脊索瘤针吸细胞学诊断探讨

 8例脊索瘤（1例骶尾部，2例颈部，5例颅底部）治疗前经针吸细胞学诊断。所有病例都有共同的细胞学表现：有两种细胞成份：一种是有丰富泡沫状或空泡状胞浆的圆形、卵圆形或多边形液滴状细胞，另一种是无胞浆空泡的小圆形、短梭形或星形细胞；多数细胞核圆形或卵圆形无明显异型，核染色质轻度增多、分布均匀，核浆比例不高；细胞单个散在或排列为松散的细胞群；涂片背景中有多少不等的粘液状物。本资料分析表明针吸细胞学结合临床及X线所见可以诊断脊索瘤。     

细胞学诊断脊索瘤二例

1　临床资料1.1　一般资料1997～ 2 0 0 0年内见 2例 ,患者均为男性 ,年龄分别为 5 5岁、6 5岁 ,均以骶部肿块为主要症状 ,同时伴有大便困难或局部疼痛而就诊。病程 6～ 14个月 ,肿瘤直径 4～ 6ｃｍ。Ｘ线检查均发现骶骨骨质有破坏 ;肛门指诊均触及肿物位于直肠后壁与骶骨前之间 ,其余无异常。1.2　细胞学检查2例均于术前做肿块针吸细胞学检查 ,涂片经ＨＥ染色及瑞氏染色镜检 ,2例瘤细胞形态特征及分布状况酷似 ;瘤细胞中等大小 ;呈圆形或卵圆形 ,胞浆丰富透亮 ,多数含有大小不等的空泡 ;核圆形 ,多位于细胞中央 ,染色质均细 ,未见核仁及核…     

颅内原发性精原细胞瘤患者临床病理特征分析及预后

目的探讨颅内原发性精原细胞瘤患者的临床病理特征及预后情况。方法选取2013年5月至2018年1月间湛江市南部战区海军第一医院收治的40例颅内原发性精原细胞瘤患者,分析患者颅内原发性精原细胞瘤的病理特征和预后。结果患者原发性精原细胞瘤发生于松果体区13例,发生于鞍上区8例。患者视力下降及视野缺损14例,垂体功能减退9例,颅高压症状11例,双下肢乏力3例,体重下降3例。镜下观察颅内原发性精原细胞瘤瘤细胞与健康者正常精小管内精原细胞较为类似,虽无明显差异,但可见瘤细胞偏大。镜下观察发现其境界较为清楚,瘤细胞胞浆透明,瘤细胞核较大,可见核分裂像,但核分裂不多见,核位于中央。镜下观察19例患者瘤细胞内有1个嗜酸性核仁,21例患者瘤细胞内有2个嗜酸性核仁,淋巴细胞及浆细胞等大量浸润,间质为纤细的纤维组织。21例患者采取肿瘤全切术,其余行部分切除术。术中取材作病理活检,1例术后6个月再次复发,病理诊断与之前一样,病变位置为三脑室。其余患者均无复发。结论颅内原发性精原细胞瘤镜下观察与健康者正常精小管内精原细胞较为类似,主要发生于蝶鞍区及松果体区。经精准化治疗,预后均较良好。     

1例双侧隐睾患者腹膜后精原细胞瘤并颈部淋巴结转移病案报道及文献回顾

目的：报道1例双侧隐睾患者腹膜后精原细胞瘤并颈部淋巴结转移病例,探讨其临床病理学特征。方法：对1例双侧隐睾患者腹膜后精原细胞瘤并颈部淋巴结转移的病例进行临床、组织病理学及免疫组化的观察。结果：显微镜下,瘤细胞被纤维组织分隔呈巢状,间质中可见淋巴细胞浸润。瘤细胞大小基本一致,圆形或多角形,细胞胞界清楚,胞质丰富透亮,核大规则,核分裂像可见;免疫组化示肿瘤细胞表达PLAP（＋＋）、CD117（＋）,CIM3和CIM5RO淋巴细胞表达阳性,不表达CK（-）、EMA（-）、Vimentin（-）、CHA（-）、S-100（-）、Syn（-）、HCG（-）、AFP（-）。结论：颈部淋巴结肿大患者,特别是成年男性,除了要考虑原发性病变．转移痛、淋巴瘤与神绎内分泌痛外．还席考虑转移件精原细胞瘤．     

肾外恶性横纹肌样瘤临床病理分析

目的探讨肾外恶性横纹肌样瘤的临床病理学特征及诊断和鉴别诊断。方法对2例肾外少见部位恶性横纹肌样瘤术后标本行HE、免疫组织化学染色（EnVision法）并结合文献复习。结果光镜下见瘤细胞椭圆形或多边形,胞浆丰富嗜酸性,似横纹肌母细胞;核卵圆形或圆形,呈泡状、核仁明显,部分细胞核偏位,似印戒细胞;少数瘤细胞胞浆内见嗜酸性小体样结构,免疫组化见瘤细胞CK、EMA及Vim均阳性,部分瘤细胞Syn阳性。结论该肿瘤是一种少见、高度恶性、病理形态独特的肿瘤。     

睾丸精原细胞瘤治疗的临床疗效分析

目的：回顾性分析睾丸精原细胞瘤的治疗效果。探索综合治疗的原则。方案：总结中山医科大学肿瘤医院１９７５年至１９９０年收治的１６３例睾丸精原细胞瘤，其中单纯手术４例，术后化疗２２例，术后放疗５２例，术后放疗加化疗８５例。以直接法计算生存结果。结果：总５年生存率７３．６２％；Ⅰ、Ⅱ、Ⅲ（Ⅳ）期分别为８４．３７％、６４．２９％和２７．２７％。单纯手术４例（Ｉ期）区域淋巴结转移５０％（２／４）；术后综合放疗     

294例睾丸精原细胞瘤的远期疗效分析

目的 总结睾丸精原细胞瘤的远期疗效并探讨其治疗策略.方法 回顾性分析294例睾丸精原细胞瘤患者的临床资料.按1997年国际抗癌联盟(UICC)的TNM分期标准,Ⅰ期260例,Ⅱ期16例,Ⅲ期18例.治疗方法为手术切除原发病灶联合化疗和(或)放疗.数据分析采用SPSS13.0统计软件,生存分析应用Kaplan-Meier法,总生存率的比较采用Log rank方法检验.结果 全组294例患者的5、10、20和30年总生存率分别为92.1%、91.8%、85.5%和71.4%.临床分期对总生存率有显著影响.Ⅰ期患者中,术后辅助治疗者与未行辅助治疗者的10年总生存率分别为97.5%和79.2%,经辅助治疗者的生存明显获益(P=0.001).Ⅱ期和Ⅲ期患者的预后均与治疗方法无关(均P＞0.05).结论 睾丸精原细胞瘤对放化疗敏感,即使出现复发转移的患者仍有长期生存可能.治疗时应充分考虑患者的生活质量,尽量避免大范围手术切除和长期化疗.     

Ⅱ期睾丸精原细胞瘤44例临床治疗

目的探讨手术及化疗在Ⅱ期睾丸精原细胞瘤治疗中的作用。方法Ⅱ期睾丸精原细胞瘤44例,均行原发肿瘤切除术,术后采用顺铂（DDP）、依托泊苷（VP16）及博莱霉素（BLM）的多疗程化疗,10例在化疗后行腹膜后淋巴结廓清术。结果8例化疗后廓清组织为坏死及纤维化组织,2例为恶性肿瘤。连续随访2—8年,5年生存率ⅡA期100％（11／11）、ⅡB期92％（22／24）、ⅡC期77．8％（7／9）。结论Ⅱ期睾丸精原细胞瘤尽早采用多疗程化疗,可控制病期进展,达到有效治疗的目的,提高患者生存率。     

睾丸精原细胞瘤免疫表型及临床病理分析

目的探讨睾丸精原细胞瘤的免疫表型、临床病理特征、诊断和鉴别诊断。方法通过光镜观察和多种免疫组化标记，分析8例睾丸精原细胞瘤病理组织学特征和免疫组化在诊断和鉴别诊断中的意义。结果8例睾丸精原细胞瘤，平均年龄41．4岁，巨检肿瘤均呈类长椭圆形，最大径平均10．4cm，包膜完整，切面灰白色鱼肉状；镜下均表现为典型精原细胞瘤的病理组织学特征；免疫组化PLAP、D2-40、CD117均为强阳性（8／8），其中2例HCG—α阳性，1例CD30阳性：而AFP、CK—LMW及Vim均为阴性（8／8）。结论睾丸精原细胞瘤好发于中年男性，其诊断主要依据典型的病理组织学特征和免疫组化检测，免疫标记物PLAP、D2-40、CD117、CD30、HCG和AFP在诊断和鉴别诊断中具有重要作用。     

诊断胰腺癌的细胞学标准

作者比较了经皮细针穿刺胰腺和经十二指肠内窥镜,两种收集胰腺细胞的方法,探讨了细胞学诊断胰腺癌的标准.标本来自39例男性,40例女性,共79例病人.细针抽吸用22号针;内窥镜从十二指肠的胰腺导管开口处抽吸.用上述方法的吸取物涂于载玻片上,立即用酒精固定,巴氏染色.涂片按以下细胞学特征评价:涂片背景,细胞构成,细胞大小差异,胞桨的特征,细胞群的表现和性质,单一细胞的数量,细胞拥挤的程度,细胞的坏死,核浆的比例,不规则的核外形,核的大小,核染色质的增多,染色质粗糙,染色质的分布,核仁的出现、数量及大小.在细针抽吸标本中极重要的是细胞大小差异、核     

Cytologic features of primary,recurrent, and metastatic dermatofibrosarcoma protuberans

BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) is a low-grade spindle cell neoplasm involving both dermis and subcutis. Its diagnosis may be difficult to render from cytologic smears, as it shares some features with other spindle cell lesions occurring in the skin and soft tissue. METHODS: Fourteen aspiration smears from 12 patients with primary, recurrent, or metastatic DFSP, examined by fine-needle aspiration biopsy (FNAB), were reviewed and compared with corresponding surgical specimens (13 aspirates) and clinical data (one aspirate). The cytologic features of DFSP were evaluated. Other spindle cell lesions in the differential diagnoses were discussed. RESULTS: Unequivocal spindle cell sarcoma diagnoses were rendered in nine aspirates, six of which were labeled correctly as DFSP in the original reports. In three aspirates, the preoperative diagnoses were inconclusive with regard to whether the tumors were benign or malignant. Two aspirates were diagnosed erroneously as benign spindle cell lesions. Cytologic features included tight clusters of bland spindle cells embedded in a collagenous/fibrillar and, often, metachromatic matrix along with dissociated, uniform, or slightly atypical spindle cells or bare nuclei. Tissue fragments showing a storiform pattern and entrapped fat tissue, reported in previous series, were less characteristic, presenting in nine and seven aspirates, respectively. CONCLUSIONS: Correct subtyping of DFSP in fine-needle aspiration smears can be difficult, due to its morphologic overlapping with other spindle cell lesions. A combination of cytology with ancillary studies and appropriate clinical information is crucial to establishing a correct diagnosis.     

Cytologic features of extragonadal germ cell tumors

BACKGROUND.

The objective of the current study was to evaluate and describe the cytologic features of extragonadal germ cell tumors (GCTs), both primary and metastasis from gonadal sites, in fine‐needle aspiration cytology.

METHODS.

Aspirates from 88 extragonadal GCTs were retrieved with their clinical features and cytologic smears. The smears were assessed for cellularity, cell patterns, and cytologic features, which were summarized. Histopathology was available in 47 cases, and cytohistologic correlation was done in all such cases.

RESULTS.

Of 88 cases, 57 with adequate cytologic material were analyzed. Each type of GCT, except for embryonal carcinoma, had characteristic morphologic features. Seminomas had dyscohesive tumor cells with well defined, vacuolated cytoplasm; prominent nucleolus; and background lymphocytes. ‘Tigroid’ background was noted in only a minority of cases. Yolk sac tumors revealed papillary fragments of tumor cells with metachromatic basement membrane‐like material in the fragments. Mixed germ cell tumors were difficult to diagnose except for cases in which more than 1 type of GCT was observed on cytologic smears. In 37% of cases with mixed GCT, only 1 component was observed on cytology.

CONCLUSIONS.

Fine‐needle aspiration cytology can reliably offer a diagnosis of GCT at extragonadal sites, even in rare locations and in patients in whom metastatic tumor may be the first clinical presentation. Immature teratoma and mixed GCTs pose a significant problem in cytology because of sampling error on needle aspiration. At extragonadal sites, the list of differential diagnoses is wider than that for gonadal GCTs. Cancer (Cancer Cytopathol) 2008. © 2008 American Cancer Society.     

针吸细胞学诊断肝细胞癌的标准探讨

目的 探讨肝细胞癌（ＨＣＣ）的针吸细胞学诊断标准。方法 分析６１例ＨＣＣ针吸细胞学涂片，并与１９例肝转移瘤和１６例肝非肿瘤病变对照，找出与ＨＣＣ有关的形态改变，用逐步Ｌｏｇｉｓｔｉ回归方法选择区别ＨＣＣ与肝转移瘤、ＨＣＣ与肝非肿瘤病变的最有用的形态特征。     

Diagnostic challenges of metastatic spindle cell melanoma on fine-needle aspiration specimens

BACKGROUND: Spindle cell melanoma is a morphologic variant of melanoma that can be difficult to diagnose on specimens obtained via fine-needle aspiration (FNA). Published cytology studies concerning this entity were based for the most part on small series. In the current study, a large series of metastatic spindle cell melanoma is described and the diagnostic pitfalls present in FNA samples addressed. METHODS: The authors retrospectively reviewed the cytologic features of 81 metastatic spindle cell melanoma specimens obtained from 67 patients. Corresponding primary tumors or metastatic tumors taken elsewhere from the same patient were also evaluated. RESULTS: The cytologic smears were mostly cellular and comprised of predominantly spindle tumor cells that frequently formed cohesive fascicles or whorls intermingled with scattered epithelioid tumor cells. The classic cytologic characteristics of conventional melanoma (predominantly dyshesive cellular distribution, cytoplasmic melanin pigments, intranuclear pseudoinclusions, macronucleoli, and binucleation or multinucleation) were noted infrequently or, if present, were more readily found in coexisting epithelioid cells. Remarkably, 9% of the cases failed to demonstrate any of the above classic characteristics. In addition, spindle cells demonstrated a wide range of cytologic atypia, from deceptively bland cells resembling reactive fibroblasts to those indistinguishable from pleomorphic high-grade sarcomatous neoplasms. When the morphologic features were compared with those of the primary tumor or metastatic melanoma taken elsewhere from the same patient, cell type discrepancy was found in 20% of the cases in that the previous counterparts demonstrated the epithelioid cell type. Spindle cells also tended to lose immunoexpression of melanoma markers. CONCLUSIONS: Spindle cell melanoma infrequently demonstrates the diagnostic cytologic features and immunoreactivity of conventional melanoma. Varying degrees of cytologic atypia and possible cell type differences from the primary counterpart or metastatic melanoma occurring elsewhere are additional sources of diagnostic challenges, especially in the metastatic setting. Familiarity with cytologic features, combined with clinical and immunoperoxidase findings, is required to avoid misinterpretation.     

薄层细胞涂片在术中诊断胰腺癌的应用价值

目的 探讨薄层细胞涂片(TLC)在胰腺癌手术中针吸穿刺细胞学诊断中的应用价值.方法 对临床和影像学诊断为胰腺癌并行剖腹探查术的221例患者,进行术中细胞学诊断,其中仅行传统涂片(CS)20例,仅行TLC 151例,同时行CS和TLC两种涂片50例,同时行FNA和穿刺冰冻20例.结果 271例次中,行CS共70例患者,不满意标本5例(7.1%);行TLC共201例患者,不满意标本9例(4.5%).两种涂片方法不满意标本所占比例,差异无统计学意义(P>0.05).行CS的70例患者,诊断阳性42例,阳性率为60.0%;行TLC的201例患者,诊断阳性164例,阳性率为81.6%,高于CS组(P<0.01).行CS的70例患者中,19例有术后病理诊断,45例有CT、MR、术中探查及细胞学4项结果,均诊断为癌,敏感性为68.9%.行TLC的201例患者中,80例有术后病理诊断,111例有CT、MR、术中探查及细胞学4项结果,均诊断为癌,敏感性为87.7%,高于CS组(P<0.01).术中同时行FNA和粗针穿刺的20例患者,FNA和活检冰冻的阳性率均为90.0%,敏感性均为90.0%,两者联合的敏感性为95.0%.9例患者送检细胞学2次,术后病理诊断均为恶性,其中7例第2次送检查到腺癌细胞.结论 TLC涂片阳性率和敏感性高,是术中诊断胰腺癌最好的方法之一,若能与冰冻活检联合应用于临床,可望进一步提高诊断的敏感性.     

Hepatoblastoma: cytomorphologic characteristics in serious cavity fluids

BACKGROUND: Hepatoblastoma (HBL) represents the most common primary hepatic tumor in children. Although the cytologic features of this tumor have been amply elucidated on fine-needle aspiration, exfoliative cytomorphologic characteristics have not been reported. The authors reviewed the cytopathologic features of six serous cavity fluids (SCF) from four patients with histologically proven HBL. METHODS: Five of the specimens evaluated were peritoneal fluids, and one specimen was pleural fluid from a patient with suspected pulmonary metastasis. Slides were prepared by cytocentrifugation and stained with Diff-Quik and Papanicolaou stains. The cytomorphologic features of each specimen were characterized, subclassified, and correlated histopathologically. RESULTS: All specimens showed hypercellular smears in a relatively clean background. Mixed embryonal and fetal subtypes of HBL disclosed three-dimensional clusters of neoplastic cells that formed straight or branched cords and acinus-like structures. The cells were moderately pleomorphic and had high nuclear-to-cytoplasmic (N/C) ratios. Occasional cells had eccentrically placed nuclei and vacuolated cytoplasm. Numerous mitotic figures were present. Rare intranuclear inclusions were noted. The anaplastic (small cell) subtype of HBL showed tight clusters of small, round, primitive cells with hyperchromatic nuclei, high N/C ratios, and prominent nuclear molding. In addition, there were numerous single cells with naked nuclei, often in an Indian-file configuration. Bile pigment, osteoid, and other mesenchymal components were absent in all specimens. CONCLUSIONS: The cytomorphologic features of HBL in SCF are quite characteristic. Although the differential diagnosis includes other childhood small, round, blue cell tumors and hepatocellular carcinoma, the above findings in the appropriate clinical-radiologic setting warrant a diagnosis of HBL.     

Cytodiagnosis of well differentiated hepatocellular carcinoma: can indeterminate diagnoses be reduced?

BACKGROUND: Distinction of well differentiated hepatocellular carcinoma (HCC) from benign hepatocellular lesions is a well recognized problem in fine-needle aspiration (FNA) cytology, sometimes leading to indeterminate reports. The aim of this study was to critically examine criteria that might allow definitive diagnosis in these cases. METHODS: FNA smears and cell blocks from 65 patients with primary hepatocellular lesions were reviewed. Seventy separate samples had been obtained. The initial reports in these samples were: HCC in 34, benign findings in 27, and indeterminate findings in 9. We defined architectural and cytological features seen in the malignant cases but not seen in the benign cases, including an assessment of reticulin in cell blocks. These criteria were then applied to the indeterminate cases. RESULTS: The most specific cytologic criteria of malignancy in well differentiated HCC were (i) numerous stripped atypical nuclei, (ii) macronucleoli, (iii) increased mitoses, and (iv) multinucleation. The most specific architectural criteria in smears were (i) widened trabeculae, (ii) well defined capillaries traversing tissue fragments, and (iii) solid islands of hepatocytes rimmed by endothelial cells. The most valuable architectural criteria in cell blocks were (i) trabeculae greater than two cells thick and (ii) reduced or absent reticulin framework. Using the above criteria a retrospective diagnosis of HCC was possible in eight of the nine indeterminate cases, all but one of which have subsequently been confirmed as malignant. CONCLUSIONS: Close attention to architectural features in both smears and cell blocks should allow most well differentiated HCCs to be diagnosed by FNA cytology. A reticulin stain should be part of the routine assessment of cell blocks. Cancer (Cancer Cytopathol) Copyright 1999 American Cancer Society.     

Cytopathologic features of olfactory neuroblastoma

BACKGROUND: Olfactory neuroblastoma (ONB) is an uncommon neoplasm arising from the olfactory mucosa. Because its cytopathology is largely limited to case reports, the goal was to evaluate a series of ONB cases, compare them with previously reported cases, and with a control group of pulmonary and cutaneous small cell neuroendocrine carcinoma (NEC). METHODS: Six fine-needle aspiration (FNA) biopsies of metastatic ONB and one case with imprint smears of primary ONB were recovered from files. Aspirates from seven FNA cases of metastatic pulmonary small cell NEC and four cases of metastatic Merkel cell carcinoma to the head and neck functioned as a control group and were compared with those of ONB. RESULTS: Seven cases from 4 patients included 3 males (ages 33-39 yrs) and 1 female (age 58 yrs). Aspirates were acquired from soft tissues of the neck (three cases), cervical lymph nodes (two cases), parietal scalp (one case), and imprint of a nasal mass (one case). A correct cytologic diagnosis of metastatic ONB (five cases) or malignant small round cell tumor (one case) was made in six cases. One aspirate was misdiagnosed as a reactive lymph node. The single primary tumor and five of six metastatic tumors were histologically confirmed. Cytologic features were similar in all cases. These included high cellularity (seven of seven cases), distribution as single forms and cell clusters (seven of seven cases), a two-cell population of intact and apoptotic nuclei (seven of seven cases), nuclear molding (seven of seven cases), paranuclear 'blue bodies' (five of seven cases), necrosis (five of seven cases), and absence of lymphoglandular bodies (seven of seven cases). Unlike prior reports, no case exhibited rosettes or fibrillar neuropil on smears. All examples from the control group displayed nearly identical cytomorphologic features to those of the study group. CONCLUSIONS: The cytopathology of metastatic ONB is nonspecific unless fibrillar neuropil is identified. Nonetheless, a cytopathologic diagnosis of metastatic ONB can be made with confidence in nearly all patients if a well documented history of ONB exists. Minus such a clinical context, aspirates of metastatic ONB may be mistaken for metastatic pulmonary small cell NEC, cutaneous neuroendocrine (Merkel cell) carcinoma, and even small cell lymphoma.     

乳腺球蛋白在术前乳腺癌和腋窝淋巴结细针穿刺吸取组织中的表达及临床意义

目的 探讨乳腺球蛋白（mammaglobin,MAM）在术前乳腺癌及腋窝淋巴结细针穿刺吸取组织中的表达及临床意义.方法 对91例原发性乳腺癌行术前细针穿刺,将吸取的组织制备涂片,采用免疫组织化学方法（EnVision法）检测MAM表达,观察MAM表达与临床病理指标的关系.同时另收集15例原发性肺癌腋窝淋巴结转移患者,分析乳腺癌腋窝淋巴结转移、乳腺癌增生性淋巴结炎和肺癌腋窝淋巴结转移三者间术前腋窝淋巴结MAM表达的区别.统计分析采用χ2检验.结果 在91例原发性乳腺癌患者中MAM的阳性表达率为74.72%（68/91）.MAM的阳性表达与雌激素受体（ER）、孕激素受体（PR）、组织学分级、细胞学分级有关（P〈0.05）,与患者的年龄、肿瘤大小、淋巴结是否转移及HER-2状态无关（P〉0.05）.腋窝淋巴结观察结果显示,MAM在乳腺癌腋窝淋巴结转移患者中呈阳性表达,在乳腺癌增生性腋窝淋巴结炎和肺癌腋窝淋巴结转移患者中均为阴性表达.结论 MAM可表达于原发性和转移性乳腺癌,细针穿刺细胞学检查结合MAM的测定对乳腺癌的诊断及鉴别具有一定辅助判断价值.MAM阳性表达与ER、PR状态、细胞学分级、组织学分级有关,有利于了解肿瘤的生物学指标及判断预后.     

Galectin-3在分化型甲状腺癌细胞中的表达及其临床意义

背景与目的:在诊治甲状腺结节时,首要问题是定性诊断。虽细针穿刺细胞学检查是术前定性诊断的重要方法,但其自身的局限性影响了诊断的正确率,本研究试图寻找可用于鉴别甲状腺良、恶性结节的分子生物学指标。方法:收集30例分化型甲状腺癌、10例甲状腺腺瘤、10例结节性甲状腺肿患者的细胞涂片标本及临床病理资料。利用免疫细胞化学技术检测galectin-3在甲状腺针吸涂片和印片细胞中的表达。以术后常规组织病理的诊断结果为金标准。结果:印片免疫细胞化学筛查方法的灵敏度96.66%,特异度100.00%,阳性预测值100.00%,阴性预测值95.23%,正确率98.00%。印片常规细胞学筛查方法的灵敏度86.66%,特异度100.00%,阳性预测值100.00%,阴性预测值83.33%,正确率92.00%。针吸细胞免疫细胞化学筛查方法的灵敏度86.66%,特异度100.00%,阳性预测值100.00%,阴性预测值83.33%,正确率92.00%。针吸常规细胞学筛查方法的灵敏度76.66%,特异度100.00%,阳性预测值100.00%,阴性预测值74.07%,正确率86.00%。galectin-3在分化型甲状腺癌的细胞中高表达,而在甲状腺腺瘤、结节性甲状腺肿的细胞中不表达,表达的差异具显著性(P<0.05)。结论:galectin-3在分化型甲状腺癌中高表达,在甲状腺腺瘤、结节性甲状腺肿中不表达。galectin-3的免疫细胞化学检测对分化型甲状腺癌和甲状腺腺瘤、结节性甲状腺肿的鉴别有参考价值。