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1.
Association between PLA2G12A polymorphism and patients with schizophrenia in a southern Chinese Han population
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Li Hui Xiao Li Yin Jie Chen Hong Liang Zhu Guang Ya Zhang Xiao Qiong Wang Jia Hong Liu Cheng Zhu Dong Wu Xu Xin Yu Guang Zhong Yin 《Human psychopharmacology》2018,33(2)
Background
Elevated phospholipase A2 (PLA2) activity is reported to be involved in the development of schizophrenia. Further study revealed an association between PLA2 groups XIIA (PLA2G12A) polymorphism and patients with schizophrenia in a northeast Chinese Han population.Objective
This study will further examine whether PLA2G12A rs3087494 polymorphism is associated with patients with schizophrenia in a southern Chinese Han population.Methods
This polymorphism was genotyped in 438 patients with schizophrenia (diagnosed according to Diagnostic and Statistical Manual of Mental Disorders‐IV) and 876 healthy controls using a case–control design. Demographic and clinical data were collected in all subjects.Results
The allele and genotype frequencies of PLA2G12A rs3087494 polymorphism significantly differed between groups (both, p < .001). These differences still were significant by adjusting for sex and age. However, there was no difference in age at onset among 3 genotype groups in patients with schizophrenia by adjusting for the variables (F = 0.22, p = .80). Stepwise multivariate regression analysis showed that this polymorphism was not associated with age at onset in patients with schizophrenia (β = .008, t = .07, p = .94).Conclusions
Our results indicated that even though PLA2G12A rs3087494 polymorphism did not influence age at onset in patients with schizophrenia, it may play an important role in the susceptibility to schizophrenia in a southern Chinese Han population. 相似文献2.
Higher serotonin transporter availability in early‐onset obsessive–compulsive disorder patients undergoing escitalopram treatment: A [11C]DASB PET study
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Junhee Lee Bo‐Hyung Kim Euitae Kim Oliver D. Howes Kang Ik Kevin Cho Youngwoo Bryan Yoon Jun Soo Kwon 《Human psychopharmacology》2018,33(1)
Objective
Early‐onset obsessive–compulsive disorder (EOCD) and late‐onset obsessive–compulsive disorder (LOCD) are distinct subtypes of obsessive–compulsive disorder (OCD). OCD patients are treated with serotonin reuptake inhibitors, but the difference in serotonin transporter (SERT) availability between medicated EOCD and LOCD is unexplored yet.Methods
Six EOCD and 6 LOCD patients were enrolled. They underwent serial [11C]DASB positron emission tomography scans during maintenance therapy with escitalopram, and their plasma concentration of escitalopram was measured simultaneously with the scan. Then, the drug‐free binding potential of SERT was calculated by pharmacokinetic–pharmacodynamic modelling.Results
In comparison with LOCD patients, SERT availability was significantly higher in the putamen of EOCD patients (U = 4, p = .026), but not in the caudate nucleus (U = 14, p = .589), thalamus (U = 16, p = .818), and dorsal raphe nucleus (U = 7, p = .093). Binding potential of putamen showed a negative correlation (r = ?.580, p = .048) with age of onset of the disease, but not with the Yale–Brown Obsessive Compulsive Scale scores.Conclusions
These findings indicate that the earlier the age of onset of OCD, the less serotonergic pathology there is and that this difference remains even after long‐term serotonin reuptake inhibitor treatment. Clinically, it might suggest that nonserotonergic treatments would be a better option for EOCD patients. 相似文献3.
Apostolova N Garcia-Bou R Hernandez-Mijares A Herance R Rocha M Victor VM 《Pharmaceutical research》2011,28(11):2910-2919
Purpose
Mitochondrial dysfunction plays a key role in sepsis. 相似文献4.
Short circuit: Disaggregation of adrenocorticotropic hormone and cortisol levels in HIV‐positive,methamphetamine‐using men who have sex with men
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Adam W. Carrico Violeta J. Rodriguez Deborah L. Jones Mahendra Kumar 《Human psychopharmacology》2018,33(1)
Objective
This study examined if methamphetamine use alone (METH + HIV?) and methamphetamine use in combination with HIV (METH + HIV+) were associated with hypothalamic‐pituitary‐adrenal (HPA) axis dysregulation as well as insulin resistance relative to a nonmethamphetamine‐using, HIV‐negative comparison group (METH‐HIV?).Methods
Using an intact groups design, serum levels of HPA axis hormones in 46 METH + HIV? and 127 METH + HIV+ men who have sex with men (MSM) were compared to 136 METH‐HIV? men.Results
There were no group differences in prevailing adrenocorticotropic hormone (ACTH) or cortisol levels, but the association between ACTH and cortisol was moderated by METH + HIV+ group (β = ?0.19, p < .05). Compared to METH‐HIV? men, METH + HIV+ MSM displayed 10% higher log10 cortisol levels per standard deviation lower ACTH. Both groups of methamphetamine‐using MSM had lower insulin resistance and greater syndemic burden (i.e., sleep disturbance, severe depression, childhood trauma, and polysubstance use disorder) compared to METH‐HIV? men. However, the disaggregated functional relationship between ACTH and cortisol in METH + HIV+ MSM was independent of these factors.Conclusions
Further research is needed to characterize the bio‐behavioral pathways that explain dysregulated HPA axis functioning in HIV‐positive, methamphetamine‐using MSM. 相似文献5.
Domínguez V Ramos N Torrents A García D Carné X 《European journal of clinical pharmacology》2012,68(5):455-458
Objective
We describe clinical trials conducted in pregnant women. 相似文献6.
Virgilijus Beiša Augustas Beiša Simonas Ūselis Kęstutis Strupas 《Central European Journal of Medicine》2012,7(3):371-375
Introduction
Differential diagnosis and treatment of recurrent hyperparathyroidism are complicated. 相似文献7.
Purpose
To achieve tunable pH-dependent drug release in tumor tissues. 相似文献8.
Thorsten Perl Anke Rhenius Christoph B. Eich Michael Quintel Daniel Heise Anselm Bräuer 《Central European Journal of Medicine》2012,7(3):284-289
Background
Perioperative hypothermia is rather common after head and neck surgery. 相似文献9.
Ingeborg M. van Geijlswijk Kristiaan B. van der Heijden A. C. G. Egberts Hubert P. L. M. Korzilius Marcel G. Smits 《Psychopharmacology》2010,212(3):379-391
Rationale
Pharmacokinetics of melatonin in children might differ from that in adults. 相似文献10.
Purpose
To investigate the physical stability of antibody-polyol formulations under thermal and mechanical stresses. 相似文献11.
Ramaekers JG Conen S de Kam PJ Braat S Peeters P Theunissen EL Ivgy-May N 《Psychopharmacology》2011,215(2):321-332
Introduction
Esmirtazapine is evaluated as a novel drug for treatment of insomnia. 相似文献12.
Purpose
To reduce the toxicity and achieve a sustainable and controllable release of cisplatin (CDDP). 相似文献13.
Monica L. Andersen Eileen Kessler Kevin S. Murnane Jessica C. McClung Sergio Tufik Leonard L. Howell 《Psychopharmacology》2010,210(3):439-448
Rationale
Modafinil is currently used as a treatment for daytime sleepiness. 相似文献14.
Lorenza De Carolis Maria Antonietta Stasi Ottaviano Serlupi-Crescenzi Franco Borsini Paolo Nencini 《Psychopharmacology》2010,212(1):105-115
Rationale
The biological underpinnings of schizophrenic polydipsia are poorly understood. 相似文献15.
Purpose
To develop a simple and inexpensive method to visualize and quantify droplet deposition patterns. 相似文献16.
Rationale
Rats raised in isolation self-administer more amphetamine than rats raised in enrichment. 相似文献17.
Rationale
Neuroanatomical evidence suggests that GABAergic deficits and progressive cortical atrophy occur with schizophrenia. 相似文献18.
Purpose
To develop and evaluate liposomal formulations prepared with an isolated mitochondrial fraction as a mitochondria-specific delivery vehicle 相似文献19.
Sheng Qi Peter Belton Kathrin Nollenberger Nigel Clayden Mike Reading Duncan Q. M. Craig 《Pharmaceutical research》2010,27(9):1869-1883
Purpose
To develop novel analytical approaches for identifying both miscibility and phase separation in hot-melt extruded formulations. 相似文献20.
Samuel R. Chamberlain Jon E. Grant Anna Costa Ulrich Müller Barbara J. Sahakian 《Psychopharmacology》2010,212(4):597-601