强氧化电位水阴道冲洗辅助治疗老年性阴道炎

将 138例老年性阴道炎病人随机分为两组 ,各 6 9例。观察组应用强氧化电位水阴道冲洗联合呋喃西林注射粉剂局部用药 ;对照组采用 1∶5 0 0 0高锰酸钾溶液阴道冲洗及阴道塞保妇康栓。结果观察组总有效率为 97.1% ,对照组为 87.0 % ,两组比较 ,差异有显著性意义 (P <0 .0 5 )。提示强氧化电位水阴道冲洗辅助治疗老年性阴道炎疗效肯定。     

止痒洗液治疗霉菌性阴道炎疗效观察

目的探讨止痒洗液治疗霉菌性阴道炎的效果.方法将300例霉菌性阴道炎病人随机分为观察组(160例)和对照组(140例),对照组采用洁尔阴洗液,观察组采用止痒洗液,均将洗液稀释后坐浴及冲洗阴道.结果观察组总有效率显著高于对照组(χ2=15.91,P＜0.01). 结论止痒洗液对霉菌性阴道炎有良好的治疗效果.     

改良冲洗器在宫颈癌放疗患者阴道冲洗中的应用

目的观察改良冲洗器在宫颈癌放疗患者阴道冲洗中的应用效果。方法将中晚期宫颈癌放疗患者90例随机分为两组各45例。观察组用改良的冲洗喷头,直接进入阴道进行阴道冲洗;对照组运用一次性灌肠袋冲洗,必须经窥阴器撑开阴道进行阴道冲洗。观察两组冲洗效果及患者舒适度情况。结果观察组宫腔积液积脓、阴道壁损伤及患者舒适度显著优于对照组(P<0.05,P<0.01)。结论改良冲洗器在宫颈癌放疗患者阴道冲洗中效果好,患者舒适度高,提高了患者的生活质量。     

宫颈癌放疗患者家庭式阴道冲洗效果观察

目的探讨宫颈癌患者放疗期间家庭式阴道冲洗对阴道清洁度和阴道粘膜反应的效果。方法将120例宫颈癌放疗患者随机分为对照组和观察组各60例。对照组进行传统阴道冲洗,即在医院由专职护士操作;观察组进行家庭式阴道冲洗,即经护士在医院指导后回家自行冲洗。观察两组患者在放疗后第2、4、6周阴道清洁度和阴道粘膜反应情况。结果两组患者放疗期间阴道清洁度和阴道粘膜反应比较,差异无显著性意义(均P>0.05)。结论家庭式阴道冲洗在宫颈癌放疗期间替代传统阴道冲洗是可行的,且简单、方便、经济、有效。     

宫颈癌放疗患者家庭式阴道冲洗效果观察

目的 探讨宫颈癌患者放疗期间家庭式阴道冲洗对阴道清洁度和阴道粘膜反应的效果。方法 将120例宫颈癌放疗患者随机分为对照组和观察组各60例。对照组进行传统阴道冲洗，即在医院由专职护士操作；观察组进行家庭式阴道冲洗，即经护士在医院指导后回家自行冲洗。观察两组患者在放疗后第2、4、6周阴道清洁度和阴道粘膜反应情况。结果 两组患者放疗期间阴道清洁度和阴道粘膜反应比较，差异无显著性意义（均P〉0．05）。结论 家庭式阴道冲洗在宫颈癌放疗期间替代传统阴道冲洗是可行的,且简单、方便、经济、有效。     

硝呋太尔胶囊联合硝呋太尔制霉素阴道软胶囊治疗念珠菌性阴道炎临床观察

目的:观察硝呋太尔胶囊联合硝呋太尔制霉素阴道软胶囊治疗念珠菌性阴道炎的临床疗效.方法:将门诊80例念珠菌阴道炎患者随机分为治疗组及对照组各40例.治疗组给硝呋太尔胶囊口服,联合硝呋太尔制霉素阴道软胶囊;对照组给氟康唑口服.用SPSS13.0统计数据.结果:治疗组40例中,痊愈38例,有效1例,无效1例,痊愈率95.00％.对照组40例中,痊愈32例,有效5例,无效3例,有效率80.00％.两组组总痊愈比较差异有统计学意义(P＜0.05).治疗组痊愈率比对照组高.结论:硝呋太尔胶囊联合硝呋太尔制霉素阴道软胶囊治疗念珠菌性阴道炎疗效好,复发率低,无明显不良反应.     

纳米银抗菌凝胶治疗细菌性阴道炎的疗效及对阴道乳酸杆菌影响的观察

目的:观察纳米银抗菌凝胶治疗细菌性阴道炎的疗效及时阴道乳酸轩茸影响.方法:将240例细菌性阴道炎患者分为两组,分别用纳来银抗菌凝胶治疗120例为治疗组,另120例用甲硝哇辁治疗为对照组.结果:纳米银抗菌凝胶治疗细菌性阴道炎的有效率较甲硝哇栓治疗高(P<0.05),特别是痊愈率更高(P<0.01);治疗后阴道乳酸杆菌检出率(%)及检出量(%)也较甲硝哇栓治疗高(P<0.01),差异有统计学意义,结论:纳米银妇女外用抗菌凝胶疗效好,治疗期间对患者阴道乳酸杆菌无不良影响,值得推广.     

宫颈癌放射性皮肤损伤的标准化护理

目的减轻宫颈癌同期放化疗患者放射性皮肤损伤程度。方法将434例宫颈癌同期放化疗患者随机分为观察组与对照组各217例。两组均接受放疗联合同期化疗,对照组按常规进行放射性皮肤损伤防护;观察组根据患者放疗剂量及患者局部情况设计标准化防护方案、规范评估方法、统一防护操作技术防护流程,进行严格质量控制。结果观察组放射性皮肤损伤严重程度显著轻于对照组,会阴部卫生清洁合格率及内裤穿着合格率显著高于对照组(均P0.01)。结论标准化防护方案的实施可有效减轻宫颈癌同期放化疗患者放射性皮肤损伤程度,提高患者卫生防护行为。     

煤矿事故致伤患者的口腔护理

目的 探讨煤矿事故致伤患者的口腔护理方法.方法 将因煤矿事故致伤经口气管插管需行口腔护理的危重患者45例(口内没有伤口)随机分成观察组(25例)和对照组(20例).观察组用擦洗与冲洗相结合的方法进行口腔护理;对照组按传统方法进行口腔护理.结果 观察组口臭、口腔感染发生率显著低于对照组(P＜0.01,P＜0.05);而舌苔转薄率显著高于对照组(P＜0.05).结论 采用擦洗联合冲洗法可提高煤矿事故致伤患者的口腔护理效果.     

保妇康栓治疗老年性阴道炎60例临床观察

目的:观察保妇康栓治疗老年性阴道眼的临床效果.方法:选取老年性阴道眼患者60例,随机分为两组,试验组30例,采用保妇康栓阴道给药,对照组30例采用甲硝唑阴道给药,比较两组疗效.结果:试验组治愈率90.％,对照组治愈率86.6％,两组相比差异无显著性(P＜0.05).结论:保妇康栓治疗老年性阴道炎疗效显著,它可做为妇科常见病的首选药.     

Electrophysiological effects of sevoflurane in comparison with propofol in children with Wolff-Parkinson-White syndrome

OBJECTIVE: To evaluate the electrophysiological effects of sevoflurane in children with Wolff-Parkinson-White (WPW) syndrome undergoing radiofrequency ablation. METHODS: We performed a prospective study of 15 patients with WPW syndrome who were scheduled for an electrophysiological study (EPS) and radiofrequency ablation. Anesthesia was induced with fentanyl (2 microg/kg), propofol (3 mg/kg), and vecuronium (0.1 mg/kg), and initially maintained using propofol (100 microg/kg), with bolus administration of fentanyl and vecuronium as required. Four intracardiac catheters were introduced for the EPSpropofol, which included measurements of sinus-node function, sinoatrial-node conduction, refractory periods (atrial, AV-node, accessory pathway anterograde and retrograde, and ventricular), and the characteristics of induced orthodromic tachycardia. The propofol was then replaced with sevoflurane (1 MAC adjusted for age) and the measurements were repeated (EPSsevoflurane). The EPSpropofol and EPSsevoflurane data were compared using the Wilcoxon signed-rank test. RESULTS: The mean (SD) age was 9.3 (6) years. After administration of sevoflurane, the duration of the antegrade effective refractory period of the accessory pathway increased (EPSpropofol, 283 (22) ms; EPSsevoflurane, 298 (25) ms; P = .004), as did the duration of the minimum pacing cycle with 1:1 atrioventricular conduction (EPSpropofol, 244 (41) ms; EPSsevoflurane, 273 (28) ms; P = .028). No significant changes were observed in the other parameters. Ablation of the accessory pathway was achieved in all patients. CONCLUSIONS: Sevoflurane partially modified the properties of the accessory pathway but did not prevent ablation.     

Reversal of vecuronium with neostigmine in patients with diabetes mellitus

Reversal of vecuronium-induced neuromuscular blockade with neostigmine was compared in two groups of 16 subjects: patients with Type 2 diabetes mellitus and normal controls. When the first twitch of the train-of-four had returned to 25% of the control value, neostigmine 40 microg x kg(-1) and atropine 20 microg x kg(-1) were given to reverse the neuromuscular blockade. The train-of-four ratio was lower at 3 min, 6 min, 9 min, 12 min and 15 min after reversal in the diabetic group than in the control group but the differences did not reach statistical significance. Fifteen minutes after reversal, the number of patients in whom recovery from neuromuscular blockade was judged insufficient to guarantee good respiratory function (train-of-four ratio < 0.74) did not differ between the groups. However, 15 min after reversal, the number of patients with a train-of-four ratio < 0.9 was significantly higher in the Diabetic Group than in the Control Group (15 vs. 10, p = 0.033).     

Treatment of Osteoporosis in Men with Fluoride Alone or in Combination with Bisphosphonates

Alendronate has been approved as a first antiresorptive drug for treatment of osteoporosis in men. Except for fluoride, in some countries so far there has been no approved anabolic substance for the treatment of male osteoporosis. From small studies in men and male patients included in studies on postmenopausal osteoporosis there is sufficient evidence that fluoride has the same osteoblast-stimulating potency in men and women. In our own study on 64 men with idiopathic osteoporosis without prevalent fractures, a low-dose intermittent fluoride regimen (15 mg fluoride ions 3 months on, 1 month off) resulted in an average gain of lumbar spine BMD of 3% per year and a lower rate of incident fractures as compared with patients treated with calcium only. A combination of fluoride with an antiresorptive drug may improve the therapeutic results in terms of pattern of biochemical marker response and gain in BMD. This was shown for postemopausal osteoporosis in several studies using fluoride and hormone replacement therapy (HRT). Encouraged by a Dutch study using etidronate/fluoride in corticoid-induced osteoporosis, we performed a pilot study in 33 men with severe established primary osteoporosis giving cyclically etidronate for 14 days followed by fluoride plus calcium/vitamin D for 76 days. This combined regimen resulted in significantly higher increases of BMD than fluoride or etidronate alone. In an ongoing trial we are studying a continuous, combined treatment of alendronate and fluoride plus calcium/vitamin D in established idiopathic osteoporosis in men. The results of a preliminary evaluation look very promising. A large study with a bisphosphonate plus fluoride, taking fractures as the primary endpoint and bone biopsies to assess safety, would be very valuable.     

Chemiluminescence of neutrophils in patients with glomerulonephritis treated with methylprednisolone

The effect of high dose methylprednisolone (Solu-Medrol, Up John) (1000 mg) on chemiluminescence (CL) of peripheral blood neutrophils in patients with various primary glomerulopathies was determined. Contrary to the well-established influence of corticosteroids onin vitro suppression of leukocytic chemiluminescence, our studies disclose a remarkable enhancement of neutrophil chemiluminescent activity in patients receiving pulse methylprednisolone infusion. Subsequent administrations of the drug did not result in any significant change of the analysed parameters. Increased chemiluminescence returned to the pretreatment values within approximately seven days. A possible explanation for the observed phenomenon is discussed.     

Comparison of clofibrate with halofenate in diabetics with hyperlipidaemia.

In a double-blind, randomized study which lasted 48 weeks the effects of clofibrate and halofenate were compared in maturity-onset diabetics with hyperlipidaemia. With the use of both clofibrate and halofenate serum cholesterol values were lowered only slightly. Both agents significantly reduced triglyceride values, but the decreases were modest and transient. Both drugs significantly lowered serum urate values, although the effect of halofenate was distinctly greater. Halofenate, but not clofibrate, had a considerable hypoglycaemic effect on the patients, most of whom were also receiving oral antidiabetic medicines. The drugs produced a number of clinical and biochemical adverse reactions, and in about 20% of all patients the trial had to be discontinued prematurely. The management of hyperlipidaemia in maturity-onset diabetics is briefly discussed, and it is concluded that neither clofibrate nor halofenate is to be recommended.     

Tomographic studies of rCBF with99mTc-HM-PAO SPECT in comparison with PET in patients with primary brain tumors

^99mTc-hexamethyl-propyleneamine-oxime (HM-PAO) was developed as a radiotracer of regional cerebral blood flow (rCBF) with SPECT. THe purpose of this study was to investigate if HM-PAO is able to trace rCBF in primary brain tumors. In 10 patients with glioblastoma grade IV the intracerebral distribution of HM-PAO was studied in comparison with C¹⁵O₂ steady state inhalation technique and PET for rCBF evaluation. In all instances the cerebral HMPAO distribution was comparable with rCBF pattern as confirmed by a significant correlation of tumor to cortex ratios. The results indicate the clinical usefulness of HMPAO for tracing rCBF in brain tumors.     

Detection of Endoparasites with Zoonotic Potential in Dogs with Gastrointestinal Disease in the UK

We report a substantial prevalence study in symptomatic pet dogs of important zoonotic parasitic enteric infections. A total of 4526 dogs which had a faecal sample submitted to a diagnostic laboratory in the UK between 2003 and 2005 were included in the study. The most common parasite was Giardia spp., which was found in 380/4526 dogs (8.4%, 95% CI 7.6–9.2%). Surprisingly, Cryptosporidium spp. infection was detected in only 29/4526 (0.6%, 95% CI 0.4–0.9%). Toxocara canis was found in 63/4526 dogs (1.4%; 95% CI 1.1–1.8%). Prevalence of Giardia (P < 0.001) was significantly higher in dogs <12 months of age, with nearly one‐fifth of all symptomatic dogs under 6 months being infected with Giardia. Some seasonality was detected with a higher prevalence of Cryptosporidium oocyst shedding found from October to December. These data are of importance for veterinarians in judging the likelihood of enteric parasitic infection in an individual with clinical signs. Moreover, they provide information to direct future work in determining the risk to the human population from parasitic zoonoses of dogs.