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1.
Suk Keun Lee Yeon Sook Kim Hee Soo Oh Kyu Ho Yang Eun Cheol Kim Je Geun Chi 《Anatomical record (Hoboken, N.J. : 2007)》2001,263(3):314-325
In an effort to better understand the interrelationship of the growth and development pattern of the mandible and condyle, a sequential growth pattern of human mandibles in 38 embryos and 111 fetuses were examined by serial histological sections and soft X‐ray views. The basic growth pattern of the mandibular body and condyle appeared in week 7 of fertilization. Histologically, the embryonal mandible originated from primary intramembranous ossification in the fibrous mesenchymal tissue around the Meckel cartilage. From this initial ossification, the ramifying trabecular bones developed forward, backward and upward, to form the symphysis, mandibular body, and coronoid process, respectively. We named this initial ossification site of embryonal mandible as the mandibular primary growth center (MdPGC). During week 8 of fertilization, the trabecular bone of the mandibular body grew rapidly to form muscular attachments to the masseter, temporalis, and pterygoid muscles. The mandible was then rapidly separated from the Meckel cartilage and formed a condyle blastema at the posterior end of linear mandibular trabeculae. The condyle blastema, attached to the upper part of pterygoid muscle, grew backward and upward and concurrent endochondral ossification resulted in the formation of the condyle. From week 14 of fertilization, the growth of conical structure of condyle became apparent on histological and radiological examinations. The mandibular body showed a conspicuous radiating trabecular growth pattern centered at the MdPGC, located around the apical area of deciduous first molar. The condyle growth showed characteristic conical structure and abundant hematopoietic tissue in the marrow. The growth of the proximal end of condyle was also approximated to the MdPGC on radiograms. Taken together, we hypothesized that the MdPGC has an important morphogenetic affect for the development of the human mandible, providing a growth center for the trabecular bone of mandibular body and also indicating the initial growth of endochondral ossification of the condyle. Anat Rec 263:314–325, 2001. © 2001 Wiley‐Liss, Inc. 相似文献
2.
Skeletons of human fetuses of different ages allow the study of the considerable transformations of the mandibular joint and the mandible in this relative short stage of life. The condyle is anchored in the mandible by a conical process. The tip of this cone extends to the anLage of the 2nd milk molar. The conical process can be recognized macroscopically up to newborn age. It can also be identified by modern imaging methods. The cone can be well distinguished from the surrounding bone of the mandible. The mandibular joints of fetuses in the 31st, the 32nd, the 39th week and of a newborn were dissected, removed, and histologically investigated. The conical process of the condyle was clearly observed. The cartilage on the condyle is characterised by a layered structure which is typical for a center of growth. In the cartilage of young fetuses, blood vessels were found, reaching from the trabecular bone to the articular space. At this stage of life, blood vessels are also present in the central part of the discus articularis. 相似文献
3.
4.
Ossification of the presumptive trabecular bone in the mandibular condyle and the presumptive cortical bone in the mandibular
corpus of the pig mandible was investigated during development, using micro-computed tomography (microCT). Three-dimensional
architecture and mineralization characteristics were assessed from ten pigs of different developmental ages. In the condyle,
increases in trabecular thickness and separation and a decrease in the trabecular number, led to an unchanged bone volume
fraction. A conversion from rod-like into plate-like trabeculae was observed. Bone volume and trabecular thickness were always
higher in the corpus, where an increase in bone volume fraction was caused by an increase in the trabecular thickness and
a decrease in separation. A transition from a plate-like structure into a more compact structure took place. The average degree
of mineralization in the condyle and the corpus increased with age. In the corpus, the degrees of mineralization were higher
than in the condyle. The differences between the condyle and corpus and the changes with age could be explained by differences
in the distribution of mineralization within the trabecular elements. Generally, the degrees of mineralization increased from
the surface toward the centers of the trabecular elements, indicating growth of the trabecular elements by the surface apposition
of new mineral. 相似文献
5.
Lee YJ Lee SS Park BG Woo SD Kim EC Kim YS Lee SK Chi JG 《The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology》2006,288(12):1234-1242
The mandibular primary growth center (MdPGC) of human fetus was conspicuously defined in the soft X-ray view of fetal mandibles. As the peripheral adaptive growth of mandible advances during the postnatal period, the MdPGC image became overshadowed by condensed cortical bones in soft X-ray view. In this study, we traced a sclerotic sequela of MdPGC during the postnatal period. Panoramic radiograms of 200 adults and soft X-ray views of 30 dried adult mandibles were analyzed by statistical methods. The former clearly showed an MdPGC below the middle portion of apices of canine and first premolar, which was distinguishable from mental foramen, and the latter also showed the MdPGC at the same area as a radiating and condensed radiopaque image, measuring 0.5-1.0 cm in diameter. This MdPGC position was seldom changed in the elderly people, even in the edentulous mandibles. Additionally, in the radiological examination, the benign tumors including odontogenic cysts hardly involved the MdPGC, while the malignant tumors of both primary and metastatic cancer frequently destroyed the MdPGC. 相似文献
6.
Tanaka E Sano R Kawai N Langenbach GE Brugman P Tanne K van Eijden TM 《Annals of biomedical engineering》2007,35(9):1617-1621
A switch to a soft diet, associated with reduced forces applied to the mandible during mastication, may result in an alteration
of the degree of mineralization in the mandible. This alteration may be regionally different. The aim of this study was to
analyze this alteration by examination of the degree of mineralization in the mandible of growing rats fed with a hard or
soft diet. Fifteen Wistar male rats were used in this investigation. After weaning, six rats were fed with a hard diet and
the remaining nine rats with a soft diet. After 9 weeks, three-dimensional reconstructions of the cortical and trabecular
bone of their mandibles were obtained using a microCT system. The degree of mineralization was determined for the trabecular
bone in the condyle and for the cortical bone in the anterior and posterior areas of the mandibular body. In both diet groups
the degree of mineralization was significantly (p < 0.01) lower in the trabecular than in the cortical bone. In the mandibular body, the anterior area showed a significantly
(p < 0.01) higher degree of mineralization than the posterior area in both diet groups. In both areas the soft diet group had
a significantly (p < 0.05 or 0.01) higher degree of mineralization than the hard diet group. The trabecular bone in the condyle of the hard
diet group showed a significantly (p < 0.01) higher degree of mineralization than in the soft diet group. The present results indicate the importance of proper
masticatory muscle function for craniofacial growth and development. 相似文献
7.
Trabecular bone ratio of the mandibular condyle according to the presence of teeth: a micro-CT study
Choi DY Sun KH Won SY Lee JG Hu KS Kim KD Kim HJ 《Surgical and radiologic anatomy : SRA》2012,34(6):519-526
Purpose
During mastication, mechanical pressure from the dentition is transmitted to the trabecular bone of the mandible. The occlusal forces, which could thus affect condylar growth, vary with tooth loss, age, and sex. The trabecular bone of the mandibular condyle is denser in dentate subjects than in edentate subjects. However, since the different tooth groups (incisor, premolar, and molar) have different functions, they could exert different effects on the mandibular condyle. The aim of this study was to elucidate the bone quantity of the Korean mandibular condyle according to the presence of teeth using micro-computed tomography (micro-CT), thereby clarifying the influences of tooth presence on the condylar microstructure.Methods
Thirty-one sides were scanned and reconstructed into a 3D structure using a micro-CT system. The specimen was sectioned vertically, passing through the medial and lateral poles of the mandibular condyle (P0) to enable measurement of the trabecular bone ratio. Likewise, three additional images, parallel with P0, were acquired. Mean and standard deviation values were calculated, and the t test, one-way ANOVA and post hoc analysis were performed to examine the differences among each group, classified according to the presence of teeth and according to sex.Results
The density of the trabecular bone of the mandibular condyle was significantly associated with the presence of the molars, but not the incisors or premolars. There were significant differences between sexes.Conclusions
The present study has provided data regarding the bone quantity of the trabeculae of the mandibular condyle according to the presence or absence of teeth. 相似文献8.
Li C Suttie JM Clark DE 《The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology》2005,282(2):163-174
Annual antler renewal presents the only case of epimorphic regeneration (de novo formation of a lost appendage distal to the level of amputation) in mammals. Epimorphic regeneration is also referred to as a blastema-based process, as blastema formation at an initial stage is the prerequisite for this type of regeneration. Therefore, antler regeneration has been claimed to take place through initial blastema formation. However, this claim has never been confirmed experimentally. The present study set out to describe systematically the progression of antler regeneration in order to make a direct histological comparison with blastema formation. The results showed that wound healing over a pedicle stump was achieved by ingrowth of full-thickness pedicle skin and resulted in formation of a scar. The growth centers for the antler main beam and brow tine were formed independently at the posterior and anterior corners of the pedicle stump, respectively. The hyperplastic perichondrium surmounting each growth center was directly formed in situ by a single type of tissue: the thickening distal pedicle periosteum, which is the derivative of initial antlerogenic periosteum. Therefore, the cells residing in the pedicle periosteum can be called antler stem cells. Antler stem cells formed each growth center by initially forming bone through intramembranous ossification, then osseocartilage through transitional ossification, and finally cartilage through endochondral ossification. There was an overlap between the establishment of antler growth centers and the completion of wound healing over the pedicle stump. Overall, our results demonstrate that antler regeneration is achieved through general wound healing- and stem cell-based process, rather than through initial blastema formation. Pedicle periosteal cells directly give rise to antlers. Histogenesis of antler regeneration may recapitulate the process of initial antler generation. 相似文献
9.
Peter Proff Tomas Gedrange Reiner Franke Harald Schubert Jochen Fanghnel Brbel Miehe Winfried Harzer 《Annals of anatomy》2007,189(3):269-275
The condylar cartilage of the mandible is considered a secondary growth center and represents a joint cartilage different from other cartilage structures regarding its histological structure, its histochemical and immunohistochemical properties and its growth pattern. This study aimed to histologically and histomorphometrically investigate the condylar cartilage after anterior mandibular displacement similar to functional orthopedic treatment. A total of 12 pigs (sus scrofa domesticus) aged 10 weeks were divided into an experimental group and a control group comprising 6 animals each. The experimental animals were provided bilaterally with synthetic occlusal build-ups in the posterior area which induced anterior displacement of the mandible in terminal occlusion. After 4 weeks, the temporomandibular structures were removed en bloc and the condylar cartilage was analyzed histologically and histomorphometrically. As a result, the experimental animals displayed a significantly increased total cartilage thickness of the posterocranial mandibular condyle which was primarily caused by an increase in thickness of the hypertrophic and chondogenic layers. Similarly, the proliferative layer showed a significant increase, whereas significant differences in thickness were absent in the articular layer. Increased cell proliferation was not observed in the experimental animals as compared to the controls. The changes found in the condylar cartilage area suggest that the zonal structure of the condylar cartilage may be modified by an altered spatial relationship between the mandibular condyle and the glenoid fossa. 相似文献
10.
The pterygopalatomaxillary suture is considered as having an important role in the posteroanterior growing of the maxilla.
To determine whether this suture is a growing suture in the fetus, we performed a histological study of this suture in a fetus
aged of 16 weeks of amenorrhea. Serial sections (5 μm) of the pterygopalatomaxillary suture area have been performed. Fibrous
sutures are separating four pieces of ossification (maxilla, palatine bone, lateral and medial plates of the pterygoid process).
A fibroblastic growing site has been observed on the dorsal aspect of the pterygopalatomaxillary suture, in contact to the
anterior border of the lateral plate of the pterygoid process. The posteroanterior growing of maxilla is dependent on a growing
suture located on the anterior border of the pterygoid process. The pterygoid process (via its lateral plate) makes the junction
between the maxilla and both the cranial base and the condylar mandibular site of growth. 相似文献
11.
A cylinder of gelatin containing silver spongy granules was placed in and lay within the masseter muscle, the periosteum, and the mandible, and terminated in the medial pterygoid muscle of young (3 month-old) growing miniature pigs. On the basis of an animal sacrificed one week after placement of the cylinder, it was found that the suspending gelatin was removed by cellular activity. Nine months later the remaining animals were sacrificed. Periodic X-rays were taken during the course of the experiment. After sacrifice, the mandible and associated tissues were histologically examined. The results of this study suggest that the silver granules in the muscles maintained their location during growth; the silver granules in the mandible moved forward with mandibular growth. "Slippage" appeared to occur external to the fibrous layer of the periosteum; the site of movement was revealed by the trail of the silver granules. The described method should prove of value in studying the growth interrelationships between bone, periosteum, and muscle. 相似文献
12.
A cylinder of gelatin containing silver spongy granules was placed in and lay within the masseter muscle, the periosteum, and the mandible, and terminated in the medial pterygoid muscle of young (3 month-old) growing miniature pigs. On the basis of an animal sacrificed one week after placement of the cylinder, it was found that the suspending gelatin was removed by cellular activity. Nine months later the remaining animals were sacrificed. Periodic X-rays were taken during the course of the experiment. After sacrifice, the mandible and associated tissues were histologically examined. The results of this study suggest that the silver granules in the muscles maintained their location during growth; the silver granules in the mandible moved forward with mandibular growth. “Slippage” appeared to occur external to the fibrous layer of the periosteum; the site of movement was revealed by the trail of the silver granules. The described method should prove of value in studying the growth interrelationships between bone, periosteum, and muscle. 相似文献
13.
Ichiro Takahashi Itaru Mizoguchi Masanori Nakamura Manabu Kagayama Hideo Mitani 《Anatomical record (Hoboken, N.J. : 2007)》1995,241(3):328-336
Background: The effects of biomechanical stress on the growth and development of the mandibular condyle have been studied by many investigators. However, the role of the lateral pterygoid muscle in this development is not clear. Methods: Hyperfunction of the lateral pterygoid muscles of male 3-weekold Sprague-Dawley rats was induced by electrical stimulation, and the responses of the mandibular condyles were compared to control tissues by a double-fluorescent staining technique using polyclonal antibodies against type I and type II collagen. Electrical stimulation consisted of repeated application (5 seconds on/5 seconds off) of a Hz current for up to 7 days. Results: In the first 2 days, cartilaginous tissues rich in type II collagen disappeared in the anterior and posterior areas, which were loaded by tensional force due to direct and indirect attachment of the lateral pterygoid muscles. Tissues in these areas were replaced by intramembranous bone that was reactive for type I collagen at 7 days. By the end of the experiment, the trabecula of the condyle was remodled more perpendicularly, thus resisting the compressive force due to hyperfunction of the lateral pterygoid muscles. Conclusions: These results suggest that the activity of the lateral pterygoid muscle might play a significant role in the differentiation of progenitor cells and in the maturation and calcification of chondrocytes in mandibular condyles. © 1995 Wiley-Liss, Inc. 相似文献
14.
Msx1 is a regulator of bone formation during development and postnatal growth: in vivo investigations in a transgenic mouse model 总被引:1,自引:0,他引:1
Orestes-Cardoso S Nefussi JR Lezot F Oboeuf M Pereira M Mesbah M Robert B Berdal A 《Connective tissue research》2002,43(2-3):153-160
The present study is devoted to Msx1 distribution and function from birth to 15 months, events and periods still unexplored in vivo using Msx1 knock in transgenic mice. The study is focused on the mandible, as an exemplary model system for Msx1-dependent neural crest-derived skeletal unit. The transgenic line enabled study of morphological abnormalities in Msx1 null mutation mice and Msx1 protein expression in Msx1+/- heterozygous mice. In Msx1 null mutation, the most striking feature was an inhibition of the mandibular basal convexity, the absence of teeth and alveolar bone processes, and absence of endochondral ossification in the mandibular condyle. At birth, in Msx1+/- heterozygous animals, we identified for the first time a double Msx1 aboral-oral and disto-proximal gradient field developmental pattern located in the low border of the mandibular bone in relation with this bone segment modeling. Msx1 expression involved both osteoblast and osteoclast cells. A distinct pattern characterized bone surfaces: Periosteum osteoblast differentiation was related to Msx1 down-regulation, while in the endosteum both differentiated osteoblasts and osteoclasts expressed the homeoprotein. In postnatal stages, Msx1 expression was maintained in the alveolar bone processes and dento-alveolar cells in relation with tooth function. Our data suggest that Msx1 play a role in a site-specific manner not only in early patterning but also in skeletal growth and modeling by acting on heterogenous bone cell populations. 相似文献
15.
De la Cuadra Blanco C Peces Peña MD Rodríguez-Vázquez JF Mérida-Velasco JA Mérida-Velasco JR 《Cells, tissues, organs》2012,195(5):392-399
The present study seeks to determine the main events that occur in the development of the tensor veli palatini (TVP). A light microscope was used on serial sections of 60 human specimens from weeks 6 to 16 of development. The TVP becomes visible in an embryo of 14.5 mm greatest length (GL; week 6) from a common blastema with the medial pterygoid muscle. In embryos of Carnegie stage 20 (week 7), the TVP is differentiated and relates to the anlage of the pterygoid hamulus. At week 8 of development, when the palatal shelves become horizontal, the presence of the anlage of the palatine aponeurosisis distinguished and is reached by the TPV. In an embryo of 30 mm GL, the chondrification nucleus of the pterygoid hamulus and the synovial bursa of the TVP are identifiable. At week 9, the TVP is continuous with the palatine aponeurosis. At week 13, a connective tissue lamina appears between the TVP and the intramembranous ossification center for the anterior process of the malleus, which we know as the goniale and interpret as an attachment of the muscle to the primary vertebrate jaw or incudomalleal joint. The TVP from its origin, innervation and relation to the goniale appears to be a muscle of mastication that, at the end of the embryonic period, reaches the palatine aponeurosis anlage and the mesenchyme of the auditory tube and specializes in the movements of the soft palate and the auditory tube. 相似文献
16.
目的:探讨全新世女性群体颏孔位置、颏孔开口方向、下颌孔位置等在不同时代的表现特点,并探讨可能
存在的时代间变异。方法:对中国全新世201 例女性下颌骨的颏孔、下颌孔的体质特征进行分类和记录,然后用
SPSS 19.0 软件进行出现率统计及时代间差异显著性检验。结果:所比较的性状在不同时代间的表现特点具有一
定相似性:颏孔位置主要在下颌第2 前臼齿(P4)下面,颏孔开口方向主要为“后上”,下颌孔位置( 水平方向)
主要为“下颌支中点之后”,下颌孔位置( 垂直方向)主要为“齿槽面之上”。同时,不同时代间也存在一些差异,
近代人群颏孔位置相对靠后、下颌孔位置相对较高。结论:从青铜铁器时代到近代,女性的颏孔位置有相对后移
趋势;这些变化可能与该时段内下颌骨尺寸变小有一定的相关性。下颌孔位置时代间差异较小。 相似文献
17.
S. Orestes-Cardoso J.-R. Nefussi F. Lezot M. Oboeuf M. Pereira M. Mesbah 《Connective tissue research》2013,54(2-3):153-160
The present study is devoted to Msx1 distribution and function from birth to 15 months, events and periods still unexplored in vivo using Msx1 knock in transgenic mice. The study is focused on the mandible, as an exemplary model system for Msx1-dependent neural crest-derived skeletal unit. The transgenic line enabled study of morphological abnormalities in Msx1 null mutation mice and Msx1 protein expression in Msx1+/ m heterozygous mice. In Msx1 null mutation, the most striking feature was an inhibition of the mandibular basal convexity, the absence of teeth and alveolar bone processes, and absence of endochondral ossification in the mandibular condyle. At birth, in Msx1+/ m heterozygous animals, we identified for the first time a double Msx1 aboral-oral and disto-proximal gradient field developmental pattern located in the low border of the mandibular bone in relation with this bone segment modeling. Msx1 expression involved both osteoblast and osteoclast cells. A distinct pattern characterized bone surfaces: Periosteum osteoblast differentiation was related to Msx1 downregulation, while in the endosteum both differentiated osteoblasts and osteoclasts expressed the homeoprotein. In postnatal stages, Msx1 expression was maintained in the alveolar bone processes and dento-alveolar cells in relation with tooth function. Our data suggest that Msx1 play a role in a site-specific manner not only in early patterning but also in skeletal growth and modeling by acting on heterogenous bone cell populations. 相似文献
18.
Iacopo Cioffi Leo J. van Ruijven Ambrosina Michelotti Geerling E.J. Langenbach 《Anatomical record (Hoboken, N.J. : 2007)》2010,293(8):1387-1392
The degree of mineralization of bone (DMB) in the human mandibular condyle is heterogeneous, and differences in DMB have been related to variations in bone turnover caused by local strains. The lateral pterygoid muscle inserts at the anterior surface of the condyle. The aim of this study is to analyze the DMB at the attachment of this muscle as compared with a control region. It was hypothesized that, DMB at the attachment sites of lateral pterygoid muscles was lower than at the control regions, because of the larger number of loadings and subsequently higher remodeling rates. Also, as the human lateral pterygoid muscle is heterogeneous in its internal architecture, variations in DMB within the attachment sites were expected. 10 human mandibular condyles were scanned in a micro CT system. Within each condyle, two regions, that is, the pterygoid fovea and a posterior (control) region where no muscle was inserted, were selected to analyze regional differences in DMB. The attachment site was further divided into eight subregions to analyze subregional differences. At the pterygoid fovea the DMB of cortical bone was significantly lower than at the control region (p = 0.003) and increased in medio‐lateral direction. The results of this study could suggest an influence of the lateral pterygoid muscle on bone turnover at this site. Anat Rec 293:1387–1392, 2010. © 2010 Wiley‐Liss, Inc. 相似文献
19.
Vertical and horizontal movements of the lower jaw (mandible) of ketamine-anesthetized guinea pigs were recorded in association with electromyographic (EMG) activity in the anterior digastric, lateral pterygoid, medial pterygoid, and deep masseter muscles during spontaneously occurring rhythmic jaw movements (SRJMs) and during rhythmical jaw movements induced by the intravenous administration of apomorphine (ARJMs). Both ARJMs and SRJMs were near periodic and occurred at frequencies in the 2- to 5-Hz range. However, the profiles of the mandibular movements and associated patterns of jaw muscle EMG activity differed dramatically for SRJMs versus ARJMs. SRJMs were characterized by prominent lateral excursions of the mandible that occurred in association with both the jaw opening and closing movements. The lateral excursions were directed to the left side on some SRJM cycles and to the right side on others. The direction of the lateral component alternated irregularly, but no more than three consecutive cycles with horizontal movements to the same side were observed at any time. Each SRJM cycle was generated by the occurrence of one of two coordinated sequences of EMG activity. One sequence produced right-sided cycles, the other produced left-sided cycles. Each sequence was initiated by an EMG burst in the digastric muscle ipsilateral to the direction of the horizontal excursion of the mandible, followed by EMG bursts in the contralateral digastric, lateral pterygoid, and medial pterygoid muscles. The EMG bursts in the digastrics and contralateral lateral pterygoid muscles were associated with jaw opening and the initial stage of lateral movement. EMG activity in the contralateral medial pterygoid muscle was associated with the onset of closing and a second stage of lateral movement. Masseter muscle activity was also observed during SRJMs, but only in a subset of the animals tested (3 of 12). When present, the masseter activity began well after the onset of jaw closing. No significant horizontal mandibular movements were observed during ARJMs. The mandibular trajectories during opening and closing always remained close to the midline. The opening phase of ARJM cycles was associated with bilaterally synchronized activity in the digastric and lateral pterygoid muscles. The closing phase was associated with bilaterally symmetric activity in the masseter muscles. The medial pterygoid muscles displayed little or no EMG activity during ARJMs. The durations of the EMG bursts recorded in the masseter muscle were correlated with cycle time during SRJMs, as were the burst durations of the digastric and lateral pterygoid muscles during ARJMs.(ABSTRACT TRUNCATED AT 400 WORDS) 相似文献
20.
Maria Luisa Tagliaro Raquel Mattos De Oliveira Dalva Maria Pereira Padilha Sidia Maria Callegari‐Jacques Emílio Ant?nio Jeckel‐Neto 《Anatomical record (Hoboken, N.J. : 2007)》2009,292(3):431-438
Degenerative changes in the temporomandibular joint (TMJ) associated with aging can affect mandibular shape and reduce growth potential when stimulated by functional appliance therapy. This study was designed to evaluate the morphological changes in the mandibles of male mice associated with aging and biomechanical stimulus. Every 3 days over the course of 1 month, the lower incisors were trimmed by 1 mm to induce mandibular advancement (MA) when the animal was feeding. The left mandibles of the 23 experimental and 27 control animals were subsequently dissected, and digital images were obtained to analyze nine linear/angular measurements. Because mandibular morphology depends on the maintenance of condylar cartilage, the surfaces of the condylar cartilage and the ascending ramus of the mandible were also analyzed by scanning electron microscopy (SEM). The linear measurements of the mandible showed changes according to age in the control group and a growth response in the mandibular condyle in 7‐ and 15‐month‐old mice after MA. Moreover, SEM analysis revealed depressions in the anterior region of the condylar cartilage and inclined vascular grooves in the ascending ramus in the 7‐ and 15‐month‐old experimental mice. Although the growth potential is reduced in mice after 6 months of age, the results showed that continuous growth of the mandible occurs after maturation, except in the condyle, and that biomechanical stimulus of the TMJ of male mice leads to condylar growth. These results suggest that mature and old individuals can favorably respond to maxillary functional orthopedic therapy. Anat Rec, 292:431–438, 2009. © 2009 Wiley‐Liss, Inc. 相似文献