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吡喹酮及阿苯达唑单用或联用抗囊尾蚴效果观察 总被引:1,自引:0,他引:1
目的 为筛选吡喹酮及阿苯达唑两种药物治疗脑囊虫病的最佳方案。方法 1)吡喹酮单剂 ,按 2 0mg/kg·d× 6d(每日每公斤体重 2 0mg ,分 3次服用 ,共服 6天 )或 10mg/kg·d× 12d给药 ,间隔 2~ 3个月后重复第一疗程。 2 )阿苯达唑单剂 ,按 15mg/kg·d× 15d给药 ,间隔 2~ 3个月后重复第一疗程。3)阿苯达唑与吡喹酮联合用药 ,第一疗程给予阿苯达唑 2 0mg/kg·d× 12d ,后续吡喹酮30mg/kg·d×12d ,间隔 2~ 3个月后重复第一疗程。 4)吡喹酮及阿苯达唑联合递增用药 ,第一疗程给予阿苯达唑2 0mg/kg·d×12d ,后续吡喹酮 30mg/kg·d× 12d ,间隔 2~ 3个月后 ,据第一疗程服药反应和囊尾蚴感染轻重给予吡喹酮 30mg/kg·d× 12d或 5 0mg/kg·d× 12d ,2~ 3个月后再给予吡喹酮 5 0mg/kg·d×12d。结果 1~ 4种疗法的总有效率分别为 6 8.1% ,5 5 .0 % ,96 .1%和 98.1% ,按 χ2 检验 ,1、2种疗法的总有效率差异无显著性 (P >0 .0 5 ) ,3、4种疗法的总有效率差异也无显著性 (P >0 .0 5 ) ,但 4种疗法间的总有效率差异有非常显著性 (P <0 .0 1) ,其中 3、4种疗法的总有效率明显高于 1、2种 (P <0 .0 0 5 )。结论 4种治疗方案均有抗囊尾蚴作用 ,但联合用药的总有效率明显优于单剂疗法 相似文献
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食蟹猴寄生虫驱治 总被引:1,自引:0,他引:1
对 13 0只野生食蟹猴的体内寄生虫检查 ,发现有瓦物松吸虫阳性猴 88只 ,消化道线虫阳猴 85只 ,分批进行不同药物、不同剂量的药物驱治实验。其结果 :三氯苯达唑 3 0 m g/kg.d× 2 d,驱除瓦特松吸虫转阴率为 82 .4% ( 14 /17) ;吡喹酮 10 0 m g/kg.d× 2 d,驱除瓦特吸虫转阴率为 5 7% ( 10”18)。二者转阴率经 X2检验 ( P>0 .0 5 )差异不显著。阿苯达唑片剂 2 0 0 m g× 3 d,驱除消化道线虫转阴率为 84.7% ( 72 /85 ) ,2个月内 3个疗程的转阴率可达 98.9% ( 84/85 ) 相似文献
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左旋吡喹酮250mg/kg和417mg/kg灌胃一次治疗人工感染血吸虫小鼠、减虫率分别为50.0%和71.9%.右旋吡喹酮用上述两种同样剂量灌胃一次治疗感染小鼠,减虫率分别为-5.9%和4.3%,几无抗虫作用.吡喹酮衍生物S-01、S-02和S-04分别用235.5mg/kg,qd×3d;233.0mg/kg,qd×3d和213.8mg/kg,qd×3d(均为0.64mmol/kg/d×3d)治疗感染小鼠,减虫率分别为10%、6%和12%,该三种衍生物抗虫作用均较吡喹酮差. 相似文献
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目的直接比较吡喹酮和阿苯达唑治疗大鼠异盘肺吸虫病的效果和毒性反应。方法吡喹酮和阿苯达唑均按100mg 相似文献
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目的比较阿苯达唑咀嚼片和吡喹酮两组药物治疗华支睾吸虫病的疗效和副作用,为我市开展华支睾吸虫病的群防群治工作选择高效、安全的药物。方法分别应用以上两组药物治疗华支睾吸虫阳性者,治毕1个月以改良加藤氏(Kato-katz)厚涂片法检查粪便样本,以虫卵阴转率为疗效评价指标,并了解药物副作用情况。结果阿苯达唑咀嚼片组在轻度感染组和中重度感染组的转阴率为92.56%,83.33%;吡喹酮组为98.59%,100%。两组药物疗效的分层比较:轻度感染组P=0.115,中度和重度感染组P=0.494,两组药物疗效差异没有统计学意义。阿苯达唑咀嚼片服药后随访254人,其中3人出现腹痛或恶心等现象,吡喹酮组治后随访73人,25人出现腹痛或恶心等副反应(!2=77.31,P<0.001),吡喹酮组病人出现副作用的几率远大于阿苯达唑咀嚼片组。结论阿苯达唑与吡喹酮的疗效没有差异,但副作用较少,在人群普查普治时应首先考虑用阿苯达唑。 相似文献
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关于吡喹酮治疗血吸虫病的研究,国内已有很多报道,但单剂疗法在山区治疗血吸虫病的效果观察尚不多见。本组于1984年12月在凉山彝族自治州西南山区西昌县大兴乡对当年查出的血吸虫病患者采用吡喹酮40mg/kg单剂顿服疗法与60mg/kg二次分服疗法进行对比观察。 相似文献
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用阿苯达唑每日10mg/kg共3天或每日20mg/kg共3天治疗贾第虫病共63例。甲硝咪唑每日20mg/kg共3天治疗30例。结果包囊阴转率分别为:阿苯达唑71.9~93.5%,甲硝咪唑96.7%。表明阿苯达唑为有效抗贾第虫药物,其疗效与所用剂量有关。 相似文献
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目的 探索高颅压型脑囊虫病临床治疗的有效方法。方法 选择住院的156例高颅压患为临床治疗观察对象。根据病人的具体情况选择联合应用阿苯达唑、吡喹酮,以不同的抗囊方法及剂量进行治疗,一般3~5个疗程,每个疗程间隔2~3个月。结果 对于绦虫现症病人15例,全部驱下绦虫,驱虫率100.00%;伴有皮下结节50例,疗后均消失,消失率为100.00%。脑神经症状疗后有明显改善,93例癫痫治疗后86例未再发作。疗后脑CT复查,其中56例颅内未见异常,原CT病灶已吸收;有95例可见散在钙化灶,5例除钙化灶外,仍可见有低密度灶,但较原片明显减少;10例行脑脊液分流术,侧脑室及三脑室已基本恢复正常。结论 联合应用阿苯达唑、吡喹酮剂量递增疗法是抗囊虫治疗的有效方法;密切观察病情,及时恰当地对症治疗是保障病人安全和抗囊虫治疗顺利实施的重要措施。 相似文献
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Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD. 相似文献
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Jiageng Zhu Jun Li Ruipeng Ji Jianghao Su Mingshun Shen Zhigang Cao 《南京医科大学学报(自然科学版)》2007,21(2):125-128
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment. 相似文献
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Tao Ye * Zhi-quan Liu Jian-jun Mu Xi-han Fu Jun Yang Bao-lin Gao and Xiao-hong Zhang Department of Cardiology First Hospital of Xi'an Jiaotong University Xi'an Hanzhong Cardiovascular Institute Hanzhong 《中国医学科学杂志(英文版)》2004,19(4):248-251
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure. 相似文献
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目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险. 相似文献
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Jingming Zhu Ningning Hui Xiuhong Jiang Huaxing Zhang Chengzhang Fu 《南京医科大学学报(自然科学版)》2007,21(6):386-389
Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P<0.01);the MAP decreased(P<0.01)and the HR increased drastically(P<0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients. 相似文献
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Objective:To investigate the gene expression of osteoprotegerin(OPG) and osteoclast differentiation factor(ODF) in the bone tissue of patients with hip fracture due to osteoporosis. Methods:OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers(over 50 years old) with hip fracture(Observer Group) and 30 cases of hip facture sufferers with no osteoporosis(Control group) were analyzed with the Semi-Quantitative RT-PCR method. Results:The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion:Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption. 相似文献
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The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas: report of 9 cases 总被引:1,自引:0,他引:1
Shaoqin Chen Shengquan Zou Qibao Dai Peisheng Huang Weihua Cai Hong Li 《南京医科大学学报(自然科学版)》2007,21(6):398-401
Objective:To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas(SPTP). Methods:Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin(HE) staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results:Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin(9/9 cases), AAT(9/9 cases), NSE(9/9 cases), ACT(7/9 cases), CK20(2/9 cases), CgA(1/9 cases), S-100(3/gcases), PR(4/gcases), Syn(3/9 cases) and CD56(5/9cases), negative in CEA and ER. Conclusion:SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype. 相似文献
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Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P. 相似文献
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Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine. 相似文献
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Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center. 相似文献