal phase were measured before and after treatment,and a group of 20 healthy women were evaluated for comparison.A follow-up was arranged for one year after treatment.Results:Thirty subjects were lost to follow-up.（1） Comparison of efficacy:the markedly effective rate and the total effective rate of the treatment group were 86.67%（131/150） and 98.00%（147/150）, respectively;of the Chinese medicine group,64.58%（93/144） and 90.27%（130/144）,respectively;and of the psychological intervention group,0%（0/146） and 3.42%（5/146）,respectively.The markedly effective rate and the total effective rate in the treatment group were significantly higher than those in the Chinese medicine and psychological intervention groups（P<0.05）.（2） Comparison of STAI scoring:STAI scoring was decreased dramatically in the treatment group after treatment compared with that of the Chinese medicine group（P<0.01）, but there was no significant difference compared with the psychological intervention group.（3） Comparison of levels of sex hormones:E₂,P,PRL and FSH of the three patient groups were disordered before treatment,and significantly different from healthy women（P<0.01）.After treatment,the levels of P and FSH of the treatment group were significantly increased（P<0.01）,E₂ and PRL were significantly reduced,which were also significantly decreased compared with the psychological intervention groups（P<0.01）.（4） Follow-up:the markedly effective rate and the total effective rate of the treatment group remained higher than those of the other two groups after one year of treatment（P<0.05）.（5） Adverse reactions:no obvious adverse reactions were found among the three groups.Conclusions:Therapy with Chinese medicine combined with psychological intervention was effective for short-term and long-term treatment of cyclomastopathy and menoxenia.The mechanism might be related to the regulation of sex hormones.     

Experimental Study on Effects of Xiao pi Yi shen Oral Liquid (消疲怡神口服液)on Hypothala mus-Pituitary-Adrenal Gland-Thymus Axis in Stressed Rats

Experimental Study on Effects of Xiao pi Yi shen Oral Liquid (消疲怡神口服液)on Hypothala mus-Pituitary-Adrenal Gland-Thymus Axis in Stressed Rats@王琳@王天芳@康纯洁@刘晓兰@刘燕@张翠珍@郑君芳     

Xuefu Zhuyu Oral Liquid (血府逐瘀口服液) Prevents Apoptosis of Ischemic Myocardium Cells in Rats by Regulating SIRT1 and Its Pathway-Related Genes

Objective: To observe the changes of ischemic myocardial cells apoptosis in rats following intervention with Xuefu Zhuyu Oral Liquid(血府逐瘀口服液, XFZY), as well as changes of protein expression of silent information regulator 1(SIRT1) and SIRT1 pathway-related genes. Methods: H9c2 rat myocardial cells were divided into 6 groups: control group, oxygen glucose deprivation(OGD) group, SIRT1 siRNA group, OGD+SIRT1 siRNA group, OGD+XFZY group, and OGD+SIRT1 siRNA+XFZY group. Quantitative fluorescent polymerase chain reaction(PCR) and Western blot were used to detect the concentration variations of SIRT1 and its pathway-related genes and corresponding protein expression after XFZY intervention and SIRT1 transfection. Results: Compared with the control group, the m RNA and protein expressions of SIRT1 were decreased obviously, while the mRNA and protein levels of P53, forkhead box protein O1(FoxO1), FoxO3, FoxO4 and nuclear factor kappa B(NF-κB) were increased in the OGD group, SIRT1 siRNA group, and OGD+SIRT1 siRNA group(P0.01). Compared with the OGD group and OGD+SIRT1 siRNA group, the treatment of XFZY inhibited the decline in SIRT1 mRNA and protein expressions(P0.01), and down-regulated the mRNA and protein levels of P53, FoxO1, FoxO3, FoxO4 and NF-κB, respectively(P0.05 or P0.01). Conclusion: XFZY could prevent myocardial cells apoptosis probably by increasing the mRNA and protein expressions of SIRT1 and inhibiting the m RNA and protein expressions of P53, NF-κB, FoxO1, FoxO3 and FoxO4.