共查询到20条相似文献,搜索用时 31 毫秒
1.
M. Hernndez-Prez C. C. Snchez-Mateo V. Darias R. Rabanal 《Phytotherapy research : PTR》1994,8(8):465-469
Different extracts of Visnea mocanera L. f. (Theaceae) were evaluated for analgesic, antipyretic, antiinflammatory and ulcerogenic properties in mice and rats. The acetone extract from the leaves and the syrup from the fruits exerted central analgesic properties, associated with significant but transient antiinflammatory effects on acute inflammatory processes. The acetone extract also possessed topical antiinflammatory effects. The extracts assayed did not display antipyretic and ulcerogenic activity. Sub-acute toxicological experiments indicated a very low toxicity in mice. 相似文献
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Nicola Mascolo Aldo Pinto Francesco Capasso Abiy Yenesew Ermias Dagne 《Phytotherapy research : PTR》1988,2(3):154-156
The crude ethanol extract of the leaves of an African medicinal plant Teclea nobilis has been studied for its antipyretic, analgesic and anti-inflammatory activities. The extract exhibited marked antipyretic and analgesic activities while it was found to be weakly active against carrageenin oedema. 相似文献
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N. D. Onwukaeme 《Phytotherapy research : PTR》1995,9(4):306-308
Extracts of the stem bark of Daniellia oliveri using hexane, ethyl acetate and methanol were tested for analgesic, antipyretic and antiinflammatory activities. The hexane extract exhibited a dose related analgesic activity whilst the methanolic extract was active in the induced inflammatory condition. The ethyl acetate extract was relatively inactive and none of the extracts showed any antipyretic activity. Metabolic cage studies showed that a 70% ethanolic extract of the bark caused significant decreases in body weight, food intake, urine and stool output of rats. This extract also exhibited a competitive antagonism on histamine-induced contractions of the guinea-pig ileum and a non-competitive inhibition of acetyl choline-induced contraction of the frog rectus abdominis muscle. 相似文献
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The ethyl acetate fraction (EA) from the residue of an 85% ethanol extract of the latex of Euphorbia royleana (Euphorbiaceae) was investigated for antipyretic and analgesic properties. The results showed a dose related peripheral analgesic effect. The fraction assayed exhibited a significant antipyretic effect in hyperthermic rats and rabbits. The oral LD50 was more than 2 g/kg in rats and mice. © 1997 John Wiley & Sons, Ltd. 相似文献
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干姜乙醇提取物解热镇痛及体外抑菌作用研究 总被引:11,自引:0,他引:11
目的 研究干姜乙醇提取物(干姜醇提物)的抗炎、解热、镇痛和体外抑菌作用。方法 采用小鼠耳壳肿胀法,伤寒、副伤寒甲乙三联菌苗导致家兔发热反应以及小鼠扭体法观察干姜醇提物的抗炎、解热、镇痛作用;采用平皿二倍稀释法测定干姜醇提物的最低抑菌浓度(MIC)。结果 干姜醇提物抑制二甲苯所致小鼠耳壳肿胀及醋酸所致小鼠扭体反应,并具有明显的抑制伤寒、副伤寒甲乙三联菌苗所致家兔发热反应作用;干姜醇提物对8株菌的MIC范围为13.5~432mg/mL。结论 干姜醇提物具有明显的抗炎、解热、镇痛及体外抑菌作用。 相似文献
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Satish C. Jain R. Jain N. Mascolo F. Capasso R. Vijayvergia R. A. Sharma C. Mittal 《Phytotherapy research : PTR》1998,12(5):378-380
Pergularia daemia (Forsk.) Chiov. (Asclepiadaceae), a wild plant of the arid zone of Rajasthan, hasdemonstrated significant antiinflammatory, antipyretic and analgesic activities including the release of prostaglandin. © 1998 John Wiley & Sons, Ltd. 相似文献
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A. M. Forestieri M. T. Monforte S. Ragusa A. Trovato L. Iauk 《Phytotherapy research : PTR》1996,10(2):100-106
Antiinflammatory, analgesic and antipyretic activities and toxicity of different extracts (decoction, petroleum ether, ethanol and aqueous extracts) of: Afrormosia laxiflora (Benth. ex Bak.) Harms (leaves), Cyathula prostrata (L.) Blume (whole plant), Ficus glomerata Roxb. (leaves), Lantana camara L. (leaves), Lippia geminata H.B.K. (leaves), Lippia nodiflora (L.) Michx. (leaves) and Synedrella nodiflora (L.) Gaertn. (whole plant), were evaluated in pharmacological tests using rats and mice. 相似文献
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M. O. M. Tanira A. H. Shah A. Mohsin A. M. Ageel S. Qureshi 《Phytotherapy research : PTR》1996,10(1):33-36
The ethanol extract of the dried ripe fruit of Foeniculum vulgare (500 mg/kg) was tested for diuretic, analgesic, antipyretic, antimicrobial, cytotoxic activities and its effect on bile secretion in rats. Also, the acute toxicity after 0.5, 1 and 3 g/kg was investigated in mice. The extract showed diuretic, analgesic, antipyretic activities and it enhanced bile secretion. As an antimicrobial agent, the extract inhibited the growth of Staphylococcus aureus and Bacillus subtilis and showed a marked mitodepressive effect. At a dose of 3 g/kg, it caused piloerection and it depressed locomotor activity but caused no deaths when administered acutely to mice. 相似文献
9.
目的:卡巴匹林钙(考察卡巴匹林钙)的解热镇痛作用,为临床用药提供药效学资料。方法:用小鼠醋酸扭体和电刺激大鼠尾部疼痛模型考察卡巴匹林钙的镇痛作用;用啤酒干酵母致大鼠发热模型考察卡巴匹林钙的解热作用;并测定小鼠口服给药和静脉注射给药的急性毒性。结果:小鼠口服卡巴匹林钙对腹腔注射醋酸致扭体反应有明显镇痛作用,作用强度与剂量相关;大鼠口服卡巴匹林钙对电刺激大鼠尾部疼痛亦有明显镇痛作用,疼痛电压阈值的提高和镇痛维持时间与剂量呈正相关,镇痛起效时间与剂量呈负相关。结论:卡巴匹林钙口服对动物发热模型和疼痛模型具有明显的解热镇痛作用,其镇痛作用较解热作用起效快,但解热作用维持时间长。 相似文献
10.
R. E. opez-Garcia R. M. Rabanal V. Darias D. Martín-Herrera M. C. Carreiras B. Rodríguez 《Phytotherapy research : PTR》1991,5(6):273-275
Several extracts and fractions from Cedronella canariensis (L.) have been submitted to analgesic, antipyretic and antiinflammatory tests on rats and mice. The experimental results obtained justified the utilization of this species as an anticatarrh and antiinfluenza agent in Canarian folk medicine. Its acute toxicity turned out to be low as measured in mice. 相似文献
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The root of Hemidesmus indicus R. Br., commonly known as Indian Sarsaparilla, is used traditionally to treat a wide variety of illnesses including rheumatism, leprosy, impotence, urinary tract and skin infections. The anticancer, antioxidant, anti‐inflammatory, antipyretic, analgesic, antimicrobial, antidiabetic, hepatoprotective, cardioprotective, renoprotective, neuroprotective and immunomodulatory properties of H. indicus have been investigated in numerous in vivo and in vitro studies. Among these, the antioxidant and antimicrobial activity was well documented. This review details the phytochemistry and therapeutic applications of H. indicus root. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
15.
Nisar M Adzu B Inamullah K Bashir A Ihsan A Gilani AH 《Phytotherapy research : PTR》2007,21(7):693-695
A methanol extract of Zizyphus oxyphylla Edgew leaves has been investigated for its analgesic and antipyretic activities in Adult Wistar and Swiss albino mice of either sex at 50, 100 and 200 mg/kg orally. The extract demonstrated marked antipyretic activity against Brewer's yeast-induced pyrexia in rats. The extract demonstrated significant peripheral analgesic effect in the acetic acid-induced writhing test in mice. The phytochemical tests revealed that the extract contained alkaloids, anthraquinones, flavonoids, glycosides, phenols, resins, saponins and tannins using standard procedures. In conclusion, the present study suggests that the methanol extract of Zizyphus oxyphylla Edgew leaves possesses potent antipyretic and antinociceptive activities and thus validates its use in the treatment of pain and fever. 相似文献
16.
The aqueous and methanol extracts of Achillea ageratum L. (Asteraceae) have been evaluated for analgesic, antipyretic and antiinflammatory properties in mice and rats in several experimental models. The aqueous extract exhibited significant activity in the analgesic and antiinflammatory assays but was unable to reduce hyperthermia. Moreover, the methanol extract exerted effects in three pharmacological actions. The phytochemical investigation of this latter extract revealed the presence of flavonic compounds: luteolin, quercetin and 7-O-β-luteolin. © 1997 John Wiley & Sons, Ltd. 相似文献
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Some pharmacological actions of ethanol extracts of M. elliptica, M. bracteata, M. quinquenervia and M. styphelioides as well as the volatile oil of M. elliptica were experimentally investigated. The ethanol extracts of the plants were nontoxic (LD50 are 102.5, 260.0, 147.5 and 168.0 mg/kg b.wt, respectively). The extracts inhibited spontaneous contraction of smooth muscle of isolated rabbit intestine and rat uterus. They produced myocardial inhibition and decreased the motility of Taenia worms. Ethanol extracts of M. elliptica, M. bracteata, M. quinquenervia and M. styphelioides had no antipyretic, antiinflammatory or molluscicidal activities, whereas the ethanol extract of M. styhphelioides had an analgesic effect in mice. The volatile oil of M. elliptica inhibited the intestinal motility but stimulated the myocardial contractions of rabbits. It had analgesic, molluscicidal and antimicrobial activities, but lacked both antipyretic and antiinflammatory effects. 相似文献
18.
目的:比较栽培与野生苦参的清热、利尿、镇痛方面的药效学作用。方法:以干酵母致大鼠高热模型比较栽培苦参与野生苦参的解热作用;以代谢笼收集大鼠不同时间点的排尿量和总尿量比较栽培与野生苦参的利尿效果;采用热板和扭体法比较观察其对小鼠的镇痛作用。结果:栽培与野生苦参(1,2,4 g.kg-1剂量)均能明显降低酵母菌致热模型大鼠的体温;明显增加大鼠不同时间段的排尿量和排尿总量;栽培与野生苦参3,6 g.kg-1剂量均可明显提高小鼠的热板痛阈值、明显延长小鼠出现扭体的潜伏期并明显减少小鼠的扭体次数,表明其具有非常明显的镇痛作用。结论:栽培苦参与野生苦参都具有明显的清热、利尿和镇痛方面的作用,药效学作用强度比较野生与栽培苦参无显著差异,本实验结果为栽培苦参代替野生苦参提供了实验依据。 相似文献
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The dried ethanol extract of the whole plant of Cuscuta campestris Yuncker was studied for its analgesic, antipyretic, antiinflammatory as well as CNS-depressant activities. The extract was given orally at doses of 50 and 100 mg/kg. A significant protection against the p -benzoquinone-induced writhing response in mice was observed. A marked lowering of the body temperature of both hyperthermic as well as normothermic mice was produced. Therefore, the extract possesses a hypothermic rather than an antipyretic effect. A marked inhibition of the carrageenan-induced rat hind paw oedema was also obtained. Regarding its CNS action, the extract produced a decrease in the motor activity of mice placed on a rotarod. In the conditioned avoidance reaction test the percentage of failure to avoid electric shock was shown to be increased after administration of the extract without any effect on the escape behaviour of the trained rats. Therefore, the CNS-depressant activity of the extract seems to be due to a tranquillizing effect. It could be concluded that the extract possesses analgesic, hypothermic, antiinflammatory as well as CNS-depressant activities. 相似文献