共查询到20条相似文献,搜索用时 15 毫秒
1.
A. K. M. Moinul Hossain Barry L. Shulkin Michael J. Gelfand Humayun Bashir Najat C. Daw Susan E. Sharp Helen R. Nadel Jeffrey S. Dome 《European journal of nuclear medicine and molecular imaging》2010,37(7):1300-1308
Purpose
The purpose of this analysis was to evaluate the utility of FDG PET/CT scanning in patients with Wilms’ tumors. 相似文献2.
OBJECTIVES: To determine if there is added value to oncology studies performed with a dedicated in-line positron emission tomography (PET)/computed tomography (CT) scanner as compared with PET read side by side with diagnostic CT (DCT). METHODS: Forty-one consecutive oncology patients referred for PET/CT who had contemporary DCT scans for review were enrolled. Body regions assessed on a DCT scan were assessed on PET/CT and by side-by-side reading of PET and DCT (SBS PET/DCT). Lesions identified on DCT, the CT portion of PET/CT, SBS PET/DCT, and the reading of fused PET/CT images were scored as benign or malignant. The PET portion of the PET/CT study was read by 2 teams: the first read the SBS PET/DCT scan and the other read the complete fused PET/CT scan. For discordant lesions, the final diagnosis was determined by pathologic findings (n = 6) or imaging follow-up (n = 21). RESULTS: Twenty-seven (16.1%) of the 168 lesions were discordant when comparing analysis of fused PET/CT and SBS PET/DCT. Sixteen (9.5%) were fundamentally discordant, and 11(6.6%) were discordant in degree of confidence. For all discordant lesions only, the sensitivity, specificity, negative predictive value, positive predictive value, and accuracy for PET/CT were 100%, 33%, 100%, 94%, and 78%, respectively, and for SBS PET/DCT, they were 38%, 50%, 19%, 73%, and 30%, respectively (P < 0.001 for sensitivity, P = not specific for specificity). The 2 main causes for misclassification on SBS PET/DCT were incorrect localization (n = 12) and changes occurring in the time gap between DCT and PET/CT (n = 4). CONCLUSIONS: In-line PET/CT offers better lesion localization in comparison to the visual fusion of PET and CT, especially for small lymph nodes, lesions adjacent to mobile organs, or lesions adjacent to the chest or abdominal wall. 相似文献
3.
Kjell Någren Christer Halldin Juha O. Rinne 《European journal of nuclear medicine and molecular imaging》2010,37(8):1575-1593
Alzheimer’s disease (AD) is a common degenerative neurological disease that is an increasing medical, economical, and social
problem. There is evidence that a long “asymptomatic” phase of the disease exists where functional changes in the brain are
present, but structural imaging for instance with magnetic resonance imaging remains normal. Positron emission tomography
(PET) is one of the tools by which it is possible to explore changes in cerebral blood flow and metabolism and the functioning
of different neurotransmitter systems. More recently, investigation of protein aggregations such as amyloid deposits or neurofibrillary
tangles containing tau-protein has become possible. The purpose of this paper is to review the current knowledge on various
18F- and 11C-labelled PET tracers that could be used to study the pathophysiology of AD, to be used in the early or differential diagnosis
or to be used in development of treatment and in monitoring of treatment effects. 相似文献
4.
Ekhlas Abdelmonem Ibrahem Nasr Shaban 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(1):196-201
Aims
The point of this research is to investigate the potential role of (18-F-FDG/PET) in the identification of hepatocellular carcinoma (HCC) and its metastases.Patients and method
The present study was performed on 22 patients (15 newly diagnosed, 7 previously treated).18F-FDG was injected IV 1?h before the scan. Non-contrast-enhanced CT was performed trailed by PET in the same session. PET/CT scans were performed on (Philips Gemini-NM system). The whole study took around 20–30?min.Results
PET/CT revealed increased local liver tumor 18-F-FDG uptake in 13/17 of those patients (6 solitary uptakes and 7 multi-nodular uptakes). Primary tumor SUV max. extended from 3 to 11 (mean 6.1) and liver tumor background ratio (TBR) varied from 0.4 to 3 (mean 2.05). 18-F-FDG PET/CT showed extrahepatic metastasis in 6 newly diagnosed patients. It also showed local tumor recurrence in 4 treated patients; 3 of them with no metastasis and 1 previously treated patient had local recurrence and distant metastasis. PET/CT has 76.5% sensitivity, 60% specificity, 86.7% PPV, 42.9% NPV and 59% accuracy in defining HCC and its extrahepatic metastases.Conclusion
This study affirms the achievability of 18-F-FDG PET/CT for identification of primary HCC and its extrahepatic metastases. 相似文献5.
Nakamoto Y Nogami M Sugihara R Sugimura K Senda M Togashi K 《Annals of nuclear medicine》2011,25(2):93-99
Purpose
Positron emission tomography (PET)/computed tomography (CT) with 18F-fluorodeoxyglucose is widely used for post-therapeutic surveillance of malignant lymphoma. Debate still exists as to whether intravenous contrast media during the CT stage of a PET/CT scan should be used. The purpose of this study was to investigate the clinical value of contrast agent in PET/CT in patients with lymphoma following treatment. 相似文献6.
《Gait & posture》2020
BackgroundGait disturbance is one of the most common symptoms among patients with idiopathic Parkinson’s disease (IPD). Nevertheless, Parkinson’s disease subtype clustering according to gait characteristics has not been thoroughly investigated.Research questionThe aim of this study was to identify subgroups according to gait pattern among patients with IPD.MethodsThis study included 88 patients with IPD who underwent 18F-fluorinated-N-3-fluoropropyl-2-β-carboxymethoxy-3-β-4-iodophenyl-nortropane positron emission tomography (18F-FP-CIT PET) and three-dimensional gait analysis (3DGA) between January 1, 2014 and December 31, 2016. We performed cluster analysis using temporal-spatial gait variables (gait speed, stride length, cadence, and step width) and divided patients into four subgroups. The kinematic and kinetic gait variables in 3DGA were compared among the four subgroups. Furthermore, we compared the uptake patterns of striatum among the four subgroups using 18F-FP-CIT PET.ResultsThe patients were clustered into subgroups based on gait hypokinesia and cadence compensation. Group 1 had decreased stride length compensating with increased cadence. Group 2 had decreased stride length without cadence compensation and wider step width. Group 3 had relatively spared stride length with decreased cadence. Group 4 had spared stride length and cadence. The uptake of posterior putamen was significantly decreased in Group 3 compared with Group 4.SignificanceGait hypokinesia and cadence can help to classify gait patterns in IPD patients. Our subgroups may reflect the different gait patterns in IPD patients. 相似文献
7.
Treglia G Taralli S Calcagni ML Maggi F Giordano A Bonomo L 《Journal of computer assisted tomography》2011,35(3):387-393
8.
Svante Nyberg Maria Eriksdotter Jönhagen Zsolt Cselényi Christer Halldin Per Julin Hans Olsson Yvonne Freund-Levi Jan Andersson Katarina Varnäs Samuel Svensson Lars Farde 《European journal of nuclear medicine and molecular imaging》2009,36(11):1859-1863
Purpose
Current positron emission tomography (PET) radioligands for detection of Aβ amyloid in Alzheimer’s disease (AD) are not ideal for quantification. To improve the signal to noise ratio we have developed the radioligand [11C]AZD2184 and report here the first clinical evaluation.Methods
Eight AD patients and four younger control subjects underwent 93-min PET measurements with [11C]AZD2184. A ratio approach using the cerebellum as reference region was applied to determine binding parameters.Results
Brain uptake of [11C]AZD2184 peaked within 1 min at 3–4% of injected radioactivity. AD patients had high radioactivity in cortical regions while controls had uniformly low radioactivity uptake. Specific binding peaked within 30 min at which time standardized uptake value ratios (SUVR) ranged between 1.19 and 2.57.Conclusion
[11C]AZD2184 is a promising radioligand for detailed mapping of Aβ amyloid depositions in Alzheimer’s disease, due to low non-specific binding, high signal to background ratio and reversible binding as evident from early peak equilibrium. 相似文献9.
We report 4 cases of lung cancer in patients with pneumoconiosis detected by F18–fluorodeoxyglucose–positron emission tomography/computed tomography (FDG-PET/CT), which could differentiate lung cancer and pneumoconiosis. FDG-PET/CT may be useful in cancer screening for patients with pneumoconiosis. 相似文献
10.
11.
Tatsuhiro Terada Masamichi Yokokura Etsuji Yoshikawa Masami Futatsubashi Satoshi Kono Takashi Konishi Hiroaki Miyajima Takanori Hashizume Yasuomi Ouchi 《Annals of nuclear medicine》2016,30(8):579-587
Background
The neuroinflammatory glial response contributes to the degenerative process in Parkinson’s disease (PD). However, the pattern of microglial progression remains unclear.Methods
We evaluated microglial activation in early stage PD patients by quantifying changes in neuroinflammation using PET with [11C]DPA713, a selective PET tracer for microglial activation. Eleven PD patients (Hoehn and Yahr stages 1–2) without dementia underwent the [11C]DPA713 PET scan two times with 1 year apart. The binding potential (BPND) was estimated with the simplified reference tissue model. Voxelwise and regions of interest analyses were used to compare the regional BPND among groups.Results
Significant increase in [11C]DPA713 BPND was found extrastriatally in the occipital, temporal and parietal cortex in PD patients, and the degree of BPND became much higher over the brain regions predominantly in the temporal and occipital cortex 1 year later.Conclusion
The current results indicated that an extrastriatal spreading of microglial activation reflects one of PD pathophysiology occurring at an early stage.12.
Makoto Otsuka Yasuo Kuwabara Yuichi Ichiya Sinichi Hosokawa Masayuki Sasaki Tsuyoshi Yoshida Toshimitsu Fukumura Motohiro Kato Kouji Masuda 《Annals of nuclear medicine》1997,11(3):251-257
Both the striatal18F-dopa uptake and brain glucose metabolism were studied by PET with 6-l-[18F]fluorodopa (FD) and [18F]fluorodeoxyglucose (FDG) in 9 patients with multiple system atrophy (MSA) and 15 patients with idiopathic Parkinson’s disease (PD). Five of the 9 MSA patients were diagnosed as having olivopontocerebellar atrophy, whereas 2 had striatonigral degeneration and 2 demonstrated Shy-Drager syndrome. The FD uptake ratios to the occipital cortex in the MSA patients at 120 min after the administration of FD were 2.07 ± 0.31 (mean ± SD) and 1.96 ± 0.29 in the caudate and the putamen, respectively, and decreased compared to those in the controls (2.72 ± 0.11, 2.71 ± 0.10). The same ratios in the PD patients were 2.07 ± 0.36 and 1.74 ± 0.24, respectively, which also decreased, but the decreased uptake in the putamen was more prominent. The caudate-putamen index (CPI) (%), which was calculated by a formula based on the difference in the uptakes in the caudate and putamen divided by the caudate uptake, indicated 5.6 ± 4.6 in the MSA patients and 14.8 ± 5.4 in the PD patients. The CPI for all PD patients was more than 7.0, which was the mean + 2SD for the controls, but the CPI for 3 MSA patients was more than 7.0 (accuracy: 88%). The glucose metabolic rates for each region in the PD patients showed no difference from the normal controls. The frontal and the temporal cortical glucose metabolism and the caudate, the putaminal, the cerebellar and the brainstem glucose metabolism in the MSA patients decreased significantly in comparison to those in the controls. But, as the glucose metabolic rates in such regions of each patient overlapped in the two groups, the accuracy of the FDG study for differentiation was lower than that of the FD study. The putaminal glucose metabolic rates, for example, in 3 PD patients were less than 6.8 (mg/min/100 ml), which was the mean — 2SD for the controls, while those in 3 MSA patients were more than 6.8 (accuracy: 75%). In addition, the combination of these two methods slightly improved the accuracy. The glucose metabolism is useful for evaluating the regional metabolic activity of the brain, and the FD study, which is specific to the dopamine system, seems to be more useful for differentiating between MSA and PD. 相似文献
13.
Toyama T Hoshizaki H Seki R Isobe N Oshima S Taniguchi K Higuchi K Seki H Hatori T Kurabayashi M Endo K 《Annals of nuclear medicine》2004,18(6):463-468
OBJECTIVE AND METHODS: The aim of this study was to evaluate myocardial viability in patients after acute myocardial infarction (AMI). We compared 201Tl SPECT after 201Tl with GIK (10% glucose 250 ml, insulin 5 U and KCl 10 mEq) infusion (GIK-201Tl) with resting 201Tl and 99mTc-pyrophosphate (PYP) dual SPECT, positron emission computed tomography (PET) using 18F-fluorodeoxyglucose (18F-FDG) in 21 patients with their first AMI, who all underwent successful reperfusion. GIK-201Tl SPECT, 201Tl and 99mTc-PYP dual SPECT were done within 10 days after admission and 18F-FDG-PET was performed at 3 weeks. GIK-201Tl SPECT was obtained after 30 min of GIK-201Tl infusion. 18F-FDG (370 MBq) was injected intravenously after oral glucose (1 g/ kg) loading, and then PET was obtained. PET and SPECT images were divided into 20 segments. Regional tracer uptake was scored using a 4-point scoring system (3 = normal to 0 = defect), and summed to a regional uptake score (RUS). Regional area means the infarcted area in which 99mTc-PYP accumulated. The number of decreased uptake segments (ES) was then determined. The infarcted area was defined as the area of 99mTc-PYP uptake. RESULTS: The ESs for the GIK-201Tl and 18F-FDG-PET images were significantly lower than the number of 99mTc-PYP uptake segments. The RUS for GIK-201Tl was higher than that for resting-201Tl imaging and similar to those for 18F-FDG-PET. CONCLUSIONS: In the detection of myocardial viability following AMI, GIK-201Tl imaging is useful with findings similar to those of 18F-FDG-PET. 相似文献
14.
Yuki Tanabe Yoshifumi Sugawara Rieko Nishimura Kohei Hosokawa Makoto Kajihara Teruhiko Shimizu Tadaaki Takahashi Shinya Sakai Shigeki Sawada Motohiro Yamashita Haruhiko Ohtani 《Annals of nuclear medicine》2013,27(8):781-785
The present report describes a case of typical carcinoid tumor with intense fluorodeoxyglucose (FDG) uptake. The most of tumor cells were characterized by eosinophilic cytoplasm resulting from accumulation of mitochondria, which was called an oncocytic carcinoid tumor. Glucose transporter type 1 (GLUT-1) was expressed in a membranous pattern in the oncocytic component. Oncocytic carcinoid tumors could show intense FDG uptake due to the numerous intracellular mitochondria and the membranous overexpression of GLUT-1. Thus, it could be a potential pitfall of interpreting FDG-PET/CT image. 相似文献
15.
Besson FL Parienti JJ Bienvenu B Prior JO Costo S Bouvard G Agostini D 《European journal of nuclear medicine and molecular imaging》2011,38(9):1764-1772
Purpose
The aim of this study was to conduct a systematic review and perform a meta-analysis on the diagnostic performances of 18F-fluorodeoxyglucose positron emission tomography (FDG PET) for giant cell arteritis (GCA), with or without polymyalgia rheumatica (PMR). 相似文献16.
17.
Insang Hwang Ari Chong Seung-Il Jung Eu-Chang Hwang Sun-Ouck Kim Taek-Won Kang Dong-Deuk Kwon Kwangsung Park Soo-Bang Ryu 《Annals of nuclear medicine》2013,27(2):140-145
Objective
The aim of this study was to investigate the frequency of secondary evaluation to detect prostate cancer that was primarily manifested as abnormal hypermetabolism detected by 18-fluoro-2-deoxyglucose (FDG) positron emission tomography–computed tomography (PET/CT). We also evaluated the association of maximum standardized uptake values (SUVmax) on PET/CT with clinicopathologic results.Materials and methods
We evaluated PET/CT reports from a total of 12,037 patients to find cases with abnormal prostate hypermetabolism. Patients with known prostate cancer or a recent prostate procedure were excluded. We analyzed the frequency of secondary evaluations such as digital rectal exams (DRE), levels of serum prostate-specific antigen (PSA), and/or biopsy to confirm prostate cancer. Biopsied patients were categorized into benign and cancer groups. Clinicopathologic characteristics were compared between the groups.Results
Among 12,037 PET/CT images, 184 (1.5 %) showed abnormal hypermetabolism in the prostate. Secondary evaluation was carried out in 120 patients. Biopsy was performed in 38 patients and prostate cancer was confirmed in 23 patients. The median serum PSA level was 3.2 and 49.7 ng/mL in the benign group and cancer group, respectively. The SUVmax was higher in the cancer group (5.7 ± 5.1) than in the benign group (4.8 ± 2.7), but the difference was not statistically significant (p = 0.37). In the cancer group, a high serum PSA level (≥20 ng/mL) was detected in 78.3 % of the patients. The Gleason score was 7 in 34.7 % and 8–10 in 56.5 % of prostate cancer patients.Conclusions
Hypermetabolism in the prostate was incidentally detected in 1.5 % of patients, and only 65.2 % of these patients underwent further evaluation (DRE and/or serum PSA levels). Among cases of incidentally detected hypermetabolism in the prostate, patients with abnormal findings (DRE and/or PSA levels) showed high positivity by biopsy, and more than two-thirds of the positive biopsies showed significant prostate cancer. Therefore, patients with hypermetabolism in the prostate should not be ignored and should be secondarily evaluated by DRE and PSA level. 相似文献18.
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