贝伐单抗联合吉西他滨和厄洛替尼在转移性胰腺癌的Ⅲ期临床研究

1文献来源 van Cutsem E Phase III trial of , Vervenne WL, Bevacizumab in Bennouna J, et al. combination with Gemcitabine and pancreatic cancer 2231-2237. Erlotinib in patients with metastatic [J]. J Clin Oncol, 2009,27（13）：     

Bevacizumab加FU/LV:有望成为转移性结直肠癌一线化疗方案

1 文献类型 治疗2 证据水平 2b3 文献来源 Fairooz K,Herbert L,Lurwitz F,et al.Phase Ⅱ, randomized trial comparing Bevacizumab pluse Fluorouracil (FU)/Leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer [J]. J Clin Oncol, 2003,21(1):60-65     

肿瘤缓解分级和ERCC1核蛋白表达可以预测胃食管肿瘤患者新辅助化疗的临床效果

1文献来源 Fareed KR,Al-Attar A,Soomro IN,et al.Tumour regression and ERCC1 nuclear protein expression predict clinical outcome in patients with gastro-oesophageal cancer treated with neoadjuvant chemotherapy[J].Br J Cancer,2010,102（11）：1600-1607.     

小细胞肺癌预防性全脑照射的决策分析

1 文献来源 Lee J J, analysis for patients with Bekele BN, Zhou X, et al. Decision prophylactic cranial irradiation for small-cell lung cancer [J]. J Clin Oncol, 2006,24：3597-3603.     

EGFR-TKI有效肺癌经“药物间歇”后再获TKI敏感

1文献来源Becker A, Crombag L, Heideman DA, et al. Retreatment with Erlotinib: Regain of TKI sensitivity following a drug holiday for patients with NSCLC who initially responded to EGFR-TKI treatment [J]. Eur J Cancer, 2011,47(17):2603-2606. 2证据水平1c。     

BEACOPP在PET中期评价阳性晚期霍奇金淋巴瘤患者的疗效分析

1文献来源 Gallamini A, Patti C, Viviani S, et al. Early chemotherapy intensification with BEACOPP in advanced stage Hodgkin lymphoma patients with a interim-PET positive after two ABVD courses [J]. Br J Haematol, 2011,152（5） ：551-560.     

探讨依维莫司联合他莫昔芬对激素受体阳性及HER2阴性转移性乳腺癌患者的作用

1文献来源Bachelot T,Bourgier C,Cropet C,et al.Randomized phase Ⅱ trial of Everolimus in combination with Tamoxifen in patients with hormone receptor-positive,human epidermal growth factor receptor2-negative metastatic breast cancer with prior exposure to aromatase inhibitors:A GINECO study[J].J Clin Oncol,2012,30(22):2718-2724.2证据水平1b。     

低剂量螺旋CT筛查高危人群可降低肺癌死亡率

1 文献来源 The National Lung Screening Trial Research Team.Aberle DR, Adams AM, Berg CD,et al.Reduced lung-cancer mortality with low-dose computed tomographic screening[J].N Engl J Med,2011,365(5):395-409. 2 证据水平 1a. 3 背景 肺癌是一种异质性很强的肿瘤,长久以来,为降低肺癌死亡率进行的筛查总因为其侵袭性和异质性而收效甚微.低剂量螺旋CT可检出处于早期阶段的肿瘤而被广泛用于各种癌症的筛查,该方法是否适用于肺癌的筛查尚缺乏大规模系统研究.     

螺旋CT筛查Ⅰ期肺癌患者生存率的研究

1文献类型 诊断。 2证据水平1b。 3文献来源 The International Early Lung Cancer Action Program Investigators．Survival of patients with stage Ⅰlung cancer detectionon CT screening [J]．NEng J Med，2006，355（17）：1763—1771．     

原位RRM1和ERCC1蛋白表达水平预测吉西他滨为基础化疗方案对非小细胞肺癌的疗效

1 文献来源 Reynolds C, Obasaju C, Schell M J, et al. Randomized phase IU trial of Gemcitabine-based chemotherapy with in situ RRM1 and ERCC1 protein levels for response prediction in non-small-cell lung cancer[J]. J Clin Oncol, 2009,27（34）：5808-5815.