Lymphomatoid papulosis in an 8-month-old child. 9-year remission

We report a case of lymphomatoid papulosis remarkable for its unusually early onset and spontaneous remission which has now lasted for 9 years.     

Merkel Cell Polyomavirus Detection in a Patient with Familial Epidermodysplasia Verruciformis

We report a case of Merkel cell polyomavirus detection in the skin of a patient with epidermodysplasia verruciformis (EDV) and a family history remarkable for an unusual inheritance pattern for EDV.     

Lichen nitidus with hyperpigmentation

Lichen nitidus in its monosymptomatic form is a rare condition. In this report a patient is described with a remarkable hyperpigmentation of the lesions. The nosological significance of this finding is discussed.     

Trichobacteriosis: case report and dermoscopic study

The authors report a case of axillary trichobacteriosis in a 16 year-old patient whose complaints were bromhidrosis and hyperhidrosis axillaris. Although it can be diagnosed clinically, dermoscopy may be useful in some cases and reveal remarkable academic images.     

Systemic hyalinosis of delayed onset

We report a 46-year-old Japanese male with systemic hyalinosis. The condition had not been present during youth but was clearly evident in the patient's forties. The present case is remarkable because of a delayed onset.     

A unique presentation of calcinosis cutis in a patient with cystic fibrosis after double lung transplants

Calcinosis cutis is the deposition of insoluble calcium salts in the skin and subcutaneous tissue. We report the case of a 28-year-old Caucasian woman with cystic fibrosis in whom strikingly symmetrical and reticulate calcinosis cutis developed on the lower extremities, which was noted on histology to spare the eccrine glands. Careful review of the literature fails to reveal any previous report with these remarkable cutaneous and histologic manifestations.     

Leg ulcerations due to livedo vasculitis: successful combined therapy with pentoxifylline and nifedipine

We report a patient with livedo vasculities with painful leg alterations in whom prolonged combined therapy with pentoxifylline and nifedipine of 2 years duration induced a remarkable and long-lasting improvement of the disease. During the period no occurrence of the ulcerations has been observed.     

Coexistence of palmoplantar lichen planus and lupus erythematosus with response to treatment using acitretin

Lichen planus and lupus erythematosus may occur as an overlap syndrome. Here we report the clinical characteristics of a 49-year-old man with palmoplantar lichen planus and lupus erythematosus. He showed a remarkable clinical response to treatment with acitretin, which resulted in prolonged remission of the disorder.     

Management of recalcitrant vitiligo in Vogt-Koyanagi-Harada syndrome: Adjuvant ablative fractional laser

The course of dermatologic findings in Vogt-Koyanagi-Harada disease is variable. Herein, we report the remarkable repigmentation of widespread facial vitiligo lesions in an adolescent girl with Vogt-Koyanagi-Harada disease. The patient was treated with a combination of fractional erbium:YAG laser, topical tacrolimus, and phototherapy.     

Familial occurrence of multiple basalomas associated with hyperostotic spondylosis

We report on brother and sister suffering from hyperostotic spondylosis and multiple basal cell carcinomas. Localisation and multiplicity of the tumors are remarkable. On account of the family tree, we assume recessive inheritance.     

Facial superficial porokeratosis

A case of exclusively facial superficial porokeratosis occurring in a young man is reported. These lesions were asymptomatic and remarkable because of their location. Histopathology revealed a typical superficial porokeratosis. Exclusively facial porokeratosis is an unusual clinical presentation. To our knowledge, it is the second report of a case with exclusively facial involvement.     

Papillon-Lefévre Syndrome

Papillon-Lefèvre syndrome is a rare autosomal recessive disorder of palmoplantar keratinization in which there is a unique association of the palmoplantar hyperkeratosis and premature loss of both deciduous and permanent teeth. We report three patients with papillon-lefèvre syndrome who showed a remarkable degree of improvement after treatment with an oral retinoid.     

Circumscribed scleroderma combined with lichen sclerosus et atrophicus

We report on two patients suffering from circumscribed scleroderma as well as lichen sclerosus et atrophicus. The cases are remarkable because it was possible to demonstrate histopathologic markers of both conditions in the same specimen.     

Salivary gland lymphoplasmacytoid lymphoma with nodular cutaneous amyloid deposition and lambda chain paraproteinaemia

Summary We report the case of an 83-year-old woman who developed a lymphopiasmacytoid lymphoma of the salivary glands with extension to the skin of the cheeks and laterofcrvical area. The most remarkable feature was the massive amyloid deposition that gave the cutaneons lesions a distinctive clinical appearance, similar to that observed in cases of modular cutaneous amyloidosis. An IgM-lambda paraprotein was also detected in the serum.     

Linear immunoglobulin a bullous disease of childhood responsive to intravenous immunoglobulin monotherapy

We report a case of linear immunoglobulin A bullous disease in a 9-year-old boy who presented with rapidly progressive severe disease and could not tolerate dapsone because of high liver enzymes within a week after a low dose of dapsone in association with an underlying fatty liver. He showed remarkable improvement with intravenous immunoglobulins used as monotherapy, with a rapid clearance and a sustained remission after stopping the treatment.     

Myelodysplastic syndrome following treatment of malignant melanoma with vincristine, ACNU, and dacarbazine

Therapy-related myelodysplastic syndrome is a rare adverse effect in melanoma patients elicited by chemotherapy. We report a case of myelodysplastic syndrome following treatment of malignant melanoma with alkylating agents. Peripheral blood showed a remarkable suppression of three cell lineages, and the bone marrow was slightly hypercellular. However, no morphological abnormalities were detected in the peripheral blood or the bone marrow, and chromosomal analysis was normal.     

Pachyonychia congenita tarda

Pachyonychia congenita is a distinct hereditary disorder of keratinization, in which dystrophy of all nails is associated with palmoplantar keratoderma and other hyperkeratoses. Recently a late-onset type has been reported. We report a second family with late-onset pachyonychia congenita, showing a remarkable clinical heterogeneity. Furthermore, one patient demonstrated a number of associated hyperkeratoses not previously recognized. Acitretin proved useful in the treatment of this late-onset form of pachyonychia congenita.     

Eosinophilic Panniculitis

Abstract: Eosinophilic pannicuiitis is a pooriy defined entity with variabie ciinicai features. We report a case of rapidiy eniarging, asymptomatic subcutaneous scalp nodules in a 6-year-old biack boy with atopic dermatitis. The noduies resolved spontaneously over two to three days. Biopsy specimens were remarkable for eosinophilic pannicuiitis without evidence of epidermal change or vasculltis. We beiieve that this is the youngest reported patient with this disorder.     

Acanthosis nigricans with severe obesity, insulin resistance and hypothyroidism: improvement by diet control.

We report on a 27-year-old man with acanthosis nigricans (AN) associated with severe obesity, insulin resistance and hypothyroidism. A very low-calorie diet treatment decreased his weight and then ameliorated the insulin-resistant state. These effects were followed by remarkable improvement of the AN prior to the correction of the hypothyroidism. This confirms that AN may be mainly attributed to insulin resistance rather than hypothyroidism per se.     

Primary cutaneous nocardiosis caused by Nocardia takedensis with pulmonary dissemination in an immunosuppressed patient

We present a remarkable case of primary cutaneous nocardiosis with pulmonary dissemination due to Nocardia takedensis in a 76‐year‐old man suffering from marginal zone lymphoma and hypogammaglobulinaemia. We also discuss an alternative treatment to trimethoprim‐sulfamethoxazole, which could be contraindicated due to haematological and cutaneous toxicities. This case report is of interest due to the emergence of cutaneous nocardiosis in dermatology.