Foldable silicone versus poly(methyl methacrylate) intraocular lenses in combined phacoemulsification and trabeculectomy

PURPOSE: To compare the outcome of phacotrabeculectomy with implantation of poly(methyl methacrylate) (PMMA) or foldable silicone intraocular lenses (IOLs). METHODS: Thirty patients were randomized to receive a 5.5 mm PMMA IOL through a 5.0 mm incision or a foldable silicone IOL (Allergan SI-30) through a 3.2 mm incision. Visual acuity, intraocular pressure (IOP), bleb survival, inflammation, endothelial cell changes, and complications were examined at intervals up to 6 months. RESULTS: There was no difference between the 2 groups in final visual outcome, final IOP control, bleb survival, and endothelial cell changes. Two months after surgery, there was significantly more inflammation in the silicone IOL group than in the PMMA group (P <. 05). The silicone group had a significantly higher combined complication rate including iris capture, choroidal effusion, and epiretinal membrane formation (P <.05). CONCLUSIONS: Foldable silicone IOLs were comparable to conventional PMMA lenses in visual outcome, IOP control, bleb formation, and endothelial changes. However, some silicone lenses are associated with an increased risk of recurrence of inflammation and a higher final complication rate in combined cataract and filtration surgery.     

肝素表面修饰的亲水性丙烯酸酯人工晶状体在超声乳化联合小梁切除术中的应用

目的比较肝素表面修饰的亲水性丙烯酸酯人工晶状体和非肝素表面修饰的亲水性丙烯酸酯人工晶状体在晶状体超声乳化及人工晶状体植入联合小梁切除手术后的前房炎症反应。方法29例(29眼)施行晶状体超声乳化及后房型人工晶状体植入联合小梁切除手术者分为A组和B组:A组(15例)植入非肝素表面修饰的亲水性丙烯酸酯人工晶状体,B组(14例)植入肝素表面修饰的亲水性丙烯酸酯人工晶状体。于术后1d、7d、1月及3月随访观察。结果术后1d两组的房水闪光值和细胞计数均显著上升,术后7d下降明显,其后逐渐下降,术后3个月基本恢复至术前水平。两组间房水闪光值和细胞计数在术后1d和第7d差异有统计学意义(P<0.05),而术后第1月、3月两组间差异无统计学意义(P>0.05)。术后3个月,两组间最佳矫正视力及眼压的差异均无统计学意义(P>0.05)。结论肝素表面修饰的亲水性丙烯酸酯人工晶状体可改善人工晶状体的生物相容性,较非肝素表面修饰者更能减轻术后炎症反应,尤其有利于白内障联合青光眼术后早期阶段的视力康复。     

超聲乳化後房人工晶體植入聯合小梁切除術

我們對23例曾行三聯術的青光眼合并白内障患者進行了臨床觀察,報告如下.1 資料和方法1.1 一般資料青光眼合并白内障患者23例(23眼),男9例(9眼),女14例(14眼).年齡56～79歲,平均65.6歲.原發性開角型青光眼5眼(21.5%),慢性閉角型青光眼5眼(21.5%),急性閉角型青光眼9眼(39.1%),繼發性青光眼4眼(17.3%).晶體核硬度:Ⅰ～Ⅳ級,術前視力光感至0.1有16眼,0.1至0.3有7眼.眼壓術前27～81.98mmHg,平均為23～36 mmHg(1mmHg=0.133KPa).     

白内障超声乳化及人工晶状体植入联合小梁切除术临床观察

目的 评价白内障超声乳化及折叠式人工晶状体植入联合小梁切除术的疗效。方法 对１６例９１８眼）青光眼合并白内障施行白内障旋转切削亏声乳化摘出及折叠式人工晶状体植 梁切除术。结果 １６例术后３月眼压均控制（７２．２％）。结论 该术式具有视力恢复较好,降眼压效果确实,并发症少的优点。     

超声乳化人工晶体植入联合隧道内小梁切除术

目的　探讨青光眼白内障联合手术的最佳方法。方法　对 96例青光眼合并白内障患者施行超声乳化及人工晶体植入联合隧道内小梁切除。结果　术前视力 <0 1者 84眼 ,0 1～ 0 3者12眼 ,术后视力 <0 1者 2 6例 ,占 2 7 0 8% ,0 1～ 0 5者 3 9例 ,占 40 62 % ,>0 5者 3 1例 ,占3 2 2 9%。术前眼压最高 60mmHg以上 ,最低 2 3mmHg ,术后 85例眼压降至正常范围 10例 ,术后经局部滴药后降至正常 ,1例出现恶性青光眼 ,平均眼压 12 85± 2 5mmHg。并发症主要是角膜水肿及虹膜炎。术后随访 5～ 2 6月 ,15例视力下降 ,5例眼压再增高。结论　白内障超声乳化人工晶体植入联合隧道内小梁切除术是目前治疗青光眼合并白内障的良好方法     

超声乳化人工晶体植入联合小梁切除术的临床分析

目的：探讨超声乳人工晶体植入联合小梁切除术的方法,评价其疗效。方法：对５５例６２只青光眼合并白内障行超声乳化人工晶体植入联合小梁切除术。结果：术后视力恢复迅速,３６眼〉０．５,术后眼压控制好,５４眼眼压〈１８ｍｍＨｇ,术后有角膜水肿等并发症。结论：超声乳化工晶体植入联合小梁切除术安全有效。     

Hydrophobic acrylic versus heparin surface-modified polymethylmethacrylate intraocular lens: a biocompatibility study

Background The implant of intraocular lenses (IOLs) following cataract surgery induces a foreign-body reaction to the IOL and a response on the part of the lens epithelial cells (LECs). The purpose of this study was to compare these aspects after the implantation of two different IOL materials.Methods Thirty-six cataract patients were randomised to receive two different foldable lens: an acrylic hydrophobic IOL (Acrysof MA30BA) and a heparin surface-modified (HSM) polymethylmethacrylate IOL (Pharmacia & Upjohn 809C) after phacoemulsification. Slit-lamp biomicroscopy with specular technique was used to assess the inflammatory cell adhesion on the anterior IOL surface, anterior capsule opacification (ACO) and membrane growth from the rhexis edge at 7, 30, 90, 180 and 360 days after surgery.Results The 809C group showed a higher percentage of patients with slight inflammatory cell adhesion on the anterior cell surface and a higher small cellular density during the whole follow-up period. The epithelioid cell response was greater in the 809C group than the Acrysof group but the difference between the two groups was not statistically significant. The ACO increased during the follow-up in both groups but was significantly higher in the 809C group.Conclusion Acrysof lenses are more biocompatible than HSM IOLs, showing a lower grade of inflammatory cell adhesion and ACO. The implantation of these lenses may be particularly indicated in patients with pathologies predisposing to blood–aqueous barrier damage.The authors have no proprietary or financial interest in any products or devices discussed in this paper and have not received any payment as reviewers or evaluators     

青光眼白内障联合术植入不同材料人工晶状体效果评价

目的比较青光眼白内障联合术中植入不同材料人工晶状体（IOL）的临床效果。方法回顾性分析行青光眼白内障联合术70例（76眼），其中植入PMMA IOL30例（36眼），硅胶IOL23例（23眼），丙烯酸酯折叠IOL17例（17眼）。对治疗效果进行评价，平均随访期限为10．5月。结果3组间术后眼压和最佳矫正视力差异无统计学意义。前房纤维素样渗出物和IOL表面沉积物发生率，硅胶组高于PMMA组和丙烯酸酯组，但差异无统计学意义。后发障发生率，丙烯酸酯组和硅胶组显著低于PMMA组，差异有统计学意义。结论行青光眼白内障联合术植入PMMA，硅胶与丙烯酸酯IOL在降眼压和提高视力方面具有相似的效果。但硅胶IOL的前房纤维素样渗出物及IOL表面沉积物发生率高于PMMA和丙烯酸酯IOL。丙烯酸酯和硅胶IOL的后发障发生率低于PMMA IOL。     

小梁切除术后白内障超声乳化手术分析

目的:探讨分析抗青光眼小梁切除术后白内障超声乳化摘除联合人工晶状体植入术的手术方法、技巧及效果分析。方法:我院2007-01/2010-12对87例87眼抗青光眼小梁切除术后发生白内障的病例行白内障超声乳化摘除联合人工晶状体植入术,随访6mo,分析术后视力、眼压、并发症等情况。结果:术后随访6mo,87眼术后视力均有不同程度的提高,其中78眼（90％）视力≥0.3;术后眼压均较术前下降;术后并发症主要有角膜水肿（15眼,17％）、虹膜反应（11眼,13％）、前房出血（5眼,6％）、后囊膜混浊（10眼,11％）。结论:对抗青光眼小梁切除术后出现的白内障,行透明角膜切口的白内障超声乳化摘除联合人工晶状体植入术可显著提高视力,保持滤过泡和眼压的稳定,恢复眼前节的组织结构。     

小梁切除联合超声乳化人工晶状体植入术的临床疗效观察

目的：为了观察不同类型青光眼伴有白内障病人的小梁切除联合白内障超声乳化吸除并后房型人工晶状体植入三联术后3个月的视力、眼压以及并发症发生的情况。方法：82例（91只眼）,青光眼合并白内障患者行小梁切除联合超声乳化后房型人工晶体植入。结果：术后3个平均眼压低于15mmHg(1mmHg－0．134kPa）,平均视力好于0．54。结论：小梁切除联合白内障超声乳化吸除并后房型人工晶状体植入术具有切口小,眼压控制好,滤过泡形佳,能获得一定的视力。     

青光眼合并白内障超声乳化人工晶状体植入联合小梁切除术的效果

目的探讨青光眼合并白内障行超声乳化吸出、人工晶状体植入联合小梁切除术的效果。方法青光眼合并白内障44例（47眼）,行超声乳化吸出及折叠式人工晶体植入联合全巩膜隧道内小梁切除术,术后观察眼压、视力、滤过情况等,随访1～36个月。结果47眼术后眼压均可控制在正常范围,长期随访眼压未升高,术后矫正视力：数指2眼（4．26％）,0．1～0．633眼（70．21％）,0．8-1．212眼（25．53％）,术后并发症主要是虹膜反应、角膜水肿及瞳孔散大。结论白内障行超声乳化及折叠式人工晶状体植入联合巩膜隧道内小梁切除术可有效控制眼压,提高视力。     

改良小梁切除术联合超声乳化人工晶状体植入术治疗青光眼合并白内障

目的观察改良小梁切除术联合超声乳化人工晶状体植入术治疗青光眼合并白内障的临床疗效。方法选取我院2010年1月至2011年6月青光眼合并白内障患者60例(60眼),均行改良小梁切除术联合超声乳化人工晶状体植入术。随访3～6个月,观察患者随访末期的视力、眼压、滤过泡及并发症情况。结果 60例(60眼)患者术前视力<0.1者30眼,0.1～<0.3者18眼,0.3～0.5者12眼;术后至随访末期,除2眼因眼内炎致视力丧失外,其余患者视力均有不同程度提高,其中视力<0.1者9眼,0.1～<0.3者16眼,0.3～<0.5者20眼,0.5及以上者15眼;术前、术后比较差异有统计学意义(P<0.05)。术后眼压为(14.58±2.32)mmHg(1kPa=7.5mmHg),与术前(29.08±7.59)mmHg相比,差异有显著统计学意义(P<0.01)。术中出现晶状体后囊膜破裂2眼,均未出现玻璃体脱出等其他并发症;术后出现角膜水肿24眼,眼内炎2眼,不同程度前房纤维素样渗出8眼,浅前房6眼。结论改良小梁切除术联合超声乳化人工晶状体植入术治疗青光眼合并白内障可降低眼压、改善视力,且并发症少。     

透明角膜切口白内障超声乳化联合青光眼手术的疗效分析

目的:观察透明角膜切口白内障超声乳化人工晶状体植入联合小梁切除术(以下简称超声乳化三联术)治疗青光眼合并白内障的临床疗效和安全性。方法:回顾性分析使用透明角膜切口超声乳化三联术治疗各种类型的青光眼合并白内障患者127例(128眼)手术前、后的视力和眼压,手术并发症和滤过泡情况。结果:术后视力迅速恢复,矫正视力较术前明显提高,随访6mo～2a,113眼≥0.5(88.3%);眼压较术前明显降低,11眼术后眼压<20mmHg,16眼加滴1～2种降压药后眼压控制满意且稳定。术后并发症少,功能性滤过泡83.6%。结论:透明角膜切口超声乳化白内障吸除人工晶状体植入联合小梁切除术治疗青光眼合并白内障,不但能良好地控制眼压,迅速恢复视力。而且并发症少,手术适应证广,在白内障青光眼并存情况下采用超声乳化三联手术是安全、有效、可靠的治疗方法。     

Long-term results of combined 1-way phacoemulsification, intraocular lens implantation, and trabeculectomy

PURPOSE: To analyze the results of 1-way phacoemulsification and posterior chamber intraocular lens (IOL) implantation combined with trabeculectomy. SETTING: Department of Ophthalmology and Neurosurgery, University of Siena, Siena, Italy. METHODS: This retrospective study comprised 42 eyes of 36 patients with glaucoma and cataract who had phacoemulsification with posterior chamber IOL implantation combined with trabeculectomy. The mean follow-up of 28.24 months +/- 10.99 (SD) (range 11 to 52 months) included measurement of intraocular pressure (IOP), visual acuity, visual field, endothelial cell loss, and notation of complications. RESULTS: There was a statistically significant postoperative improvement in visual acuity (P < .001). Mean preoperative best corrected visual acuity (BCVA) was 20/200 (range 20/30 to hand movements). Mean 1 year postoperative BCVA was 20/30 (range 20/20 to 20/60). The preoperative mean IOP of 24.06 mm Hg decreased to 15.36 mm Hg at 1 year (P < .001). All 42 eyes had a postoperative IOP of less than 21.00 mm Hg. Mean central cornea endothelial cell density preoperatively was 2238 +/- 396 cells/mm2 (range 1697 to 2906 cells/mm2) and postoperatively, 2005 +/- 397 cells/mm2 (range 1302 to 2801 cells/mm2). Early postoperative complications consisted of a choroidal detachment in 2 patients (4.76%). Three and 4 days after surgery, respectively, 2 patients (4.76%) had surgery to remove viscoelastic substance under the IOL. Late complications included posterior synechias in 3 eyes (7.14%). One year after surgery, because of a significant decrease in vision, a neodymium:YAG laser posterior capsulotomy was necessary in 2 eyes, 1 with an acrylic IOL (3.70%) and 1 with a silicone lens (9.09%). CONCLUSION: Combined phacoemulsification, posterior chamber IOL implantation, and trabeculectomy was safe and effective in patients with coexisting glaucoma and cataract.     

Inflammation after phacoemulsification in diabetic retinopathy. Foldable acrylic versus heparin-surface-modified poly(methyl methacrylate) intraocular lenses

PURPOSE: To evaluate inflammation after cataract surgery in patients with nonproliferative diabetic retinopathy (NPDR) and compare results with 2 intraocular lenses (IOLs): a foldable hydrophobic acrylic and a heparin-surface-modified (HSM) poly(methyl methacrylate) (PMMA). SETTING: Department of Ophthalmology, University of Vienna, Vienna, Austria. METHODS: Patients with NPDR were randomized for implantation of an HSM PMMA IOL (811C, Pharmacia) through a 6.0 mm sclerocorneal incision (30 patients) or a foldable hydrophobic acrylic IOL (AcrySof, Alcon) through a 4.0 mm sclerocorneal incision (32 patients). Both IOLs had 6.0 mm optics. All patients were treated according to a standardized protocol. The degree of flare in the anterior chamber was measured with the Kowa 1000 laser flare-cell meter 1 day preoperatively and 1 day, 1 week, and 1 and 3 months postoperatively. RESULTS: In both IOL groups, flare was highest on the first postoperative day and decreased to preoperative levels by 3 months after surgery. There was no statistically significant difference in relative flare values between the 2 groups. CONCLUSION: There was no difference in postoperative inflammation in eyes with a foldable hydrophobic acrylic IOL implanted through a small incision and those with a rigid HSM PMMA IOL. Postoperative inflammation results indicate that the lenses are equally suitable for the use in patients with diabetic retinopathy.     

超声乳化白内障摘出联合小梁切除术疗效观察

目的探讨超声乳化白内障摘出人工晶状体植入联合小梁切除术的疗效和安全性。方法对３６例（３６眼）青光眼合并白内障患者行超声乳化白内障摘出人工晶状体植入联合小梁切除术，术后观察眼压、视力、滤过泡等情况。结果术前用药后平均眼压为（２３．６２±１２．３３）ｍｍＨｇ，术后１周、３月平均眼压为（１６．３７±５．３８）ｍｍＨｇ、（１５．７２±４．９６）ｍｍＨｇ。术后矫正视力数指１眼，０．１～０．５者２６眼，０．６～１．２者９眼。结论超声乳化白内障摘出人工晶状体植入联合小梁切除术安全有效，适用于青光眼合并白内障患者。     

亲水性丙烯酸酯折叠人工晶状体在白内障超声乳化吸除术中的应用

目的:观察亲水性丙烯酸酯ACR6D SE折叠人工晶状体在白内障超声乳化手术中的应用效果.方法:对145例(204眼)白内障患者行超声乳化白内障吸除及ACR6D SE人工晶状体植入术,观察术中术后并发症、术后视力,术后随访时间≥3mo.结果:术中术后并发症为后囊膜破裂1眼(0.5%),人工晶状体脱位2眼(1.0%),角膜水肿12眼(5.9%),后囊膜混浊4眼(2.0%),术后眼压升高1眼(0.5%),前房渗出3眼(1.5%).结论:ACR6D SE人工晶状体能较好的提高视力;术后反应轻,并发症少.     

小梁切除术后晶状体超声乳化术的临床观察

目的 评价青光眼小梁切除术后的白内障进行超声乳化人工晶状体植入术的效果.方法 对28例（30眼）青光眼小梁切除术后的白内障,采用超声乳化人工晶状体植入术,随访6月,观察术后视力及眼压等情况.结果 30眼术后视力均较术前明显提高,术后1月平均眼压较术前略有下降.结论 小梁切除术后白内障采用超声乳化人工晶状体植入术,可以保存原有青光眼滤过泡,术后反应轻,视力恢复好,手术安全可靠.