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1.
Cristina Partenope Gabriella Pozzobon Giovanna Weber Fernando Carceller Assunta Albanese 《Pediatric blood & cancer》2023,70(3):e30168
Aims
This study analysed the clinical features of a cohort of children with intracranial germ cell tumours (IC-GCTs). We retrospectively reviewed timelag between symptoms onset, clinic-radiological findings, diagnosis and outcomes.Methods
Symptoms at diagnosis were divided into four groups: (1) raised intracranial pressure (RICP); (2) visual impairment; (3) endocrinopathies; (4) other. Total diagnostic interval (TDI), defined as the interval between symptom onset (including retrospective recall of symptoms) and definitive diagnosis of IC-GCT, was calculated and compared to survival rates.Results
Our cohort included 55 children with median follow-up of 78.9 months (0.5–249.9). The majority (63.6%) had germinomas and 10.9% were metastatic at diagnosis. IC-GCTs were suprasellar (41.8%), pineal (36.4%), bifocal (12.7%) or in atypical sites (9.1%). The most common presenting symptoms were related to RICP (43.6%); however, by the time of tumour diagnosis, 50.9% of patients had developed endocrine dysfunctions. All pineal GCTs manifested with RICP or visual impairment. All suprasellar GCTs presented with endocrinopathies. TDI ranged between 0.25 and 58.5 months (median 4 months). Pineal GCTs had the shortest TDI (median TDI 1 month versus 24 months in suprasellar GCTs, p < .001). TDI > 6 months was observed in 47.3% of patients and was significantly associated with endocrine presenting symptoms. No statistically significant difference was found in progression-free survival and overall survival between patients with TDI > 6 months and with TDI ≤ 6 months.Conclusion
Approximately half of the IC-GCT patients in this cohort had TDI > 6 months. These presented mostly with endocrine deficits. TDI > 6 months was not associated with increased relapse or mortality rates. 相似文献2.
Elisabeth J. M. Straathof Kirsten R. Heineman Elisa G. Hamer Mijna Hadders-Algra 《Acta paediatrica (Oslo, Norway : 1992)》2020,109(7):1423-1429
Aim
To determine the prevalence of prevailing head position to one side (PHP) in young infants and to evaluate its associations with reaching performance, neurological condition and perinatal and socio-economic factors.Methods
Observational study in 500 infants (273 boys) 2-6 months corrected age, representative of the Dutch population (median gestational age 39.7 weeks (27-42); birthweight 3438 g (1120-4950). Prevailing head position to one side and reaching performance were assessed with the Infant Motor Profile; neurological condition with the Standardized Infant NeuroDevelopmental Assessment. Socio-economic information and perinatal information were obtained by questionnaire and medical records. Associations were analysed with uni- and multivariable statistics.Results
Prevailing head position to one side was observed in 100 infants (20%), and its prevalence decreased from 49% at 2 months to 0% at 6 months. Only in infants aged 4-5 months PHP was significantly associated with worse reaching and an at-risk neurological score. Prevailing head position to one side was weakly associated with prenatal substance exposure, post-natal admission to a paediatric ward and paternal native Dutch background.Conclusion
Prevailing head position to one side at 2-3 months is a frequently occurring sign with limited clinical significance. Yet, PHP at 4-5 months is associated with a worse functional and neurological condition. Therefore, PHP at 4-5 months could serve as a red flag indicating possible challenges in later development.3.
Aims and study design
The Hammersmith Infant Neurological Examination proved effective in predicting locomotor function in very preterm infants after 9 months of age. We performed the examination in a cohort of 103 very preterm infants (gestational age below 32 weeks) as early as 3 months' post-term age, and longitudinally at 6, 9 and 12 months. Our aim was to establish the frequency distribution of the optimality scores at each age period, to explore the predictive value of the examination from 3 months onwards as to developmental outcome and locomotor function at 2 years, and to explore its longitudinal consistency.Results
The results showed that this standardized neurological examination can be performed in preterm infants as early as 3 months' post-term age to predict motor outcome at 2 years, and that its high predictive value is consistent across the first year of life due to an effective combination of different items for each age period.Conclusions
We confirm the high predictive value of this neurological examination in very preterm infants after 9 months and extend it to the assessments performed as early as 3 months post-term. This is of great relevance as in very preterm infants early prediction of motor function is essential for a prompt planning of therapeutic interventions. 相似文献4.
Caroline Vuong Ibtissame Moussa Maud M. van Muilekom Harriët Heijboer Eva Rettenbacher Lotte Haverman Jos Twisk Karin Fijnvandraat Corien L. Eckhardt 《Pediatric blood & cancer》2023,70(12):e30691
Background
Sickle cell disease (SCD) is characterized by vaso-occlusive crises (VOCs) that impair the health-related quality of life (HRQoL). The aim of this study is to evaluate the impact of hospitalization for VOCs on HRQoL in children with SCD over time.Methods
In this longitudinal cohort study, children aged 8–18 years diagnosed with SCD at the Amsterdam UMC were included between 2012 and 2021. HRQoL was annually measured as part of standard care using the Pediatric Quality of Life Inventory. The impact of hospitalization for VOC on HRQoL was evaluated using linear mixed models 3, 6, 9, and 12 months after hospitalization. The effect of frequency of hospitalization for VOC on HRQoL was evaluated over the last 12 months.Results
In total, 94 children with SCD were included with a median age of 11.8 years (interquartile range [IQR]: 9–14). Thirty-seven patients (39%) had been hospitalized for a VOC. Hospitalization for VOC led to a decrease of 3.2–4.8 points in total HRQoL compared to patients without hospitalization, most pronounced 3 months after hospitalization. Recurrent admission for VOC in the last 12 months was associated with a decrease of 2.3 points in total HRQoL (p = .04). The most affected subscale was physical functioning.Conclusion
The adverse effects of hospitalization for VOC in children with SCD persist up to 12 months after hospitalization. After hospitalization for VOC, extra attention and support for its negative impact on HRQoL are recommended. This study also underlines the importance of systematically measuring HRQoL, allowing clinicians to intervene accordingly. 相似文献5.
Objective
To predict neuromotor outcome in Very Low Birth Weight infants at 1 year using Movement Assessment of Infants scale at 4 and 8 months of corrected age. 相似文献6.
Objectives
To determine the prevalence and determinants of xerophthalmia among children aged 0–60 months. 相似文献7.
Objective
To compare the neurodevelopmental outcomes, at 30–42 months adjusted age, between infants exposed to antenatal indomethacin and those unexposed to antenatal indomethacin. 相似文献8.
Objective
To find the association between neonatal Peak serum bilirubin (PSB) levels and the neurodevelopmental outcomes at 6 months in term infants with neonatal hyperbilirubinemia. 相似文献9.
Objective
To check the validity of Integrated Management of Neonatal and Childhood Illness (IMNCI) algorithm for young infants (0–2 months). 相似文献10.
Objective
To compare continuous positive airway pressure (CPAP) vs. traditional mechanical ventilation (MV) at 24 h of age as predictors of neurodevelopmental (ND) outcomes in extremely low birth weight (ELBW) infants at 18–22 months corrected gestational age (CGA). 相似文献11.
Background
Recent ecological research from Latin America has shown that infant health could be promoted through exclusive breastfeeding in infants aged 0–3 months and partial breastfeeding throughout the remainder of infancy. 相似文献12.
Veena Kalra Naveen Sankhyan Suvasini Sharma Sheffali Gulati Rama Choudhry Benu Dhawan 《Indian journal of pediatrics》2009,76(8):795-799
Objective
To prospectively assess the outcome of children diagnosed with Guillain-Barré syndrome (GBS), followed up for a median duration of 25 months. 相似文献13.
Woolford SJ Clark SJ Sallinen BJ Geiger JD Freed GL 《Pediatric surgery international》2012,28(5):455-460
Purpose
Criteria for adolescent bariatric surgery include failure of ≥6 months of organized weight loss attempts. We wished to explore whether adolescents, initially wanting surgery, change their mind during a 6-month weight loss program and how many meet the treatment failure criterion. 相似文献14.
Laura A Zimmerman Diana L Bartlett Kyle S Enger Kimiko Gosney Warren G Williams 《BMC pediatrics》2007,7(1):28
Background
Beginning with the 2004–05 influenza season, the Advisory Committee on Immunization Practices (ACIP) strengthened their existing encouragement that children aged 6–23 months receive influenza vaccination by creating a formal recommendation. 相似文献15.
S. Viaux-Savelon C. Leclere E. Aidane N. Bodeau L. Camon-Senechal S. Vatageot R. Feldman D. Cohen 《Neuropsychiatrie de l'enfance et de l'adolescence》2014
Objective
This paper presents the psychometric properties of a French adaptation of the Coding Interactive Behavior (CIB), a scale developed by Ruth Feldman and largely used to study mother–infant interaction.Methods
The original manual has been translated in French and adapted to French terminology of concepts. Then Ruth Feldman controlled the translation with the help of a bilingual psychologist. The scale was administered to 74 clinical and non-clinical dyads recruited in an obstetric clinic, at birth and 2 months postpartum. Confirmatory factor analyses were employed to assess factorial structure using Cronbach's alpha. Inter-rater reliability was estimated with Interclass Correlation Coefficients (ICC).Results
Inter-rater reliability of the training was good with a median ICC equal to 0.88. Confirmatory factor analyses supported a comparable latent factor structure as reported in the original CIB with α ranging from 0.67 to 0.96 at birth and 0.63 to 0.95 at 2 months. Inter-rater reliabilities at birth and 2 months were good with ICC ranging from 0.85 to 1 for each item.Conclusion
The results indicate that the French version of CIB shares the same latent factor structure as its original counterpart and is a useful tool to assess early mother–infant interaction. 相似文献16.
Olivia Lullmann Amy L. Conrad Emily J. Steinbach Tammy Wilgenbusch Lyndsay A. Harshman Ellen van der Plas 《Pediatric transplantation》2023,27(4):e14505
Background
Pediatric chronic kidney disease (CKD) patients are at risk for cognitive deficits with worsening disease progression. Limited, existing cross-sectional studies suggest that cognitive deficits may improve following kidney transplantation. We sought to assess cognitive performance in relationship to kidney transplantation and kidney-specific medical variables in a sample of pediatric kidney transplant patients who provided cross-sectional and longitudinal observations.Methods
A retrospective chart review was conducted in patients who completed pre- and/or post-transplant neurocognitive testing at the University of Iowa from 2015–2021. Cognitive outcomes were investigated with developmentally appropriate, standardized measures. Mixed linear models estimated the impact of transplant status on cognitive function (z-scores). Subsequent post-hoc t-tests on change scores were limited to patients who had provided pre- and post-transplant assessments.Results
Thirty eight patients underwent cognitive assessments: 10 had both pre- and post-transplant cognitive assessments, 11 had pre-transplant assessments only, and 17 had post-transplant data only. Post-transplant status was associated with significantly lower full-scale IQ and slower processing speed compared to pre-transplant status (estimate = −0.32, 95% confidence interval [CI] = −0.52: −0.12; estimate = −0.86, CI = −1.17: −0.55, respectively). Post-hoc analyses confirmed results from the mixed models (FSIQ change score = −0.34, 95% CI = −0.56: −0.12; processing speed change score = −0.98, CI = −1.28: −0.68). Finally, being ≥80 months old at transplant was associated with substantially lower FSIQ compared to being <80 months (estimate = −1.25, 95% CI = −1.94: −0.56).Conclusions
Our results highlight the importance of monitoring cognitive function following pediatric kidney transplant and identify older transplant age as a risk factor for cognitive deficits. 相似文献17.
Styliana Vasileiadou Göran Wennergren Frida Strömberg Celind Nils Åberg Rolf Pettersson Bernt Alm Emma Goksör 《Pediatric allergy and immunology》2018,29(3):283-289
Background
The prevalence of allergic rhinitis has increased, but the cause of this rise is partly unknown. Our aim was to analyse the prevalence, risk factors, and protective factors for allergic rhinitis in 12‐year‐old Swedish children.Methods
Data were collected from a prospective, longitudinal cohort study of children born in western Sweden in 2003. The parents answered questionnaires when the children were 6 months to 12 years. The response rate at 12 years was 76% (3637/4777) of the questionnaires distributed.Results
At the age of 12, 22% of children had allergic rhinitis and 57% were boys. Mean age at onset was 7.8 years, and 55% reported their first symptoms after 8 years. The most common trigger factors were pollen (85%), furry animals (34%), and house dust mites (17%). A multivariate analysis showed that the adjusted odds ratios and 95% confidence intervals for the independent risk factors for allergic rhinitis at 12 were as follows: parental allergic rhinitis (2.32, 1.94‐2.77), doctor‐diagnosed food allergy in the first year (1.75, 1.21‐2.52), eczema in the first year (1.61, 1.31‐1.97), and male gender (1.25, 1.06‐1.47). Eating fish once a month or more at age of 12 months reduced the risk of allergic rhinitis at 12 years of age (0.70, 0.50‐0.98) as did living on a farm with farm animals at 4 years (0.51, 0.32‐0.84). Continuous farm living from age 4 to 12 seemed to drive the association.Conclusions
Allergic rhinitis affected > 20% of 12‐year‐olds, but was lower in children who ate fish at 12 months or grew up on a farm with farm animals. 相似文献18.
Pradeep Kumar Sharma M. Jeeva Sankar Savita Sapra Rohit Saxena C. Venkat Karthikeyan Ashok Deorari Ramesh Agarwal Vinod Paul 《Indian journal of pediatrics》2011,78(12):1485-1490
Objective
To determine the growth and neurosensory outcomes of infants with birth weight ≤1,500 g or gestation ≤32 wks at 18 months corrected age. This prospective cohort study was conducted at a Level III neonatal unit in India. The neonates with birth weight ≤1,500 g or gestation ≤32 wks were included in the study. 相似文献19.
Fei-Teng Kong Wen-Ying Liu Yun-Man Tang Lin Zhong Xue-Jun Wang Gang Yang Hou-Ping Chen 《World journal of pediatrics : WJP》2010,6(1):55-59
Background
The diagnosis and treatment of intussusception is often confusing in infants aged younger than 3 months. This study aimed to discuss the particularity of diagnosis and treatment of intussusception in this age group. 相似文献20.
Houda Ben Ayed Sourour Yaïch Maïssa Ben Jmaa Jihene Jedidi Mariem Ben Hmida Maroua Trigui Mondher Kassis Raouf Karray Yosra Mejdoub Habib Feki Jamel Damak 《Pediatrics international》2018,60(1):76-82