食物构成对大鼠核黄素营养状况及需要量的影响

选初断乳ＳＤ大鼠，用两个水平蛋白质（酪蛋白１２％和２０％）、淀粉（３０％和６５％）、核黄素（１２μｇ／ｄ和２４μ／ｄ）组成２×２析因实验，研究大鼠核黄素营养状况及需要量与膳食因素的关系，实验期８周。结果表明，核黄素摄入量增加，动物生长、肝脏核黄索浓度和全血谷耽甘肽还原酶活性系数（ＢＧＲＡＣ）均明显改善。增加蛋白质摄入量，核黄素在肝脏中储备增加，但同时ＢＧＲＡＣ上升，提示组织可利用核黄素水平降低。淀粉摄入量增加，肝脏核黄素浓度和ＢＧＲＡＣ均有改善，提示整体核黄素营养水平有所提高。实验显示，核黄素需要量与膳食中蛋白质和淀粉摄入量有关，高蛋白、低淀粉组动物，核黄素需要量相对较高。     

深圳市小学生核黄素营养状况的监测分析

目的：了解深圳市小学生核黄素营养状况,为改进其健康状况提供了科学依据。方法：按照随机抽样的原则,采用荧光分光光度法探讨了深圳市568名小学生机体核黄素营养状况。结果：根据陈学存的评价标准,7－9岁龄组正常和充裕营养状况的学生占总数82．5％,不足的学生为15．3％,缺乏的学生为2．2％,7－9岁组男生核黄素水平明显高于女生（P＜0．01）。10－15岁年龄组正常和充裕营养状况的学生占总数的78．1％,不足的学生为21．3％,缺乏的学生为0．6％,10－15岁年龄组男生核黄素水平高于女生,但无显差异,结论提示深圳市小学生核黄素营养状况不足较为常见,女生的核黄素水平低于男生,高年龄组合格率低于低年龄龄组,应在家庭和学校膳食中进行调整,注意年龄和性别差异,增加核黄素的供给量,必要时可进行干预性补充。     

系统性红斑狼疮患者核黄素营养状况分析

[目的]了解系统性红斑狼疮患者核黄素营养状况。[方法]对系统性红斑狼疮患者进行核黄素4h负荷试验,用荧光光度法测定核黄素含量。[结果]系统性红斑狼疮患者核黄素不足226例,正常25例,充裕7例。[结论]系统性红斑狼疮患者核黄素营养水平普遍低下。     

河南某煤矿矿工核黄素营养状况评价

为了解煤矿工人核黄素营养状况，对河南某煤矿矿工进行核黄素营养状况调查。调查结果显示矿工核黄素人均日摄入量仅占ＲＤＡ的３７％；体格检查发现患有核黄素缺乏体征的人数占被检人数的４１％尿负荷试验证实核黄素不足和缺乏的人数占被测人数的６０％。建议：调整矿工的膳食结构，增加核黄素的日摄入量，以改善核黄素的营养状况。     

核黄素缺乏大鼠血浆与红细胞核黄素及衍生物浓度的变化

目的:探讨核黄素缺乏大鼠血浆与红细胞核黄素及其衍生物浓度动态变化,为用血浆与红细胞核黄素及其衍生物水平评价核黄素营养状况提供依据。方法:以无核黄素饲料喂养4w造成大鼠核黄素缺乏,第5w改喂含核黄素的正常饲料。用高效液相色谱法测定血浆与红细胞核黄素及衍生物浓度的动态变化,同时测定核黄素尿排量、全血谷胱甘肽还原酶活性系数(BGRAC)、红细胞还原性谷胱甘肽浓度及血浆丙二醛浓度变化。结果:核黄素缺乏后血浆核黄素水平迅速下降,随之其衍生物水平也显著下降;红细胞核黄素及其衍生物水平变化晚于血浆的变化;BGRAC也有显著变化,但幅度较小;核黄素缺乏导致其尿排量也呈大幅度迅速下降趋势。改喂含核黄素正常饲料1w后,上述变化呈不同程度恢复。结论:血浆与红细胞核黄素浓度可作为评价核黄素营养状况的灵敏指标,需进行人体试验验证。     

高原地区不同运动项目运动员核黄素营养状况的调查

核黄素又名维生素 B2 ,化学名 6 ,7-三甲基 - 9- (1’- D-核糖醇基 ) -异咯嗪 ,是数种酶系统的重要辅基的组成部分 ,具有十分重要的作用。为了解高原地区运动员核黄素营养状况与膳食的关系 ,我们对云南省体委 4种运动项目的运动员进行膳食调查及核黄素营养状况的检查 ,现将结果报道如下。1　对象与方法1.1　调查对象　云南省体委 4种运动项目竞走 (14人 )、中长跑 (2 3人 )、击剑 (佩剑、花剑、重剑 2 8人 )和男排 (8人 )共 73名运动员 ,其中男 5 9人 ,女 14人。1.2　方法1.2 .1　膳食调查　采用 5日称重法调查一日三餐食物摄入量 ,用 5日…     

聊城156名中专女生核黄素与铁营养状况

缺铁性贫血(IDA)及核黄素缺乏是发展中国家最常见的营养缺乏性疾病,其中青春期女生的发病率较高.为探讨核黄素含量和IDA的关系,以改善女生的营养状况,降低贫血和核黄素缺乏的患病率,笔者于2001年5～6月对聊城某中等学校女生进行了调查.     

190例儿童核黄素营养状况与贫血关系调查

对190名17～58月龄儿童进行的横断面调查发现:核黄素缺乏率达62.4％。贫血率及缺铁率各为19.6％及51.4％。核黄素缺乏者的平均血红蛋白(Hb)浓度及铁蛋白(SF)浓度低于核黄素正常者,且其贫血率(23.8％)及缺铁率(68.8％)显著高于核黄素正常者(6.3％及17.4％)。发现BGRAC与Hb、lgSF均显负相关。提示核黄素缺乏与贫血及缺铁有联系。     

女大学生铁营养状况与免疫功能及核黄素营养状况关系的研究

女大学生铁营养状况与免疫功能及核黄素营养状况关系的研究首都医科大学营养与食品卫生教研室（北京１０００５４）马忠杰王惠琴信东王庶沈家琴张宏伟田桂英铁对免疫功能的影响国内外学者已有不少研究，但各家看法不尽相同［１］。维生素Ｂ２对铁营养状况关系的研究是近年...     

Riboflavin Status in Acutely Ill Patients and Response to Dietary Supplements

Background: Although a number of studies have reported riboflavin deficiency in free‐living older people, no data are available on riboflavin intake and status in older people during acute illness. Methods: To determine the riboflavin response to dietary supplements during acute illness, 297 hospitalized, acutely ill older patients are randomly assigned to receive a daily oral nutritional supplement containing 1.3 mg of riboflavin or a placebo for 6 weeks. Outcome measures are riboflavin intake and riboflavin biochemical status at baseline, 6 weeks, and 6 months using the erythrocyte glutathione reductase activation coefficient (EGRAC), a measure of riboflavin tissue saturation. EGRAC values are inversely proportional to riboflavin status. Results: Fifty‐six percent of patients (167/297) have suboptimal riboflavin status (EGRAC > 1.30). No significant correlation is found between EGRAC and either total energy or riboflavin intakes. Significant correlations are found between total energy intake and riboflavin intakes both in hospital and at home (r = 0.67, P < .0001 and r = 0.57, P < .0001, respectively). Smokers and patients with chronic obstructive pulmonary disease (COPD) have lower riboflavin status (high EGRAC values) compared with nonsmokers and those without COPD. Riboflavin status improves significantly in the supplement group at 6 weeks compared with the placebo group, but status declines between 6 weeks and 6 months, after patients stop taking the supplements. Conclusions: A high proportion of acutely ill patients have suboptimal riboflavin status. Supplementation with a physiological amount of riboflavin in a mixed‐nutrient supplement significantly improves riboflavin status, but the effect is transient and status deteriorates again after patients stop taking the supplements.     

Riboflavin deficiency in cystic fibrosis: three case reports

Three cases of clinical riboflavin deficiency are reported in children aged 2–10 years attending a regional Cystic Fibrosis clinic. Riboflavin deficiency presented as angular stomatitis in all three patients. Patients were confirmed to be riboflavin deficient by assaying the activity of erythrocyte glutathione reductase. Patients were not on routine supplements of water-soluble vitamins before presentation and were treated with riboflavin supplements as part of a water-soluble vitamin complex. At presentation, one patient had poor nutritional status, but two patients were adequately nourished, receiving overnight Gastrostomy feeds. Data on these two patients indicate an adequate dietary intake of riboflavin, suggesting a mechanism for increased requirements, inadequate absorption or utilization. Additional deficiencies of thiamin, pyridoxine and iron were also observed. This paper reports the occurrence of a vitamin deficiency not previously reported in the cystic fibrosis population.     

煤矿工人核黄素需要量的初步探讨

<正> 煤矿工人由于其特殊作业条件,受煤尘、毒气以及噪声和振动的影响,使机体对维生素的需要量增加,因而,煤矿工人核黄素的需要量可能较一般人高。目前,国内尚未见煤矿工人核黄素需要量的报导,为此,我们于1990年3～4月对西山矿务局白家庄矿井下工人进行了核黄素需要量的初步研究。     

核黄素在脂质代谢中的作用

核黄素是机体多种氧化还原酶的辅酶，具有递氢作用。核黄素缺乏时脂质过氧化反应增强，而脂质过氧化是多种心血管病变的诱因，同时核黄素参与脂质动员，对脂质沉积性肌病的治疗较为有效。     

褐家鼠耐饥性研究

实验室研究发现，褐家鼠有较强的耐饥能力，平均达１０８ｈ，最长达２２９ｈ，这种能力能使其渡过许多灾害条件．研究还发现，耐饥性与年龄、性别、体重以及供水与否没有显著关系。     

深圳市学龄前儿童硫胺素,核黄素及铁的营养状况

深圳市学龄前儿童缺铁性贫血检出率为10．6％，1～3岁年龄组（13．5％）高于4～6岁年龄组（9．72％）；男童（14．4％）明显高于女童（5．3％）．提示儿童的缺铁性贫血与性别有关。学龄前儿童中硫胺素缺乏者占20．4％．1～3岁年龄组（30．9％）高于4～6岁年龄组（17．2％）；核黄素不足者占13．2％，1～3岁年龄组（25．5％）高于4～6岁年龄组（9．4％）．核黄素不足儿童的缺铁性贫血检出率（16．1％）高于核黄素营养正常儿童（9．3％）硫胺素缺乏儿童的核黄素不足检出率（31．3％）明显高于硫胺素营养正常的儿童（8．6％），提示核黄素不足与硫胺素营养状况有关。     

Experimental and Clinical Evidence of the Effectiveness of Riboflavin on Migraines

Riboflavin, a water-soluble member of the B-vitamin family, plays a vital role in producing energy in mitochondria and reducing inflammation and oxidative stress. Migraine pathogenesis includes neuroinflammation, oxidative stress, and mitochondrial dysfunction. Therefore, riboflavin is increasingly being recognized for its preventive effects on migraines. However, there is no concrete evidence supporting its use because the link between riboflavin and migraines and the underlying mechanisms remains obscure. This review explored the current experimental and clinical evidence of conditions involved in migraine pathogenesis and discussed the role of riboflavin in inhibiting these conditions. Experimental research has demonstrated elevated levels of various oxidative stress markers and pro-inflammatory cytokines in migraines, and riboflavin’s role in reducing these marker levels. Furthermore, clinical research in migraineurs showed increased marker levels and observed riboflavin’s effectiveness in reducing migraines. These findings suggest that inflammation and oxidative stress are associated with migraine pathogenesis, and riboflavin may have neuroprotective effects through its clinically useful anti-inflammatory and anti-oxidative stress properties. Riboflavin’s safety and efficacy suggests its usefulness in migraine prophylaxis; however, insufficient evidence necessitates further study.     

Metabolome Characteristics of Liver Autophagy Deficiency under Starvation Conditions in Infancy

The liver function is essential for metabolism, detoxification, and bile synthesis, even in the neonatal period. Autophagy plays significance roles in THE adult liver, whereas the role of liver autophagy in the early neonatal period largely remains unclear. To clarify the importance of liver autophagy in the neonatal starvation period, we generated liver-specific autophagy-deficient (Atg5^flox/flox; Albumin-Cre) mice and investigated under starvation conditions comparing with control (Atg5^flox/+; Albumin-Cre) mice, focusing on serum metabolites and liver histopathology. As a result, autophagy in the liver was found to unessential for the survival under postnatal starvation. A metabolomics analysis of serum metabolites by gas chromatography-tandem mass spectrometry showed a significant difference between the groups, especially after 12-h starvation, suggesting the synergistical adaption of metabolic pathways, such as the “malate-aspartate shuttle”, “aspartate metabolism”, “urea cycle”, and “glycine and serine metabolism”. Liver-specific autophagy-deficiency under postnatal starvation conditions can cause a characteristic metabolic alteration suggesting a change of the mitochondrial function. Neonates seemed to maintain ketone production under starvation conditions, even in the autophagy-deficient liver, through a change in the mitochondrial function, which may be an adaptive mechanism for avoiding fatal starvation.