小儿免疫及原发性免疫缺陷病

051252脐血IgE值用于预报食物过敏高危儿童的研究/李斐…∥中华儿科杂志.-2004,42(2).-117～120方法:随机选取婴儿118人,随访至出生后4个月,诊断及分组采用标准问卷调查和食物皮肤点刺试验,应用纸片放射免疫吸附法测定脐血IgE值。结果:4个月时,经确诊为食物过敏患儿组的脐血IgE值高于未发生食物过敏的婴儿组及不能确诊为食物过敏的婴儿组(P<0.05);当脐血IgE值的预报界值定为0.9IU/L(CBIgE0.9)或0.5IU/L(CBIgE0.5)时,高脐血组FA检出率高于低脐血组(P<0.01),提示脐血IgE升高是导致食物过敏的危险因素之一;CBIgE0.9预报食物过敏的…     

孕期妇女免疫球蛋白及婴儿脐血免疫球蛋白E的检测及分析

目的　探讨婴儿食物过敏发生的危险因素。方法　妊娠妇女 10 7例 ,以妊娠期有无过敏史将其分为有妊娠期过敏史 (AH)组及无妊娠期过敏史 (NAH)组 ,测定 10 7例孕母妊娠早期及分娩时血清IgE、IgA、IgM值 ,并测定其所娩新生儿脐血中的IgE、IgA值 ,进行比较。 结果　两组孕母妊娠早期血清IgE、IgA、IgM差异无显著性意义 (P >0 0 5 ) ,分娩时AH组孕母血清IgE值较NAH组高 (P <0 0 5 ) ;两组妇女妊娠期IgE均随孕龄增加而逐渐升高 ;AH组孕母所生婴儿的脐血IgE值高于NAH组 ;两组分娩时母血、脐血IgE无明显相关及回归关系。结论　正常妊娠期妇女血清IgE值随孕龄增加而逐渐上升 ,AH组孕妇分娩时血清IgE值较NAH组增高 ;孕母过敏史、胎儿宫内致敏现象、妊娠期母亲大量摄入大分子食物抗原可能是婴儿发生食物过敏的早期危险因素     

影响脐血IgE值因素的研究

目的　本研究对影响脐血IgE值的可疑因素进行分析 ,探讨影响儿童食物过敏的可疑因素。方法　选取孕期妇女 10 5名及其所生婴儿 ,采用标准问卷调查获取资料 ,对影响脐血IgE的因素进行分析。 结果　母亲的过敏性疾病史、父亲过敏性疾病史中的皮炎表现型、孕期妇女过敏性疾病发作史、有过敏史妇女孕后期摄入过量的牛奶和鸡蛋均与脐血IgE值的上升有关 ,且上述 5个因素对脐血IgE水平的影响依次降低。 结论　母亲的过敏性疾病史和父亲过敏性疾病史中的皮炎表现型是导致新生儿脐血IgE值升高的主要危险因素 ;同时 ,妊娠期加强对有过敏史妇女的保护 ,防止过敏性疾病的复发 ,在孕后期控制有过敏史妇女牛奶、鸡蛋等大分子食物致敏原的摄入 ,有助于降低脐血IgE值。     

脐血免疫球蛋白E、白细胞介素-4、白细胞介素-12在婴幼儿变态反应性疾病中的表达及3a随访分析

目的 探讨脐血IgE、IL-4、IL-12水平对婴儿变态反应性疾病发生的预测价值及三者之间的相互变化关系.方法 应用美国IMX型化学发光检测仪,采用免疫荧光方法测定129例新生儿脐血IgE水平；采用双抗体夹心ELISA法测定新生儿脐血IL-4、IL-12水平,并进行3 a随访.根据是否出现变态反应情况分为变态反应组和正常组.结果 变态反应组脐血IgE、IL-4水平均较正常组明显增高(Pa＜0.01),而IL-12水平较后者明显降低(P＜0.01).变态反应性疾病患儿脐血的3种介质相关分析显示IL-4与IgE呈显著正相关(r=0.878,P＜0.01)；IL-12与IgE呈显著负相关(r=-0.643,P＜0.01)；IL-12与IL-4呈显著负相关(r=-0.711,P＜0.01).结论 脐血IgE、IL-2、IL-5水平检查可预测婴儿变态反应性疾病的发生,从而发现高危儿,对儿童避免变态反应性疾病的发生和指导医疗保健有重要意义.     

脐血主要过敏相关指标所反映的生命早期致敏状况研究

目的探讨生命早期的致敏状况。方法选取2009年6月至2010年3月在本院产科登记检查并分娩的健康孕妇146例,及其配偶和婴儿。通过父母问卷调查和父母过敏原皮肤点刺试验确定父母特应质情况,根据父母特应质情况分组。分娩时检测脐血总IgE,鸡蛋、牛奶特异性IgE,ECP及母体总IgE含量,随访婴儿6周、3个月、6个月特应性皮炎的发生情况。结果在146例孕妇所产婴儿中,父母双方至少一方特应质组67例,双方均为非特应质79例。脐血总IgE、ECP平均值及阳性率在父母特应质组中均较非特应质组高,但差异无统计学意义。脐血总IgE与母亲总Ig无相关性。婴儿生后6周、3个月、6个月特应性皮炎的发生率在脐血总IgE、ECP增高组中较高,差异有统计学意义(P<0.05)。脐血中可检测到极微量的鸡蛋、牛奶特异性IgE,且与父母特应质无相关性。结论胎儿在母体子宫内可被食物抗原致敏。脐血总IgE、特异性IgE、ECP或可作为宫内致敏的指标,其与父母特应质、母亲IgE水平无相关性,脐血IgE、ECP与婴儿早期特应性皮炎的发生有一定的相关性。     

高危新生儿血清心肌肌钙蛋白I浓度变化的研究

目的探讨高危新生儿血清心肌肌钙蛋白I（cWnI）浓度变化趋势。方法选择2009年4～12月本院产科出生、具有高危因素的新生儿,分为缺氧组、感染组及早产组,选择足月健康新生儿20例为对照组。分别测定脐血,生后1天及4天血清cTnI水平,并作对比分析。结果（1）缺氧、感染及早产组脐血、生后1天cTnI值均高于对照组（P〈0．05）;缺氧组及感染组生后4天血eTnI值高于对照组（P〈0．05）,早产组与对照组差异无统计学意义（P〉0．05）。（2）各组脐血、生后1天及4天血cTnI值均呈逐渐增高趋势;对照组、缺氧组和感染组各时间点血cTnI值差异有统计学意义（P〈0．01）,感染组和早产组生后1天血cTnI值与脐血差异无统计学意义（P〉0．05）,生后4天血cTnI值高于脐血,差异有统计学意义（P〈0．05）。（3）感染组血cTnI恢复正常时间23天至5个月;缺氧组恢复正常时间4天至3．5个月;早产组恢复正常时间15天至1．5个月。结论缺氧、感染、早产等高危因素对新生儿血eTnI值的影响不同,动态监测所有高危儿血cTnI值十分必要。     

脐血IgE水平测定预测婴儿变态反应疾病

为评价脐血IgE(CB-IgE)是否可作为一项在婴儿早期预测变态反应疾病的有用指标。应用UniCAP100型测定仪,用荧光酶免疫方法检测了300名足月新生儿的脐血IgE(CB-IgE)。对这些新生儿进行随访,观察其变态反应疾病的发病情况。脐血IgE(CB-IgE)≥0.35KU/L为A组共100名,CB-IgE<0.35KU/L为B组共200名。A组在随访的10月～13个月中发生变态反应疾病者(婴儿湿疹、婴儿哮喘)显著高于B组(25％VS.5％,X~2=5.96,P≤0.05)。A组中有20例患儿的CB-IgE≧0.45KU/L(占80％),与其父母有变态反应病史呈明显相关性。其中有64％的父母有过敏性鼻炎或荨麻疹等变态反应病史。本文结果提示脐血IgE≥0.45KU/L,婴儿变态反应疾病的发病率明显增高。脐血IgE高水平加上父母亲有变态反应病史对预测婴儿变态反应疾病有一定意义。     

脐血细胞因子与特应性疾病发生风险的前瞻性研究

目的探讨特应质夫妇所生婴儿发生特应性疾病的风险。方法应用ELISA法检测30名特应质及26名非特应质父母婴儿脐血IL_4、IL_10、IFN_γ、IgE、IL_4/IFN_γ水平,并对这些新生儿进行随访,观察过敏症状的发生情况。结果特应质组IL_4、IL_10均高于非特应质组,两组差异显著(t=4.48、5.99,P均<0.05);IL_12、IFN_γ含量两组间无明显差异(t=-0.77、1.70,P均>0.05);特应质组IL_4/IFN_γ比值高于非特应质组(t=2.80,P<0.05),两组间差异显著。以≥0.35kU/L为脐血IgE升高的界值,特应质组阳性率明显高于非特应质组(χ2=5.73,P<0.05)。在6～9个月的随访中,特应质组发生过敏性疾病的人数明显高于非特应质组(分别为75%、38.5%;χ2=7.36,P<0.05)。结论特应质夫妇的婴儿出生时就有潜在的过敏倾向;父母特应质病史与脐血IgE升高有一定相关性,脐血中IgE水平高的婴儿发生过敏性疾病的机率明显增高;脐血细胞因子检测对预测特应性疾病发生有一定的临床意义。     

伴或不伴食物过敏湿疹患儿治疗前后的 生活质量比较

目的探讨湿疹患儿及其家庭治疗前后的生活质量。方法将湿疹患儿分为食物过敏组(FA组,46例)及非食物过敏组(N-FA组,47例)。应用湿疹面积及严重度指数(EASI)对患儿进行评估;对两组湿疹患儿进行规范化干预治疗2个月后,采用食物过敏生活质量问卷-父母版(FAQLQ-PF)和婴儿皮肤病生活质量指数量表(IDQOL)评估治疗前后的生活质量。结果两组患儿在年龄、性别、过敏家族史及喂养方式的差异无统计学意义(P均0.05);FA组中鸡蛋过敏34例(73.91%),牛奶过敏20例(43.48%),胡萝卜过敏2例(4.35%)。两组患儿的EASI、FAQLQ、IDQOL评分在治疗后均有显著下降,与治疗前比较,差异有统计学意义(P均0.05)。治疗前,FA组FAQLQ-PF各模块及总分与N-FA组的差异无统计学意义(P均0.05);治疗两个月后,FA组FAQLQ总分(1.33±1.08)较N-FA组(0.79±0.80)高,差异有统计学意义(Z=2.83,P=0.005);FA组在情绪影响、食物的焦虑、社交/饮食限制模块与N-FA组比较差异亦有统计学意义(Z=2.13~2.89,P均0.05)。结论食物过敏患儿的家长更易担心患儿的情绪变化及社交、饮食受到限制。FAQLQ-PF对于食物过敏生活质量的评估更具特异性。     

婴儿期食物过敏的预后研究

目的了解婴儿期食物过敏（FA）的预后及影响因素。方法对119例患儿进行回顾性研究,采用Kaplan-Meier法计算食物耐受的累积概率,非条件Logistic回归模型分析食物耐受形成的预测因素和其他过敏性疾病发生的影响因素。结果鸡蛋、牛奶耐受的累计概率在诊断后1年分别为31％、42％;2年为62％、63％;3年为80％、77％;4年后均可达100％。牛奶、鸡蛋过敏患儿的皮肤点刺试验阳性强度是持续牛奶、鸡蛋敏感的预测因素（OR=2．535,95％CI：1．159～5．543;OR=2．654,95％CI：1．302～5．410,P均〈0．05）。本组13例患儿发生其他FA,危险因素是持续鸡蛋敏感（OR=6．109,95％CI：1．818～20．527,P〈0．05）;4例发生变态反应性鼻炎,15例发生支气管哮喘,危险因素是持续鸡蛋敏感和呼吸道过敏症状（OR=3．596,95％CI：1．429～9．045;OR：4．235,95％CI：1．152～15．563,P均〈0．05）。结论至少75％的鸡蛋或牛奶过敏患儿在诊断后3年内可获耐受。10．9％、12．6％和3．4％的FA儿童发生其他FA、支气管哮喘和变态反应性鼻炎。加强持续FA高危儿的筛查和管理,可能有助于改善FA的预后。     

Breast feeding and allergic diseases in infants-a prospective birth cohort study.

AIMS: To investigate the effect of breast feeding on allergic disease in infants up to 2 years of age. METHODS: A birth cohort of 4089 infants was followed prospectively in Stockholm, Sweden. Information about various exposures was obtained by parental questionnaires when the infants were 2 months old, and about allergic symptoms and feeding at 1 and 2 years of age. Duration of exclusive and partial breast feeding was assessed separately. Symptom related definitions of various allergic diseases were used. Odds ratios (OR) and 95% confidence intervals (CI) were estimated in a multiple logistic regression model. Adjustments were made for potential confounders. RESULTS: Children exclusively breast fed during four months or more exhibited less asthma (7.7% v 12%, OR(adj) = 0.7, 95% CI 0.5 to 0.8), less atopic dermatitis (24% v 27%, OR(adj) = 0.8, 95% CI 0.7 to 1.0), and less suspected allergic rhinitis (6.5% v 9%, OR(adj) = 0.7, 95% CI 0.5 to 1.0) by 2 years of age. There was a significant risk reduction for asthma related to partial breast feeding during six months or more (OR(adj) = 0.7, 95% CI 0.5 to 0.9). Three or more of five possible allergic disorders-asthma, suspected allergic rhinitis, atopic dermatitis, food allergy related symptoms, and suspected allergic respiratory symptoms after exposure to pets or pollen-were found in 6.5% of the children. Exclusive breast feeding prevented children from having multiple allergic disease (OR(adj) = 0.7, 95% CI 0.5 to 0.9) during the first two years of life. CONCLUSION: Exclusive breast feeding seems to have a preventive effect on the early development of allergic disease-that is, asthma, atopic dermatitis, and suspected allergic rhinitis, up to 2 years of age. This protective effect was also evident for multiple allergic disease.     

婴儿牛奶蛋白过敏的危险因素：多中心调查分析

目的 通过多中心临床研究了解婴儿牛奶蛋白过敏（CMPA）发生的危险因素。方法 以2016年6月至2017年5月于深圳市6家医院儿科门诊就诊的1 829例1~12月龄婴儿为调查对象,通过问卷调查,筛选CMPA可疑病例,然后进行食物回避激发试验以确诊CMPA。采用多因素logistic回归分析调查婴儿CMPA发生的危险因素。结果 1 829例患儿中,82例确诊为CMPA（4.48%）。多因素logistic回归分析显示,母亲食物过敏（OR=4.91,95% CI：2.24~10.76）、母亲孕期使用抗生素（OR=3.18,95% CI：1.32~7.65）、开始添加辅食月龄小于 < 4个月（OR=3.55,95% CI：1.52~8.27）是CMPA的独立危险因素（P < 0.05）,而纯母乳喂养（OR=0.21,95% CI：0.08~0.58）和 > 6个月添加辅食（OR=0.38,95% CI：0.17~0.86）是CMPA的保护因素（P < 0.05）。结论 小于4月龄添加辅食、母亲食物过敏、母孕期使用抗生素是婴儿CMPA发生的危险因素。     

Breast feeding and allergic diseases in infants-a prospective birth cohort study

Aims: To investigate the effect of breast feeding on allergic disease in infants up to 2 years of age. Methods: A birth cohort of 4089 infants was followed prospectively in Stockholm, Sweden. Information about various exposures was obtained by parental questionnaires when the infants were 2 months old, and about allergic symptoms and feeding at 1 and 2 years of age. Duration of exclusive and partial breast feeding was assessed separately. Symptom related definitions of various allergic diseases were used. Odds ratios (OR) and 95% confidence intervals (CI) were estimated in a multiple logistic regression model. Adjustments were made for potential confounders. Results: Children exclusively breast fed during four months or more exhibited less asthma (7.7% v 12%, OR_adj = 0.7, 95% CI 0.5 to 0.8), less atopic dermatitis (24% v 27%, OR_adj = 0.8, 95% CI 0.7 to 1.0), and less suspected allergic rhinitis (6.5% v 9%, OR_adj = 0.7, 95% CI 0.5 to 1.0) by 2 years of age. There was a significant risk reduction for asthma related to partial breast feeding during six months or more (OR_adj = 0.7, 95% CI 0.5 to 0.9). Three or more of five possible allergic disorders—asthma, suspected allergic rhinitis, atopic dermatitis, food allergy related symptoms, and suspected allergic respiratory symptoms after exposure to pets or pollen—were found in 6.5% of the children. Exclusive breast feeding prevented children from having multiple allergic disease (OR_adj = 0.7, 95% CI 0.5 to 0.9) during the first two years of life. Conclusion: Exclusive breast feeding seems to have a preventive effect on the early development of allergic disease—that is, asthma, atopic dermatitis, and suspected allergic rhinitis, up to 2 years of age. This protective effect was also evident for multiple allergic disease.     

Association of food allergy with asthma severity and atopic diseases in Jewish and Arab adolescents

Aim: To investigate the prevalence of reported food allergy and its association with atopic diseases and asthma severity among Jewish and Arab adolescents. Subjects and methods: The self‐report questionnaire of the International Study of Asthma and Allergies in Childhood (ISAAC) was administered to adolescents aged 13–14 years from randomly selected junior high schools in Israel. Questions regarding food allergy were added. Results: A total of 11 171 questionnaires were available for analysis. Food allergy was reported by 3.6% of participants: 1.9% milk, 0.6% egg, 0.6% peanut and 0.4% sesame. On multivariate analysis, food allergy was strongly associated with current asthma (OR, 2.5; 95% CI, 1.8–3.3), atopic eczema (OR, 3.2; 95% CI, 2.4–4.3) and allergic rhinitis (OR, 2.4; 95% CI, 1.8–3.1). Arabs were significantly more allergic to peanut (OR, 2.5; 95% CI, 1.5–4.1), egg (OR, 3.5; 95% CI, 2.1–5.9) and sesame (OR, 2.3; 95% CI, 1.2–4.5) than Jews, and less allergic to milk (OR, 0.6; 95% CI, 0.4–0.9). Asthmatic subjects with food allergy had significantly more parameters of severe asthma than those without food allergy (p < 0.001). Conclusions: The prevalence of allergy to specific foods differs between Jews and Arabs. Asthmatic adolescents with food allergy report more severe asthma than those without food allergy.     

Geographic variability of childhood food allergy in the United States

Objective The aim of this study was to describe the distribution of childhood food allergy in the United States. Methods A randomized survey was administered electronically from June 2009 to February 2010 to adults in US households with at least 1 child younger than 18 years. Data were analyzed as weighted proportions to estimate prevalence and severity of food allergy by geographic location. Multiple logistic regression models were constructed to estimate the association between geographic location and food allergy. Results Data were analyzed for 38 465 children. Increasing population density corresponded with increasing prevalence, from 6.2% in rural areas (95% confidence interval [CI] = 5.6-6.8) to 9.8% in urban centers (95% CI = 8.6-11.0). Odds of food allergy were graded, with odds in urban versus rural areas highest (odds ratio [OR] = 1.7, 95% CI = 1.5-2.0), followed by metropolitan versus rural areas (OR = 1.4, 95% CI = 1.2-1.5), and so on. Significance remained after adjusting for race/ethnicity, gender, age, household income, and latitude. Conclusions An association between urban/rural status and food allergy prevalence was observed.     

Effect of locally produced complementary foods on fat‐free mass,linear growth,and iron status among Kenyan infants: A randomized controlled trial

The impact of quality complementary food products on infant growth and body composition has not been adequately investigated. This study evaluated the effect on fat‐free mass (FFM) accrual, linear growth, and iron status of locally produced complementary food products comparing to a standard product. In a randomized, double‐blind trial, 499 infants at 6 months received nine monthly rations of (a) WinFood Classic (WFC) comprising germinated amaranth (71%), maize (10.4%), small fish (3%), and edible termites (10%); (b) WinFood Lite (WFL) comprising germinated amaranth (82.5%), maize (10.2%), and multimicronutrient premix; or (c) fortified corn–soy blend plus (CSB+). Primary outcomes were changes in FFM, length, and plasma ferritin and transferrin receptors (TfR). FFM was determined using deuterium dilution. Analysis was by intention to treat, based on available cases. Compared with CSB+, there were no differences in change from 6 to 15 months in FFM for WFC 0.0 kg (95% CI [?0.30, 0.29]) and WFL 0.03 kg (95% CI [?0.25, 0.32]) and length change for WFC ?0.3 cm (95% CI [?0.9, 0.4]) and WFL ?0.3 cm (95% CI [?0.9, 0.3]). TfR increased in WFC group 3.3 mg L^?1 (95% CI [1.7, 4.9]) and WFL group 1.7 mg L^?1 (95% CI [0.1, 3.4]) compared with CSB+. Compared with the increase in Hb in CSB+ group, there was a reduction in Hb in WFC of ?0.9 g dl^?1 (95% CI [?1.3, ?0.5]) and a lower increase in WFL ?0.4 g dl^?1 (95% CI [?0.8, 0.0]). In conclusion, the tested WinFoods had the same effect on FFM and length as CSB+, whereas Hb and iron status decreased, suggesting inhibited iron bioavailability from the amaranth‐based WinFoods.     

Human serum amyloid A (SAA) and high sensitive C-reactive protein (hsCRP) in preterm newborn infants with nosocomial infections

Human serum amyloid A (SAA) and high sensitive C-reactive protein (hsCRP) and their relation to suggestive nosocomial infections (NIs) were investigated in very preterm (VPT) newborn infants. In a retrospective analysis, information of suggestive NI was matched to levels of SAA and hsCRP in 224 serum samples from 72 VPT newborn infants. As a control group, 35 healthy-term newborn infants were chosen. Of the 224 serum samples, 145 samples were not associated with nosocomial infections. However, 79 were associated with NI: of these 79, 42 were found to be culture-proven NI. Trimmed mean (alpha= 0.05) levels for SAA and hsCRP in VPT newborn infants were higher than in control term newborn infants (1.74, 2.67 mg/L vs. 0.78, 0.16 mg/L; p = 0.01 and <0.0001, respectively), and higher in the NI group than in the non-NI group (5.14, 5.74 mg/L vs. 1.03, 1.18; p < 0.01 and <0.0001; respectively). The areas under the curve (AUC) for hsCRP, calculated from the receiver-operator characteristic (ROC) curves, was greater (0.816; 95% CI 0.759-0.864) than for SAA (0.610; 95% CI 0.543-0.675). CONCLUSION: Identifying and monitoring of bacterial and fungal infections in VPT might be further improved by the use of SAA and hsCRP.     

Maternal antibiotics and decreased periventricular leukomalacia in very low-birth-weight infants

OBJECTIVE: To investigate the effect of maternal antibiotics, given in the predelivery period, on neonatal outcomes. DESIGN: Retrospective cohort study. SETTING: A single level 3 neonatal intensive care unit. PATIENTS: All infants with birth weights 1500 g or less cared for from July 1994 to July 2000 (n = 834) were included in the study. Mothers were classified as receiving antibiotics if they received any parenteral antibiotics in the predelivery period. Infants whose mothers received antibiotics were compared with infants whose mothers received no antibiotics. MAIN OUTCOME MEASURES: The main outcome variables studied included intraventricular hemorrhage (IVH), cystic periventricular leukomalacia (PVL), sepsis, and mortality. RESULTS: Of 834 mothers, 374 (45%) received antibiotics prior to delivery. On univariate analysis, there were no differences in the relative risk (RR) of mortality (1.26; 95% confidence interval [CI], 0.86-1.79) or grades 3 to 4 IVH (RR, 1.39; 95% CI, 0.82-1.90) between the antibiotics and no-antibiotics groups. Infants born to mothers receiving antibiotics had an increased risk of culture-proven sepsis (RR, 1.4; 95% CI, 1.02-1.64) and a decreased risk of cystic PVL (RR, 0.26; 95% CI, 0.09-0.79) compared with infants whose mothers did not receive antibiotics. After controlling for confounding variables, maternal antibiotics were not associated with a decrease in the risk of mortality (adjusted risk [AR], 1.0; 95% CI, 0.5-2.1), grades 3 to 4 IVH (AR, 1.0; 95% CI, 0.5-1.9), or sepsis (AR, 0.9; 95% CI, 0.7-1.4). However, the use of maternal antibiotics was associated with a decreased risk of developing cystic PVL (AR, 0.09; 95% CI, 0.02-0.5). CONCLUSIONS: In our population of very low-birth-weight infants, maternal antibiotics were associated with a decreased risk of cystic PVL. Maternal antibiotics do not change the risk of mortality, sepsis, or severe IVH.     

新生儿重症监护病房中低出生体重儿嗜酸性粒细胞增多危险因素分析

目的分析新生儿重症监护病房(NICU)中低出生体重儿嗜酸性粒细胞增多的危险因素。方法回顾性分析2019年1月1日至2020年3月31日在北京大学第三医院儿科NICU住院的496例低出生体重儿的病例资料,因各种原因剔除196例,根据嗜酸性粒细胞是否增多分为嗜酸性粒细胞增多组和对照组,各150例。通过单因素分析进行筛选,再通过非条件Logistic回归分析低出生体重儿嗜酸性粒细胞增多的影响因素。结果 (1)两组患儿嗜酸性粒细胞均在生后第3周达到高峰,然后逐渐下降,嗜酸性粒细胞增多组嗜酸性粒细胞升高持续时间更长。(2)母亲有妊娠期高血压、胎膜早破、儿童出生后患食物过敏、感染、贫血、输血、支气管肺发育不良(BPD)、白细胞增多、血小板增多在两组患儿分别为59例(39.3%)、33例(22.0%); 47例(31.3%)、31例(20.7%);10例(6.7%)、1例(0.7%); 54例(36.0%)、15例(10.0%); 133例(88.7%)、88例(58.7%); 67例(44.7%)、26例(17.3%); 75例(50.0%)、23例(15.3%); 61例(40.6%)、43例(...