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1.
研究地奥心血康对高脂血症大鼠血脂及脂蛋白的影响。用高脂饲料喂服雄性wistar大鼠,复制高脂血症大鼠模型。动物分5组:1、正常对照组:给予基础饲料+生理盐水。2、高脂模型组:高脂饲料+生理盐水。3-4、地奥心血康010、020g/kg组:高脂饲料+地奥心血康;5、阳性药肌醇烟酸酯组:高脂饲料+肌醇烟酸酯(01g/kg),连续灌胃给药10d后采血,测定血清甘油三脂(TG),总胆固醇(TC),高密度脂蛋白(HDL-C),计算低密度脂蛋白(LDL-C)。地奥心血康020、010g/kg均能明显降低高脂血症大鼠TC、TG、LDL-C(P<005P<001(与高脂模型组比),分别使TC降低30%、19%;TC降低45%、20%;使LDL-C降低57%、31%;020g/kg也能升高HDL-C,为12%。地奥心血康能降低高脂血症大鼠TC、TG、LDL-C水平而升高HDL-C水平  相似文献   

2.
加钙海带对实验性动物高脂血症的影响   总被引:2,自引:0,他引:2  
谢露 《广西医学》2000,22(5):945-947
目的:探讨钙与海带高速血脂的协同作用。方法:对比加钙海带制剂与海带对实验性动物高脂血症的影响。结果:加钙海带制剂降低实验性高血脂小白鼠血清甘油三酯(TG)的作用大于海带(P〈0.01),而且前者降低实验性高血脂大白鼠血清低密度脂蛋白胆固醇(LDL-C)和升高血清高密度脂蛋白胆固醇(HDL-C)的作用均大于后者(P〈0.05)。结论:钙与海带对实验性动物高脂血症的影响有协同作用。  相似文献   

3.
采用血脂康与多烯康分别治疗高脂血症,血脂康组总有效率达93.8%,用药4周TC、TG、LDL-C、动脉粥样硬化指数(AS指数)均有显著下降(P〈0.01),用药8周进一步下降(P〈0.01),HDL-C明显升高(P〈0.05)。多烯康组用药8周TC、TG、LDL-C、AS指数亦有明显下降,但HDL-C无显著变化。结论:血脂康调脂作用明显优于多烯康。  相似文献   

4.
血脂康与脂必孕对高胆固醇血症的调脂作用比较   总被引:4,自引:0,他引:4  
肖超烈  贺淑梅 《广东医学》2000,21(5):430-431
目的 比较两种国产中药血脂康和脂必孕的调脂作用。方法 60例高脂血症患者(实际完成57例)随机分成两组,服药前及服药后4,8周则血脂。结果 (1)两种药物在4周时TC分别下降19%(P〈0.001)和11%(P〈0.05),TG分别下降21%,23%(P均〈0.01);LDL-C分别下降27%(P〈0.05),14%((P〉0.05);脂必孕在8周时LDL-C下降22%(P〈0.05),HDL-C  相似文献   

5.
应用放射免疫方法测定24例先天性心脏病(CHD)患者血浆内此素-1(ET-1)及骨源性类洋地黄素(EDLF)水平。结果显示:血浆ET-1水平CHD组明显高于正常对照组(P〈0.01),CHD-LR组明显高于CHD-RL组(P〈0.01);血浆EDLF水平CHD组明显低于正常对照组(P〈0.01),CHD-LR组略高于CHD-RL组(P〉0.05)。提示ET-1及EDLF在CHD的病理生理过程中起一  相似文献   

6.
化脂灵治疗高脂血症的临床研究   总被引:11,自引:0,他引:11  
用随机、对照的方法,将181例原发性高脂血症患者按1:0.8比例分化脂灵组100例,对照组81例。治疗前、后1个月分别观察其血甭总胆固醇(CH)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、极低密度脂蛋白胆固醇(VLDL-C)的变化。结果,化脂灵组治疗前后比较,效果显著(P〈0.05 ̄0.01)。两组治疗后比较,其中TG、CH、LDL-C化肥灵组优于对照组(P〈0.05)。另外,还观察了血  相似文献   

7.
①目的观察海通片对高脂血症大鼠血脂的调节作用。②方法观察海通片预防性用药(30d)和治疗性用药(15d)对外原性高脂血症大鼠血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)和高密度脂蛋白(HDL)含量的影响。③结果海通片预防性用药可使大鼠HDL升高(t=2.241~2.766,P均<0.05),治疗性用药可使升高的TC迅速降至正常水平(t=2.370~3.087,P<0.05,0.01),并使血清TG和LDL含量显著降低(t=2.296~4.124,P<0.05,0.01)。④结论海通片对高脂血症大鼠有调节血脂作用。  相似文献   

8.
观察了维脂泰胶囊对高脂血症的降脂作用。将患者随机分为治疗组56例,对照组降脂平25例,月见草效丸37例,疗程均为4个月。结果,治疗组治疗前后TC,TG,TC-HDL-C/HDL-C均有显著差异,P〈0.01,疗效明显优于月见草油丸组,P〈0.01;与降脂平组相比,HDL-C及TC-HDL-C/HDL-C改变有显著差异,P〈0.05。  相似文献   

9.
将91例原发性高脂血症随机分为3组,分别用普伐他汀(P)、非诺贝特(F)、鱼油(FO)12周,结果3组甘油三酯(TG)、低密度脂蛋白(DL-C)、载脂蛋脂白B100(ApoB100)均明显降低(P〈0.05-0.001);高密度脂蛋白(HDL-C)均升高,但仅F组有显著意义(P〈0.05-0.001);胆固醇(TC)、P组、F组显著降低(P〈-0.05-0.001);HLD-C与TG3组均呈负相关  相似文献   

10.
益肾降脂片对慢性肾衰病人血脂及过氧化脂质影响   总被引:9,自引:0,他引:9  
本文将106例慢性肾衰病人随机分为两组,治疗组用益肾降脂片(由冬虫夏草、绞股蓝总甙、黄芪、葛根组成);对照组用西药治疗。结果:治疗组BUM、SCr明显下降(P〈0.01),与对照组同期比较,有显著性差异(P〈0.05);临床疗效也明显高于对照组(P〈0.05),治疗组降低Tch、TG作用明显优于对照组(P〈0.01和0.05),同时治疗组还有降低LDL-C和LPO作用,提高HDL-C作用,对照组和  相似文献   

11.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

12.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

13.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

14.
目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.  相似文献   

15.
Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P<0.01);the MAP decreased(P<0.01)and the HR increased drastically(P<0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.  相似文献   

16.
Objective:To investigate the gene expression of osteoprotegerin(OPG) and osteoclast differentiation factor(ODF) in the bone tissue of patients with hip fracture due to osteoporosis. Methods:OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers(over 50 years old) with hip fracture(Observer Group) and 30 cases of hip facture sufferers with no osteoporosis(Control group) were analyzed with the Semi-Quantitative RT-PCR method. Results:The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion:Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

19.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

20.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

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