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1.
A.M. Aguiar-Santos S. Montenegro Z. Medeiros A. Rocha C.N.L. Morais A.R. Silva C. Bonfim T.R. Costa E.S.C. Sarinho 《Allergologia et immunopathologia》2018,46(2):167-174
Background
Although it is well known that allergic diseases involve a strong Th2 immune response, with production of high levels of specific IgE allergen, knowledge on the association between filarial infection and allergies, among paediatric patients is scarce.Objective
To evaluate the allergic response patterns in cases of filarial infection by comparing peripheral eosinophils, total IgE levels, immediate hypersensitivity and cytokine levels in children and adolescents in Brazil.Methods
This was an exploratory study with three groups: (I) with filarial infection and without allergic diseases; (II) without filarial infection and with allergic diseases; and (III) without filarial infection and without allergic diseases. The prick test and specific IgE tests for aeroallergens were performed using five antigens. Peripheral eosinophils and total IgE were also evaluated. IL-4 and IL-5 were determined using whole-blood culture stimulated by three antigens.Results
Eosinophilia and elevated levels of total IgE (≥400 IU/dl) were observed in all groups. The prick test was positive in 56.6% of the cases. Group I presented hypersensitive responses similar to the allergic disease groups. In the whole-blood culture stimulated by Dermatophagoides pteronyssinus, average IL-4 production did not differ significantly among the groups, but IL5 production resulting from stimulation was greater in the allergic disease groups (p < 0.05).Conclusions
The allergic response pattern in group with filarial infection was similar to that of the groups with and without allergic diseases, but the response to IL-5 in the culture stimulated by D. pteronyssinus was an exclusive characteristic of the allergic group. 相似文献2.
Jui-Cheng Chen Cheng-Chih Tsai Chang-Chi Hsieh Alice Lan Chun-Chih Huang Sew-Fen Leu 《Allergologia et immunopathologia》2018,46(4):354-360
Background
Probiotics could be beneficial to health and some of them have shown to modulate immune responses.Aim
The aim of this study is to investigate if the probiotic strains including Lactobacillus and Pediococcus strains are able to alleviate allergic reactions in an ovalbumin-induced airway allergy model.Methods
Lactobacillus multi-species preparation (LMP) was gavaged to BALB/c for total six weeks and BALB/c was challenged with ovalbumin in the last two weeks. A barometric whole-body plethysmography was used to assess enhanced pause (Penh) of airway hyperreactivity (AHR). Immunoglobulins (Ig) such as IgE, IgG1, IgG2a and cytokines such as IL-12, IFN-γ, IL-4, IL-5, TNF-α and IL-13 in bronchoalveolar lavage fluid were assayed using ELISA kits.Results
The results showed this LMP significantly reduced Th2 cytokines and enhanced Th1 cytokines production. OVA-specific IgE and IgG1 was lower in the probiotics-treated mice whereas IgG2a was increased. Most importantly, this murine model showed LMP supplementation significantly reduced AHR.Conclusions
Overall, this Lactobacillus multi-species preparation seemed to suppress OVA-sensitized airway hyperreactivity, thus serving as a possible candidate for therapeutic uses for allergic airway symptoms. 相似文献3.
Anil Kumar Jain Manmohan Puri Devika Tayal Ritu Singhal Rohit Sarin 《The Indian journal of tuberculosis》2018,65(4):285-289
Background
Allergic bronchopulmonary aspergillosis (ABPA) is characterized by an allergic inflammatory response to colonization by Aspergillus species, most commonly Aspergillus fumigatus.Aim
To study the prevalence of ABPA in asthmatic patients presenting to our institute.Materials and methods
All consecutive asthma patients attending our allergy clinic Out Patient Department (OPD) over a period of 20 months were tested with skin prick test (SPT) for Aspergillus antigens and those who were found positive were further evaluated for ABPA using Greenberger's criteria.Results
Seventy consecutive asthmatic patients were screened by SPT using Aspergillus antigens. Thirteen patients (18.57%) were found to be SPT positive, out of which nine patients (12.9%) were diagnosed as having ABPA using Greenberger's criteria. ABPA was common among 25–35 age group with no gender predilection. ABPA patients had longer duration of illness, predominantly mixed pattern in PFT, higher mean absolute eosinophil count (AEC) and serum total IgE compared to non-ABPA asthmatic patients. Specific IgE for A. fumigatus was positive in all ABPA patients and serum precipitins were positive in seven patients (77.58%). Chest X-ray abnormalities were seen in five patients (55.6%) and HRCT showed central bronchiectasis in eight patients (88.9%) with varying other radiological features. None were sputum fungal culture positive and five patients (55.6%) have been misdiagnosed as pulmonary tuberculosis in the past.Conclusion
The prevalence of ABPA is significantly higher in bronchial asthma patients presenting to tertiary care centers and hence awareness is required among physicians for early diagnosis and management of ABPA to achieve better asthma control and to avoid permanent lung damage. 相似文献4.
Objective
To assess the efficacy of alternate day (thrice a week) Directly Observed Treatment Short-course (DOTS) regimen spanning six to nine months in providing sustained cure for skeletal tuberculosis (TB) under programmatic conditions.Design
Retrospective cohort study.Setting
An urban district tuberculosis centre in India under the Revised National Tuberculosis Programme.Participants
A cohort of 218 patients treated with alternate day DOTS regimen for skeletal TB between 2007 and 2012.Methods
All patients with the diagnosis of skeletal TB registered between 2007 and 2012 who successfully completed treatment were followed up for evidence of disease recurrence or relapse using structured interviews conducted between August 2013 and October 2015 after ensuring a minimum follow up of two years.Results
Of the 200 patients eligible for follow up in this study, 117 (58.5%) had a minimum follow up of two years. The remaining 83 cases could not be traced. 105 (89.7%) of these 117 patients were symptom free for two years or more after the completion of treatment. There were four cases who had a relapse of the disease within two years of completion of treatment. Eight cases were administered further ATT soon after the completion of treatment under DOTS.Conclusions
This study confirms the efficacy of the alternate day DOTS regimen in successfully treating all forms of skeletal TB, including spinal TB, with a success rate of 89.7%. 相似文献5.
Inês Mota Ângela Gaspar Filipe Benito-Garcia Magna Correia Cristina Arêde Susana Piedade Graça Sampaio Graça Pires Cristina Santa-Marta Luís-Miguel Borrego Mário Morais-Almeida 《Allergologia et immunopathologia》2018,46(6):565-570
Introduction
Lipid transfer proteins (LTPs) are panallergens found in many plant foods. They are a common cause of food-induced anaphylaxis (FIA) in adults living in the Mediterranean area. LTPs have also been proposed as a main cause of food-dependent exercise-induced anaphylaxis (FDEIA).Objectives
Describe clinical characteristics and allergen sensitization profiles in patients with FIA related to LTP.Materials and Methods
Forty-three patients were included, aged 3–52 years with a clinical history of FIA and proven sensitization to LTP. Patients were tested with a multiple plant food and pollen panel and specific IgE to LTP allergens. LTP sensitization was assessed by in vivo (Pru p 3, LTP extract) and/or by in vitro tests (specific IgE, ImmunoCAP/ISAC®).Results
Median age of first anaphylactic episode was 24 years (range 2–51), 44% had asthma, 74% were atopic and 42% had pollinosis (olive, mugwort, plane tree, wall pellitory and cypress). Co-sensitization to profilins was found in 22%. Overall in our center, LTP-induced anaphylaxis represents 17% of all causes of FIA. Foods implicated in anaphylactic reactions were: fresh fruits 51%, tree nuts 42%, vegetables (including peanut) 40% and seeds 14%. Seven patients had FDEIA.Conclusions
LTPs are important allergens of FIA in Portugal. Clinical reactivity to several taxonomically unrelated plant foods may raise suspicion toward LTP sensitization. The association of LTP-induced anaphylaxis with pollinosis is relevant in our country. The unpredictable clinical expression depends on the effect of cofactors such as exercise. The management of avoidance plans can be challenging due to LTP being a widely cross-reacting allergen in plant foods. 相似文献6.
Background
Food protein-induced allergic proctocolitis is a frequent cause of rectal bleeding in infants. Characteristics of infants with multiple food allergies have not been defined.Objective
This study aimed to identify characteristics of infants with proctocolitis and compare infants with single and multiple food allergies.Methods
A total of 132 infants with proctocolitis were evaluated retrospectively. All of the infants were diagnosed by a paediatric allergist and/or a paediatric gastroenterologist according to guidelines. Clinical features of the infants, as well as results of a complete blood count, skin prick test, specific immunoglobulin E, and stool examinations or colonoscopy were recorded.Results
Cow's milk (97.7%) was the most common allergen, followed by egg (22%). Forty-five (34.1%) infants had allergies to more than one food. Infants with multiple food allergies had a higher eosinophil count (613 ± 631.2 vs. 375 ± 291.9) and a higher frequency of positive specific IgE and/or positive skin prick test results than that of patients with a single food allergy. Most of the patients whose symptoms persisted after two years of age had multiple food allergies.Conclusions
There is no difference in clinical presentations between infants with single and multiple food allergies. However, infants with multiple food allergies have a high blood total eosinophil count and are more likely to have a positive skin prick test and/or positive specific IgE results. 相似文献7.
Tarek Mohamed Ali Ahmad El Askary 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):1045-1050
Background
Inconsistent results have been described regarding the part of fetuin-A and testosterone in arterial stiffness in type 2 diabetes mellitus (T2DM).Aim
To look into the links of serum fetuin-A and testosterone levels with brachial-Ankle pulse wave velocity (baPWV), a marker of arteriosclerosis and common carotid intima media thickness (ccIMT), a marker of early atherosclerosis, in diabetic Saudi men patients.Subjects and methods
One hundred and fifty adult male patients with T2DM and 60 non-diabetic control subjects were enrolled from different Saudi Arabia Taif hospitals. Biochemical analysis, anthropometric measurements, blood pressure, baPWV and ccIMT were investigated.Results
Stepwise regression in diabetic patients revealed that the most important predictor of ba-PWV was serum fetuin-A followed by serum glucose and the most important predictor of ccIMT was serum fetuin-A followed by serum HDL then serum triglycerides.Conclusions
Only fetuin-A levels not testosterone are negatively associated with early markers of atherosclerosis. 相似文献8.
T.A. Gonzaga F.A. Alves M.F.A. Cheik C.P. de Barros E.R.M.A. Rezende G.R.S. Segundo 《Allergologia et immunopathologia》2018,46(3):241-246
Background
The food atopy patch (APT) test has been used in previous studies to help the diagnosis of non-IgE mediated food allergies (FA). The aim of this study was to evaluate the efficacy of different cow's milk APT preparations to predict oral tolerance in children with previous non-IgE-mediated cow's milk allergy (CMA) diagnosis.Methods
Thirty-two patients non-IgE-mediated CMA diagnosed by oral food challenge (OFC) were enrolled to perform APT with three different cow's milk preparations (fresh, 2% in saline solution, 2% in petrolatum) and comparing with a new OFC after at least three months of diet exclusion.Results
Only six (18.7%) subjects presented positive OFC to cow's milk. No differences in gender, onset symptoms age, OFC age, Z-score, and exclusion period were found between positive and negative OFC patients. Preparations using fresh milk and powdered milk in petrolatum presented sensitivity equal to zero and specificity 92.3% and 96.1%. The preparation using powdered milk in saline solution showed sensitivity and specificity of 33.3% and 96.1%. Two patients presented typical IgE symptoms after OFC.Conclusion
Cow's milk APT presented a low efficacy to predict tolerance in patients with previous non-IgE-mediated CMA and should not be used in clinical routine. The presence of typical IgE reactions after OFC hallmark the necessity of previous IgE-mediated investigation for this patient group. 相似文献9.
Irene Fuertes de Vega Carola Baliu-Piqué Jordi Bosch Mestres Andrea Vergara Gómez Xavier Vallés Mercè Alsina Gibert 《Enfermedades infecciosas y microbiología clínica》2018,36(3):165-168
Background
There are very few data available regarding risk factors associated with antibiotic resistant-Neisseria gonorrhoeae.Methods
A study was conducted on 110 samples from 101 patients with gonococcal infection, in order to describe their characteristics and compare them with the antimicrobial susceptibility profile of their samples.Results
An association was observed between resistant infections and heterosexual men, older age, concurrent sexually transmitted infection, and unsafe sexual behaviors.Conclusion
There is a need for improved data on the risk factors associated with antibiotic resistant gonococcal infection in order to identify risk groups, and to propose public health strategies to control this infection. 相似文献10.
11.
Ana Márcia Tomé Camargos Ana Carolina Oliveira Gonçalves Maurílio de Souza Cazarim Cristina Sanches Leonardo Régis Leira Pereira André Oliveira Baldoni 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(3):279-283
Introduction
DM spending in the world is high, and Brazilian studies of public spending caused by DM are scarce.Objective
To estimate the annual direct cost for the municipal health sphere, related to DM2 treatment, in patients with and without glycemic control.Method
A cross-sectional study carried out in a city in the interior of Minas Gerais state, with patients with DM2, being municipal PHS users. Data were collected from the computerized system of the municipality and patient records, and analyzed using the IBM SPSS v.19 statistical package. The response variable was categorized into controlled A1c (≤7%) and uncontrolled A1c (>7%).Results
Glycemic control in 56.6% of the patients was unsatisfactory; the mean cost of pharmacotherapy for DM2 was US$ 3.14 per year for patients in the control group and US$ 45.54 per year for uncontrolled patients.Conclusion
Patients with unsatisfactory glycemic control are more expensive for the municipal health system. 相似文献12.
Mahmoud Abdallah El-Husseiny Ashraf Abdel-Hameed Abdel-Moneim Mohammed Arafat Abdel-Maksoud Kamel Suliman Hammad 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(4):491-495
Objective
The study was performed to evaluate the technique of laproscopic minigastric bypass for metabolic syndrome patients.Study design
The patients were enrolled in a combined prospective study and had a retrospectively gathered outcome analysis.Patient and methods
The study includes thirty patients; 24 females and 6 males suffering from metabolic syndrome with a mean age of 33.15?±?10.17?years (range, 20–59), who fulfilled the criteria for bariatric surgery with BMI >35 with associated co-morbidities, all patients underwent laparoscopic mini-gastric bypass.Results
BMI and WC were significantly reduced post-operatively; also co-morbidities as DM, hypertension and dyslipidemia were resolved or controlled. The mean operative time was 90?±?12.6?min (range, 80–120). No mortality was reported within 30?days of surgery.Conclusion
Laparoscopic mini gastric bypass is an effective procedure for the treatment of obesity, HTN, type 2 DM and dyslipidemia, technically feasible, safe operation with a low rate of major postoperative complications. 相似文献13.
A.O. Grøn E.-M. Dalsgaard A.R. Ribe S. Seidu G. Mora A.M. Cebrián-Cuenca M. Charles 《Primary Care Diabetes》2018,12(4):289-304
Background and aim
Individuals with severe mental illness (SMI) who suffer from type 2 diabetes (T2DM) are likely to be sub-optimally treated for their physical condition. This study aimed to review the effect of interventions in this population.Methods
A systematic search in five databases was conducted in July 2017.Results
Seven studies on multi-faced interventions were included. These comprised nutrition and exercise counselling, behavioural modelling and increased disease awareness aiming to reduce HbA1c, fasting plasma glucose, body mass index and weight.Conclusion
Non-pharmacologic interventions in individuals with SMI and T2DM could possibly improve measures of diabetes care, although with limited clinical impact. 相似文献14.
Background
In recent years, the prevalence of asthma has risen in developed countries, and its extent related to a change in our indigenous microbiota. Helicobacter pylori disappearance across the population represents a fundamental change in our human microbiota and has preceded the rise in asthma prevalence.Objective
To assess the relationship between childhood asthma and Helicobacter pylori infection.Methods
Quantitative determination of Helicobacter pylori IgG among 90 asthmatic children and 90 – age and gender – matched non-atopic, non-asthmatic healthy children was performed using ELISA in serum of all participants.Results
Helicobacter pylori IgG seropositivity was found in 25.6% of asthmatics compared to 44.4% of controls. Asthmatics showed lower median Helicobacter pylori IgG titre compared to healthy controls. We also detected a significant inverse relationship between Helicobacter pylori IgG titre and asthma severity.Conclusion
Helicobacter pylori seropositivity protects against childhood asthma and inversely correlates to its clinical and functional severity. 相似文献15.
Inés Oliveira Souto Izaskun Alejo-Cancho Joaquim Gascón Brustenga Aida Peiró Mestres Jose Muñoz Gutiérrez Miguel J. Martínez Yoldi 《Enfermedades infecciosas y microbiología clínica》2018,36(1):21-23
Introduction
Zika virus is mainly transmitted through the bites of infected Aedes mosquitoes, although mother-to-child and sexual transmission have also been described. The presence of Zika virus in semen after infection seems to be not uncommon, but the duration of viral persistence has not been well-determined.Methods
Molecular, serological and cell culture methods were used for the diagnosis and follow up of a case of Zika virus infection imported from Venezuela. Serial samples of serum, urine and semen were analyzed to investigate the persistence of the Zika virus.Results
Zika virus was detected in semen samples up to 93 days after the onset of symptoms.Conclusions
Our results confirm the persistence of Zika virus in semen samples for long periods after infection. 相似文献16.
Y. Lv M. Cui Z. Lv J. Lu X. Zhang Z. Zhao Y. Wang L. Gao N.M. Tsuji H. Yan 《Clinics and research in hepatology and gastroenterology》2018,42(5):462-469
Background
Myeloid-derived suppressor cells (MDSCs) exert their suppressive effects on multiple immune response and contribute to the development of many diseases. However, limited data is available on the involvement of MDSCs in human chronic HBV infection.Objective
To investigate whether the progression of chronic HBV infection was associated with imbalance of MDSCs.Methods
The percentages of MDSCs, regulatory T (Treg), Th1 and Tc1 cells in the peripheral blood from chronic hepatitis B (CHB) patients and healthy controls (HC) were determined by flow cytometry. Plasma levels of IL-10, TGF-β and IFN-γ were measured using enzyme-linked immunosorbent assay. The potential association of the frequencies of MDSCs with clinical parameters was assessed.Results
The percentages of MDSCs and Treg cells were significantly higher in CHB patients than those in HC. The percentages of MDSCs were negatively correlated with Th1 cells. Increased plasma IL-10 level and decreased IFN-γ level were found in CHB patients compared with HC. Moreover, the frequencies of MDSCs and plasma IL-10 levels were positively correlated with serum HBV DNA loads, as well as liver function impairment.Conclusion
The expanded peripheral MDSCs may contribute to poor viral clearance and disease progression during chronic HBV infection. 相似文献17.
Vimal Upreti Vijay Maitri Pawan Dhull Ajay Handa M.S. Prakash Anil Behl 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(4):509-512
Context
Vitamin D supplementation in type 2 diabetes mellitus patients may lead to improved glycemic control by improving insulin secretion and decreasing insulin resistance.Aims
To investigate effect of oral vitamin D supplementation on glycemic control, in patients with type 2 diabetes mellitus and coexisting hypovitaminosis D.Settings and design
Randomized, Parallel Group, Placebo Controlled Trial carried out in a tertiary care hospital of Indian Armed Forces.Methods and material
Sixty patients with coexisting type 2 diabetes mellitus and hypovitaminosis D were randomized into cases and controls and were supplemented with oral Vitamin D and microcrystalline cellulose respectively for six months. Subjects' HbA1c and vitamin D levels were monitored at the beginning and end of the study, fasting plasma glucose (FPG) & post prandial plasma glucose (PPPG) during monthly OPD visits.Statistical analysis used
Intra-group comparison was made by paired t test & unpaired t test was used for inter-group (A v/s B) comparisons. Repeated measures ANOVA was undertaken to compare values over time.Results
The two groups were comparable for all parameters at baseline. Case group showed significant decrease in mean HbA1c levels (7.29% to 7.02%; P?=?0.01), mean FPG levels (131.4 to 102.6?mg/dl; P?=?0.04) and mean PPPG levels (196.2 to 135.0?mg/dl; P?<?0.001). Incidentally, significant improvement in systolic as well as diastolic blood pressure and total cholesterol was also noted in the cases, while for LDL cholesterol improvement tended towards significance (p?=?0.05).Conclusions
We found that oral vitamin D supplementation was associated with improved glycemic control and other metabolic parameters in patients with type 2 diabetes mellitus. Supplementation to achieve normal levels of vitamin D can be a promising adjuvant therapy for T2DM patients & coexisting hypovitaminosis D. 相似文献18.
Raquel Almodovar Juan C. Torre Alonso Enrique Batlle Concepción Castillo Eduardo Collantes-Estevez Eugenio de Miguel Senén González Jordi Gratacós Azucena Hernández Xavier Juanola Luis F. Linares Manuel J. Moreno Mireia Moreno Victoria Navarro-Compán Carlos Rodríguez Lozano Jesus Sanz Agustí Sellas Estíbaliz Loza Pedro Zarco 《Reumatología clinica》2018,14(3):155-159
Objective
To standardize clinical evaluation of patients with axial spondyloarthritis (SpA) and psoriatic arthritis (PsA) using a checklist.Methods
Qualitative study that included: 1) nominal group (18 experts); 2) literature reviews of measures used in the assessment of patients with axial SpA or PsA; and 3) focus groups, one with rheumatologists and another with patients, organized to become familiar with their opinion on medical assistance. Taking this into account, the experts selected the measures to be included in the checklist based on their relevance, feasibility, and the outcome type.Results
The checklist includes measures for the evaluation of personal history, physical examination, activity and function, laboratory tests, imaging studies and treatments. It also defines risk factors of radiographic progression, predictors of the response to biological therapies, and comprises measures of excellence.Conclusions
This checklist for patients with axial SpA and PsA could help standardize daily clinical practice and improve clinical management and patient prognosis. 相似文献19.
Ivan Sanz Muñoz Silvia Rojo Rello Raúl Ortiz de Lejarazu 《Enfermedades infecciosas y microbiología clínica》2018,36(9):572-575
Introduction
The aim of this study was to analyze the presence of antibodies against both Yamagata and Victoria influenza B lineages and to check the response after seasonal trivalent vaccination.Materials and methods
Haemagglutination inhibition assays were performed with pre-and post-vaccination serum samples from 174 individuals ≥65 years of age vaccinated with seasonal trivalent influenza vaccines during the 2006–2007, 2008–2009, 2009–2010 and 2010–2011 vaccine campaigns.Results
33.9% of individuals showed pre-vaccine protective antibodies (≥1/40) against B/Yamagata lineage and 41.4% against B/Victoria lineage. The annual trivalent vaccine induced significant homologous seroconversion in 14–35.6% of individuals in each vaccine campaign.Conclusions
The population ≥65 years has low-moderate seroprotection against B influenza lineages. Trivalent vaccination induced a slight increase of seroprotection. The trivalent vaccine should be administered to all individuals ≥65 years in all vaccine campaigns. 相似文献20.
Reem M. Al Haj Ahmad Hayder A. Al-Domi 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):1091-1094