磁共振动态增强扫描SI-T曲线对前列腺良恶性病变的鉴别诊断

目的探讨磁共振动态增强扫描(DCE-MRI)信号强度-时间曲线(signal intensity-time curve,SI-T曲线)对前列腺良恶性病变的鉴别诊断价值。方法对30例经病理证实的前列腺癌(Pca)患者和32例良性前列腺增生(BPH)患者行MRI平扫,动态增强扫描及延迟扫描,观察病变的MRI表现特征并分别绘制前列腺癌病灶和增生结节的SI-T曲线,重点分析其信号强度变化及SI-T曲线的走形趋势。结果在磁共振动态增强扫描早期Pca癌灶和BPH增生结节均呈明显强化,有助于病变的检出。SI-T曲线参数:峰值时间Pca组早于BPH组,强化程度和强化率Pca组均高于BPH组(P<0.05)。结论磁共振动态增强扫描SI-T曲线对BPH和Pca的鉴别诊断有较明确的价值。     

前列腺癌的MRI动态增强特征与微血管密度和前列腺特异性抗原的相关性的初步研究

目的评价前列腺癌的动态增强特征与微血管密度（MVD）和前列腺特异性抗原（PSA）的相关性,为前列腺癌的诊断提供帮助. 资料与方法对32例前列腺癌患者进行MRI动态增强扫描,设立40例良性前列腺增生（BPH）患者进行对照,观察病灶的动态增强MRI的强化参数：开始时间、最大信号强度及早期强化率,获得感兴趣区的病理标本,进行免疫组织化学MVD的测定,比较分析前列腺癌和BPH的动态增强参数、两者的MVD和PSA的相关关系. 结果前列腺癌的MRI动态增强的强化参数开始时间、最大信号强度及早期强化率与BPH不同（P分别＜0.01、0.05、0.01）.前列腺癌的MVD的测定水平高于BPH（P＜0.001）.前列腺癌和BPH的MRI动态增强参数中的最大信号强度和早期强化率与MVD有相关性（P＜0.05或0.01）.前列腺癌的血清PSA与MVD的水平具有相关性（P＜0.05）. 结论前列腺癌MRI动态增强特征、前列腺癌的MVD与PSA的水平具有一定的相关性,MRI动态增强与PSA的测定相结合能为前列腺癌的诊断提供帮助.     

Dynamic contrast-enhanced MRI in normal and abnormal prostate tissues as defined by biopsy, MRI, and 3D MRSI.

This study characterized dynamic contrast-enhanced (DCE) MRI of prostate tissues: cancerous peripheral zone (PZ), normal PZ, stromal benign prostatic hyperplasia (BPH), and glandular BPH. MRI, MRSI, and DCE MRI were performed on 25 patients. Tissues were identified with MRI, MRSI, and (when available) biopsy results. Motion between MRI and DCE MRI, and within DCE MRI was assessed and manually corrected. To assess tissue and patient effects, native T1's were measured in 12 of 25 patients, and DCE MRI results were normalized to muscle enhancement. Regions of cancer had a higher peak enhancement (P < 0.006), faster enhancement rate (P < 0.0008), and faster washout slope (P < 0.05) than normal PZ tissues. Stromal BPH had the fastest enhancement rate (P < 0.003) of all tissues and tended to have the greatest enhancement. Intersequence motion averaged 2.6 mm and reached 7.9 mm. Motion within DCE MRI was generally minimal (<2 pixels), but one case showed a large shift that would have confounded the results. Native T1's were similar across the prostatic tissues. Interpatient variability in DCE MRI was only partially reduced by normalization to muscle. DCE MRI of the prostate discriminated PZ cancer from normal PZ tissues and predominantly stromal and glandular BPH.     

磁共振DWI及动态增强扫描在前列腺疾病诊断中的价值

目的探讨磁共振扩散加权成像(DWI)和动态增强扫描(DCE-MRI)在前列腺疾病中的诊断价值。方法经穿刺活检或手术病理证实的20例前列腺癌及31例前列腺增生(BPH)患者进行了MR常规扫描、DWI和DCE-MRI扫描,测量病变的表观扩散系数(ADC)值,观察病灶常规MRI、DWI和动态增强MRI特征,绘制信号强度-时间曲线(SI-T曲线),SI-T曲线分成3型:Ⅰ型为信号强度早期增高后仍持续增高;Ⅱ型为信号强度早期增高后出现平台期;Ⅲ型为信号强度早期增高后出现下降期。经方差分析比较不同组织和病灶间差异。结果经DCE-MRI检查,20例前列腺癌患者中17例病灶区呈Ⅲ型曲线,2例呈Ⅱ型曲线,1例呈Ⅰ型曲线;31例前列腺增生患者中26例呈Ⅰ型曲线,4例呈Ⅱ型曲线,1例呈Ⅲ型曲线。前列腺癌组与BPH组的SI-T曲线类型分布的差异有统计学意义(P<0.01)。20例前列腺癌病灶于DWI上为高信号,于ADC图上呈明显低信号,ADC值为(1.18±0.08)×10-3 mm2/s,未被癌组织侵及的外围叶于DWI、ADC图上均呈等信号,ADC值为(2.67±0.09)×10-3 mm2/s;31例前列腺增生患者中央叶和外围叶于DWI、ADC图上均呈等信号,ADC值分别为(1.87±0.07)×10-3 mm2/s、(2.64±0.11)×10-3mm2/s。除前列腺增生的外围叶与未被癌组织侵及的外围叶之间差异无统计学意义(P>0.05)外,前列腺增生、前列腺癌、前列腺增生的外围叶和未被癌组织侵及的外围叶各组之间差异均有统计学意义(P<0.05)。DCE-MRI和DWI联合应用在前列腺癌诊断的敏感度、特异度和准确度均达80%以上。结论 DCE-MRI、DWI在前列腺癌和前列腺增生中具有特征性影像学表现,2种方法联合应用提高了MRI诊断前列腺癌的诊断和分期准确率。     

MRI在前列腺疾病诊断中的应用及其进展

目的探讨动态增强MRI(DCE-MRI)及扩散加权成像(DWI)对前列腺良恶性疾病的诊断价值。资料与方法对15名正常自愿者及48例经病理证实的前列腺疾病患者行MRI常规平扫、DWI及DCE-MRI,分析正常前列腺内外带、前列腺增生症(BPH)及前列腺癌(PCa)的DEC-MRI信号变化,时间信号-强度(SI-T)曲线特征及表观扩散系数(ADC)值的变化情况。结果DCE-MRI及DWI对良恶性前列腺疾病的检出具有较高的敏感性及特异性。达峰时间(Tmax)从高到低依次为正常前列腺外周叶、正常中央叶、BPH及PCa(P=0.000);强化程度(SI%)从高到低为BPH,正常中央叶、PCa及正常外周叶(P=0.000);强化率(R)从高到低为PCa、BPH、正常中央叶及正常外周叶(P=0.000)。ADC值从高到低为正常外周叶、正常中央叶、BPH及PCa(P=0.000)。结论DCE-MRI及DWI可明显提高PCa及BPH的鉴别诊断率。     

3D dynamic contrast-enhanced MRI of rectal carcinoma at 3T: correlation with microvascular density and vascular endothelial growth factor markers of tumor angiogenesis

PURPOSE: To determine how dynamic contrast-enhanced (DCE) MRI at 3T correlates with rectal carcinoma angiogenesis. MATERIALS AND METHODS: Three-dimensional (3D) DCE MRI was performed in 38 patients (23 males, 15 females, mean age 60 years) with histologically-confirmed rectal carcinoma at 3T. Time-intensity curves (TICs) were used to measure peak enhancement ratio (ER(peak)), time to peak enhancement (T(peak)), first enhancement time (T(first-enhance)), and uptake rate for rectal tumor, normal rectal wall, and gluteal muscle. After tumor resection, microvascular density (MVD) and vascular endothelial growth factor (VEGF) expression were determined using immunohistochemistry (IHC) stains on available specimens (N = 24) to correlate with DCE MRI. RESULTS: Rectal carcinoma showed higher ER(peak) (3.0 +/- 0.9 vs. 1.9 +/- 0.9, P < 0.001), higher uptake rate (2.8 +/- 1.5/minute vs. 1.2 +/- 0.9/minute, P < 0.001), earlier T(peak) (88 +/- 56 seconds vs. 124 +/- 72 seconds, P = 0.027), and earlier T(first-enhance) (34 +/- 6 seconds vs. 40 +/- 7 seconds, P = 0.008) than normal rectal wall. Adenocarcinoma had shorter T(peak) compared to signet cell carcinoma (77 +/- 48 seconds vs. 160 +/- 62 seconds, P = 0.004). T(peak) was negatively correlated with MVD (r = -0.516, P = 0.01) and the mean T(peak) was significantly earlier for the VEGF-positive group compared to the VEGF-negative group (57 +/- 17 seconds vs. 107 +/- 64 seconds, P = 0.021). CONCLUSION: DCE MRI parameters help predict rectal tumor angiogenesis measured by MVD and VEGF expression and discriminate malignant from normal tissue.     

大鼠C6脑胶质瘤生长的MRI评价及与其病理组织学的关系

目的:探讨大鼠C6脑胶质瘤MR I所测参数与其组织病理学的相关性。材料和方法:运用立体定向方法建立大鼠C6胶质瘤模型,并于C6细胞植入后1、2、3周行MR I平扫及增强扫描,同期取脑行病理组织学检查,对MR I所测肿瘤体积、肿瘤增强程度和EI与MVD和VEGF表达进行相关分析。结果:大鼠C6脑胶质瘤MR影像表现与文献报道相似,新生肿瘤血管和VEGF表达主要位于肿瘤周边;随着C6细胞植入时间的延长,肿瘤体积、EI、MVD逐渐增大,其差别具有统计学意义;VEGF表达与MVD呈正相关,二者分别与肿瘤体积、肿瘤增强程度、EI之间呈正相关。结论:MR I能够反映大鼠C6脑胶质瘤的动态生长特征,与VEGF表达和MVD的动态变化密切相关。     

表观扩散系数和MR动态增强对前列腺中央腺体疾病的价值

目的评估表观扩散系数(ADC)及MR动态增强(DCE-MRI)对前列腺中央腺体病变的诊断价值。方法对经病理证实的50例前列腺中央腺体疾病患者进行扩散加权扫描(DWI)和DCE-MRI扫描,其中16例为前列腺癌(PCa),34例为前列腺增生(BPH)。分析基质增生为主型BPH(sBPH)、腺体增生为主型BPH(gBPH)和PCa的ADC值差别特点及信号强度-时间(SI-T)曲线特征。结果 gBPH、sBPH和PCa的平均ADC值分别为(1.33±0.25)×10-3 mm2/s、(1.04±0.22)×10-3 mm2/s、(0.71±0.32)×10-3 mm2/s,两两比较各组间有统计学差异(P<0.05)。SI-T曲线参数:达峰时间(Tmax)从高到低依次为sBPH、gBPH及PCa(P<0.05),强化程度(SI%)从高到低依次为sBPH、PCa及gBPH(P<0.05),强化率(R)从高到低依次为PCa、gBPH及sBPH(P<0.05)。结论 MR动态增强及ADC对前列腺中央腺体的病变有重要的诊断价值。     

星形细胞瘤MR征象与VEGF表达的相关性研究

目的 :探讨星形细胞瘤MRI征象与血管内皮生长因子 (VEGF)表达程度的相关性。方法 :对 3 3例经手术和病理证实的星形细胞瘤分别行术前常规横断面T1WI、T2 WI平扫和Gd DTPA增强后三维T1WI ,术后取肿瘤组织行VEGF表达和微血管密度 (MVD)免疫组化染色 ,计算每一例肿瘤标本的VEGF表达程度和MVD ,将VEGF表达程度分别与MRI征象、MVD及病理分级进行相关分析。结果 :星形细胞瘤病理分级越高 ,VEGF表达越强 (P <0 .0 1) ;肿瘤周围水肿程度、囊变与坏死、强化形态与程度以及肿瘤MVD等与VEGF表达强度密切相关。结论 :星形细胞瘤MRI表现与VEGF表达强度具有密切的相关性 ,MRI对星形细胞瘤的分级诊断和判断其生物学行为及预后有较高的价值。     

Dynamic contrast-enhanced (DCE) derived transfer coefficient (ktrans) is a surrogate marker of matrix metalloproteinase 9 (MMP-9) expression in brain tuberculomas

PURPOSE: To correlate dynamic contrast-enhanced (DCE) MRI derived perfusion indices with immunohistochemically obtained vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in a cellular fraction of brain tuberculomas (BT). MATERIALS AND METHODS: Thirteen BT patients underwent DCE MRI. Perfusion indices (cerebral blood volume [CBV], transfer coefficient [ktrans] and leakage [ve]) maps were generated for the quantitative analysis. The CBV was corrected for the leaky blood-brain barrier (BBB). The relative CBV (rCBV), ktrans, and ve were calculated by placing 10 regions of interest (ROIs) showing the highest values in the lesion. The percentage area of VEGF and percentage area of MMP-9 and microvessel density (MVD) were quantified from 10 fields per lesion with maximal expression of the excised BT. Pearson correlation analysis between physiological indices and quantitative VEGF, MMP-9, and MVD was performed for each ROI. RESULTS: The average value of rCBV, ktrans, ve, VEGF, MMP-9, and MVD were 3.53+/-0.37, 2.04+/-0.40 min(-1), 0.71+/-0.09, 12.51+/-2.56, 18.09+/-2.06, 10.87+/-1.99, respectively. The ktrans (r=0.918, P<0.001) and ve (r=0.899, P<0.001) showed significant correlation with MMP-9, while rCBV correlated significantly with MVD (r=0.962, P<0.001) and VEGF (r=0.868, P<0.001). CONCLUSION: We conclude that the expression of MMP-9, a marker of BBB disruption and disease activity in BT correlates with DCE-derived ktrans and thus has the potential to be used as its surrogate marker.     

Perioperative prediction by MRI of prostate volume six to twelve months after laser-induced thermotherapy of benign prostatic hyperplasia

The purpose of this study was to predict prostate volume outcome 6-12 months after interstitial, laser-induced thermotherapy (LITT) for benign prostatic hyperplasia (BPH) on the basis of prostate magnetic resonance (MR) images obtained within 48 hours before and after LITT. Twenty patients (age, 64.2 +/- 7.4 years) with symptomatic BPH had LITT of the transitional zone of the prostate. MRI was performed within 48 hours before and after LITT, and 6-12 months after LITT (late follow-up). MRI included axial and sagittal T2-weighted fast spin-echo (FSE) images and contrast-enhanced, axial T1-weighted images. Volumes of different prostatic compartments (total prostate, transitional zone, peripheral zone, LITT lesions) were measured by planimetry. Subtraction of LITT lesion volume less than 48 hours after LITT from total and transitional zone volume before LITT, respectively, predicted respective prostatic volumes at late follow-up. Pearson correlations of predicted and measured total prostate and transitional zone volumes were 0.972 and 0.975, respectively. Total prostate volume at late follow-up was accurately predicted (difference, -0.5 +/- 5.7 cc; P = 0.6981, two-tailed paired t-test). Transitional zone volume was underestimated (difference, -3.1 +/- 4.7 cc; P = 0.0075). Peripheral zone volume was overestimated (difference, 2.6 +/- 3.5 cc; P = 0.0034). Perioperative MRI allows accurate prediction of prostate volume 6-12 months after LITT for BPH. Underestimation of transitional zone volume may be due to ongoing growth of BPH. LITT appears to affect peripheral zone tissue outside the target region. J. Magn. Reson. Imaging 2001;13:64-68.     

Differentiation of prostatic carcinoma and benign prostatic hyperplasia: correlation between dynamic Gd-DTPA-enhanced MR imaging and histopathology

One of the major factors limiting the staging accuracy of conventional magnetic resonance imaging (MRI) for prostatic carcinoma, is the similarity in signal intensity between tumor and coexisting benign prostatic hyperplasia (BPH). As neovascularity is an independent indicator of pathological state, dynamic contrast-enhanced MRI may yield additional information. This study correlates the histopathological findings from 12 radical prostatectomy patients on a region-by-region basis, with pharmacokinetic modeling of dynamic contrast-enhanced (0.2 mmol dimeglumine gadopentetate/kg), fast multiplanar spoilt gradient-recalled echo images, using a two-compartment simplex minimization technique. Quantitative analysis demonstrated differences in the amplitude of the initial contrast upslope and contrast exchange rate between tumor and fibromuscular BPH (P<0.03 and P<0.03, respectively) and for the contrast exchange rate between tumor and fibroglandular BPH (P<0.04), providing improved delineation of intraprostatic tumor extent compared with conventional imaging techniques.     

MR扩散加权成像在前列腺病变中的诊断价值

目的：探讨DWI在前列腺病变诊断中的价值。方法：分别对30例前列腺癌（PCa）、30例良性前列腺增生（BPH）患者和30名健康志愿者进行前列腺DWI扫描,分析三者的DWI图、ADC图的信号表现,以及癌灶、增生结节灶、正常前列腺的ADC值,以及前两者病灶ADC值与其周围正常外周带ADC值的相对比值变化规律。所有BPH和PCa病例均经手术或穿刺活检病理证实。结果：①PCa、BPH患者和健康志愿者（各30例）DWI表现：PCa表现为高信号影为主;增生结节呈稍高信号为主,强度低于外周带,并且信号不均匀;健康志愿者外周带呈稍高信号为主,中央带呈等信号为主,外周带信号高于中央带,二者分界清晰;②PCa癌灶平均ADC值（0.878±0.056）×10^-3mm^2/s;BPH增生结节灶平均ADC值（1.379±0.201）×10^-3mm^2/s;健康者前列腺中央带平均ADC值（1.287±0.041）×10^-3mm^2/s;健康者前列腺外周带平均ADC值（1.636±0.064）×10^-3mm^2/s;③PCa癌灶、BPH增生结节灶（各30例）的平均ADC值与其周围正常外周带ADC值的相对比值平均分别为0.54±0.05,0.85±0.06。结论：正常前列腺外周带、BPH、正常前列腺中央带、PCa在DWI图像上信号有较大差别,PCa癌灶信号最高。正常前列腺外周带、BPH、正常前列腺中央带、PCa癌灶的ADC值依次下降。BPH、PCa癌灶ADC值与其周围正常外周带组织ADC值的相对比值有明显差别。ADC值≤0.97×10^-3mm^2/s,特别是同时ADC相对比值≤0.62,是PCa DWI诊断的可靠依据,有临床诊断意义。     

MR characteristics of prostatic carcinoma and benign prostatic hyperplasia at 1.5 T

Sixty-one patients with histologically proven disorders of the prostate [prostatic carcinoma (PC), 41; benign prostatic hyperplasia (BPH), 9; PC and BPH, 11] underwent magnetic resonance imaging at 1.5 T. Using single [spin echo (SE) 400/30] and dual (SE 1,600/30, 90) SE sequences, multislice contiguous scans were obtained in transverse, sagittal, and coronal planes through the prostate. In 27 patients (PC 14, BPH 6, PC and BPH 7) multiecho sequences with eight echoes (SE 1,600/30, 60, 90, 120, 150, 180, 210, 240) were acquired and T2 images were calculated in the planes with best depiction of circumscribed prostatic pathology. In these patients the Bhattacharyya coefficient, a quantitative criterion for the discrimination between normal and pathological tissue, derived by means of mathematical decision theory, was applied. This analysis showed the best discrimination between PC and normal prostate with echo time (TE) 90 and 120 ms [error rate (ER) for confusing these tissues 20-30%]. There was no significant difference between the signal intensities of PC and BPH at any parameter setting, but PC could be discriminated from the compressed peripheral glandular regions that often accompany BPH [minimal ER (20-30%) at TE 90 and 120 ms]. This distinction is of clinical value, since PC usually arises in the periphery of the prostate. Calculated T2 images did not show advantages for the detection of PC.     

CT征象联合免疫组织化学指标鉴别诊断肺癌的研究

目的研究肺癌环氧化酶2(COX-2)、血管内皮生长因子(VEGF)、微血管密度(MVD)表达与CT征象及增强表现之间的相关性。资料与方法对经病理证实的25例肺癌及35例肺良性病变行CT扫描,并应用P-V法对其病理标本进行免疫组织化学分析,研究COX-2、VEGF、MVD表达水平与CT征象及增强表现之间的相关性。结果肺癌组COX-2、VEGF、MVD表达水平明显高于肺良性病变组;COX-2、VEGF、MVD表达与某些CT征象及增强表现密切相关。结论COX-2、VEGF、MVD可作为临床评价肿瘤发展,估计肿瘤预后的重要分子生物学指征。某些CT征象及增强表现可以反映肺癌的血供特点,可根据它们来推测肿瘤的侵袭、转移及预后情况。     

Combined dynamic contrast enhanced breast MR and proton spectroscopic imaging: a feasibility study

PURPOSE: To investigate the feasibility of combined dynamic contrast enhanced (DCE) and magnetic resonance spectroscopy (MRS) in evaluating breast lesions. METHODS: Nine patients with positive mammograms scheduled for either biopsy or mastectomy were examined on a 1.5-T MR scanner. DCE was performed with administration of gadolinium-DTPA contrast using a two-dimensional spoiled gradient recall echo (SPGR) sequence. Proton spectroscopy (TR/TE = 2000/272 msec) was performed using PRESS single slice (10 mm). Lesion time intensity curves were classified as persistent (type 1), plateau (type 2), or washout (type 3) pattern enhancement. Choline (Cho) signal-to-noise ratios (SNRs) and enhancement patterns were compared between benign and malignant lesions as determined by histopathology. RESULTS: Five patients had breast carcinoma and four had benign lesions. Type 1 enhancement was found in two benign cases, type 2 enhancement in two of four benign and four of five malignant lesions, and one malignant case exhibited a type 3 pattern. Choline SNR was significantly different (P < 0.003) between benign and malignant lesions (2.0 +/- 0.3 vs. 5.7 +/- 1.4; P < 0.003). Choline SNR was less than 4.0 in all of the benign lesions, including the two lesions with type 2 enhancement. CONCLUSION: Proton MRS appears to be a promising technique for classification of breast lesions when DCE results are equivocal. A combination of DCE and MRS is feasible, and may have improved specificity compared to either modality alone.     

MR 动态增强联合扩散加权成像对壶腹区良恶性病变的鉴别

目的：研究M R动态增强联合扩散加权成像（DWI）在鉴别壶腹区良恶性病变的价值。方法回顾性分析43例胆总管下段狭窄患者的M R动态增强及DWI的数据。其中包括32例恶性病变和11例慢性炎症。1位影像医生对壶腹周围良恶性病变的M R动态增强信号强度及DWI信号进行分析,另外2位影像医生对壶腹周围病变的M R动态增强影像以及M R动态增强联合DWI影像进行评估。应用 Logistic回归分析比较灵敏度及特异性。结果壶腹周围良恶性病变MR动态增强表现差异无统计学意义;DWI影像中,壶腹周围癌比炎症更多地表现为高信号,表观扩散系数（ADC）图表现为低信号（P＜0．001）。2位读片者在结合DWI影像后对恶性壶腹周围病变的诊断灵敏度均有提高,分别从84．4％提高到96．9％和从87．7％提高到96．6％。结论 M R动态增强联合DWI可提高鉴别壶腹周围区良恶性狭窄的诊断准确率。     

Can pre-operative contrast-enhanced dynamic MR imaging for prostate cancer predict microvessel density in prostatectomy specimens?

The aim of this study was to correlate quantitative dynamic contrast-enhanced MRI (DCE MRI) parameters with microvessel density (MVD) in prostate carcinoma. Twenty-eight patients with biopsy-proven prostate carcinoma were examined by endorectal MRI including multiplanar T2- and T1-weighted spin-echo and dynamic T1-weighted turbo-FLASH MRI during and after intravenous Gd-DTPA administration. Microvessels were stained on surgical specimens using a CD31 monoclonal antibody. The MVD was quantified in hot spots by counting (MVC) and determining the area fraction by morphometry (MVAF). The DCE MRI data were analyzed using an open pharmacokinetic two-compartment model. In corresponding anatomic locations the time shift (t) between the beginning of signal enhancement of cancer and adjacent normal prostatic tissue, the degree of contrast enhancement and the contrast exchange rate constant (k₂₁) were calculated. The MVC and MVAF were elevated in carcinoma (p<0.001 and p=0.002, respectively) and correlated to k₂₁ (r=0.62, p<0.001 and r=0.80, p<0.001, respectively). k₂₁-values of carcinoma were significantly higher compared with normal peripheral but not central zone tissue. t was longer in high compared with low-grade tumors (p=0.025). The DCE MRI can provide important information about individual MVD in prostate cancer, which may be helpful for guiding biopsy and assessing individual prognosis.     

~(90)Sr-~(90)Y对人良性前列腺增生细胞增殖与凋亡影响的研究

目的　探讨放射性核素90 Sr 90 Y对良性前列腺增生 (BPH)组织细胞增殖与凋亡的影响。方法　采用DNA原位末端标记法和免疫组织化学法分别测定BPH组织和经放射性核素90 Sr 90 Y腔内照射后的BPH组织中细胞凋亡和Ki 67的表达情况。结果　经90 Sr 90 Y腔内照射后的BPH组织中增殖指数 (PI)较未照射组明显下降 (P <0 0 1 ) ,而两者细胞凋亡指数 (AI)相比差异无显著性 (P >0 0 5)。结论　放射性核素90 Sr 90 Y腔内照射可抑制前列腺细胞增殖 ,未发现诱导细胞凋亡的证据     

良性前列腺增生与前列腺癌的MSCT多期强化特征的比较

目的探讨良性前列腺增生(BPH)和前列腺癌(PCa)的多层CT(MSCT)多期扫描的强化特征。方法35例BPH和27例PCa病人术前行MSCT扫描,观察BPH和PCa的CT强化峰值到达的期相、最大强化幅值及时间-密度曲线,并计算曲线升段的斜率。结果两组病例强化峰值到达的期相及时间-密度曲线类型分布的差异有统计学意义(P<0.01)。BPH和PCa的斜率分别为0.45±0.25和0.76±0.34,PCa的斜率大于BPH的斜率(P<0.05)。而BPH和PCa的最大强化幅值分别为(44.057±10.261)HU和(46.778±11.140)HU,两组之间的差异无统计学意义(P>0.05)。结论MSCT多期扫描能够显示BPH、PCa的血供情况及强化特征,对前列腺病灶的显示和鉴别诊断起重要作用。