Granular Cell Myoblastoma of the Vulva

A case of multiple granular cell myoblas-tomata of the vulva in a 26-year-old woman is described.
The pathology and possible histogenesis of the condition is discussed. Evidence in favour of a neural origin is increasing.
An outline is given of the treatment and prognosis of granular cell myoblastoma.     

Merkel Cell Carcinoma of the Vulva

Merkel cell carcinoma is a very rare tumor. This is why it is not known whether this neoplasm behaves differently in the vulvar location than at other sites. We present a patient with a Merkel cell carcinoma assessed with a light optical microscope, immunohistochemistry, and electron microscope. Only eight previous cases have been reported in the literature. We discuss pathologic findings, such as histologic trabecular pattern under the optical microscope and neurosecretory granules (similar to Merkel cell carcinoma of the skin) under the electron microscope. Also discussed are the results of immunohistochemistry for low-molecular-weight cytokeratin, neuron-specific enolase, chromogranin, and Leu 7, and molecular study of N-ras,K-ras,N-myc,and p53 genes. Little is known about Merkel cell carcinoma of the vulva, but it seems to have a more aggressive behavior and poorer prognosis than Merkel cell carcinoma at other sites.     

Pediatric Granular Cell Tumors of the Vulva: A Report of 4 Cases and a Review of the Literature

Background

Granular cell tumors (GCTs) are rare soft tissue lesions that can involve the female genital tract, including the vulva. Although malignant tumors are aggressive and uncommon, benign and atypical lesions still have associated risks, including recurrence and multisite development.

外阴硬化性苔癣合并外阴鳞状细胞癌一例

外阴硬化性苔藓（vulva lichen sclerosis,VLS）是女性慢性难治性皮肤病。主要发生于外阴及肛周皮肤,以外阴皮肤变白、瘙痒为主要特征,若伴有外阴疼痛及硬结明显者应警惕发展为外阴鳞状细胞癌（vulva squamous cell carcinoma,VSCC）。本文介绍了一例有40余年VLS病史的56岁女性,于大阴唇部位取材,组织病理示“外阴硬化性苔藓,轻度”,后因阴蒂部位粘连,且疼痛明显,行外阴粘连分离术,见阴蒂色暗红,呈小菜花状,并分别用活检钳及冷刀两次病理取材后组织病理证实为VSCC,遂行扩大性外阴切除术+双侧腹股沟淋巴结切除术。术后进一步给予放疗+化疗。本例提示了对于VLS病史较长,且局部硬结,疼痛明显者,应警惕癌变,若阴蒂处疼痛且粘连者,应行粘连分解,暴露阴蒂,必要时重复取材,以免漏诊误诊。     

Basal Cell Carcinoma of the Vulva with Groin Node Metastasis

There have been five previous well-documented cases of rectastatic vulvar basal cell cancer in the literature. We now present the sixth case—an 86-year-old patient with vulvar basal cell cancer metastatic to an ipsilateral groin node. She was treated with radical vulvectomy and bilateral inguinofemoral lymphadenectomy and remains free of disease 1 year later.     

Granulosa Cell Tumours: A Study of 37 Cases

Objectives

To evaluate the clinico-pathological features, surgical procedures and postoperative treatment and their relation to survival in women with granulosa cell tumours.

Methods

Data of 37 women with granulosa cell tumours were collected and reviewed retrospectively. Mann–Whitney test, log rank test and Kaplan–Meier survival analysis were applied appropriately.

Results

Thirty-seven women of median age 48.6 years were diagnosed in stage Ia (45.9 %), stage Ic (27 %), stage III (16.2 %) and unstaged (10.8 %). The median follow up was 5 years. Overall survival was 93 % at 5 years. Disease-free survival at 5 years was 63 %. Tumour stage and residual disease were associated with poor prognosis (p < 0.001). Mitotic rate and tumour grade were not of prognostic significance.

Conclusions

Stage of disease and residual disease are valuable prognostic factors. Prospective studies with large sample sizes and long-term follow up are needed to confirm our findings.     

Bilateral Juvenile Granulosa Cell Tumours Associated with Skeletal Enchondromas

Asynchronous bilateral granulosa cell tumours of the ovary occurred in a patient with enchondromas. The first tumour, presenting at age 15, was misdiagnosed initially as an androblastoma. The second tumour presented 7 years and 3 pregnancies later. The possible therapeutic and pathogenetic implications of these observations are discussed.     

Retrospective Analysis of 32 Cases of Ovarian Granulosa Cell Tumours

The Journal of Obstetrics and Gynecology of India - Granulosa cell tumour (GCT) comprises 2–5% of ovarian malignancies. They are hormonally active tumours and may present with menstrual...     

Pyoderma Gangrenosum of the Vulva

EDITORIAL COMMENT: These 2 cases illustrate that blood dyscrasia should be considered and excluded (full blood examination) in patients presenting with unusual ulcerative lesions of the vulva because incisional biopsy may fail to provide the diagnosis and wider excision may lead to rapid deterioration in the patient's condition — if pyoderma gangrenosum is diagnosed the treatment of associated ulcera-tion is not surgical. Serology for syphilis should also be performed in patients with unusual vulval ulcers.