Emergency ambulatory treatment of dysfunctional metrorrhagia in adolescents

The authors compared the therapeutic efficacy of oestrogen-progestogen combinations with pure progestagen in the urgent treatment of adolescent metrorrhagia. Two groups of adolescents were studied whose haemorrhages were attributed exclusively to disfunction. Every medicine was evaluated as to: 1) effectiveness in completely spotting haemorrhage, 2) any persistence of bleeding, 3) side effects. The therapy was given during 2 consecutive menstrual cycles. Results following treatment with oestrogen-progestogen combinations were favourable, even though side effects were more noticeable.     

Medium term treatment and prophylaxis of dysfunctional metrorrhagia in adolescence

The authors compared the therapeutic effectiveness of these different pharmacological methods of preventing dysfunctional menometrorrhagia in adolescents, which were: 1) chorionic gonadotropin, 2) cyclofenil, 3) ovariostatics. Therapy was given during 2 menstrual cycles, and effects were evaluated both during the treatment and for the succeeding 2 cycles. Parameters followed were: a) clinical recovery, b) persistence of spotting, c) effectiveness in inducing ovulation. The results were equally good both in treatment with ovariostatics and ovulation inducers. The latter proved however, more effective during follow-up. Side-effects were very rare, so much so that, in no case was it necessary to suspend treatment.     

Acute intermittent porphyria and pregnancy (case report)

A case of acute intermittent porphyria [AIP] known before pregnancy is reported in a patient who delivered by elective caesarean section. The pathogenesis of the disease, its symptoms and diagnosis are described as well as specific aspects of its clinical manifestation and differential diagnosis during pregnancy The therapeutic approach both during and out of pregnancy is discussed.