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1.
N. Alvarez Zallo I. Aguinaga-Ontoso I. Alvarez-Alvarez B. Marin-Fernandez F. Guillén-Grima C. Azcona-San Julián 《Allergologia et immunopathologia》2018,46(1):9-14
Background
This study examined the relationship between different food groups and the adherence to a Mediterranean diet during pregnancy and the risk of wheezing and eczema in children aged 12–15 months.Methods
The study involves 1087 Spanish infants from the International Study of Wheezing in Infants (Estudio Internacional de Sibilancias en Lactantes, EISL). The study of the association of the different food consumption and Mediterranean diet with wheezing, recurrent wheezing and eczema was performed using different models of unconditional logistic regression to obtain adjusted prevalence odds ratios (OR) and 95% confidence intervals (95% CI).Results
No association was found between a good adherence to the Mediterranean diet during pregnancy and the development of wheezing (p = 0.372), recurrent wheezing (p = 0.118) and eczema (p = 0.315). The consumption once or twice a week of white fish (OR: 1.95[1.01–3.75]), cooked potatoes (OR: 1.75[1.22–2.51]) and industrial pastry (OR: 1.59[1.13–2.24]), and the consumption more than three times a week of industrial pastry (OR: 1.47 [1.01–2.13]) during pregnancy increases the risk of “wheezing” at 12 months. Instead, high fruit consumption during the pregnancy has a protective effect against “wheezing” in 12-month-old infants (OR: 0.44 [0.20–0.99]). No statistically significant differences were observed between food intake during pregnancy and “recurrent wheezing”. No statistically significant differences were observed between the consumption of any food during pregnancy and the presence of eczema at 12 months.Conclusions
The present study showed that the consumption of Mediterranean diet during pregnancy did not have a protective effect for wheezing, recurrent wheezing or eczema. 相似文献2.
Background
Recurrent wheezing during the first year of life is a major cause of respiratory morbidity worldwide, yet there are no studies on its prevalence in Portugal.Objective
Determine the prevalence and severity of recurrent wheezing, treatments employed and other related aspects, in infants during their first year of life in Setúbal, Portugal.Methods
This is a cross-sectional study of a random sample of infants aged 12–15 months living in Setúbal district. It uses a validated questionnaire answered by parents/caregivers at local healthcare facilities where infants attend for growth/development monitoring and/or vaccine administration.Results
Among the 202 infants surveyed, 44.6% (95% CI 37.7–51.4) had at least one episode of wheezing; and 18.3% (95% CI 12.9–23.6) had recurrent wheezing. There was significant morbidity associated to recurrent wheezing in terms of severe episodes (17.3%–95% CI 12–22.5), visits to the emergency department (26.2%–95% CI 20.1–32.2) and hospital admissions (5.4%–95% CI 2.2–8.5); 10.4% (95% CI 6.1–14.6) used inhaled corticosteroids and 7.9% (95% CI 4.1–11.6) used a leukotriene receptor antagonist.Conclusions
The prevalence of recurrent wheezing in infants during the first year of life is high and is associated with significant morbidity, presenting as a relevant public health problem. An important proportion of infants’ progress with a more severe condition, resulting in high use of health resources (visits to emergency department and hospitalisations). The prevalence of recurrent wheezing in this district of Portugal stays between those related in other European and Latin American Centres, suggesting that maybe some of the well-known risk factors are shared with affluent countries. 相似文献3.
Jose Manuel Mella Estanislao Jesús Gómez Mariana Omodeo Matias Manzotti Mariela Roel Lisandro Pereyra Carolina Fischer Nicolás Panigadi Raquel González Pablo Luna Silvia Cecilia Pedreira Daniel Gustavo Cimmino Luis Alberto Boerr 《Gastroenterologia y hepatologia》2018,41(5):293-301
Background
Most pancreatic cysts (PCs) found incidentally by CT and MRI scans might not be clinically important according to the Fukuoka guidelines, the American Gastroenterological Association (AGA) guidelines and European guidelines.Aims
To determine and compare the prevalence of incidental clinically important PCs (CIPCs).Methods
Abdominal contrast-enhanced CT or MRI scans performed during a one-year period were retrospectively reviewed to identify incidental PCs. CIPCs were defined as those cysts that would be capable of triggering further evaluation with endoscopic ultrasound, immediate surveillance (within 3–6 months) and/or surgery. Prevalence was calculated as the number of patients with CIPCs per 100 subjects imaged (%).Results
Sixty patients (mean age 70±14 years) out of 565 were found to have incidental PCs, representing a prevalence of 8.7% (95% CI 6.3–11.5) in CT scans and 27.5% (95% CI 16–41) in MRI scans. Seven patients (11.6%, 95% CI 5–22) had CIPCs based on size ≥ 30 mm (n=5), size ≥ 30 mm and pancreatic duct (PD) dilation (n=1) and PD dilation and presence of solid component (n=1). Based on the Fukuoka guidelines, the prevalence of CIPCs was 1.2% (95% CI 0.4–2.5) in CT scans (6/507) and 1.7% (95% CI 0.1–9) in MRI scans (1/58). Based on the AGA and European guidelines, the prevalence of CIPCs was 0.2% (95% CI 0.1–1) in CT scans (1/507) and 1.7% (95% CI 0.1–9) in MRI scans (1/58). Patients with PCs initially classified as “AGA- or European-positive” had a higher surgical probability and this decision was taken earlier in the follow-up.Conclusions
In our cohort, the prevalence of important incidental pancreatic cysts was not negligible at around 1% according to current guidelines. 相似文献4.
M. Bedolla-Barajas J. Morales-Romero T.I. Bedolla-Pulido T.R. Bedolla-Pulido C. Meza-López N.A. Pulido-Guillén 《Allergologia et immunopathologia》2018,46(5):431-437
Introduction
The association regarding the exposure to pets, especially cats and dogs, and the prevalence of allergic diseases is inconsistent.Objective
We analyzed the role played by early exposure to dogs or cats in the prevalence of allergic diseases amongst school-aged children.Method
Through a cross-sectional study, we examined 756 children, aged 6–7; these candidates were selected through cluster sampling. We inquired about the exposure that these children had had to dogs and cats, and whether these pets spent most of their time indoors or outdoors during the first year of the child's life. In order to identify the prevalence of allergic diseases and their symptoms, each child's parent completed the International Study of Asthma and Allergies in Childhood questionnaire.Results
Exposure to outdoor dogs was associated to nocturnal coughing, odds ratio (OR) 0.64, with a confidence interval of 95% (95% CI) 0.43–0.95 and with atopic dermatitis (OR: 0.39; 95% CI: 0.20–0.76). Interestingly, exposure to outdoor cats was associated to nocturnal coughing (OR: 0.51; 95% CI: 0.32–0.83) and current rhinitis symptoms (OR: 0.59; 95% CI 0.36–0.97). After carrying out the multivariate analyses, only exposure to dogs, both indoor and outdoor, was significantly associated to a decrease in the prevalence of atopic dermatitis OR 0.40 (95% CI: 0.20–0.79) and OR 0.38 (95% CI: 0.18–0.83), respectively.Conclusion
Our findings suggest that exposure to dogs, whether they be indoor or outdoor pets, is associated to a decreased prevalence in atopic dermatitis. 相似文献5.
J.A. Castro-Rodriguez I. Atton G. Villarroel C.A. Serrano 《Allergologia et immunopathologia》2018,46(5):460-466
Background
Low levels of serum CC16 were reported in asthmatic adults, but the studies on children were scarce and conflicting. The aim of this study was to compare serum CC16 levels in pre-school children with recurrent wheezing assessed using an asthma predictive index (API).Methods
We performed a case-control study based on API, with all enrolled pre-school children who had recurrent wheezing episodes (>3 episodes/last year confirmed by a physician) and had presented at one paediatric clinic in Santiago, Chile. The population was divided according to stringent API criteria into positive or negative.Results
In a one-year period, 60 pre-schoolers were enrolled. After excluding 12, 48 pre-schoolers remained (27 males, age range from 24 to 71 months) and completed the study; 34 were API positive and 14 were API negative. There were no significant differences in demographics between groups. The level of serum CC16 levels for pre-schoolers with a positive API and negative API were (median 9.2 [7.1–11.5] and 9.4 [5.5–10], p = 0.26, respectively). The area under the curve for the serum CC16 levels to predict a positive API was 0.6, 95% CI [0.43–0.77], p = 0.3. A correlation between serum CC16 levels and age was found (r = 0.36 [0.07–0.59], p = 0.01], but not between serum CC16 levels and peripheral eosinophils blood.Conclusion
There was no evidence that serum CC16 levels played a role in recurrent wheezing and a positive API in pre-school children. More studies are needed to confirm this finding. 相似文献6.
Juan Martínez Candela Javier Sangrós González Francisco Javier García Soidán José Manuel Millaruelo Trillo Javier Díez Espino Daniel Bordonaba Bosque Luis Ávila Lachica 《Nefrología : publicación oficial de la Sociedad Espa?ola Nefrologia》2018,38(4):401-413
Introduction
Type 2 diabetes mellitus and chronic kidney disease (CKD) are conditions which have a high prevalence in individuals ≥ 65 years of age and represent a major public health problem.Objectives
To determine the prevalence of CKD, its categories and its relationship with various demographic and clinical factors in elderly patients with type 2 diabetes mellitus in Spain.Methods
Observational, cross-sectional, multicenter, Spanish epidemiological study. Patients with known type 2 diabetes mellitus, age ≥ 65 years of age treated in Primary Care were included. We collected demographic, anthropometric and analytical variables from the previous 12 months, including the albumin-to-creatinine ratio and estimated glomerular filtration rate to evaluate renal function.Results
The prevalence of CKD was 37.2% (95% CI, 34.1–40.3%), renal failure was 29.7% (95% CI, 26.8–32.6%) and increased albuminuria was 20.6% (95% CI, 17.3–23.9%), moderately increased albuminuria was 17.8% (95% CI, 14.7–20.9%) and severely increased albuminuria was 2.8% (95% CI, 1.4–4.2%). In turn, the prevalence of CKD categories were: G1 1.3% (95% CI, 0.6–2%), G2 6.2% (95% CI, 4.6–7.8%), G3a 17.2% (95% CI, 14.8–19.6%), G3b 9.8% (95% CI, 7.9–11.7%), G4 2% (95% CI, 1.1–2.9%) and G5 0.7% (95% CI, 0.2–1.2%).In the multivariate analysis, after adjusting for the remaining variables, CKD was associated with elderly age (OR 5.13, 95% CI, 3.15–8.35), high comorbidity (OR 3.36. 95% CI, 2.2–5.12) and presence of antihypertensive treatment (OR 2.43. 95% CI, 1.48–4.02).Conclusions
CKD is frequent in the diabetic population ≥ 65 years of age and is associated with elderly age, high comorbidity and with treated hypertension. No relationship has been found with gender and time in years since onset of diabetes. 相似文献7.
Alireza Ansarimoghaddam Hosein Ali Adineh Iraj Zareban Sohrab Iranpour Ali HosseinZadeh Framanfarma Kh 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(2):195-201
Objective
Metabolic syndrome is an important metabolic disorder which impose noticeable burden on health system. We aimed to review and imply the prevalence of it in Middle-East countries.Methods
present study was a systematic review to present overview about metabolic disorder in Middle East. Electronic literature search of Medline database and Google scholar were done for English-language articles without time filtering, as well as for population-based or national studies of the prevalence of metabolic syndrome. The fallowing search terms were used simultaneously: prevalence of “metabolic syndrome” and “national study”, “prevalence of metabolic syndrome in Middle East”, “prevalence of metabolic syndrome” and “name of country”, “metabolic syndrome &name of country”. Additionally, relevant articles in bibliography were searched. Analysis of data was carried out in STATA version 11.0.Results
out of 456 studies in first-step searching (selecting by title) 59 studies were recruited and reviewed. Prevalence of metabolic syndrome fluctuated by country and time of study. This amount was 2.2–44% in Turkish, 16–41% in Saudi-Arabia, 14–63 in Pakistan, 26–33 in Qatar, 9–36 in Kuwait, 22–50 in Emirate, 6–42 in Iran, and up to 23 in Yemen. Pooled estimate was 25%. Attributable risk for cardiovascular disease, coronary heart disease, and stroke was 15.87, 11.7, and 16.23, respectively.Conclusion
The prevalence rate of metabolic syndrome is high and it is noticeable cause for stroke, coronary heart disease, and cardiovascular disease. 相似文献8.
Krishnaveni Viswanathan P.S. Rakesh Shibu Balakrishnan A. Shanavas Varun Dharman 《The Indian journal of tuberculosis》2018,65(1):48-51
Background
Chronic lung diseases are one of the leading causes of morbidity in developing countries. A community based survey was undertaken with an objective to estimate the prevalence of chronic respiratory diseases and to describe the profile of people with CRDs in the rural area Nilamel health block in Kollam district, Kerala, southern India.Methods
A household information sheet and a translated respiratory symptom questionnaire based on International Union against Tuberculosis and Lung Disease (IUATLD) bronchial symptoms questionnaire was administered to 12,556 people above 15 years, selected randomly from Nilamel health block.Results
Prevalence of self reported asthma was 2.82% (95% CI 2.52–3.12) and that of chronic bronchitis was 6.19% (95% CI 5.76–6.62) while other CRDs which did not fit to either constitute 1.89%. Prevalence of asthma among males was 2.44% (95% CI 2.05–2.85) while that of females was 3.14% (95% CI 2.71–3.57). Chronic bronchitis prevalence was 6.73% and 5.67% among males and females respectively.Conclusion
Although India has devised a programme to combat cancer, diabetes, cardio vascular disease and stroke, none have been devised for chronic respiratory illness till date. Considering high prevalence and its contributions to morbidity and mortality, a comprehensive programme to tackle chronic respiratory diseases is needed. 相似文献9.
10.
Marina Pontello Cristelli Joan Carles Trullàs Federico Cofán Naira Rico Christian Manzardo Juan Ambrosioni Josep Lluis Bedini Asunción Moreno Fritz Diekmann Jose Maria Miro 《The Brazilian journal of infectious diseases》2018,22(3):193-201
Background
In people living with HIV, much is known about chronic kidney disease, defined as a glomerular filtration rate under 60 mL/min. However, there is scarce data about prevalence and risk factors for milder impairment (60–89 mL/min).Objective
The present study aims to assess the influence of sex, antiretroviral therapy, and classical risk factors on the occurrence of mild decreased renal function in a large Spanish cohort of HIV-infected patients.Methods
Cross-sectional, single center study, including all adult HIV-1-infected patients under antiretroviral treatment with at least two serum creatinine measures during 2014, describing the occurrence of and the risk factors for mildly decreased renal function (eGFR by CKD-EPI creatinine equation of 60–89 mL/min).Results
Among the 4337 patients included, the prevalence rate of mildly reduced renal function was 25%. Independent risk factors for this outcome were age older than 50 years (OR 3.03, 95% CI 2.58–3.55), female sex (OR 1.23, 95% CI 1.02–1.48), baseline hypertension (OR 1.57, 95% CI 1.25–1.97) or dyslipidemia (OR 1.48, 95% CI 1.17–1.87), virologic suppression (OR 1.88, 95% CI 1.39–2.53), and exposure to tenofovir disoproxil-fumarate (OR 1.67, 95% CI 1.33–2.08) or ritonavir-boosted protease-inhibitors (OR 1.19, 95% CI 1.03–1.39).Conclusions
Females and patients over 50 seem to be more vulnerable to renal impairment. Potentially modifiable risk factors and exposure to tenofovir disoproxil-fumarate or ritonavir-boosted protease-inhibitors are present even in earlier stages of chronic kidney dysfunction. It remains to be determined whether early interventions including antiretroviral therapy changes (tenofovir alafenamide, cobicistat) or improving comorbidities management will improve the course of chronic kidney disease. 相似文献11.
Ramfis Nieto-Martínez Jeffrey I. Mechanick Imperia Brajkovich Eunice Ugel Alejandro Risques Hermes Florez Juan Pablo González-Rivas 《Primary Care Diabetes》2018,12(2):126-132
Objective
The prevalence of diabetes in multiple regions of Venezuela is unknown. To determine the prevalence of diabetes in five populations from three regions of Venezuela.Methods
During 2006–2010, 1334 subjects ≥20 years were selected by multistage stratified random sampling from all households from 3 regions of Venezuela. Anthropometric measurements and biochemical analysis were obtained. Statistical methods were calculated using SPSS 20 software.Findings
Mean (SE) age was 44.8 years (0.39) and 68.5% were females. The prevalence of diabetes was 8.3% (95% CI, 6.9%–10.0%), higher in men than women (11.2% and 7.0% respectively; p = 0.01). The prevalence adjusted by age and gender was 8.0% (95% CI, 6.9%–9.9%). This figure increased with age, with the lowest prevalence in the 20–29 year old group (1.8% [95% CI, 0.6%–4.8%]) and the highest in the oldest group (26.8% [95% CI, 16.2%–40.5%]). Subjects with overweight or obesity had no increased risk of diabetes compared with those with normal weight. However, in women, the presence of abdominal obesity was associated with an increase of the risk of diabetes by 77% (OR 1.77 [95% CI, 1.1%–2.9%]). The prevalence of prediabetes was 14.6% (95% CI, 12.8%–16.7%), and only 48.2% were aware of their diabetes condition.Conclusion
In this study, 8.3% of the subjects had diabetes and 14.6% prediabetes. Less than half of the subjects with diabetes were aware of their condition. These results point to a major public health problem, requiring the implementation of diabetes prevention programs. 相似文献12.
S.B. Erdem D. Can S. Girit F. Çatal V. Şen S. Pekcan H. Yüksel A. Bingöl I. Bostancı D. Erge R. Ersu 《Allergologia et immunopathologia》2018,46(2):119-126
Background
The presence of atopy is considered as a risk factor for severe respiratory symptoms in children. The objective of this study was to examine the effect of atopy on the course of disease in children hospitalised with viral pneumonia.Methods
Children between the ages of 1 and 6 years hospitalised due to viral pneumonia between the years of 2013 and 2016 were included to this multicentre study. Patients were classified into two groups as mild–moderate and severe according to the course of pneumonia. Presence of atopy was evaluated with skin prick tests. Groups were compared to evaluate the risk factors associated with severe viral pneumonia.Results
A total of 280 patients from nine centres were included in the study. Of these patients, 163 (58.2%) were male. Respiratory syncytial virus (29.7%), Influenza A (20.5%), rhinovirus (18.9%), adenovirus (10%), human metapneumovirus (8%), parainfluenza (5.2%), coronavirus (6%), and bocavirus (1.6%) were isolated from respiratory samples. Eighty-five (30.4%) children had severe pneumonia. Atopic sensitisation was found in 21.4% of the patients. Ever wheezing (RR: 1.6, 95% CI: 1.1–2.4), parental asthma (RR: 1.5, 95% CI: 1.1–2.2), other allergic diseases in the family (RR: 1.8, 95% CI: 1.2–2.9) and environmental tobacco smoke (RR: 1.6, 95% CI: 1.1–3.5) were more common in the severe pneumonia group.Conclusions
When patients with mild–moderate pneumonia were compared to patients with severe pneumonia, frequency of atopy was not different between the two groups. However, parental asthma, ever wheezing and environmental tobacco smoke exposure are risk factors for severe viral pneumonia in children. 相似文献13.
Carlos H. Orces Carlos Lorenzo 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(2):147-153
Aims
To examine the prevalence of prediabetes and diabetes among subjects aged 60 years and older in Ecuador.Materials and methods
The present study used data from the National Survey of Health, Wellbeing, and Aging to describe the prevalence of prediabetes and diabetes among older adults. Logistic regression models were assembled to examine the association between certain demographic and health characteristics of participants and prediabetes and diabetes prevalence rates.Results
Of 2298 participants, the prevalence of prediabetes and diabetes was 36.9% (95% CI: 34.2%–39.6%) and 16.7% (95% CI: 14.9%–18.7%) among older adults in Ecuador, respectively. Notably, higher diabetes prevalence rates were seen among women, black subjects, residents in the urban coastal region, and obese participants than those without. In general, the prevalence of diabetes widely varied across provinces of the country, with higher rates seen in provinces along the coastal region of the country. After adjustment for age, gender, and BMI, residents in the urban coast, subjects with greater number of comorbidities, and those classified as having hypertension, and hypertriglyceridemia had significantly higher odds of having diabetes than those without.Conclusions
Prediabetes and diabetes are prevalent among older adults in Ecuador. The increased prevalence of these metabolic disorders was particularly associated with obesity. Thus, the present findings may assist health care authorities to implement healthy lifestyle interventions among older Ecuadorians at risk for diabetes. 相似文献14.
Marcio Nucci Paula Rocha Braga Simone A. Nouér Elias Anaissie 《The Brazilian journal of infectious diseases》2018,22(6):455-461
Background
The impact of central venous catheter (CVC) removal on the outcome of patients with candidemia is controversial, with studies reporting discrepant results depending on the time of CVC removal (early or any time during the course of candidemia).Objective
Evaluate the effect of time to CVC removal, early (within 48 h from the diagnosis of candidemia) vs. removal at any time during the course of candidemia, on the 30-day mortality.Methods
Retrospective cohort study of 285 patients with candidemia analyzing CVC removal within 48 h (first analysis) or at any time (second analysis).Results
A CVC was in place in 212 patients and was removed in 148 (69.8%), either early (88 patients, 41.5%) or late (60 patients, 28.3%). Overall, the median time to CVC removal was one day (range 1–28) but was six days (range 3–28) for those removed later. In the first analysis, APACHE II score (odds ratio [OR] 1.111, 95% confidence interval [95% CI] 1.066–1.158), removal at any time (OR 0.079, 95% CI 0.021–0.298) and Candida parapsilosis infection (OR 0.291, 95% CI 0.133–0.638) were predictors of 30-day mortality. Early removal was not significant. In the second analysis APACHE II score (OR 1.122, 95% CI 1.071–1.175) and C. parapsilosis infection (OR 0.247, 95% CI 0.103–0.590) retained significance.Conclusions
The impact of CVC removal is dependent on whether the optimal analysis strategy is deployed and should be taken into consideration in future analyses. 相似文献15.
Diego Urrunaga-Pastor Mirella Guarnizo-Poma Enrique Moncada-Mapelli Luis G. Aguirre Herbert Lazaro-Alcantara Socorro Paico-Palacios Betzi Pantoja-Torres Vicente A. Benites-Zapata 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(2):155-161
Aims
To determine the association between free triiodothyronine (FT3), free thyroxine (FT4) and free-triiodothyronine-to-free-thyroxine ratio (FT3/FT4) levels and Metabolic Syndrome (MetS).Materials and methods
We carried out an analytical cross-sectional study in euthyroid adults of both sexes, who attended the outpatient service of a private clinic in Lima-Peru during the 2014–2016 period. Participants were divided into tertiles (low, intermediate and high) according to their FT3, FT4, and FT3/FT4 ratio values. MetS was defined when three or more metabolic criteria were met by the participants. ROC curves were constructed, and Youden’s Index were used to identify the optimal cut-points of each thyroid marker. We elaborated crude/adjusted Poisson regression models to evaluate the association between the thyroid markers and the presence of MetS. The reported association measure was the prevalence ratio (PR) with their respective 95% confidence intervals (95% CI).Results
We analyzed 245 participants, the average age was 38.5?±?10.3?years, 29.8% were males, and the prevalence of MetS was 31%. In the adjusted Poisson regression models, the prevalence of MetS was higher among the high FT3 tertile compared to the low tertile (aPR?=?2.01; 95% CI: 1.22–3.34). The prevalence of MetS was higher among the intermediate FT3/FT4 ratio tertile and the high FT3/FT4 ratio tertile compared to the low tertile, (aPR?=?1.78; 95% CI: 1.02–3.10) and (aPR?=?2.80; 95% CI: 1.67–4.72); respectively. The highest areas under the curve (AUC) were found for FT3 and FT3/FT4 ratio with areas of 0.654 (95% CI: 0.58–0.73) and 0.649 (95% CI: 0.57–0.72); respectively.Conclusion
Elevated levels of FT3 and FT3/FT4 ratio were associated with MetS in a euthyroid population. 相似文献16.
Marie Doualla-Bija Yonathan Lobe Batchama Jude Moutchia-Suh Vicky Joceline Ama Moor Félicité Kamdem Fernando Kemta Lekpa Henry Luma Namme 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):1007-1011
Background
Evidence from epidemiological studies suggests an important association between gout and the metabolic syndrome (MetS). However, to the best of our knowledge, prevalence of metabolic syndrome in gout has not been reported in sub-Saharan African (SSA) settings.Objectives
The aim of this study was to determine the prevalence and characteristics of MetS in gout in a SSA population.Method
After prior ethical clearance, we carried out a cross-sectional study involving gout patients in a referral hospital in Douala-Cameroon. Metabolic syndrome was defined using International Diabetes Foundation criteria. Associations between variables were assessed using logistic regression.p?<? 0.05 was considered significant.Results
On 174 gout patients (48.3% females) who consented to participate in the study, the median (IQR) age was 55.00 (14.25) years, and the median (IQR) duration of gout was 7.5 (10.0) years. Prevalence of metabolic syndrome was 54.6% (95% CI: 47.9%–62.8%). One hundred and forty-seven (84.5%) participants had central obesity, 62 (35.6%) raised triglycerides, 79 (45.4%) reduced HDL-C, 129 (74.1%) raised blood pressure, and 85 (48.9%) had raised fasting plasma glucose. On logistic regression analyses, gout patients with metabolic syndrome significantly had a higher body mass index (OR: 1.09, 95% CI: 1.02–1.17), and higher levels of serum uric acid (OR: 1.02, 95% CI: 1.01–1.04).Conclusions
About 1 out of every 2 gout patients in this population have metabolic syndrome. These gout patients with metabolic syndrome significantly have a higher body mass index, and higher levels of serum uric acid. Cohort studies are required to clearly establish the direction of the relationship between gout and metabolic syndrome. 相似文献17.
Rafael Garcia-Carretero Luis Vigil-Medina Inmaculada Mora-Jimenez Cristina Soguero-Ruiz Rebeca Goya-Esteban Javier Ramos-Lopez Oscar Barquero-Perez 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(5):625-629
Background
The aim of our study was to determine whether prediabetes increases cardiovascular (CV) risk compared to the non-prediabetic patients in our hypertensive population. Once this was achieved, the objective was to identify relevant CV prognostic features among prediabetic individuals.Methods
We included hypertensive 1652 patients. The primary outcome was a composite of incident CV events: cardiovascular death, stroke, heart failure and myocardial infarction. We performed a Cox proportional hazard regression to assess the CV risk of prediabetic patients compared to non-prediabetic and to produce a survival model in the prediabetic cohort.Results
The risk of developing a CV event was higher in the prediabetic cohort than in the non-prediabetic cohort, with a hazard ratio (HR)?=?1.61, 95% CI 1.01–2.54, p?=?0.04. Our Cox proportional hazard model selected age (HR?=?1.04, 95% CI 1.02–1.07, p?<?0.001) and cystatin C (HR?=?2.4, 95% CI 1.26–4.22, p?=?0.01) as the most relevant prognostic features in our prediabetic patients.Conclusions
Prediabetes was associated with an increased risk of CV events, when compared with the non-prediabetic patients. Age and cystatin C were found as significant risk factors for CV events in the prediabetic cohort. 相似文献18.
Ferdos Zaman Sedigheh Nouhjah Hajieh Shahbazian Nahid Shahbazian Seyed Mahmoud Latifi Alireza Jahanshahi 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(5):721-725
Aims
Early identification of at-risk groups is an important step in preventing gestational diabetes and its subsequent side effects. This study aimed to evaluate the risk factors of gestational diabetes based on the International Association of Diabetes and Pregnancy Study Groups criteria in Ahvaz.Material and Methods
In a cross-sectional case control study, 520 pregnant women involving life after gestational diabetes Ahvaz cohort study (LAGAs) were investigated for risk factors of gestational diabetes mellitus.Result
The prevalence of overweight and obesity were 40% and25.8% in the GMD group and in 35.8% and 16.2% in the control group respectively (p?=?0.002). According to NCEP-ATP III criteria, 16.9% of women with GDM and 6.9% of mothers in the control group had metabolic syndrome in first visit of pregnancy (p?<?0.001. Logistic regression showed that there is a significant relationship between maternal age[OR?=?1.05(95% CI, 1.01–1.10)] (p?=?0.01), previous GDM [OR?=?5.60(95% CI, 2.21–14.18)] (p?=?0.001), positive family history of diabetes[OR?=?1.86(95% CI, 1.19–2.94)] (p?=?0.006), pre-pregnancy BMI [OR?=?1.05(95% CI, 1.007–1.11)] (p?=?0.04) and metabolic syndrome in first visit of pregnancy[OR?=?2.34 (95% CI, 1.038–5.30)] (p?=?0.04) with GDM.Conclusion
Factors including maternal age, previous GDM, family history of diabetes, pre-pregnancy BMI reported in previous studies around the world. A significant association between metabolic syndrome in the first visit of pregnancy and GDM is novel finding of this study. Therefore screening of pre-pregnancy metabolic syndrome in women at risk of gestational diabetes is recommended. 相似文献19.
Background
The U.S. Food and Drug Administration recently issued a safety communication requiring new warnings of increased leg and foot amputation risk be added to canagliflozin drug labelling. However, the risk associated with other sodium-glucose co-transporter 2 inhibitors (SGLT2i) remains uncertain.Aim
This meta-analysis aimed to evaluate the potential risks of diabetic foot syndrome (DFS) and amputation associated with SGLT2i.Methods
Relevant databases were searched from inception to June 14, 2017 to identify randomized controlled trials (RCTs) that evaluated risks of DFS and amputation associated with SGLT2i use. A random effects model was performed to estimate odds ratios (ORs) and 95% confidence intervals (CIs) using STATA 14.Results
Fourteen RCTs involving 26,167 patients were eligible for this meta-analysis. SGLT2i were not significantly associated with increased risk of DFS compared with placebo (OR 1.05, 95% CI: 0.58–1.89). No significant association was observed in the subgroup and sensitivity analysis on DFS risk either. Although SGLT2i, as a class, were not significantly associated with amputation risk (OR 1.40, 95% CI: 0.81–2.41), subgroup analysis showed an increased incidence of amputation in participants using canagliflozin (OR 1.89, 95% CI: 1.37–2.60), compared with oral anti-diabetic drugs and placebo, but not in those using empagliflozin (OR 1.02, 95% CI: 0.71–1.48).Conclusion
Current evidence from RCTs suggests that canagliflozin may be positively associated with an increased risk of amputation. Due to limited data, large-scale studies are required to further clarify the association between amputation and individual SGLT2i drugs. 相似文献20.
Masoume Mansouri Roshanak Abasi Morteza Nasiri Farshad Sharifi Sedyghe Vesaly Omid Sadeghi Nayere Rahimi Nasrin Akbary Sharif 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(3):393-398