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This critical review examines the putative role played by peroxisome proliferator-activated receptor alpha (PPARalpha) in the hypolipidemic activity induced by peroxisome proliferators/PPARalpha agonists. The hypolipidemic effect of peroxisome proliferators mediated in rodents by hepatic PPARalpha activation is independent of PPARalpha in humans, and is transduced by direct suppression of hepatocyte nuclear factor-4alpha by the CoA-thioesters of hypolipidemic peroxisome proliferators. A novel target for hypolipidemic drugs in humans and an updated risk assessment for human hypolipidemic drugs are implied. 相似文献
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Xingguo Cheng Jonathan Maher Matthew Z Dieter Curtis D Klaassen 《Drug metabolism and disposition》2005,33(9):1276-1282
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AhR and PPARalpha: antagonistic effects on CYP2B and CYP3A, and additive inhibitory effects on CYP2C11 总被引：1，自引：0，他引：1
Shaban Z Soliman M El-Shazly S El-Bohi K Abdelazeez A Kehelo K Kim HS Muzandu K Ishizuka M Kazusaka A Fujita S 《Xenobiotica; the fate of foreign compounds in biological systems》2005,35(1):51-68