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吴世蓉 《现代中药研究与实践》2002,16(3):24-24
丹参是唇形科植物丹参 Salvia miltiorrhizaBge.的干燥根及根茎[1] 。其味苦性微寒 ,归心、肝经。具有祛瘀止痛 ,活血通络 ,清心除烦的功效。其分布广泛。其中以安徽、山西等地产量最大 ,此外尚有甘肃丹参、褐毛丹参、滇丹参等几种植物的根亦作丹参入药 [2 ]。丹参的活性成分为两类 ,一类为脂溶性的二萜醌类 ,具有抗菌、抗炎及扩张血管作用 ,另一类为水溶性的酚酸类化合物 ,具有明显的抗凝 ,溶纤及很强的抗脂质过氧化作用。本文作者用高效液相色谱法对丹参中丹参酮 A 和原儿茶醛进行测定 ,比较了不同产地丹参中丹参酮 A 和原儿茶醛的含… 相似文献
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丹参和白花丹参叶的化学成分药理研究及临床应用 总被引:1,自引:0,他引:1
目的:探讨丹参和白花丹参叶的化学成分药理研究及临床应用,为新药的研制奠定基础。方法:通过参阅大量相关文献,对丹参和白花丹参叶的化学成分、药理研究及临床应用进行分析总结。结果:丹参和白花丹参叶所具有的抗氧化作用均能较好的预防脑梗塞,与根相比叶对脑缺血的保护作用更强,在对心脑血管疾病的防预治疗中被广泛应用;白花丹参叶中的水提物对糖尿病代谢紊乱症状的改善能够起到长期稳定的效果;另外丹参叶在治疗扁平疣、冠心病心绞痛等方面也具有较好的效果。结论:丹参和白花丹参叶均具有稳定的药理作用,但目前在抗氧化和保护脑梗塞的药理研究中仍以白花丹参叶为主,对于丹参叶的药理研究和临床应用则很少。因此对丹参叶主要化学成分进行深入的药理研究是很有必要的。 相似文献
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用理化、薄层等方法,对丹参和甘肃丹参的化学成分、抑菌作用等方面进行了比较研究。结果表明:二者的化学成分、抑菌作用具有明显为差别,肯定了甘肃丹参为丹参伪品的结论,并为丹参的真伪鉴别提供了科学的依据。 相似文献
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AIM: Ursolic acid (UA), a pentacyclic triterpenoid, is used as an anti-inflammatory and anti-cancer agent. There were few studies on the effects of UA on differentiation, and this is the first time to elucidate the potential effect and molecular mechanism of UA on inducing differentiation in the human leukemia cell line U937. METHODS: Wright-Giemsa staining, nitroblue tetrazolium reduction assay and flow cytometric analysis were utilized to demonstrate the differentiation of U937 cells induced by UA. Western blotting and immunofluorescence assay were used to investigate the possible mechanism. RESULTS: It was found that UA could induce the differentiation of U937cells and Akt-activity was significantly increased during differentiation. Additionally, LY294002, a PI3K-Akt inhibitor, could block the differentiation of U937 cells induced by UA. CONCLUSION: UA could induce the differentiation of U937 cells by activating the PI3K/Akt pathway, and it could be a potential candidate as a differentiation-inducing agent for the therapy of leukemia. 相似文献
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ZHAO Ren-Ping LIN Sen-Sen YUAN Sheng-Tao YU Bo-Yang BAI Xian-Shu SUN Li ZHANG Lu-Yong 《中国天然药物》2014,(1):24-29
AIM: To investigate the anticancer activity of DT-13 under normoxia and determine the underlying mechanisms of action. METHODS: MDA-MB-435 cell proliferation, migration, and adhesion were performed to assess the anticancer activity of DT-13, a saponin from Ophiopogonjaponicus, in vitro. In addition, the effects of DT-13 on tumor growth and metastasis in vivo were evaluated by orthotopic implantation of MDA-MB-435 cells into nude mice; mRNA levels of vascular endothelial growth factor (VEGF), C-C chemokine receptor type 5 (CCR5) and hypoxia-inducible factor 1a (HIF-1a) were evaluated by real-time quantitative PCR; and CCR5 protein levels were detected by Western blot assay. RESULTS: At 0.01 to 1 umol·L -1, DT-13 inhibited MDA-MB-435 cell proliferation, migration, and adhesion significantly in vitro. DT-13 reduced VEGF and CCR5 mRNAs, and decreased CCR5 protein expression by down-regulating HIF-1 a. In addition, DT-13 inhibited MDA-MB-435 cell lung metastasis, and restricted tumor growth slightly in vivo. CONCLUSION: DT-13 inhibited MDA-MB-435 cell proliferation, adhesion, and migration in vitro, and lung metastasis in vivo by reducing VEGF, CCR5, and HIF-la expression. 相似文献
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OBJECTIVE: To evaluate systematically the clinical efficacy and safety of Qingkailing(QKL) injection in the treatment of acute stroke.METHODS: Searches for randomized controlled trials into acute stroke treated with QKL injection were performed in the China National Knowledge Infrastructure Database, China Science and Technology Journal Database, Wan fang Database,Chinese Biomedical Literature Database, PubMed and Cochrane Library, from January 1979 to March2013. Two reviewers independently retrieved the RCTs and extracted the information. The Cochrane risk of bias method was used to assess the quality of the included studies, and a Meta-analysis was conducted with Review Manager 5.2 software.RESULTS: A total of 13 studies with 1110participants were included. The quality of the studies was generally low. The Meta-analysis indicated that the combined use of QKL and Western Medicine was significantly superior to control group therapy in terms of the total effective rate. The relative risk(RR) in the acute cerebral hemorrhage(ACH) sub-group was 1.17 [95%confidence interval(CI)(1.08, 1.26), P=0.0001]. In the acute cerebral infarction(ACI) sub-group, RR was 1.27 [95% CI(1.14, 1.42), P0.0001], and in the ACH and ACI mixed sub-group, RR was 1.34 [95% CI(1.20,1.50),P0.00001]. Additionally, QKL promoted the absorption of hematoma [mean difference(MD)=﹣3.73, 95%CI(﹣4.48, ﹣2.98), P0.000 01],decreased neurological damage in ACI [MD=﹣5.60, 95% CI(﹣8.50, ﹣2.70), P=0.0002] and ACH[MD= ﹣ 4.08, 95% CI( ﹣ 8.00, ﹣ 0.16), P=0.04],promoted the recovery of awareness [RR=1.56, 95%CI(1.09, 2.21), P=0.01] and reduced the whole blood viscosity coefficient [MD=﹣ 0.75, 95% CI( ﹣1.47, ﹣0.03), P=0.04]. There were no adverse drug reactions reported in the included studies.CONCLUSION: Based on this systematic review,QKL combined with conventional therapy was effective compared with control treatment.However, because the articles used in the study were not of high quality, further studies should be conducted into the efficacy and safety of QKL in treating acute stroke. 相似文献
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Effects of feeding tyrosine and phenylalanine on the accumulation of phenylethanoid glycosides to Cistanche deserticola cell suspension culture 总被引:1,自引:0,他引:1
AIM: To investigate the effects of feeding phenylalanine (Phe) and tyrosine (Tyr) on the accumulation of total phenolic compounds and four phenylethanoid glycosides (PeGs) to a cell suspension culture of the parasitic plant Cistanche deserticola.METHOD: A cell suspension culture of C. deserticola was established and precursors of different concentrations were fed. In each group, the cell was sampled at the 24^th day after inoculation. The content of total phenolic compounds and four PeGs compounds were determined using the Folin-Ciocalteu method and an HPLC method, respectively.RESULTS: In the Phe fed cells, the maximum PeGs yield was achieved when Phe was fed at 1.5 mmol·L^-1 and the yield reached 1.13 times the control cell concentration. In the Tyr fed cells, the maximum yield of PeGs was 1.60 times of control when 0.75 mmol·L^-1 Tyr was fed to the cells. Furthermore, it was found that the salidroside yield was 4.01 times of control group when 5 mmol·L^-1 Tyr was fed.CONCLUSION: Tyr is a better precursor for PeGs accumulation compared with Phe, and the rate limiting enzymes might be involved in the Tyr branch. 相似文献
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Tao Huang Lijian Yang Shuyong Jia Xiang Mu Mozheng Wu HangYe Weizhe Liu Xinnong Cheng 《Journal of traditional Chinese medicine》2013,(6):757-760
OBJECTIVE; To observe capillary blood flow at acu- points during acupuncture treatment of primary dysmenorrhea and gain new insights into its anal- gesic mechanism. METHODS: Patients with primary dysmenorrhea were enrolled and randomly assigned to a treat- ment or control group. Subjects' symptoms were differentiated into various Traditional Chinese Medi- cine (TCM) syndromes and treated for 10 sessions with puncturing acupuncture or self-pressing right-hand Hegu (LI 4), adding other acupoints based on syndrome. Laser speckle was used tocompare the change in the vasomotor amplitude and perfusion of the capillaries in Hegu (LI 4) be- fore and during the treatment. Each subject was re- quired to finish the period pain symptoms observa- tion form, verbal rating scales, numerical rating scale, pain rating index, face rating scale, Zung self-rating depression scale, Zung self-rating anxi- ety scale, and numerical rating scale before and af- ter treatments. RESULTS: After 10 sessions, the symptom scores, pain index (PI), and visual analog scale (VAS) de- creased significantly in treatment group. The vol- ume of blood flow in Hegu (LI 4) declined slightly. No significant evidence supported that needling caused capillary contraction, but the capillary vaso- motor amplitude at Hegu (LI 4) increased remark- ably. CONCLUSION: Acupuncture can increase the capil- lary blood flow, thus promoting the flow of Qi and blood in terms of TCM theory, which facilitates pain relief. 相似文献
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Yin Chen Halmurat·Upur Meizuo Zhong Renaguli·Aizezi 《Journal of traditional Chinese medicine》2014,(1):30-33
OBJECTIVE: To investigate the relationship in ma- lignant-neoplasm patients of hypercoagulability between syndromes differentiated with the theory of abnormal hilit in traditional Uyghur medicine(TUM). METHODS: A total of 248 patients with malignant tumors were enrolled. Based on the theory of TUM they were divided into two groups: abnormal Sav- da and abnormal Non-Savda(including abnormal Khan, abnormal Sepra and abnormal Belghem types); fifty healthy volunteers were selected as controls. Platelet(PLT), prothrombin time(PT), plas- ma fibrinogen(FIB), thrombin time(TT), activated partial thromboplastin time(aPTT) and D-Dimer(D-D) were measured in both groups. RESULTS: Compared with the control and abnor-mal Non-Savda groups, in the abnormal Savda group the PLT count increased(P0.05), the PT was lengthened(P0.01), and the FIB significantly in- creased(P0.01). D-Ds in the three groups were sig- nificantly different(P0.05). No significant differ- ence was found inTT and aPTT values(P0.05). CONCLUSION: Hypercoagulability existed in pa- tients with malignant tumors in the different types of TUM syndromes, especially in the abnormal Sav- da group; this was characterized by increased blood viscosity, platelet aggregation and thrombo- sis. D-D appears to be a significant predictor for the therapeutic effect of TUM in relation to malignant tumor therapies. 相似文献
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Yi Chen Huasheng Tong Wang Zhang Xingqin Zhang Zhigguo Pan Junming Qiu Ruihuan Pan Lei Su 《Journal of traditional Chinese medicine》2013,(6):743-751
OBJECTIVE: To investigate the curative effects of Xuebijing (XBJ) injection, a Chinese patent medi- cine, on severe pulmonary contusion (PC). METHODS: Sixty-three patients with PC were ran- domized to conventional therapy plus XBJ injec- tion (n=33) or conventional therapy alone (n=30). Between groups differences in corticosteroid treat- ment, immune regulation therapy, hemofiltration, infusion volume, transfusion volume and antibiotic period were measured, as were intensive care unit(ICU)-free time, ventilation time, 28-day mortality rate and incidence of ventilation-associated pneu- monia (VAP). Serum concentrations of procalcito- nin (PCT), tumor necrosis factor-a (TNF-a), interleu- kin (IL)-6, and 11_-10, white blood cell (WBC) counts and percentages of human leukocyte antigen DR/ CD14+ (HLA-DR/CD14+) peripheral blood mononu- clear cells were compared. Markers of ventilation were determined by blood gas analysis and ventila- tor parameters. RESULTS: WBC counts and serum concentrations of PCT, TNF-a, 11.-6 and IL-10 were reduced signifi- cantly more quickly, and CD14+ percentage was in- creased significantly earlier, in the XBJ group than in the control group (P〈0.05 each). The level of ven- tilation and oxygenation index were ameliorated earlier in the XBJ than in the control group (P〈 0.05). XBJ treatment significantly reduced ICU-free time, ventilation time and incidence of VAP (P〈0.05 each), but had no effect on 28-day mortality rate (P〉0.05). CONCLUSION: XBJ treatment can shorten ICU-free and ventilation times and reduce the incidence of VAP, improving outcomes in patients with severe PC. XBJ may act by regulating inflammation and im- munity, alleviating systemic inflammatory response syndrome induced by trauma. 相似文献
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JIN Shi-Ying HAN Jin JIN Shi-Xiao LV Qing-Yuan BAI Jin-Xia CHEN Hong-Ge LI Rui-Sheng WU Wei YUAN Hai-Long 《中国天然药物》2014,(1):71-80
AIM: To improve the absorption and bioavailability of baicalin using a nanocrystal (or nanosuspension) drug delivery system. METHODS: A tandem, ultrasonic-homogenization-fluid bed drying technology was applied to prepare baicalin-nanocrystal dried powders, and the physicochemical properties of baicalin-nanocrystals were characterized by scanning electron microscopy, photon correlation spectroscopy, powder X-ray diffraction, physical stability, and solubility experiments. Furthermore, in situ intestine single-pass perfusion experiments and pharmacokinetics in rats were performed to make a comparison between the microcrystals of baicalin and pure baicalin in their absorption properties and bioavailability in vivo. RESULTS: The mean particle size of baicalin-nanocrystals was 236 nm, with a polydispersity index of 0.173, and a zeta potential value of-34.8 mV, which provided a guarantee for the stability of the reconstituted nanosuspension. X-Ray diffraction results indicated that the crystallinity of baicalin was decreased through the ultrasonic-homogenization process. Physical stability experiments showed that the prepared baicalin-nanocrystals were sufficiently stable. It was shown that the solubility of baicalin in the form of nanocrystals, at 495 ug·mL-1, was much higher than the baicalin-microcrystals and the physical mixture (135 and 86.4 ug·mL- 1, respectively). In situ intestine perfusion experiments demonstrated a clear advantage in the dissolution and absorption characteristics for baicalin-nanocrystals compared to the other formulations. In addition, after oral administration to rats, the particle size decrease from the micron to nanometer range exhibited much higher in vivo bioavailability (with the AUC(0-t) value of 206.96 ± 21.23 and 127.95 ± 14.41 mg·L-1·h-1, respectively). CONCLUSION: The nanocrystal drug delivery system using an ultrasonic-homogenization-fluid bed drying process is able to improve the absorption and in vivo bioavailability of baicalin, compared with pure baicalin coarse powder and micronized baicalin. 相似文献
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OBJECTIVE: To research the curative effect of Chi- nese herbs for clearing away heat, promoting diure- sis, nourishing the kidney, and consolidating es- sence in children with Henoch-Schonlein purpura nephritis(HSPN) with internal accumulation of damp-toxin using randomized controlled observa- tions on large samples. To seek the mechanism of the therapy and its scope of indications. METHODS: Overall, 186 children with HSPN were randomly divided into two groups: treatment group(n=126) treated with Chinese herbs for clear- ing heat and promoting diuresis and a control group(n=60) treated with Western Medicine. The treatment was carried out for three courses of 4 weeks each. We recorded changes in patient urine routines, 24 h urinary protein, blood-coagulating series, immunoglobulin and T-cell subgroups, and improvements in main symptoms. We evaluated the alleviation of clinical symptoms and the im- provement of proteinuria, hematuria, and other lab-oratory test results. Finally, we analyzed the patient population suitable for this therapy according to the relationship between the grouping of patient body weight and curative effect. RESULTS: Damp-heat syndrome improved in the treatment group, with a significant difference in to- tal effective rate after a 4-week treatment(χ2= 13.5220, P=0.0002) and in curative rate after a 12-week treatment(χ2=6.3410, P=0.0118), com- pared to those in the control group.The curative ef- fect in the treatment group was greater than that in the control group but there was no statistical dif- ference between the two groups. The curative ef- fect after a 4-week treatment of patients in the treatment group weighing 30 kg or less based on Traditional Chinese Medicine(TCM) signs and uri- nary protein was significantly greater than that in the control group. However, there was no statistical difference in the curative effect on urinary red cells and various indexes after a 12-week treatment be- tween the two groups. CONCLUSION: Therapy for clearing away heat, pro- moting diuresis, nourishing the kidney, and consoli- dating essence using TCM is effective in children with HSPN from internal accumulation of damp-toxin. The therapy is especially suitable for patients weighing 30 kg or less. The curative effect may be related to the improvement of immune function and blood-coagulation. 相似文献