乳牙生理性根吸收的研究

本研究采用光镜和扫描电镜观察２－７岁乳牙生理性吸收的形态学表现。结果表明，乳牙根吸收面存在大量的吸收窝，窝管周牙本质突出于管间牙本质，破牙骨质细胞是根吸收的主要细胞，成牙骨质细胞和成纤维细胞也参予根吸收的细胞过程中。本实验还观察到２岁的第一乳磨牙根尖尚未发育完成，根面即有吸收窝出现。     

人乳牙根生理性吸收过程中CNP的mRNA表达

目的：研究CNP在人乳牙根生理性吸收过程中的mRNA表达及作用。方法：运用原位杂交方法检测人乳牙根生理性吸收过程中CNP的mRNA表达。结果：生理性吸收期乳牙的破牙细胞、牙髓成纤维细胞及成牙本质细胞CNP表达阳性。结论：人乳牙牙根生理性吸收过程中CNP可能促进破牙细胞的分化和活性，可能对乳恒牙替换起到一定的促进作用。     

人乳牙根生理性吸收中RANKL的mRNA表达

目的：探求核因子κB受体活化剂配体-RANKL在人乳牙根生理性吸收过程中的表达和作用。方法：临床收集牙根吸收期人乳牙10个,运用原位杂交方法检测乳牙和牙周膜细胞中RANKL的mRNA表达情况。结果：吸收期乳牙中牙周韧带成纤维细胞、牙髓成纤维细胞、成牙本质细胞表达RANKL。乳牙吸收区陷窝内可见大量破牙细胞,RANKL表达不显著。结论：乳牙根生理性吸收过程由破牙细胞调节,RANKL可能促进破牙细胞的生成和活性。     

乳牙生理性根吸收机制的研究进展

乳牙生理性根吸收是导致乳牙脱落的一种特有的生理性现象。为研究其分子机制,国内外学者进行了大量试验,结果显示核因子-κB受体活化因子及其配体和骨保护蛋白及白细胞介素等因子在这一过程中起到了重要的作用。下面就乳牙生理性根吸收的特点和分类、破牙细胞对乳牙生理性根吸收的作用和展望等作一综述。     

碘仿糊剂根充后乳牙牙根吸收情况的观察

现阶段 ,我国儿童患龋率较高 ,据范群[1] 等报道 ,约有70 %～ 80 %儿童患龋 ;同时乳牙的牙髓、根尖周疾病也相应增加 ,据不完全统计 ,约有 30 %～ 4 0 %的患龋乳牙发展成为牙髓炎、根尖周炎。由于乳牙在儿童颌骨发育中具有不可替代的作用 ,因此如何保留牙髓炎或根尖周炎患牙并使其行使功能直至被恒牙替换 ,成为每位口腔医师面临的问题。我们采用可被人体吸收的碘仿糊剂作为乳牙根管充填剂观察牙根吸收情况 ,取得了满意的效果。材料和方法1 病例选择　选取 1998年 1年之中我院门诊诊断为牙髓炎或根尖周炎的患儿共 115人 ,年龄 3～ 6岁 ,男∶…     

RANKL在人乳牙根生理性吸收过程中的表达

目的:探讨核因子κB受体活化剂配体RANKL在人乳牙根生理性吸收过程中的表达及作用。方法:运用免疫组织化学的方法检测人乳牙根生理性吸收过程中RANKL蛋白的表达。结果:乳牙的破牙细胞、牙髓成纤维细胞及成牙本质细胞胞浆中RANKL免疫组化染色阳性,且表达高于恒牙组,差异有统计学意义(P<0.05),乳牙牙周韧带成纤维细胞RANKL染色结果与恒牙组相比较差异无统计学意义(P>0.05)。结论:RANKL在人乳牙牙根生理性吸收过程中有表达,其可能对乳恒牙替换起到一定的促进作用。     

生理性根吸收的乳牙牙髓酶组织化学研究

生理性根吸收的乳牙牙髓酶组织化学研究姜娣刘月仁何宏华闫丽华采用膜ＡＴＰａｓｅ组织化学染色和显微酶定量分析技术，对２４例乳前牙和６例健康恒前牙的牙髓进行了观察。１．材料与方法：（１）实验分组：对照１组为６例１３～１６岁因正畸拔除的错位健康恒前牙。对照２...     

C型利钠利尿肽在人乳牙根生理性吸收过程中的表达

目的：探讨C型利钠利尿肽（C-type natriuretic peptide,CNP）在人乳牙根生理性吸收过程中的表达及作用。方法：运用免疫组织化学方法检测人乳牙根生理性吸收过程中CNP蛋白的表达。结果：乳牙的破牙细胞、牙髓成纤维细胞及成牙本质细胞胞浆中CNP免疫组化染色阳性,且表达高于恒牙组,差异有统计学意义（P〈0.05）,乳牙牙周韧带成纤维细胞CNP染色亦阳性。结论：CNP在人乳牙牙根生理性吸收过程中有表达,可能对乳恒牙替换起到一定的促进作用。     

复方替硝唑糊剂治疗乳磨牙根尖周炎的疗效观察

目的：观察复方替硝唑糊剂在乳磨牙有窦道型慢性根尖周炎治疗中的临床疗效。方法：用复方替硝唑糊剂或氢氧化钙甘油为根管充填材料分别对205个患牙进行根管充填并于充填后1、2年观察其疗效。结果：复方替硝唑糊剂2年根管充填成功率95．29％，氢氧化钙甘油成功率71．72％。结论：复方替硝唑糊剂是治疗乳磨牙有窦道型慢性根尖周炎较为理想的药物。     

第一恒磨牙的牙根吸收

本文报告了1例未萌出的上颌第二前磨牙引起邻近的第一磨牙严重吸收的病例。患者,11岁,因Ⅱ类错(牙合)畸形伴双牙弓拥挤而进行矫正。全景X 线片上可见到第三磨牙、上颌左侧尖牙和右侧第二前磨牙未萌出。根周X 线片显示未萌出的前磨牙已明显地导致邻近磨牙的吸收。拔下的上颌右侧第一磨牙检查,发现其3个牙根     

Prognosis of Second Molars with External Root Resorption Caused by Adjacent Embedded Third Molars

IntroductionThis prospective study was designed to determine the prognosis of second molars with external root resorption (ERR-M2s) caused by embedded third molars (EM3s) following EM3 removal and explore related predictors.MethodsThis study consecutively enrolled 58 participants who had asymptomatic second molars with apical external root resorption caused by EM3s. EM3s were extracted, and follow-up examinations were conducted at 1 week, 4 weeks, and 6 months. The primary outcome was prognosis of ERR-M2s after third molar extraction without any further intervention, as assessed via clinical and radiographic examinations. Potential predictors (sex, age, number of roots, EM3s position, type and degree of external root resorption) of prognosis were analyzed via univariable and multivariable analyses.ResultsA total of 63 ERR-M2s from 58 patients (16 males and 42 females; 19–57 years of age) were evaluated. At the last follow-up, 56 teeth (89%) remained asymptomatic and normal response to heat and cold tests. According to univariable analyses, ERR-M2s were more likely to remain normal response to heat and cold tests in younger patients. In the multivariable analysis, older age (odds ratio, 1.118; 95% confidence interval, 1.026–1.219; P < .05) and the type of all roots affected (odds ratio, 0.073; 95% confidence interval, 0.007–0.754; P < .05) were significantly associated with poor prognosis.ConclusionsAsymptomatic ERR-M2s have a high probability of remaining normal pulp without further intervention after EM3 extraction, especially in younger patients. No intervention except follow-up and observation is necessary.     

Orthodontic-induced External Root Resorption of Endodontically Treated Teeth: A Meta-analysis

Introduction

The difference in the amount of orthodontic-induced external root resorption (OIERR) of endodontically treated teeth (ETT) compared with vital pulp teeth (VPT) treatment is controversial. This systematic review and meta-analysis assessed the available evidence regarding OIERR of ETT compared with VPT.

A flow cytometric analysis of the biodefensive response of deciduous tooth pulp to carious stimuli during physiological root resorption

The present study observed biodefensive responses of deciduous tooth pulp to advancing caries lesions and analysed the role of physiological root resorption on pulpal defense potential. For this purpose, immunocompetent cell content of deciduous tooth pulp was examined using flow cytometry. A total of 49 deciduous incisor and molar teeth at various stages of physiological root resorption (carious or non-carious) to be extracted for clinical reasons were used in this study. Teeth were classified according to carious lesion depth and root resorption stage. CD3+ lymphocytes were observed to be most prevalent in the pulp and to show remarkable increase along with increase in carious lesion depth. Numbers of CD8+ lymphocytes also increased significantly as carious lesions approached the pulp. However, increase in the number of CD3+ and CD8+ cells did not significantly alter CD4+/CD8+ ratios. The study also found that while B-lymphocytes increased significantly in association with root resorption, there were no significant differences in B/CD3+ lymphocyte ratios. Thus, there was no evidence of irreversible pulpal pathosis in any groups. It can be concluded that pulp maintains its healing and defense capacity against advancing carious lesion and progressive root resorption in deciduous teeth.     

Root resorption of replanted teeth: an SEM study

Abstract— Two replanted and subsequently expelled upper central incisors were observed under a scanning electron microscope to study the changes brought about by root resorption The severity of resorption and the distribution of the affected areas were different in the two specimens. In the first case, large, deep excavations were found along a continuous bone defect which exposed the opposite root canal wall. Bacteria-like elements were found on the bottom of the eroded areas both on the outer and on the inner root surfaces. In the second case, resorption denuded the apical portion of the metal post. Erosive lacunae were visible in some areas while tubiform excavations were present close to the apical margin exposing the collagen network. The roots in the first case likely underwent inflammatory resorption while replacement resorption was thought to have occurred in the second case.     

Incidence of Root Resorption after the Replantation of Avulsed Teeth: A Meta-analysis

Introduction

An avulsion injury is a serious trauma to pulp and periodontal tissues. After avulsion and replantation, teeth are at risk of infection and root resorption, which may affect treatment outcome and survival rate. Thus, the purpose of this systematic review was to evaluate the incidence of root resorption after the replantation of avulsed teeth.

年轻恒牙震荡和移位后牙髓与牙根变化的临床研究

年轻恒牙外伤后,牙髓坏死和牙根吸收在牙齿震荡和牙齿移位中的发生率及发生的时间;牙根的表浅性吸收,置换性吸收,炎症性吸与外伤类型的关系。方法从１９８４－１９９６年在北京医科大学附属口腔医院儿科就诊的２０１例前牙外伤发生牙震荡和牙移位患者的病历资料中选择７９例１５７颗无冠折根折的外伤牙,并且如果有牙松动者使用全牙Ｈｅ     

人乳牙牙根吸收过程中根面破骨细胞的观察

目的　观察人乳牙根吸收面的破骨细胞形态特点。方法　收集和固定人滞留乳牙,制备硬组织切片,经苏木精-伊红、抗酒石酸酸性磷酸酶染色,在光镜和扫描电镜下观察破骨细胞。结果　在人乳牙根吸收面有多个破骨细胞,呈重叠状态,细胞形态不规则,体积大,细胞周缘可见丝状突起,多核,被吸收的牙本质表面高低不平。结论　人滞留乳牙牙根吸收面存在大量的破骨细胞,是研究人破骨细胞的一个来源。     

Root Resorption Caused by Jaw Infiltration of Multiple Myeloma: Report of a Case and Literature Review

Introduction

Infiltration of the maxillofacial region by multiple myeloma is common and typically appears as punched out osteolytic lesions of the jaws. Although swelling, bone pain, and tooth mobility are characteristic clinical symptoms, root resorption is rare in conjunction with myeloma nests.

Methods

A case of a 67-year-old man with multiple myeloma is presented. Root resorption of the second mandibular premolar and the first and second molars on the right side, with consecutive tooth mobility, was the initial manifestation of the disease and was primarily detected on a periapical radiograph. The treating dentist referred the patient to the department for further examination, which revealed multiple myeloma. The patient received tandem high-dose chemotherapy and autologous stem cell transplantation as standard myeloma treatment. Intravenous bisphosphonates were administered to curb the osteolytic lesions.

Results

No signs of bisphosphonate-related osteonecrosis of the jaw were observed until the end of the follow-up period.

Conclusions

Only 5 reports of myeloma-associated root resorption have been reported in the literature. In all cases, mandibular premolars or molars were involved, and the patients exhibited extensive involvement of the jaw by myeloma. This report highlights the importance of correct interpretation of clinical signs and radiographs by dental specialists in the diagnostic algorithm of systemic diseases. Furthermore, this is an example for the inevitable part of bisphosphonates in the treatment of osteolytic processes.