Does drug-induced sleep endoscopy change the treatment concept of patients with snoring and obstructive sleep apnea?

Purpose

Success rates of non-ventilation therapies for sleep disordered breathing (SDB) remain hardly acceptable. Drug-induced sleep endoscopy (DISE) tends to show the level and mechanism of obstruction and helps to specify therapy individually. Therefore, increasing success rates are expected. The objective of this study is to detect whether locations of treatment recommendations given after DISE are different to those made after clinical basic ENT (ear, nose, throat) examination (CBE).

Methods

This study included patients with obstructive sleep apnea (OSA) and primary snoring who wish or require an alternative therapy to the gold standard, continuous positive airway pressure (CPAP). After CBE, a theoretical treatment recommendation was given comprising surgery (possible surgical target: soft palate, tonsils, tongue base, epiglottis) and mandibular advancement splints (MAS) or both. A second ENT specialist conducted a DISE and independently recommended a second therapy concept without knowing the first one. A third person compared both theoretical locations of treatment recommendations (CBE vs. DISE).

Results

A total of 97 patients (eight female and 89 male, age 30–85 years, AHI 1.9–88.6/h, body mass index [BMI] 20.3–36.3 kg/m²) received two therapy recommendations. Regarding surgical options only, 63.9% of the examined patients got a different recommendation in at least one of four levels. If MAS was included, a change was found in 78.4% of the patients. Subdivided into each type of intervention, the following changes were found in the therapy concept: 24.7% (n?=?24/97) soft palate, 12.4% (n?=?12/97) tonsils, 33.0% (n?=?32/97) tongue base, 27.8% (n?=?27/97) epiglottis, 38.1% (n?=?37/97) MAS.

Conclusions

DISE shows a relevant influence on the location of treatment recommendation. Thus, a change in success rates of non-CPAP therapy in OSA and snoring appears possible.     

Speckle Tracking Echocardiography for the Assessment of the Athlete’s Heart: Is It Ready for Daily Practice?

Purpose of review

To describe the use of speckle tracking echocardiography (STE) in the biventricular assessment of athletes’ heart (AH). Can STE aid differential diagnosis during pre-participation cardiac screening (PCS) of athletes?

Recent findings

Data from recent patient, population and athlete studies suggest potential discriminatory value of STE, alongside standard echocardiographic measurements, in the early detection of clinically relevant systolic dysfunction. STE can also contribute to subsequent prognosis and risk stratification.

Summary

Despite some heterogeneity in STE data in athletes, left ventricular global longitudinal strain (GLS) and right ventricular longitudinal strain (RV ?) indices can add to differential diagnostic protocols in PCS. STE should be used in addition to standard echocardiographic tools and be conducted by an experienced operator with significant knowledge of the AH. Other indices, including left ventricular circumferential strain and twist, may provide insight, but further research in clinical and athletic populations is warranted. This review also raises the potential role for STE measures performed during exercise as well as in serial follow-up as a method to improve diagnostic yield.

     

Is the ‘driving test’ a robust quality indicator of colonoscopy performance?

Colorectal cancer is a major cause of death in the western world and is currently the second commonest cause of death from malignant disease in the UK. Recently a "driving test" for colonoscopists wishing to take part in the National Health Service Bowel Cancer Screening Program has been introduced, with the aim of improving quality in colonoscopy. We describe the accreditation process and have reviewed the published evidence for its use. We compared this method of assessment to what occurs in other developed countries. To the authors' knowledge no other countries have similar methods of assessment of practicing colonoscopists, and instead use critical evaluation of key quality criteria. The UK appears to have one of the most rigorous accreditation processes, although this still has flaws. The published evidence suggests that the written part of the accreditation is not a good discriminating test and it needs to be improved or abandoned. Further work is needed on the best methods of assessing polypectomy skills. Rigorous systems need to be in place for the colonoscopist who fails the assessment.     

Do poor people use poor quality providers? Evidence from the treatment of presumptive malaria in Nigeria

Objective To determine the differences in the quality of treatment for presumptive malaria received by different socio‐economic status (SES) groups in Nigeria. Methods The study was conducted in southeast Nigeria. A household survey was used to collect data on patterns of use of different providers for treatment of adult and childhood malaria. The quality of services provided by different provider types was assessed using treatment vignettes. Quality scores for the different providers were computed based on their responses to the different points raised in the vignettes. Patterns of household treatment seeking for fever were disaggregated by SES, and then weighted by quality score to indicate the overall quality‐weighted utilization by SES and the average quality of a visit by a member of each SES group. Equity ratios (poorest/least poor) provided the measure of inequity in quality‐weighted utilization of different providers. Results In treatment of adult malaria, higher SES groups used more of public and private hospitals, while lower SES groups used more of traditional healers. In case of children, higher SES used more of healthcare centres and private hospitals and lower SES groups used more of pharmacy shops. The lowest quality of services was measured among laboratories, patent medicine dealers (PMDs), mixed goods shops and pharmacies, all of which are private. The highest scores were observed among the two types of public providers (public hospital and healthcare centres). The quality of treatment services utilised by consumers decreased as SES decreased. However, when the quantity normalized index was used this SES disparity almost disappeared. The resulting equity ratio was 0.96 for adults and 0.94 for children. Conclusion Everybody used poor quality malaria treatment services but the poor people used providers with poor quality malaria treatment services more than others. The major driver of disparities in use of different providers by different SES was the greater number of visits of the higher SES groups, rather than the higher quality of the providers they used. Interventions should be developed to improve quality of treatment seeking behaviour and provision practices.     

Off-pump surgery for the poor ventricle?

Severely decreased ejection-fraction is an established risk-factor for worse outcome after cardiac surgery. We compare outcomes of off-pump coronary artery bypass grafting (OPCAB) and on-pump CABG (ONCABG) in patients with severely compromised EF. From 2004 to 2009, 478 patients with a decreased EF ??35% underwent myocardial-revascularization. Patients received either OPCAB (n?=?256) or ONCABG (n?=?222). Propensity score (PS), including 50 preoperative risk-factors, was used to balance characteristics between groups. PS adjusted logistic regression analysis was performed to assess mortality and major adverse cardiac and cerebrovascular events (MACCE). A composite endpoint for major non-cardiac complications such as respiratory failure, renal failure, rethoracotomy was applied. Complete revascularization (CR) was assumed when the number of distal anastomoses was larger than that of diseased vessels. There was no difference for mortality (2.3 vs. 4.1%; PS-adjusted odds ratio (PS-OR)?=?1.05; p?=?0.93) and MACCE (13.7 vs. 17.6%; PS-OR?=?1.22; p?=?0.50) including myocardial-infarction (1.4 vs. 4.9%; PS-OR?=?0.39; p?=?0.26), low cardiac output (2.3 vs. 4.7%; PS-OR?=?0.75; p?=?0.72) and stroke (2.3 vs. 2.7%; PS-OR?=?0.69; p?=?0.66). OPCAB patients presented with a trend to less frequent occurrence of the non-cardiac composite (12.1 vs. 22.1%; PS-OR?=?0.54; p?=?0.059) including renal dysfunction (PAOR?=?0.77; 95% CI 0.31?C1.9; p?=?0.57), bleeding (PAOR?=?0.42; 95% CI 0.14?C1.20; p?=?0.10) and respiratory failure (PAOR?=?0.39; 95% CI 0.05?C3.29; p?=?0.39). The rate of complete revascularization was similar (92.2 vs. 92.8%; PS-OR?=?0.75; p?=?0.50). OPCAB in patients with severely decreased EF is safe and feasible. It may even benefit these patients in regard to non-cardiac complications and does not come at cost of less complete revascularization.