3种铸造桩核冠修复后牙的临床疗效观察

目的比较整体铸造、分瓣铸造和插销式铸造桩核冠修复后牙严重牙体缺损的临床效果。方法选择180例患者的193颗后牙残冠、残根,在修复前行完善的根管治疗,其中87颗采用整体铸造桩核冠,56颗采用分瓣铸造桩核冠,50颗采用插销式铸造桩核冠的方法修复后牙严重牙体缺损。通过对修复后2年的复查结果进行临床效果评价。结果3组铸造桩核冠修复的临床效果无显著性差异(P>0.01)。结论整体铸造、分瓣铸造和插销式铸造桩核冠用于修复后牙严重牙体缺损均可取得良好的临床效果。     

桩钉嵌体修复牙冠大面积缺损后牙的临床观察

目的 观察桩钉嵌体修复牙冠大面积缺损后牙的临床效果。方法 大面积牙冠缺损的后牙72颗，31颗用桩钉嵌体修复，41颗用铸造金属桩核冠修复，随访2年。结果 桩钉嵌体的修复成功率为90．3％，与铸造金属桩核冠无明显差别（P〉0．05）。结论 桩钉嵌体是修复后牙大面积牙冠缺损的有效方法之一。     

插销式和分瓣式铸造桩核冠修复的临床研究

我们在临床上采用插销式和分瓣式铸造桩核冠对严重缺损的后牙进行修复治疗,取得满意效果,现报告如下.     

平行与层叠铸造分瓣桩核冠修复的临床对比观察

目的：比较平行与层叠铸造分瓣桩核冠修复牙冠大部分缺损的恒磨牙,并观察比较两种桩核冠临床修复的效果。方法：对52颗经过完善根管治疗的大面积缺损的磨牙,均采用铸造分瓣桩核冠,其中27颗采用平行分瓣桩核冠修复,25颗采用层叠分瓣桩核冠修复,随访3年。结果：平行分瓣桩核冠修复与层叠分瓣桩核冠修复方法的成功率依次是96.3%和92.0%,两组之间经χ2检验,无显著性差异。结论：采用平行分瓣桩核冠和层叠分瓣桩核冠修复牙冠大部分缺损的磨牙,均可取得良好的临床效果。     

直接法与间接法分瓣桩核冠修复磨牙的临床观察

目的:观察直接法与间接法制作分瓣桩核冠修复严重缺损磨牙的临床效果。方法:对42颗经过完善根管充填后的严重缺损的磨牙,19颗行间接法制作分瓣桩冠修复,23颗行直接法制作分瓣桩核修复,并随访3年。结果:两组桩核冠修复的临床效果无显著性差异(P>0.05)。结论:直接法与间接法制作分瓣桩核冠修复严重缺损磨牙均可取得良好的临床效果。     

两种桩核冠修复磨牙残根的临床观察

目的:观察分瓣铸造桩核冠和成品螺纹桩树脂核冠在磨牙残根修复中的效果。方法:对69例严重缺损的磨牙,32例进行分瓣铸造桩核冠修复(A组),37例进行螺纹桩树脂核冠修复(B组),术后对其中61例残根随访2~3年。结果:54例使用良好(A组26例,B组28例),A组和B组的成功率分别为86%和90%,总成功率为88.5%。结论:两种桩核冠用于磨牙残根修复均可取得良好的临床效果。     

纤维桩与插销桩修复磨牙严重缺损的临床研究

目的比较2种桩核材料用于磨牙严重缺损的修复效果。方法80颗磨牙缺损患牙随机分为2组,分别进行玻璃纤维桩核冠修复和铸造插销式分体桩核冠修复,2年后对修复效果进行评价。结果玻璃纤维桩组出现1颗冠折;插销式分体桩组所有患牙均未出现冠松动脱落、冠桩脱落、冠折、根折、桩折,2组差异无统计学意义(P<0.05)。结论对于磨严重牙缺损患者,选用玻璃纤维桩核冠修复或铸造插销式桩核冠修复均可,但对于缺损严重合并牙根条件差的患牙,选用玻璃纤维桩需慎重。     

后牙残根残冠的利用与修复

目的探讨后牙残根残冠修复的临床效果。方法对185例210颗后牙残根残冠经过完善的根管治疗后进行铸造桩核修复,再根据缺牙情况作为全冠或者固定桥,附着体、套筒冠的基牙利用,临床观察2年。结果185例210颗患牙修复后成功202颗,失败8颗,成功率96.1%。结论经过完善的根管治疗后铸造桩核冠修复可使后牙残根残冠得以保留并发挥功能。     

后牙分体插入式铸造桩核冠修复的临床研究

目的：探讨后牙残根残冠的分体插入式铸造桩核冠修复的方法及临床意义。方法：对68颗后牙残根残冠应用分体插入式铸造桩核修复，观察患自我感觉、临床使用效果等。结果：68颗后牙修复后随访2年半至3年，所有患均使用良好。其中2颗根管预备中发生意外侧穿，早期有轻度胀痛：2颗根管超填，偶有不适感。结论：后牙残根残冠插入式铸造桩核冠修复，既方便、简洁，又解决了共同就位道的问题。     

分根术联合铸造桩核冠技术保存修复重度缺损下颌磨牙

目的：评价分根术联合铸造桩核冠技术保存修复重度缺损下颌磨牙临床效果。方法：对23颗符合入选标准的重度缺损下颌磨牙进行根管和牙周基础治疗后予以分根,必要时进行牙半切除术或牙冠延长术。6周后,再进行铸造桩核联冠修复。结果：1颗患牙失败,另1颗失访。其余患牙都经过2年以上的临床观察,均能进行正常的咀嚼功能,无明显不适。结论：分根术联合铸造桩核冠技术保存修复重度缺损下颌磨牙疗效确切,可行。     

柠檬精油对牙周致病菌抑制作用及其安全性初步研究

目的:探讨柠檬精油对牙周致病菌的体外抗菌活性及对细胞增殖的影响。方法:采用微量液体稀释法测定柠檬精油对Pg、Fn、Aa、Pi的最小抑菌浓度(minimal inhibitory concentration,MIC)及最小杀菌浓度(minimum bactericidal concentration,MBC);以较低浓度的MIC为标准稀释LEO作为实验组,采用MTT法测定柠檬精油对HUVECs的毒性作用,明确抑菌浓度下LEO的安全性。结果:柠檬精油对牙周主要致病菌均有抑菌作用,Pg、Fn、Aa、Pi的MIC分别是9.0 g/L、4.5 g/L、4.5 g/L、9.0 g/L,Aa、Fn的 MBC是9.0 g/L,Pg、Pi的MBC未测得。1/2MIC、1/20MIC浓度的LEO能够抑制人脐静脉内皮细胞的生长,而低于1/200MIC浓度的LEO则对人脐静脉内皮细胞的生长没有影响,其中1/200MIC浓度的LEO作用明显优于0.02%的CHX。结论:体外环境中,柠檬精油对牙周致病菌Pg、Fn、Aa、Pi具有抗菌活性,低浓度应用对机体相对安全。     

Oral cancer: molecular technologies for risk assessment and diagnosis

Purpose: The effective biomarkers related to diagnosis, metastasis, drug resistance and irradiation sensitivity of oral cancers will help the pathologist and oncologist to determine the molecular taxonomy diagnosis and design the individualization treatment for the patients with oral cancers.     

Computer-assisted planning for maxillofacial prosthodontic rehabilitation

Computerized tomography (CT) planning and the use of CT derived surgical templates for implant placement have shown promise for restoring function within months after surgical reconstruction of acquired post-oncologic defects.     

Stimulated whole saliva components in children with Down syndrome

The authors report on the components of stimulated whole saliva from children with Down syndrome—including pH, flow rate, sialic acid and protein concentrations, and amylase and peroxidase activity. Saliva samples were collected from 35 children aged 6–10 years. Of the participants, 17 had Down syndrome and 18 did not. To stimulate saliva production, the children chewed a piece of parafilm for 10 minutes before the sample was collected. Soon after collecting the saliva sample, the authors measured pH using a portable pH-meter. Sialic acid levels were determined with a thiobarbituric acid assay. Protein content was determined with Folin's phenol reagent. Amylase was assayed and the authors measured the maltose produced by the breakdown of starch and peroxidase using ortho-dianisidine.
No statistically significant difference was observed in levels of sialic acid (free and total) between the two groups. Protein concentration was about 36% higher in the group with Down syndrome. However, the salivary flow rate, pH, and amylase and peroxidase activities were lower among the children with Down syndrome.     

Effect of Pingyangmycin on human venous malformation endothelial cells

Purpose: Venous malformations are common vascular anomalies with a propensity of the head and neck. Intralesional injection of Pingyangmycin (PYM, bleomycin A5 hydrochloride) is a widely used sclerotherapy method for the treatment of venous malformation.     

替牙期骨性Ⅲ类错牙合患者颞下颌关节特征的锥形束CT研究

目的:采用锥形束CT(CBCT)研究替牙期骨性Ⅲ类错牙合患者颞下颌关节的影像学特征,探讨Ⅲ类功能状态下,颞下颌关节的生长、改建机制。方法:从就诊于昆明医科大学附属口腔医院正畸科的患者中选取符合纳入标准的替牙期骨性Ⅲ类错牙合患者及骨性Ⅰ类错牙合患者各20名,使用NNT viewer 5.3图像处理软件进行三维重建及线距和角度的测量,并进行统计学分析。结果:替牙期骨性Ⅲ类错牙合患者组和替牙期骨性Ⅰ类错牙合患者组对比结果为:矢状面双侧关节前间隙偏小、双侧关节上间隙偏小、双侧关节结节斜度偏小;冠状面双侧关节内间隙偏小,双侧关节上间隙偏小,双侧关节外间隙偏小,右侧髁状突角度偏小;横截面右侧髁状突前后径偏小。结论:替牙期骨性Ⅲ类错牙合患者颞下颌关节发育不充分,呈现髁状突,关节窝深度,关节结节斜度;冠状面关节内、外间隙均较小的特征。骨性Ⅲ类错牙合患者髁状突在关节窝中处于前置近关节窝顶位置。骨性Ⅲ类错牙合患者颞下颌关节影像学特征与其功能状态相适应。     

牙髓再生的研究现状

目前,根管治疗术在临床上已得到了广泛的应用并成功的保存了患牙,但其仍有许多术后并发症。随着组织工程技术在口腔领域的应用,构建一种组织工程化牙髓进行牙髓-牙本质复合体的再生治疗成为可能。近年来国内外已有很多关于牙髓再生的研究,并且已经取得了一定成果。本文将对目前国内外牙髓再生的研究进展现状作一综述。     

Ghlorhexidine as a root canal medicament for treating inflammatory lesions in the periodontal space

Abstract— The purpose of the present study was to investigate the therapeutic effect of intra-canal application of chlorhexidine on inflammatory root resorption. Dental pulps from monkey incisors were infected and resealed prior to extraction of the teeth. Root dentin was mechanically exposed and the teeth were replanted under aseptic conditions. After 4 weeks, the experimental teeth were dressed with chlorhexidine gel and resealed. Animals were sacrificed 4 weeks later, and their jaws prepared for histologic examination. Results showed that both marginal and apical periodontal inflammation and resorption were reduced in the chlorhexidine-treated teeth. It was concluded that the use of intra-canal chlorhexidine may be a useful adjunct in the treatment of inflammatory root resorption, but further human trials need to be undertaken before its clinical use can be recommended.     

小鼠牙髓干细胞同种异体移植后体内免疫反应初探

目的:初步探究小鼠牙髓干细胞同种异体移植后的全身免疫反应。方法:牙髓干细胞分离获得自C57BL/6 小鼠牙髓组织,培养至第3 代,与纳米羟基磷灰石(n-HA)复合培养形成复合物,扫描电镜观察其生长黏附情况。40只4周龄的C57BL/6 小鼠随机分成两组。实验组将复合物移植入上背部皮下,对照组将纳米羟基磷灰石植入上背部皮下,术后均使用外科方法严密缝合创口。两组动物术后均观察4周、6周处死,分离脾脏,制成脾淋巴细胞悬液,流式细胞仪测定CD4⁺、CD8⁺的值。结果:牙髓干细胞在体外与纳米羟基磷灰石结合良好;免疫组化染色实验组4周、6周均可见牙本质涎蛋白(dentin sialoprotein,DSP)阳性表达;实验组与对照组相比,术后4周、6周CD4⁺/CD8⁺值均无明显差异。结论:牙髓干细胞同种异体移植后,尚不能够引起机体的免疫排斥反应,其在体内仍具有低免疫原性,有望成为组织工程同种异体种子细胞来源。