眼底血管造影联合频域光相干断层扫描同步检查法对渗出性老年性黄斑变性脉络膜新生血管的诊断价值

Objective To evaluate the diagnostic value of Heidelberg retinal angiography(HRA) combined with optical coherence tomography (OCT) to detect neovascularization (CNV) in exudative age-related macular degeneration (AMD) patients. Methods This is a cross-sectional study of a series of clinical cases. AMD diagnosis was established by international standard vision chart, Slit lamp microscope, direct or indirect ophthalmoscope examination. A total of 50 eyes (42 cases) of exudative AMD received HRA and frequency domain OCT scan. All 50 eyes received fundus fluorescein angiography (FFA) and frequency-domain OCT simultaneously, and among them 15 eyes also received indocyanine green angiography (ICGA) at the same time. FFA and ICGA were carried out by conventional methods, CNV was localized by real-time Localization technology of frequency domain OCT. In the radial and grid-like section from the areas with strong fluorescence, image acquisition settings are 7 μm fault for each frame, 30° intervals for radialsection, 10 vertical and 10 horizontal scan lines for grid-like section. CNV can be divided into 4 types (typical CNV, partial typical CNV, occult CNV, CNV scarring) according to their boundaries demonstrated in FFA. Based on the features of the OCT images, there were 3 types of integrated image (sub-RPE type, sub-retinal type and mixed type). Results CNV was detected in all 50 eyes. There were 4 eyes (8%) of typical CNV, 11 eyes (22%) of partial typical CNV, 32 eyes (64 %, including 27 eyes of RPE detachment and 5 eyes of passive late leakage) of occult CNV and 3 eyes (6%) of CNV scarring. There were 4 eyes (8%) of sub-RPE type (CNV under the RPE light band) , 16 eyes (32%) of sub-retinal type(interrupted light band of RPE and choroid capillary layer) and 30 eyes (60%) of mixed type of integrated image. Conclusion The image integration technology of the HRA and frequency domain OCT system provide a valuable tool to classify and measure CNV, which will benefit the clinical treatment of AMD patients.     

眼底血管造影联合频域光相干断层扫描同步检查法对渗出性老年性黄斑变性脉络膜新生血管的诊断价值

Objective To evaluate the diagnostic value of Heidelberg retinal angiography(HRA) combined with optical coherence tomography (OCT) to detect neovascularization (CNV) in exudative age-related macular degeneration (AMD) patients. Methods This is a cross-sectional study of a series of clinical cases. AMD diagnosis was established by international standard vision chart, Slit lamp microscope, direct or indirect ophthalmoscope examination. A total of 50 eyes (42 cases) of exudative AMD received HRA and frequency domain OCT scan. All 50 eyes received fundus fluorescein angiography (FFA) and frequency-domain OCT simultaneously, and among them 15 eyes also received indocyanine green angiography (ICGA) at the same time. FFA and ICGA were carried out by conventional methods, CNV was localized by real-time Localization technology of frequency domain OCT. In the radial and grid-like section from the areas with strong fluorescence, image acquisition settings are 7 μm fault for each frame, 30° intervals for radialsection, 10 vertical and 10 horizontal scan lines for grid-like section. CNV can be divided into 4 types (typical CNV, partial typical CNV, occult CNV, CNV scarring) according to their boundaries demonstrated in FFA. Based on the features of the OCT images, there were 3 types of integrated image (sub-RPE type, sub-retinal type and mixed type). Results CNV was detected in all 50 eyes. There were 4 eyes (8%) of typical CNV, 11 eyes (22%) of partial typical CNV, 32 eyes (64 %, including 27 eyes of RPE detachment and 5 eyes of passive late leakage) of occult CNV and 3 eyes (6%) of CNV scarring. There were 4 eyes (8%) of sub-RPE type (CNV under the RPE light band) , 16 eyes (32%) of sub-retinal type(interrupted light band of RPE and choroid capillary layer) and 30 eyes (60%) of mixed type of integrated image. Conclusion The image integration technology of the HRA and frequency domain OCT system provide a valuable tool to classify and measure CNV, which will benefit the clinical treatment of AMD patients.     

眼底血管造影联合频域光相干断层扫描同步检查法对渗出性老年性黄斑变性脉络膜新生血管的诊断价值

Objective To evaluate the diagnostic value of Heidelberg retinal angiography(HRA) combined with optical coherence tomography (OCT) to detect neovascularization (CNV) in exudative age-related macular degeneration (AMD) patients. Methods This is a cross-sectional study of a series of clinical cases. AMD diagnosis was established by international standard vision chart, Slit lamp microscope, direct or indirect ophthalmoscope examination. A total of 50 eyes (42 cases) of exudative AMD received HRA and frequency domain OCT scan. All 50 eyes received fundus fluorescein angiography (FFA) and frequency-domain OCT simultaneously, and among them 15 eyes also received indocyanine green angiography (ICGA) at the same time. FFA and ICGA were carried out by conventional methods, CNV was localized by real-time Localization technology of frequency domain OCT. In the radial and grid-like section from the areas with strong fluorescence, image acquisition settings are 7 μm fault for each frame, 30° intervals for radialsection, 10 vertical and 10 horizontal scan lines for grid-like section. CNV can be divided into 4 types (typical CNV, partial typical CNV, occult CNV, CNV scarring) according to their boundaries demonstrated in FFA. Based on the features of the OCT images, there were 3 types of integrated image (sub-RPE type, sub-retinal type and mixed type). Results CNV was detected in all 50 eyes. There were 4 eyes (8%) of typical CNV, 11 eyes (22%) of partial typical CNV, 32 eyes (64 %, including 27 eyes of RPE detachment and 5 eyes of passive late leakage) of occult CNV and 3 eyes (6%) of CNV scarring. There were 4 eyes (8%) of sub-RPE type (CNV under the RPE light band) , 16 eyes (32%) of sub-retinal type(interrupted light band of RPE and choroid capillary layer) and 30 eyes (60%) of mixed type of integrated image. Conclusion The image integration technology of the HRA and frequency domain OCT system provide a valuable tool to classify and measure CNV, which will benefit the clinical treatment of AMD patients.     

眼底血管造影联合频域光相干断层扫描同步检查法对渗出性老年性黄斑变性脉络膜新生血管的诊断价值

Objective To evaluate the diagnostic value of Heidelberg retinal angiography(HRA) combined with optical coherence tomography (OCT) to detect neovascularization (CNV) in exudative age-related macular degeneration (AMD) patients. Methods This is a cross-sectional study of a series of clinical cases. AMD diagnosis was established by international standard vision chart, Slit lamp microscope, direct or indirect ophthalmoscope examination. A total of 50 eyes (42 cases) of exudative AMD received HRA and frequency domain OCT scan. All 50 eyes received fundus fluorescein angiography (FFA) and frequency-domain OCT simultaneously, and among them 15 eyes also received indocyanine green angiography (ICGA) at the same time. FFA and ICGA were carried out by conventional methods, CNV was localized by real-time Localization technology of frequency domain OCT. In the radial and grid-like section from the areas with strong fluorescence, image acquisition settings are 7 μm fault for each frame, 30° intervals for radialsection, 10 vertical and 10 horizontal scan lines for grid-like section. CNV can be divided into 4 types (typical CNV, partial typical CNV, occult CNV, CNV scarring) according to their boundaries demonstrated in FFA. Based on the features of the OCT images, there were 3 types of integrated image (sub-RPE type, sub-retinal type and mixed type). Results CNV was detected in all 50 eyes. There were 4 eyes (8%) of typical CNV, 11 eyes (22%) of partial typical CNV, 32 eyes (64 %, including 27 eyes of RPE detachment and 5 eyes of passive late leakage) of occult CNV and 3 eyes (6%) of CNV scarring. There were 4 eyes (8%) of sub-RPE type (CNV under the RPE light band) , 16 eyes (32%) of sub-retinal type(interrupted light band of RPE and choroid capillary layer) and 30 eyes (60%) of mixed type of integrated image. Conclusion The image integration technology of the HRA and frequency domain OCT system provide a valuable tool to classify and measure CNV, which will benefit the clinical treatment of AMD patients.     

眼底血管造影联合频域光相干断层扫描同步检查法对渗出性老年性黄斑变性脉络膜新生血管的诊断价值

Objective To evaluate the diagnostic value of Heidelberg retinal angiography(HRA) combined with optical coherence tomography (OCT) to detect neovascularization (CNV) in exudative age-related macular degeneration (AMD) patients. Methods This is a cross-sectional study of a series of clinical cases. AMD diagnosis was established by international standard vision chart, Slit lamp microscope, direct or indirect ophthalmoscope examination. A total of 50 eyes (42 cases) of exudative AMD received HRA and frequency domain OCT scan. All 50 eyes received fundus fluorescein angiography (FFA) and frequency-domain OCT simultaneously, and among them 15 eyes also received indocyanine green angiography (ICGA) at the same time. FFA and ICGA were carried out by conventional methods, CNV was localized by real-time Localization technology of frequency domain OCT. In the radial and grid-like section from the areas with strong fluorescence, image acquisition settings are 7 μm fault for each frame, 30° intervals for radialsection, 10 vertical and 10 horizontal scan lines for grid-like section. CNV can be divided into 4 types (typical CNV, partial typical CNV, occult CNV, CNV scarring) according to their boundaries demonstrated in FFA. Based on the features of the OCT images, there were 3 types of integrated image (sub-RPE type, sub-retinal type and mixed type). Results CNV was detected in all 50 eyes. There were 4 eyes (8%) of typical CNV, 11 eyes (22%) of partial typical CNV, 32 eyes (64 %, including 27 eyes of RPE detachment and 5 eyes of passive late leakage) of occult CNV and 3 eyes (6%) of CNV scarring. There were 4 eyes (8%) of sub-RPE type (CNV under the RPE light band) , 16 eyes (32%) of sub-retinal type(interrupted light band of RPE and choroid capillary layer) and 30 eyes (60%) of mixed type of integrated image. Conclusion The image integration technology of the HRA and frequency domain OCT system provide a valuable tool to classify and measure CNV, which will benefit the clinical treatment of AMD patients.     

眼底血管造影联合频域光相干断层扫描同步检查法对渗出性老年性黄斑变性脉络膜新生血管的诊断价值

Objective To evaluate the diagnostic value of Heidelberg retinal angiography(HRA) combined with optical coherence tomography (OCT) to detect neovascularization (CNV) in exudative age-related macular degeneration (AMD) patients. Methods This is a cross-sectional study of a series of clinical cases. AMD diagnosis was established by international standard vision chart, Slit lamp microscope, direct or indirect ophthalmoscope examination. A total of 50 eyes (42 cases) of exudative AMD received HRA and frequency domain OCT scan. All 50 eyes received fundus fluorescein angiography (FFA) and frequency-domain OCT simultaneously, and among them 15 eyes also received indocyanine green angiography (ICGA) at the same time. FFA and ICGA were carried out by conventional methods, CNV was localized by real-time Localization technology of frequency domain OCT. In the radial and grid-like section from the areas with strong fluorescence, image acquisition settings are 7 μm fault for each frame, 30° intervals for radialsection, 10 vertical and 10 horizontal scan lines for grid-like section. CNV can be divided into 4 types (typical CNV, partial typical CNV, occult CNV, CNV scarring) according to their boundaries demonstrated in FFA. Based on the features of the OCT images, there were 3 types of integrated image (sub-RPE type, sub-retinal type and mixed type). Results CNV was detected in all 50 eyes. There were 4 eyes (8%) of typical CNV, 11 eyes (22%) of partial typical CNV, 32 eyes (64 %, including 27 eyes of RPE detachment and 5 eyes of passive late leakage) of occult CNV and 3 eyes (6%) of CNV scarring. There were 4 eyes (8%) of sub-RPE type (CNV under the RPE light band) , 16 eyes (32%) of sub-retinal type(interrupted light band of RPE and choroid capillary layer) and 30 eyes (60%) of mixed type of integrated image. Conclusion The image integration technology of the HRA and frequency domain OCT system provide a valuable tool to classify and measure CNV, which will benefit the clinical treatment of AMD patients.     

眼底血管造影联合频域光相干断层扫描同步检查法对渗出性老年性黄斑变性脉络膜新生血管的诊断价值

Objective To evaluate the diagnostic value of Heidelberg retinal angiography(HRA) combined with optical coherence tomography (OCT) to detect neovascularization (CNV) in exudative age-related macular degeneration (AMD) patients. Methods This is a cross-sectional study of a series of clinical cases. AMD diagnosis was established by international standard vision chart, Slit lamp microscope, direct or indirect ophthalmoscope examination. A total of 50 eyes (42 cases) of exudative AMD received HRA and frequency domain OCT scan. All 50 eyes received fundus fluorescein angiography (FFA) and frequency-domain OCT simultaneously, and among them 15 eyes also received indocyanine green angiography (ICGA) at the same time. FFA and ICGA were carried out by conventional methods, CNV was localized by real-time Localization technology of frequency domain OCT. In the radial and grid-like section from the areas with strong fluorescence, image acquisition settings are 7 μm fault for each frame, 30° intervals for radialsection, 10 vertical and 10 horizontal scan lines for grid-like section. CNV can be divided into 4 types (typical CNV, partial typical CNV, occult CNV, CNV scarring) according to their boundaries demonstrated in FFA. Based on the features of the OCT images, there were 3 types of integrated image (sub-RPE type, sub-retinal type and mixed type). Results CNV was detected in all 50 eyes. There were 4 eyes (8%) of typical CNV, 11 eyes (22%) of partial typical CNV, 32 eyes (64 %, including 27 eyes of RPE detachment and 5 eyes of passive late leakage) of occult CNV and 3 eyes (6%) of CNV scarring. There were 4 eyes (8%) of sub-RPE type (CNV under the RPE light band) , 16 eyes (32%) of sub-retinal type(interrupted light band of RPE and choroid capillary layer) and 30 eyes (60%) of mixed type of integrated image. Conclusion The image integration technology of the HRA and frequency domain OCT system provide a valuable tool to classify and measure CNV, which will benefit the clinical treatment of AMD patients.     

眼底血管造影联合频域光相干断层扫描同步检查法对渗出性老年性黄斑变性脉络膜新生血管的诊断价值

Objective To evaluate the diagnostic value of Heidelberg retinal angiography(HRA) combined with optical coherence tomography (OCT) to detect neovascularization (CNV) in exudative age-related macular degeneration (AMD) patients. Methods This is a cross-sectional study of a series of clinical cases. AMD diagnosis was established by international standard vision chart, Slit lamp microscope, direct or indirect ophthalmoscope examination. A total of 50 eyes (42 cases) of exudative AMD received HRA and frequency domain OCT scan. All 50 eyes received fundus fluorescein angiography (FFA) and frequency-domain OCT simultaneously, and among them 15 eyes also received indocyanine green angiography (ICGA) at the same time. FFA and ICGA were carried out by conventional methods, CNV was localized by real-time Localization technology of frequency domain OCT. In the radial and grid-like section from the areas with strong fluorescence, image acquisition settings are 7 μm fault for each frame, 30° intervals for radialsection, 10 vertical and 10 horizontal scan lines for grid-like section. CNV can be divided into 4 types (typical CNV, partial typical CNV, occult CNV, CNV scarring) according to their boundaries demonstrated in FFA. Based on the features of the OCT images, there were 3 types of integrated image (sub-RPE type, sub-retinal type and mixed type). Results CNV was detected in all 50 eyes. There were 4 eyes (8%) of typical CNV, 11 eyes (22%) of partial typical CNV, 32 eyes (64 %, including 27 eyes of RPE detachment and 5 eyes of passive late leakage) of occult CNV and 3 eyes (6%) of CNV scarring. There were 4 eyes (8%) of sub-RPE type (CNV under the RPE light band) , 16 eyes (32%) of sub-retinal type(interrupted light band of RPE and choroid capillary layer) and 30 eyes (60%) of mixed type of integrated image. Conclusion The image integration technology of the HRA and frequency domain OCT system provide a valuable tool to classify and measure CNV, which will benefit the clinical treatment of AMD patients.     

眼底血管造影联合频域光相干断层扫描同步检查法对渗出性老年性黄斑变性脉络膜新生血管的诊断价值

Objective To evaluate the diagnostic value of Heidelberg retinal angiography(HRA) combined with optical coherence tomography (OCT) to detect neovascularization (CNV) in exudative age-related macular degeneration (AMD) patients. Methods This is a cross-sectional study of a series of clinical cases. AMD diagnosis was established by international standard vision chart, Slit lamp microscope, direct or indirect ophthalmoscope examination. A total of 50 eyes (42 cases) of exudative AMD received HRA and frequency domain OCT scan. All 50 eyes received fundus fluorescein angiography (FFA) and frequency-domain OCT simultaneously, and among them 15 eyes also received indocyanine green angiography (ICGA) at the same time. FFA and ICGA were carried out by conventional methods, CNV was localized by real-time Localization technology of frequency domain OCT. In the radial and grid-like section from the areas with strong fluorescence, image acquisition settings are 7 μm fault for each frame, 30° intervals for radialsection, 10 vertical and 10 horizontal scan lines for grid-like section. CNV can be divided into 4 types (typical CNV, partial typical CNV, occult CNV, CNV scarring) according to their boundaries demonstrated in FFA. Based on the features of the OCT images, there were 3 types of integrated image (sub-RPE type, sub-retinal type and mixed type). Results CNV was detected in all 50 eyes. There were 4 eyes (8%) of typical CNV, 11 eyes (22%) of partial typical CNV, 32 eyes (64 %, including 27 eyes of RPE detachment and 5 eyes of passive late leakage) of occult CNV and 3 eyes (6%) of CNV scarring. There were 4 eyes (8%) of sub-RPE type (CNV under the RPE light band) , 16 eyes (32%) of sub-retinal type(interrupted light band of RPE and choroid capillary layer) and 30 eyes (60%) of mixed type of integrated image. Conclusion The image integration technology of the HRA and frequency domain OCT system provide a valuable tool to classify and measure CNV, which will benefit the clinical treatment of AMD patients.     

Laser treatment in 341 patients with exudative agerelated macular degeneration

AIM:To document the prognosis of laser treatment in patients with exudative age-related macular degeneration(AMD).· METHODS:Efficacy of the intervention was evaluated using a before-after method.· RESULTS:A total of 392 eyes of 341 patients with exudative AMD were examined.77.6% had choroideal neovascularisation(CNV).Before the use of indocyanine green(ICG) angiography,occult CNV was detected in only 1.8% of the eyes,but after the use of ICG angiography,this increased to 19.5%(P<0.001).Of the 349 eyes which were followed up,visual acuity had remained stable in 68.2% of the eyes.There was a statistically significant relationship between localisation of lesion and visual acuity changes on pre-and post-laser treatment(P<0.001).Also there was a statistically significant relationship between localisation of lesion and recurrence(P<0.05).The recurrence was less in subfoveal lesions than that in juxtafoveal and extrafoveal lesions.· CONCLUSION:ICG angiography is highly important in the treatment of occult CNV.     

渗出型老年黄斑变性的吲哚青绿血管造影特征

目的 观察渗出型老年黄斑变性(age-related macular degeneration,AMD)的吲哚青绿血管造影(indocyanine green angiography,ICGA)特征。 方法 诊断为渗出型AMD的患者31例(39只眼)，年龄50～82岁，视力范围：指数/30cm～0.7,全部完成了眼部检查、眼底彩色照相、眼底荧光素血管造影(fundus fluorescein angiography,FFA)和吲哚青绿血管造影(indocyanine green angiography,ICGA)，分析和比较FFA和ICGA图像特征。 结果 FFA诊断为隐匿性脉络膜新生血管(choroidal neovascularization,CNV)的26只眼中，ICGA诊断为典型CNV有15眼，占57.7%。FFA诊断为浆液性色素上皮脱离(不伴CNV)4只眼中，有1只眼ICGA诊断为浆液性色素上皮脱离伴典型CNV。FFA和ICGA对瘢痕组织诊断的眼数及特性相近。 结论 与FFA相比，ICGA可提高对AMD典型性CNV的诊断率，扩大对AMD的治疗范围。(中华眼底病杂志,1998,14:76-80)     

息肉状脉络膜血管病变与老年黄斑变性对比分析

目的探讨息肉状脉络膜血管病变(PCV)与湿性老年黄斑变性(AMD)临床特征的区别与联系,以指导临床。方法回顾分析已确诊的PCV及湿性AMD的眼底彩照,荧光素血管造影(FFA),吲哚青绿血管造影(ICGA),光学相干断层扫描(OCT)结果及临床资料。结果PCV15例,年龄48-70岁,平均62.3岁;湿性AMD38例,年龄50-80岁,平均65.8岁。PCV患者眼底视网膜出血、脂质渗出、桔红色结节样病灶分别为11只眼(73.3%)、6只眼(40%)、4只眼(26.7%);AMD患者45只眼中视网膜出血、脂质渗出、青灰色病灶、瘢痕形成分别为25只眼(55.6%)、18只眼(40.0%)、20只眼(44.4%)、3只眼(6.77%)。FFA显示PCV患眼脉络膜息肉状结构、出血性色素上皮脱离(PED)、浆液性PED分别为1只眼(6.7%)、7只眼(46.7%)、2只眼(13.3%),ICGA均可见息肉状扩张病灶(100%);FFA显示AMD患眼典型脉络膜新生血管(CNV)、PED分别为5只眼(11.1%)、14只眼(31.1%),ICGA显示CNV23只眼(51.1%),均未见息肉状结构。PCV的OCT表现为视网膜色素上皮及脉络膜内层呈穹窿状向视网膜神经上皮隆起,其下见结节状改变;AMD则显示视网膜色素上皮和脉络膜毛细血管层呈局部梭形或不规则强反射带。结论PCV与湿性AMD不尽相同,可能是AMD的另一种特殊类型,治疗可能应有所不同,有待于进一步研究。     

渗出型老年黄斑变性的吲哚菁绿血管造影图像特征

目的 探讨渗出型老年黄斑变性(AMD)吲哚菁绿血管造影(ICGA)与荧光素眼底血管造影(FFA)比较的图像特征。方法 对52例65眼渗出型AMD患者进行了眼底彩色照相、FFA和ICGA检查。结果 渗出型AMD的65眼中，ICGA诊断为典型性脉络膜新生血管(CNV)有33跟．占50．8％，FFA诊惭为典型性CNV有8眼，占11．6％；FFA诊断为隐匿性CNV的35眼中，ICGA诊断为边界清楚或久清楚的斑状CNV有22眼；合并黄斑出血39眼中，FFA不能发现的CNV而ICGA能发现共5眼；FFA诊断为痕痕染色的7眼中，有2眼有ICGA中发现CNV；ICGA发现CNV的供养血管(feeding vessel)有3眼。结论 ICGA比FFA发现CNV诊断率高，准确地显示黄斑出血所掩盖的CNV，ICCA有助丁发现CNV的供养血管。     

渗出型老年性黄斑变性的吲哚青绿血管造影观察

目的观察渗出型老年性黄斑变性(AMD)的吲哚青绿血管造影(ICGA)特征.方法对27例(32只眼)渗出型AMD行ICGA造影或(和)眼底荧光血管造影(FFA)检查,并对二者的造影表现特点和差异进行比较.结果 FFA检查29只眼,诊断典型性CNV11只眼(37.93%),表现为黄斑部早期有网状强荧光性CNV,后期荧光素不断渗漏,并积存在RPE脱离范围之内.晚期形成明显区域性强荧光.诊断隐匿性CNV18只眼(62.07%),表现为早期无CNV特征,晚期有不明原因的边界不清强荧光5只眼(17.24%),而表现早期有边界模糊强荧光呈进行性渗漏,晚期强荧光区明显扩大13只眼(44.82%).ICGA检查32只眼,诊断典型性CNV32只眼(100%),表现为早期有强荧光性CNV性11只眼(34.37%),中期出现强荧光性CNV15只眼(46.88%),晚期又出现新的强荧光性CNV6只眼(18.75%).表明FFA和ICGA在渗出型AMD的CNV的诊断比率上,二者有显著差异.ICGA比FFA能更精确地显示黄斑部的CNV,而对于黄斑部视网膜下出血、浆液性色素上皮脱离等视网膜病变则不如FFA显示明确.结论 ICGA能发现FFA不能发现的CNV,在显示CNV的数量、位置、范围等方面比FFA敏感和准确,是诊断渗出型AMD的CNV和指导其激光光凝的一项重要工具.     

渗出型老年性黄斑变性与息肉状脉络膜血管病变眼底形态学的对比分析

目的 观察渗出型老年性黄斑变性（AMD）与息肉状脉络膜血管病变（PCV）眼底表现的异同。 方法 回顾性分析渗出型AMD患者123例137只眼及PCV患者42例48只眼的眼底彩色像、荧光素眼底血管造影（FFA）和吲哚青绿血管造影（ICGA）检查资料。 结果 137只渗出型AMD患眼中，FFA显示16只眼为典型脉络膜新生血管（CNV），占11.7%；隐匿型CNV121只眼，占88.3%。隐匿型CNV患眼中，42只眼ICGA检查可见“热点状”（hot spots）荧光，占34.7%；74只眼表现为后期斑状强荧光，占61.2%；2只眼CNV与PCV共存 ，占1.7%。48只PCV眼中，7只眼的眼底彩色像可见特有的视网膜下橘红色结节样病灶，占14.6%； 2只眼FFA即显示出分 支状脉络膜血管网及息肉状病灶，占4.2%； 36只眼ICGA显示异常分支的脉络膜血管网及其末梢的息肉状扩张灶，占75.0%；12只眼ICGA显示多个息肉状扩张灶而未见伴有分支状脉络膜血管网，占25.0%。息肉状病灶呈葡萄串样外观者16只眼，占33.3%；，呈多个孤立并存者32只眼，占66.7%。造影后期部分息肉状病灶染料渗漏或染色，部分呈息肉状病灶中心为弱荧光，周围环状染色的“冲刷现象”。 结论 渗出型AMD与PCV不同的ICGA表现及PCV眼底特征性的视网膜下橘红色结节样病灶有助于两者的诊断与鉴别诊断.（中华眼底病杂志，2004，20：307-309）     

典型性脉络膜新生血管的眼底血管造影对比分析

目的 观察典型性脉络膜新生血管（CNV）的荧光素眼底血管造影（FFA）与吲哚青绿血管造影（ICGA）图像特征的异同。 方法 回顾分析34例（36只眼）典型性CNV患者的FFA和ICGA检查资料，并将FFA与ICGA结果进行对比分析。 结果 FFA显示典型性CNV的早期形态，在15只AMD患眼中有3只眼呈绒团状或车辐状轮廓，占20％；7只病理性近视患眼中有5只眼呈绒团状，占71.4％；14只中心性渗出性脉络膜视网膜病变中有9只眼呈绒团状，占64.3％。36只典型性CNV患眼，ICGA显示清楚的CNV20只眼，占55.6％；ICGA显示欠清楚的CNV15只眼，占41.6％；ICGA未能发现CNV的1只眼，占2.8％；ICGA可显示FFA不能显示的滋养血管6只眼，占16.7％。 结论 典型性CNV的FFA早期形态，AMD中多呈不规则形，而病理性近视和中心性渗出性脉络膜视网膜病变以绒团状居多。ICGA显示典型性CNV的轮廓边界不如FFA清楚，但可发现FFA显示不出的滋养血管。 (中华眼底病杂志, 2006, 22: 217-219)     

渗出型老年黄斑变性患者眼底相干光断层成像结果分析

目的：了解渗出型老年黄斑变性（age-related macular degeneration,AMD）患者的眼底相干光断层成像（optical coherence tomography,OCT）特征。方法：对经常规检查、荧光素眼底血管造影（fundus fluorescein angiography,FFA）、吲哚青绿脉络血管造影（indocyanine green angiography,ICGA）确诊的渗出型AMD患者38例（42只眼）行眼底OCT检查,分析其图像资料,并与其FFA和ICGA检查结果进行比较。结果：OCT图像特征：典型纤维性新生血管膜34只眼,浆液性视网膜神经上皮脱离38只眼,视网膜神经纤维层脱离合并层间水肿8只眼,出血性和浆液性视网膜色素上皮（retinal pigment epithelium,RPE）脱离分别为11只眼和9只眼。结论：渗出型AMD患者眼底OCT图像特征为典型的纤维性新生血管膜合并浆液性视网膜神经上皮脱离、视网膜神经纤维层脱离、浆液性和出血性RPE脱离。上述图像特点证实和补充了FFA和ICGA检查结果,有助于渗出型AMD的诊断和评价。     

眼底血管造影和OCT结合对CEC脉络膜新生血管分型的评估

目的应用荧光素眼底血管造影（FFA）、吲哚青绿血管造影（ICGA）和光学相干断层扫描（OCT）3种影像检查评估中心性渗出性脉络膜视网膜病变（CEC）脉络膜新生血管（CNV）的分型和性质。方法采用FFA、ICGA和Strastus-TM型OCT仪3种检查观察并相互印证53例（56眼）CEC患者的CNV的形态及类型。结果FFA图像显示,典型性CNV25眼（44.64%）,部分典型性CNV11眼（19.64%）;隐匿性CNV2眼（3.57%）,其中纤维血管性色素上皮脱离型（F-PED）1眼,晚期无源性渗漏1眼,CNV瘢痕化13眼（23.21%）。ICGA图像显示,19眼（33.93%）在ICGA与FFA早期同时显示CNV,7眼（12.5%）FFA为非典型性CNV,ICGA表现为焦点状或边界清晰的斑状,1眼ICGA早期显示病灶周围及后极部伴有限局性脉络膜血管扩张,10眼（17.85%）在ICGA晚期显示弱荧光环;CNV瘢痕化9眼（16.07%）。OCT显示,21眼（37.5%）CNV呈类圆形团块位于视网膜神经上皮下间隙;22眼（39.29%）的CNV呈纺锤形或不规则形位于色素上皮层平面;1眼（4.76%）为不规则、松散、边界不清的中等或高光反射组织;9眼（19.64%）色素上皮完整、连续,其下中等强度反射,局部视网膜隆起或不隆起。33眼伴有浆液性神经上皮脱离;2眼伴有出血性色素上皮脱离。结论采用眼底血管造影和OCT相结合评判CNV的状况可以明确病情,提供治疗的依据。     

45岁以上中心性浆液性脉络膜视网膜病变与渗出型老年性黄斑变性眼底血管造影对比分析

目的 观察45岁以上的中心性浆液性脉络膜视网膜病变（CSC）与渗出型老年性黄斑变性（AMD）患者眼底血管造影图像特征的异同。 方法 回顾分析45岁以上CSC患者32例39只眼和渗出型AMD患者20例22只眼的眼底彩色像、荧光素眼底血管造影（FFA）和吲哚青绿血管造影（ICGA）检查资料。 结果 39只CSC眼中，FFA显示典型CSC 11只眼，占282％；扩散性视网膜色素上皮病变（DRPE）28只眼，占718％。ICGA显示39只眼早期脉络膜充盈迟缓及随后的脉络膜血管扩张，占100％；中期均有多灶性脉络膜血管通透性增强，占100％，16只眼中后期呈现渗漏点强荧光，占41.0％；后期5只眼见脉络膜大血管负影，占12.8％。22只未伴明显出血的渗出型AMD眼中，ICGA显示焦点状脉络新生血管（CNV） 13只眼，占59.1％；斑状CNV 8只眼，占36.4％；结合型CNV 1只眼，占4.5％。造影早期5只眼黄斑区及周围脉络膜血管代偿性扩张，占22.7％；中期均未见脉络膜血管通透性增强，后期均未见脉络膜大血管负影。 结论 45岁以上的CSC与渗出型AMD不同的ICGA特征为局灶性或多灶性的RPE渗漏点强荧光；多灶性脉络膜血管通透性增强；造影后期脉络膜血管负影；造影期间无焦点状或斑状CNV性强荧光。     

老年性黄斑变性的吲哚青绿和荧光素眼底血管造影

目的 探讨眼底荧光素血管造影(fundus fluorescein angiography,FFA)和吲哚青绿血管造影(indocyanine green angiography,ICGA)在老年性黄斑变性(age-related macular degeneration,AMD)患者中的临床应用.方法 对AMD患者375例742只眼的FFA和ICGA检查资料进行分析总结.结果 在所有患者中,萎缩型504只眼(67.9%),渗出型238只眼(32.1%).在同步进行FFA和ICGA检查的渗出型AMD93只眼中,FFA检查发现典型性CNV 14只眼(15.1%),隐匿性CNV 79只眼(84.9%);ICGA检查发现边界清楚的CNV48只眼(51.6%),两者相比差异具有统计学意义(x2=27.97,P＜0.01).ICGA检查发现CNV的供养血管6只眼(6.5%),均位于中心凹旁或中心凹外.在发现边界清楚CNV的48只眼中,中心凹下CNV29只眼(60.4%),中心凹旁CNV 12只眼(25.0%),中心凹外CNV7只眼(14.6%).结论 与FFA相比,ICGA可以更加准确地显示CNV,发现CNV的供养血管,对AMD的临床诊断和治疗具有更重要的指导意义.