Effect of lower limb malalignment in the frontal plane on transverse plane mechanics during gait in young individuals with varus knee alignment

BackgroundVarus knee alignment has been identified as a risk factor for the progression of medial knee osteoarthritis (OA). This study tested the hypothesis that not only frontal plane kinematics and kinetics but also transverse plane lower extremity mechanics during gait are affected by varus malalignment of the knee.MethodsEighteen, otherwise healthy children and adolescents with varus malalignment of the knee were studied to examine the association between static varus malalignment and functional gait parameters. Kinematic data were collected using a Vicon motion capture system (Vicon Motion Systems, Oxford, UK). Two AMTI force plates (Advanced Mechanical Technology, Inc., Watertown, MA, USA) were used to collect kinetic data.ResultsThe results indicated that changes in transverse plane mechanics occur concomitantly with changes in knee malalignment in the frontal plane. A mechanical consequence of varus knee malalignment is obviously an increased endorotation of the foot (internal foot placement) and an increased internal knee rotation (tibia rotation) during stance phase. The linear correlation between the maximum external knee adduction moment in terminal stance and the internal knee rotation in terminal stance (r = 0.823, p < 0.001) shows that this transverse plane gait mechanics is directly in conjunction with intrinsic compressive load on the medial compartment during gait.ConclusionsUnderstanding factors that influence dynamic knee joint loading in healthy, varus malaligned knees may help us to identify risk factors that lead to OA. Thus, three-dimensional gait analysis could be used for clinical prognoses regarding the onset or progression of medial knee OA.     

Dynamic alignment and its association with knee adduction moment in medial knee osteoarthritis

Lower limb dynamic alignment represents the limb position during functional loading conditions and obtains valuable information throughout the gait cycle rather than a single instant in time. This study aims to determine whether dynamic alignment is altered in medial knee osteoarthritis (OA) and how dynamic alignment is related to knee adduction moment (KAM). Community-dwelling women (n = 17) with medial OA in at least one knee, according to the American College of Rheumatology criteria and 17 body mass index-matched women without OA were recruited. A three-dimensional motion analysis system was used to collect the gait data at self-selected habitual and maximal speeds. Clinical evaluation of lower extremities, physical function, pain, habitual level of physical activity, quality of life and physical self-efficacy were assessed. Shank adduction angle and shank mean angular velocity were significantly greater in the OA group compared to the controls from heel strike to 30% stance. KAM was not different between the groups (p = 0.542). Dynamic alignment variables were the best predictors of KAM. Health-related quality of life, habitual level of physical activity, lower extremity muscle strength and balance performance were impaired in the OA group compared to the controls. The importance of variables that contribute to dynamic alignment and the contribution of limb alignment to KAM were highlighted in this study. Detection of postural changes such as altered dynamic alignment in early stages of OA will lead to the institution of joint-protective measures including changes in footwear, orthotics, gait re-training, use of assistive devices to reduce weight-bearing loads, strengthening and balance enhancing exercises, better analgesia, or cartilage-preserving pharmacotherapy.     

Dynamic foot function changes following total knee replacement surgery

BackgroundIndividuals with knee osteoarthritis (OA) have flatter/more pronated feet than those without OA, but it is unclear whether altered foot posture and function are a cause or consequence of knee OA. The purpose of this study was to examine whether changes in foot posture and function occur after realignment of the knee following total knee replacement (TKR).Materials and methodsNineteen patients with predominantly medial compartment knee OA were tested prior to and 12 months after TKR. The Foot Posture Index (FPI) and Arch Index (AI) were measured as well as motion of the tibia, rearfoot and forefoot using a 3D motion analysis system incorporating a multisegment foot model.ResultsThere were no significant changes in FPI or AI following TKR, however gait analysis revealed significant increases in tibial external rotation (? 18.7 ± 7.0° vs ? 22.5 ± 8.7°, p = 0.002), tibial transverse plane range of motion (? 9.1 ± 4.6° vs ? 11.4 ± 6.1°, p = 0.0028) and rearfoot range of motion in the frontal plane (8.6 ± 2.6° vs 10.4 ± 2.7°, p = 0.002), and a decrease in rearfoot transverse plane range of motion (8.7 ± 5.3° vs 5.9 ± 4.1°, p = 0.038) following the procedure.ConclusionsTKR produces no change in static foot posture, but results in significant changes in rearfoot kinematics during gait. These findings suggest that rearfoot motion compensates for changes in the alignment of the knee, highlighting the ability of the foot to accommodate for proximal skeletal malalignment.     

A quantitative assessment of varus thrust in patients with medial knee osteoarthritis

Varus thrust is an abnormal lateral knee motion frequently seen in patients with medial knee osteoarthritis (OA) during gait. It is a worsening of the alignment in the stance phase of the gait cycle and closely relates to disease progression. In this study, we measured the thrust quantitatively using skin markers and examined the relationship to other static and dynamic parameters. Forty-four knees in 32 patients (mean age, 72 years; range, 64–81 years) who exhibited the radiographic OA at least grade 2 according to the Kellgren–Lawrence (K–L) scale were enrolled. Gait analysis was performed for each patient to measure the amount of thrust and knee adduction moment. The amounts of thrust in subjects with K–L grades 2 (25 knees), 3 (13 knees), and 4 (6 knees) were 2.4°(± 1.3°), 2.8°(± 1.4°), and 7.2°(± 5.3°), respectively and the knee adduction moments were 3.6(± 1.5) %BW ? Ht, 3.9(± 1.2) %BW ? Ht and 6.9(± 2.2%) BW ? Ht, respectively. The amount of thrust also exhibited significant correlation to static radiographic alignment (R = 0.47: 95% confidence interval 0.67–0.21, p = 0.0038) and showed greater correlation to the knee adduction moment (R = 0.73: 95% confidence interval 0.84–0.55, p < 0.001), which has been identified as an important dynamic index of the disease. The amount of thrust, which is able to be measured by simple inexpensive equipment, correlated to static and dynamic parameters and may offer an important clinical index for knee OA.     

Association between long-term quadriceps weakness and early walking muscle co-contraction after total knee arthroplasty

IntroductionQuadriceps weakness is one of the primary post-operative impairments that persist long term for patients after total knee arthroplasty (TKA). We hypothesized that early gait muscle recruitment patterns of the quadriceps and hamstrings with diminished knee performance at 3 months after surgery would be related to long-term quadriceps strength at 1 year after TKA.MethodsTwenty-one subjects who underwent primary unilateral TKA and 14 age-matched healthy controls were analyzed. At 3 months after TKA, the maximum voluntary isometric contraction of the quadriceps and a comprehensive gait analysis were performed. Quadriceps strength was assessed again at 1 year after surgery.ResultsQuadriceps muscle recruitment of the operated limb was greater than the non-operated limb during the loading response of gait (p = 0.03), but there were no significant differences in hamstring recruitment or co-contraction between limbs (p > 0.05). There were significant differences in quadriceps muscle recruitment during gait between the non-operated limbs of the TKA group and the healthy control group (p < 0.05). The TKA group showed a significant inverse relationship between one year quadriceps strength and co-contraction (r = ? 0.543) and hamstring muscle recruitment (r = ? 0.480) during loading response at 3 months after TKA.ConclusionsThe results revealed a reverse relationship where stronger patients tended to demonstrate lower quadriceps recruitment at 3 months post-surgery that was not observed in the healthy peer group. The altered neuromuscular patterns of the quadriceps and hamstrings during gait may influence chronic quadriceps strength in individuals after TKA.Level of evidenceIII.     

Gait and muscle activation changes in men with knee osteoarthritis

The aim was to examine the biomechanics of level- and stair-walking in men with knee osteoarthritis (OA) at different pre-determined gait speeds and to compare the results with those obtained from healthy control subjects. Special emphasis was placed on the estimation of joint loading. Fifty-four men with knee OA (50–69 years) and 53 healthy age- and sex-matched controls were enrolled in the study. The participants walked barefoot in the laboratory (1.2 m/s ± 5%), corridor (1.2; 1.5 and 1.7 m/s ± 5%), and climbing and coming down stairs (0.5 and 0.8 m/s ± 5%) separately. Joint loading was assessed with skin mounted accelerometers (SMAs) attached just above and below the more affected knee joint. The 3-D ground reaction forces (GRFs) and muscle activation with surface-electromyography (EMG) from vastus medialis (VM) and biceps femoris (BF) were also measured simultaneously. There were no differences in SMA variables between groups during level-walking, but maximal loading rate (LR_max) was higher bilaterally in the controls (P < .05). Patients loaded their lower extremity more forcefully especially during stair descent at faster speed. The distinctions in muscle activation both at level- and stair ambulation in VM and BF muscles revealed that the patients used different strategies to execute the same walking tasks. It is concluded that the differences in measured SMA and GRF parameters between the knee OA patients and the controls were only minor at constant gait speeds. It is speculated that the faster speeds in the stair descent subjected the compensatory mechanisms to the maximum highlighting the differences between groups.     

Analysis of the factors that correlate with increased knee adduction moment during gait in the early postoperative period following total knee arthroplasty

Background

Analysis of dynamic knee loading during gait is essential to prevent mechanical failures following total knee arthroplasty. External knee adduction moment during gait is the primary factor producing medial joint reaction force, and an increase in the moment is directly related to an increase in the medial compartment load on the knee.

Altered dynamic foot kinematics in people with medial knee osteoarthritis during walking: A cross-sectional study

BackgroundFootwear and insoles are used to reduce knee load in people with medial knee osteoarthritis (OA), despite a limited understanding of foot function in this group. The aim of this study was to investigate the differences in foot kinematics between adults with and without medial knee OA during barefoot walking.MethodsFoot kinematics were measured during walking in 30 adults; 15 with medial knee OA (mean age was 67.0 with a standard deviation (SD) of 8.9 years; height was 1.66 with SD of 0.13 m; body mass was 84.2 with SD of 15.8 kg; BMI was 30.7 with SD of 6.2 kg/m²; K–L grade 3: 5, grade 4: 10) and 15 aged and gender matched control participants with 12 motion analysis cameras using the IOR multi-segment foot model. Motion of the knee joint, hindfoot, midfoot, forefoot and hallux were compared between groups using clustered linear regression.ResultsThe knee OA group displayed reduced coronal plane range of motion of the midfoot (mean 3.8° vs. 5.4°, effect size = 1.1, p = 0.023), indicating reduced midfoot mobility. There was also a reduced sagittal plane range of motion at the hallux in the knee OA group compared to the control group (mean 29.6° vs. 36.3°, effect size = 1.2, p = 0.008). No statistically significant differences in hindfoot or forefoot motion were observed.ConclusionsPeople with medial knee OA display altered foot function compared to healthy controls. As foot and knee function are related, it is possible that altered foot function in people with knee OA may influence the effects of footwear and insoles.     

The in vivo relationship between anterior neutral tibial position and loss of knee extension after transtibial ACL reconstruction

BackgroundRestoration of anterior tibial stability while avoiding knee extension deficit are a common goal of anterior cruciate ligament (ACL) reconstruction. However, achieving this goal can be challenging. The purpose of this study was to determine whether side-to-side differences in anterior tibial neutral position and laxity are correlated with knee extension deficit in subjects 2 years after ACL reconstruction.MethodsIn the reconstructed and contralateral knees of 29 subjects with transtibial reconstruction, anterior tibiofemoral neutral position was measured with MRI and three-dimensional modeling techniques; terminal knee extension at heel strike of walking and during a seated knee extension were measured via gait analysis; and anterior laxity was measured using the KT-1000.ResultsKnees that approached normal anterior stability and anterior tibial position had increased extension deficit relative to the contralateral knee. On average the reconstructed knee had significantly less (2.1 ± 4.4°) extension during active extension and during heel strike of walking (3.0 ± 4.3º), with increased anterior neutral tibial position (2.5 ± 1.7 mm) and anterior laxity (1.8 ± 1.0 mm). There was a significant correlation between side-to-side difference in anterior neutral tibial position with both measures of knee extension (walking, r = − 0.711, p < 0.001); active knee extension, r = − 0.544, p = 0.002).ConclusionThe results indicate a relationship between the loss of active knee extension and a change in anterior neutral tibial position following non-anatomic transtibial ACL reconstruction. Given the increasing evidence of a link between altered kinematics and premature osteoarthritis, these findings provide important information to improve our understanding of in vivo knee function after ACL reconstruction.     

An evidence-based recommendation for the inclusion of specific local intrinsic factors in the study of knee osteoarthritis

ObjectiveAdequate characterization of the mechanical environment of the knee with osteoarthritis (OA) is important. These local intrinsic factors are difficult to measure and there is little evidence to guide their selection. This study makes an evidence-based recommendation for the inclusion of specific factors in the future study of knee OA.MethodForty-six subjects with knee OA were examined. Observed function was measured by the Timed Chair Rise (TCR). Self-reported function was measured by the WOMAC Function Scale and pain was measured by the WOMAC Pain Scale. Local intrinsic factors measured included varus/valgus alignment, anterior/posterior (A/P) laxity, proprioception, isometric knee extension (KE) strength, isometric knee flexion (KF) strength, and knee range of motion (ROM).ResultsFactors were recommended for inclusion in future research if they were significantly correlated with at least one measure of function or pain and if the factor made a significant unique contribution to a regression model when more than one local intrinsic factor was correlated with the same measure of function or pain. Alignment was correlated with pain (r = 0.48, p = 0.001) and WOMAC function (r = 0.38, p = 0.009). A/P laxity was correlated with pain (r = 0.30, p = 0.04) and WOMAC function (r = 0.37, p = 0.01). Knee ROM was correlated to WOMAC function (r = ? 0.35, p = 0.02). KE strength was correlated with TCR (r = 0.32, p = 0.03). Alignment made a significant contribution to prediction of pain (p = 0.003). A/P laxity (p = 0.004) and ROM (p = 0.008) made a significant contribution to WOMAC function.ConclusionWe recommend future knee OA studies include the variables varus/valgus alignment, A/P laxity, ROM, and KE strength.Level of EvidenceIII (correlational study).     

Correlation between static limb alignment and peak knee adduction angle during gait is affected by subject pain in medial knee osteoarthritis

BackgroundAlthough increases in knee adduction moment (KAM) and angle (KAA) during gait are considered key pathologies that produce mechanical overload in the medial compartment of knee osteoarthritis (OA), it is unclear how these pathologies are related to subjective pain. The purpose of this study was to examine how subjective pain is related to such pathologies.MethodsGait analysis was performed in 31 participants with medial knee OA. The knees were classified into three groups based on Kellgren–Lawrence (KL) grade: early (0 and 1), moderate (2), and severe (3 and 4). Subjective pain was evaluated by the Western Ontario and McMaster Universities (WOMAC) osteoarthritis index pain score. The knees were classified into low- and high-pain groups based on the pain score.ResultsThe WOMAC pain score did not correlate with either peak KAM or peak KAA. Although a positive correlation between static limb alignment and peak KAA was observed in the low-pain group, it was not observed in the high-pain group. Knee flexion angle at heel strike correlated negatively with the gap between static femorotibial angle and peak KAA in the high-pain group.ConclusionsAlthough a direct correlation between subjective pain and peak KAM or KAA was not observed, our results suggest a compensatory movement in the high-pain group of participants to reduce KAA increases in the early stance phase. Such movements would be one of the reasons why it is difficult to obtain a consistent relationship between subjective pain and load-related parameters.     

Pre-operative analysis of lower limb coronal alignment — A comparison of supine MRI versus standing full-length alignment radiographs

BackgroundIn this study we compare the results of pre-operative standing full-length alignment (SFLA) radiographs with supine MRI assessment of the lower limb alignment prior to MRI based patient specific total knee arthroplasty (TKA).MethodsImaging was performed in 45 knees (45 patients). Assessment of SFLA radiographs was performed by three independent assessors. Inter-observer correlation was high and so the mean values were calculated. This data was then compared to MRI alignment data used to create the patient specific cutting jigs.ResultsThe range of alignment on SFLA radiographs ranged from + 25° to − 13° versus + 20° to − 11° with MRI. The mean difference between techniques was 2° (range 0–8°, SD ± 3°). Supine MRI under-estimated the degree of deformity in 31/45 (69%) cases. In 25/45 (56%) cases the supine MRI result was within ± 2° of the value on SFLA radiographs, 31/45 (69%) were within ± 3° and 38/45 (84%) within ± 5°. There was no correlation between the degree of varus/valgus deformity and the magnitude of the difference between imaging modalities (Spearman's r² = 0.02, p = 0.41).ConclusionsThe findings from this study would indicate that supine MRI underestimates the degree of deformity at the knee joint, a conclusion which may be important for pre-operative planning or follow-up of corrective osteotomy or TKA.     

Tibial displacement and rotation during seated knee extension and wall squatting: A comparative study of tibiofemoral kinematics between chronic unilateral anterior cruciate ligament deficient and healthy knees

BackgroundFollowing anterior cruciate ligament (ACL) rupture, the knee becomes unstable with alterations in joint kinematics including anterior tibial displacement (ATD), and internal tibial rotation. Therapeutic exercises that promote faulty kinematics should be discouraged, especially early post-reconstruction, to avoid graft stretching and possibly longer-term osteoarthritis. Our study aimed to compare ATD and tibial rotation during two commonly prescribed exercises, namely: open kinetic chain (OKC) seated extension and closed kinetic chain (CKC) single leg wall squatting in ACL-deficient and healthy knees.MethodsEight ACL-deficient patients and eight healthy subjects matched for age, gender and sports history were assessed using Qualisys 3D-Motion Analysis System to track 17 infrared markers while performing a seated knee extension with 3 kg weight and a unilateral wall squat. We developed a model to measure joint kinematics through 70° of knee flexion and extension. ANOVA and paired t-tests compared relative ATD and tibial rotation between exercises and groups at 10° increments of flexion and extension.ResultsWe found increased ATD in the wall squat compared to the seated extension (p = 0.049). There was no difference in ATD between the healthy and ACL-deficient knees but overall the tibia was significantly more internally rotated (p = 0.003) in ACL-deficient knees, irrespective of the exercise, possibly interfering with the screw-home mechanism.ConclusionsCKC exercises, in particular wall squats, are not necessarily safer for patients with ACL-deficiency and possibly ACL-reconstruction; although generalization should only be made with appropriate caution. Clinicians require a detailed knowledge of the effect of exercise on knee joint kinematics.     

Association between in vivo knee kinematics during gait and the severity of knee osteoarthritis

BackgroundOsteoarthritis patients may exhibit different kinematics according to the disease stage. However, changes in the frontal and horizontal planes in each stage remain unclear. The purpose of this study was to investigate changes in the knee kinematic gait variables of osteoarthritis patients, including the frontal and horizontal planes, with respect to the severity of the disease.MethodsForty-five patients with knee osteoarthritis and 13 healthy young subjects were recruited for the experiment. All subjects were examined while walking on a 10-m walkway at a self-selected speed. In each trial, we calculated the angular displacements of flexion/extension, abduction/adduction, and external/internal tibial rotation. We also measured muscle strength, range of motion (ROM), and alignment. We compared the differences in osteoarthritis severity and knee kinematic variables between osteoarthritis patients and normal subjects.ResultsThe flexion angle at the time of foot contact was significantly less in patients with severe and moderate osteoarthritis than in normal subjects (both p < 0.01). The abduction angle at the 50% stance phase was significantly less in patients with severe osteoarthritis than in normal subjects (p < 0.05). The excursion of axial tibial rotation was significantly less in patients with early osteoarthritis than in normal subjects (p < 0.05).ConclusionOsteoarthritis patients had different knee kinematics during gait, depending on the progress of osteoarthritis. Early-stage patients exhibit decreased axial tibial rotation excursion, while severe-stage patient exhibit increased knee adduction.     

Patient specific cutting guides versus an imageless,computer-assisted surgery system in total knee arthroplasty

BackgroundPatient specific cutting guides (PSC) in total knee arthroplasty (TKA) have recently been introduced, in which preoperative 3-dimensional imaging is used to manufacture disposable cutting blocks specific to a patient's anatomy. The purpose of this study was to compare the alignment accuracy of PSC to an imageless CAS system in TKA.MethodsThirty-seven patients (41 knees), received a TKA using an imageless CAS system. Subsequently, 38 patients (41 knees), received a TKA using a MRI-based, PSC system.Postoperatively, standing AP hip-to-ankle radiographs were obtained, from which the lower extremity mechanical axis, tibial component varus/valgus, and femoral component varus/valgus mechanical alignment were digitally measured. Each measurement was performed by two blinded, independent observers, and interclass correlations were calculated. A student's two-tailed t test was used to compare the two cohorts (p-value < 0.05 = significant).ResultsIn the PSC cohort, 70.7% of patients had an overall alignment within 3° of a neutral mechanical axis (vs. 92.7% with CAS, p = 0.02), 87.8% had a tibial component alignment within 2° of perpendicular to the tibial mechanical axis (vs. 100% with CAS, p = 0.04), and 90.2% had a femoral component alignment within 2° of perpendicular to the femoral mechanical axis (vs. 100% with CAS, p = 0.2). Interclass correlation coefficients were good to excellent for all radiographic measurements.ConclusionWhile PSC techniques appear sound in principle, this study did not demonstrate patient specific cutting guides to obtain the same degree of overall mechanical and tibial component alignment accuracy as a CAS technique.Level of evidenceIII: Retrospective cohort study.     

Effect of walking with a modified gait on activation patterns of the knee spanning muscles in people with medial knee osteoarthritis

ObjectiveTo evaluate muscle activation patterns and co-contraction around the knee in response to walking with modified gait patterns in patients with medial compartment knee-osteoarthritis (KOA).Design40 medial KOA patients walked on an instrumented treadmill. Surface EMG activity from seven knee-spanning muscles (gastrocnemius, hamstrings, quadriceps), kinematics, and ground reaction forces were recorded. Patients received real-time visual feedback on target kinematics to modify their gait pattern towards three different gait modifications: Toe-in, Wider steps, Medial Thrust. The individualized feedback aimed to reduce their first peak knee adduction moment (KAM) by ≥ 10%. Changes in muscle activations and medial/lateral co-contraction index during the loading response phase (10–35% of the gait cycle) were evaluated, for the steps in which ≥ 10% KAM reduction was achieved.ResultsData from 30 patients were included in the analyses; i.e. all who could successfully reduce their KAM in a sufficient number of steps by ≥ 10%. When walking with ≥ 10% KAM reduction, Medial Thrust gait (KAM − 31%) showed increased flexor activation (24%), co-contraction (17%) and knee flexion moment (35%). Isolated wider-step gait also reduced the KAM (− 26%), but to a smaller extent, but without increasing muscle activation amplitudes and co-contraction. Toe-in gait showed the greatest reduction in the KAM (− 35%), but was accompanied by an increased flexor activation of 42% and hence an increased co-contraction index.ConclusionGait modifications that are most effective in reducing the KAM also yield an increase in co-contraction, thereby compromising at least part of the effects on net knee load.     

Radiographic evaluation of factors affecting bearing dislocation in the domed lateral Oxford unicompartmental knee replacement

BackgroundThe rate of bearing dislocation with the domed lateral Oxford Unicompartmental Knee Replacement (OUKR) in different series varies from 1% to 6% suggesting that dislocation is influenced by surgical technique. The aim of this study was to identify surgical factors associated with dislocation.MethodsAligned post-operative antero-posterior knee radiographs of seven knees that had dislocated and 87 control knees were compared. Component alignment and position and the alignment of the knee were assessed. All bearing dislocations occurred medially over the tibial wall.ResultsKnees that dislocated tended to be overcorrected: Compared with those that did not dislocate, they were in 2° less valgus (p = 0.019) and the tibial components were positioned 2 mm more proximal (p < 0.01). Although the relative position of the centre of the femoral component and the tibial component was the same (p = 0.8), in the dislocating group the gap between the edge of the femoral component and the top of the wall in flexion was 3 mm greater (p = 0.019) suggesting that the components were internally rotated.ConclusionsTo minimise the risk of dislocation it is recommended that the knee should not be overstuffed. This is best achieved by selecting the bearing thickness that just tightens the ligaments in full extension, and re-cutting the tibia if necessary. In addition to minimise the gap between the femoral and tibial components through which the bearing dislocates, the femoral component should be implanted in neutral rotation and should not be internally rotated.Level of evidenceLevel IV     

3D in vivo femoro-tibial kinematics of tri-condylar total knee arthroplasty during kneeling activities

BackgroundKneeling position can serve as an important posture, providing stability and balance from a standing position to sitting on the floor or vice-versa. The purpose of the current study was to determine the kinematics during kneeling activities after subjects were implanted with a tri-condylar total knee arthroplasty.Materials and methodsKinematics was evaluated in 54 knees using fluoroscopy and a three-dimensional model fitting approach.ResultsThe average knee flexion at before contact status, at complete contact and at maximum flexion was 98.1 ± 9.0°, 107.2 ± 6.7°, and 139.6 ± 12.3°, respectively. On average, there was no gross anterior displacement from before contact status to complete contact. Only slight posterior rollback motion of both condyles from complete contact to maximum flexion was observed. Three of 39 (7.7%) knees experienced anterior movement of both condyles more than 2 mm from before contact status to complete contact. Reverse rotation pattern from before contact status to complete contact and then normal rotation pattern from complete contact to maximum flexion were observed. Condylar lift-off greater than 1.0 mm was observed in 45 knees (83.3%).ConclusionThe presence of the ball-and-socket joint articulation provides sufficient antero-posterior stability in these designs to enable the patients to kneel safely without the incidence of any dislocation.Clinical relevanceThis study suggests a safe implant design for kneeling.     

The effect of knee brace and knee sleeve on the proprioception of the knee in young non-professional healthy sportsmen

BackgroundProprioception has been defined as the capacity to feel the position of a joint in space as sensed by the central nervous system. Prophylactic knee braces are supposed to help in knee injury prevention not just with a mechanical support of the joint but also improving proprioception. The main aim of this study was to determine the effects of a knee brace and a knee sleeve on knee proprioception. The secondary aim was to determine if different starting angles of the knee and different movement directions influence knee proprioception.MethodsWe tested a group of twenty healthy male sport students without knee injuries. They were tested with the brace, with the sleeve and without support. The threshold of detection of passive knee movement with a starting knee angle of 30° and 60°, both in flexion and extension was determined.ResultsWe did not find any statistically significant change in the threshold of detection of passive knee movement wearing the brace or the sleeve compared to the unsupported condition (p = 0.462, α = 0.05). We found a significantly lower proprioceptive sensitivity starting at the more flexed knee angle (p = 0.005, α = 0.05) and moving in extension than in the other test situations (p = 0.001, α = 0.05).ConclusionMovement direction and starting position appear to influence the threshold of detection of passive knee movement. The results of this study also suggest that knee supports do not influence either positively or negatively knee proprioception of uninjured active subjects.     

Infrapatellar fat pad-derived mesenchymal stem cell therapy for knee osteoarthritis

PurposeThe aim of the study was to determine if isolated mesenchymal stem cells (MSCs) derived from the infrapatellar fat pad could effectively improve clinical results when percutaneously injected into arthritic knees.Level of evidenceTherapeutic case–control study; Level III.MethodsTwenty five stem cell injections combined with arthroscopic debridement were administered to patients with knee OA. A mean of 1.89 × 10⁶ stem cells were prepared with approximately 3.0 mL of platelet-rich plasma (PRP) and injected in the selected knees of patients in the study group.ResultsThe mean Lysholm, Tegner activity scale, and VAS scores of patients in the study group improved significantly by the last follow-up visit. No major adverse events related to the injections were observed during the treatment and follow-up periods. The results were compared between the study and control groups, in which the patients had undergone arthroscopic debridement and PRP injection without stem cells. Although the preoperative mean Lysholm, Tegner activity scale, and VAS scores of the study group were significantly poorer than those of the control group, the clinical results at the last follow-up visit were similar and not significantly different between the two groups.ConclusionsThe short-term results of our study are encouraging and demonstrate that infrapatellar fat pad-derived MSC therapy with intraarticular injections is safe, and provides assistance in reducing pain and improving function in patients with knee OA.