Deep cerebral venous thrombosis: imaging in eight cases

Deep cerebral venous thrombosis (DCVT) is a rare, potentially fatal disease. We carried out a retrospective analysis of eight patients presenting with DCVT, using CT and MRI data. Digital subtraction angiography (DSA), MR angiography (MRA) (2D phase-contrast), and angiography were performed in four, four and two patients, respectively. Direct (venous abnormalities) and indirect (parenchymatous involvement) signs of thrombosis were assessed. Follow-up MRI and MRA were performed on two patients. CT was initially normal in two patients, demonstrated a “cord sign” in deep veins in five and deep venous infarcts in three. When performed within a week of admission (seven patients), MRI showed thrombosis as into intense or high signal in deep veins on sagittal T1-weighted spin-echo images in all patients, and on axial T2-weighted spin-echo images in two. Deep venous infarcts were found in five patients. Direct or indirect signs of sagittal or lateral sinus thrombosis were present on CT in two patients and on MRI in five. CT angiography, MRA and DSA were concordant with MRI findings. CT venography showed persistent flow in thrombosed veins. MRI follow-up demonstrated progressive deep venous recanalisation. Received: 5 December 1996 Accepted: 30 July 1998     

Magnetic resonance imaging of cerebral venous thrombosis secondary to "low-dose" birth control pills

The clinical and radiographic features of cerebral deep venous thrombosis in a 21-year-old white woman are presented. This nulliparous patient presented with relatively mild clinical symptoms and progressing mental status changes. The only known risk factor was "low-dose" oral contraceptive pills. The magnetic resonance image (MRI) showed increased signal intensity from the internal cerebral veins, vein of Galen, and straight sinus. The diagnosis was confirmed by arterial angiography.     

脑静脉窦和静脉血栓形成的影像学诊断与分析

目的 探讨脑静脉窦和静脉血栓形成(CVST)的影像特征及诊断体会.方法 回顾性分析28例CVST患者的影像学表现、影像诊断特征.结果 (1)CVST的CT及MRI影像学表现只有少数病例可见典型的"条索状"直接征象(3.57%);最常见的间接征象为非典型性的脑出血(50.00%)及脑梗死(CT:32.14%,MRI:39.29%),发病部位以双侧性较多(75.00%).(2)大部分CVST患者的磁共振静脉成像(MRV)或CT静脉血管成像(CTV)出现静脉窦连续性中断,充盈缺损区,完全性或虫蚀状改变等直接征象(CTV:100%,MRV:83.33%),还可出现远端静脉窦增粗及引流静脉扩张等间接征象.结论 CVST的CT及MRI常规影像学表现无明显特异性,而CTV和MRV影像学表现具有较高的特异性,若怀疑CVST应尽早行MRV或CTV检查以明确诊断.     

脑静脉窦和静脉血栓形成的影像学诊断与分析

目的 探讨脑静脉窦和静脉血栓形成(CVST)的影像特征及诊断体会.方法 回顾性分析28例CVST患者的影像学表现、影像诊断特征.结果 (1)CVST的CT及MRI影像学表现只有少数病例可见典型的"条索状"直接征象(3.57%);最常见的间接征象为非典型性的脑出血(50.00%)及脑梗死(CT:32.14%,MRI:39.29%),发病部位以双侧性较多(75.00%).(2)大部分CVST患者的磁共振静脉成像(MRV)或CT静脉血管成像(CTV)出现静脉窦连续性中断,充盈缺损区,完全性或虫蚀状改变等直接征象(CTV:100%,MRV:83.33%),还可出现远端静脉窦增粗及引流静脉扩张等间接征象.结论 CVST的CT及MRI常规影像学表现无明显特异性,而CTV和MRV影像学表现具有较高的特异性,若怀疑CVST应尽早行MRV或CTV检查以明确诊断.     

成人永存镰状窦的64层CTA诊断并复习文献

目的分析成人永存镰状窦的64层CTA表现,提高对大脑深静脉发育异常的进一步认识。方法对9例经CTA诊断为永存镰状窦的成人患者,采用MSCT重组技术对成像进行分析。结果 9例患者均因临床疑诊颅内动脉病变而接受CTA检查。永存镰状窦显示从大脑大静脉或直窦前部与上矢状窦中后1/3处或邻近的条带状血管样结构。结论 64层CTA是成人永存镰状窦无创、有效的检查方法。     

脑静脉窦血栓形成的MRI诊断(附15例分析)

目的 :探讨MRI对脑静脉窦血栓 (VST)的诊断价值。方法 :回顾性分析 15例VST患者的完整临床和影像学资料。全部行MR检查 ,其中 9例行增强扫描 ,8例行脑静脉MRA检查 ;12例曾行CT检查 ,其中 4例行增强扫描。结果 :上矢状窦受累 12例合并横窦血栓 11例 ,窦汇 7例、乙状窦 6例、下矢状窦、直窦受累 6例 ,海绵窦受累 1例。血栓在T1WI上均呈等、高不均匀信号 ,并出现脑组织肿胀 ,脑沟变浅 ,脑回模糊 ,在T2 WI上信号因发病时间不同而有所不同 ,8例T2 WI脑实质无异常信号 ,7例T2 WI脑实质出现异常信号。增强扫描 9例全部出现静脉异常强化。MRA表现为受累静脉窦信号较淡、边缘模糊且不规则的血流信号或血流信号完全消失。 12例CT检查中 2例见“空delta征” ,4例表现为梗塞、出血等不典型改变。结论 :MRI是诊断VST的首选检查方法 ,并对VST的预后评价有重要意义     

C T及MR I对儿童大脑大静脉畸形的应用价值

目的：探讨CT及 MRI对儿童大脑大静脉畸形(VGAW)的临床应用价值。方法对10例 VGAW儿童的 CT 及 MRI图像进行回顾性分析。结果 CT及MRI表现：大脑大静脉瘤样扩张10例;直窦扩张8例;窦汇扩张6例;其他静脉窦扩张6例;供血血管：基底动脉6例,大脑后动脉2例;大脑前动脉1例;其他血管1例;合并症：出血4例,血栓2例,钙化2例。结论 CT 及MRI均可明确诊断儿童的 VGAW,且发现异常供血血管,CT在观察钙化方面具有优势,MRI在观察出血、血栓方面具有优势。     

An arachnoid granulation in the straight sinus

We report CT, MRI and angiographic findings of an arachnoid granulation in the straight sinus in a young man. Its density and signal intensity were isodense and isointense with cerebrospinal fluid on CT and MRI, respectively. The lesion appeared as a filling defect on MR venography and conventional angiography. Received: 2 November 1999/Accepted: 3 February 2000     

Cerebral venous angiomas: MR findings

Seven patients with suspected cerebral venous angioma studied by either CT or angiography were imaged with magnetic resonance. Six of seven cases demonstrated a stellate appearance on contrast enhanced CT. In two patients this finding was verified by angiography. Flow void was identified on both T1- and T2-weighted pulse sequences. In one patient a field echo sequence demonstrated high intensity signal within the venous angioma. Magnetic resonance proved superior to CT in the identification of these lesions. A stellate configuration with an emanating transcortical vein and centrifugal drainage (transcortical venous flow) from the angioma into a sinus was present in all cases. Centripetal drainage via thalamostriate and internal cerebral veins was not seen. There was no evidence of mass effect, scar, or hemorrhage. Four of the angiomas were located in a frontal lobe and three in a cerebellar hemisphere. This distribution of the lesions is similar to that reported in the literature in which the frontal lobe is the most common location followed by the cerebellar hemisphere. An embryological explanation is cited and supported by a review of the literature.     

脑血管畸形的MRI诊断：与CT,脑血管造影对比分析

报道了６４例脑动静脉畸型和８例脑海绵状血管瘤的ＭＲＩ表现，并对ＭＲＩ、ＣＴ及脑血管造影在脑血管畸形诊断中的应用价值进行了对比分析。６４例脑动静脉畸形的ＭＲＩ均见到典型征象──流空信号簇。２９例见到粗大的供应动脉或／和引流静脉，１４例见到扩大的静脉窦。结果表明，ＭＲＩ对于脑动静脉畸形及其并发症的诊断优于ＣＴ，并可弥补脑血管造影的不足。ＭＲＩ与ＣＴ的联合应用对脑海绵状血管瘤的定性诊断很有意义。     

脑静脉窦闭塞的影像学表现

目的探讨脑静脉窦血栓形成的影像学表现,进一步提高对本病的认识。方法回顾性地分析36例脑静脉窦血栓形成的影像学(包括MR I,CT和DSA)资料,男15例,女21例,年龄23~59岁。结果MR上T1加权像及T2加权像脑实质内出现异常信号26例,其中散在脑实质内出血并长T1长T2异常信号者16例,长T1长T2信号者6例,4例可见脑室扩大,4例脑肿胀,显示脑沟、池变窄。25例脑静脉窦不强化,但可见皮层静脉异常强化。CT上见脑肿胀并出血者10例,伴脑缺血性低密度者5例,且可见随时间推移静脉窦密度减低;DSA证实,上矢状窦闭塞15例,单侧横窦闭塞8例,乙状窦闭塞7例,直窦闭塞4例,下矢状窦闭塞2例。结论脑静脉窦闭塞的影像表现与动脉性闭塞完全不同。CT和MR检查对诊断脑静脉窦闭塞具有重要意义,DSA仍为诊断该病的金标准。     

颅内静脉窦血栓形成的早期MRI诊断及病理基础

目的:研究颅内静脉窦血栓形成(CVST)的MR表现及其病理基础,旨在提高早期诊断水平.方法:回顾分析经临床和影像学方法确诊的11例CVST患者.MR检查技术包括平扫、增强扫描及MRV;其中4例行CT平扫检查;3例行DSA检查.结果:11例CVST累及上矢状窦5例,横窦1例,乙状窦1例,直窦1例,上矢状窦及横窦及乙状窦联合受累2例,横窦及乙状窦联合受累1例.CVST的直接征象:急性期血栓3例,T1 WI呈等信号或等高混杂信号,T2 WI呈低信号,周围可见稍高信号的环,为增厚的硬膜;亚急性期血栓8例,T1 WI及T2 WI均以高信号为主.增强扫描受累静脉窦可见空"三角"征或"充盈缺损"征.MRV可显示受累静脉窦不显影或者充盈缺损形成.CVST的继发脑损害包括脑肿胀、出血及梗死等.结论:磁共振检查对CVST的早期诊断具有重要价值.对于T2 WI呈低信号的急性期血栓,应仔细观察围是否有较高信号的环形改变,进一步行增强扫描结合MRV检查可作出早期准确的诊断.     

Diffusion-weighted magnetic resonance imaging of dural sinus thrombosis

Magnetic resonance imaging (MRI) is useful to diagnose dural sinus thrombosis. However, the representative appearance of dural sinus thrombosis on diffusion-weighted MRI has not been established. This study was aimed at determining whether cytotoxic or vasogenic edema is more predominant in the affected cerebral parenchyma and assessing the time courses and prognosis of dural sinus thrombosis lesion. The studies on sixteen patients with dural sinus thrombosis who underwent diffusion-weighted MRI were retrospectively reviewed. The diagnosis was confirmed by digital subtraction angiography in 11 patients and magnetic resonance angiography in five patients. Diffusion-weighted images with echo-planar imaging were obtained using two or three b values, with the highest b value of up to 1,000 s/mm(2). A region of interest was placed on an area of abnormal signal intensity to calculate apparent diffusion coefficients (ADCs). Nine of the 16 patients had lesions with an increased ADC, whereas, three of these nine patients also had lesions with a decreased ADC. Among 11 patients who underwent initial MRI within 7 days of their last episode, eight had lesions with an increased ADC, of whom three had lesions mixed with both decreased and increased ADC areas. Follow-up studies of these three patients revealed the development of hemorrhagic infarction in two and subcortical hemorrhage in one. Vasogenic edema develops more predominantly and earlier in dural sinus thrombosis, though cytotoxic edema was also associated with the pathological changes in the early phase. Decrease of ADC value is presumed to reflect severe pathological conditions and indicate possible future development of infarction or hemorrhage.     

Origin of high signal intensity in the cavernous sinus in MR angiographic source images: correlation between MR and conventional angiography

OBJECTIVE: To investigate the origin of a high signal intensity in a cavernous sinus on magnetic resonance (MR) angiography. METHODS: Time-of-flight MR angiography was performed in 20 patients scheduled for conventional angiography for disease not related to carotid cavernous fistula. Venous drainage pattern was assessed, and flow rate to a cavernous sinus was semiquantitatively evaluated on conventional angiography. RESULTS: Two sinuses showed high signal intensity in the anterior portion. These were associated with direct venous drainage to the anterosuperior aspect of the cavernous sinus from the superficial middle cerebral vein, and their flow rates were among the 10% of the sides with the highest flow rates. Two other sinuses showed high signal intensity in the posterior portion. Their flow rates from the superficial petrosal sinus were also among the 10% of the sides with the highest flow rates. CONCLUSION: High signal intensity in the anterior or posterior portions of the cavernous sinus is probably a result of inflow from the superficial middle cerebral vein and the superior petrosal sinus, respectively.     

静脉性脑梗死MR影像特点

目的回顾总结静脉性脑梗死MRI及MRV影像表现,旨在提高影像诊断水平。方法对15例静脉性脑梗死的MR表现进行了回顾性分析,其中9例临床治疗后复查MR表现明显好转,临床症状明显改善。15例均行常规MRI平扫,其中9例同时进行MR增强及3DCE-MRV,6例行2DTOF MRV。结果 15例脑内多发病灶9例,单发病灶6例,其中2例脑梗死伴出血改变。15例中发生于额叶4例,顶叶6例,颞叶3例,枕叶1例,小脑1例。静脉栓塞部位11例为上矢状窦,1例直窦及左横窦,1例右侧横窦及乙状窦,2例皮层大脑浅静脉。9例行增强扫描,5例病灶内不规则强化,2例脑膜强化,3例无强化.7例MRV均显示栓塞的静脉血流信号丢失或缺损,3例出现异常静脉侧支或引流静脉异常扩张。结论静脉性脑梗死MR影像表现具有特征性,MRI结合MRV可以作为首选的无创检查方法,对静脉栓塞早期诊断和治疗有重要作用。     

颅内动静脉瘘的CT和MRI诊断价值

目的:探讨CT和MRI对颅内动静脉瘘的诊断价值。方法:回顾性分析18例颅内动静脉瘘的CT和MRI表现。18例均经DSA检查明确诊断。其中12例行CT检查;16例行MRI检查,同期6例行MRA检查。结果:颅内动静脉瘘的CT和MRI的特征性表现为脑沟、脑裂、基底池内血管影增粗、增多,呈散在分布,受累及的静脉窦增粗,且病变区没有畸形血管团。海绵窦硬脑膜动静脉瘘在T2WI上表现为局部流空信号增宽,MRA原始图像显示局部有较丰富的异常纤细血流信号。结论:认识颅内动静脉瘘的CT和MRI表现,有助于早期诊断及治疗。MRI对显示软脑膜血管扩张优于CT。选择性脑血管造影是确诊本病的可靠手段。     

SPECT脑血流灌注显像在老年人脑梗塞中的应用

目的：评价ＳＰＥＣＴ脑血流灌注显像在老年病中的临床应用价值。材料和方法：４６例脑梗塞患者行９９ｍＴｃ－ＥＣＤ脑血流灌注显像，并与ＣＴ、ＭＲＩ、对照。其中４例行Ｄｉａｍｏｘ脑血流负荷检查。结果：４６例脑梗塞患者４５例脑血流灌注异常，占９７．８％．３３例同时做过ＣＴ，其灵敏度９６．７％．２５例做过ＭＲＩ，灵敏度９６％。ＳＰＥＣＴ脑血流显像灵敏度与ＣＴ及与ＭＲＩ间无显著性差异（Ｐ＞０．０５）。７例ＳＰＥＣＴ图像上出现＂交叉性小脑神经失联络征＂。４例行Ｄｉａｍｏｘ脑血流负荷检查，１例原梗塞灶血流明显改善；两例显示病灶范围更广泛；另１例除小脑血流分布改善外．余处未见明显改变。４例中３例有＂交叉性小脑神经失联络征＂，使用Ｄｉａｍｏｘ后小脑血流改善。结论：本组病例ＳＰＥＣＴ灵敏度与ＣＴ及ＭＲＩ无显著差异；ＳＰＥＣＴ脑血流灌注显像可探测梗塞后存活的脑组织，为临床治疗提供客观依据；结合Ｄｉａｍｏｘ脑血流负荷检查有望进一步提高诊断的阳性率     

Non-traumatic neurological emergencies: imaging of cerebral ischemia

Cardiovascular disease is the leading cause of death worldwide with almost one-third of all cardiovascular deaths ascribed to stroke. Imaging modalities, such as CT, MRI, positron emission tomography (PET), and single photon emission CT (SPECT) provide tremendous insight into the pathophysiology of acute stroke. Computed tomography is considered the most important initial diagnostic study in patients with acute stroke, because underlying structural lesions, such as tumor, vascular malformation, or subdural hematoma, can mimic stroke clinically. Diffusion-weighted imaging (DWI) has the ability to visualize changes in diffusion within minutes after the onset of ischemia and has become a powerful tool in the evaluation of patients with stroke syndrome. Territories with diffusion and perfusion mismatch may define tissues at risk, but with potential recovery. An alternative strategy with CT technology uses rapid CT for dynamic perfusion imaging, with similar goals in mind. Angiography can be performed in the hyperacute stage if thrombolytic therapy is being considered. Indications for diagnostic angiography include transient ischemic attacks in a carotid distribution, amaurosis fugax, prior stroke in a carotid distribution, a high-grade stenotic lesion in a carotid artery, acquiring an angiographic correlation of magnetic resonance angiography (MRA) or computed tomographic angiography (CTA) concerning stenotic findings. In 50% of all angiograms performed in the hyperacute stage, occlusion of a vessel is observed; however, the need for angiography has been made less necessary due to the improvements of MRA, duplex ultrasound, and CTA. Numerous etiologies can lead to infarction. In children, pediatric stroke is very uncommon. The most common cause is an embolus from congenital heart disease with right-to-left shunts. Also a dissection of large extracranial vessels may result in cerebral infarction, and although the brain is equipped with numerous venous drainage routes, the occlusion of a large sinus or a widespread vein obstruction will eventually lead to venous infarction. Thus, optimal stroke care requires not only early and exact identification of ischemia, but also a close collaboration between the clinician and radiologist.     

Cerebrotendinous xanthomatosis: cranial CT and MRI studies in eight patients

Summary We report the findings on cranial computed tomography (CT) and magnetic resonance imaging (MRI) and their correlation with the clinical manifestations, disease severity and biochemical abnormalities in eight patients with cerebrotendinous xanthomatosis. CT revealed cerebral atrophy in seven cases, cerebellar atrophy in four and focal low density lesions in the cerebral white matter in two. T2-weighted MRI showed high signal lesions in the cerebral white matter, focal in four cases and diffuse in one, and in the globus pallidus in three patients, two of whom also had lesions in the cerebellar white matter. While severely affected patients showed variable CT and MRI abnormalities, our cases did not show the dramatic findings expected from the neurological manifestations. Diffuse lesions in the cerebral and cerebellar white matter have been emphasized in previous reports, but in our study the focal lesions in the cerebral white matter were also present; the globus pallidus was frequently involved.     

脑静脉窦栓塞动物模型的建立方法

目的:探讨经皮穿刺静脉插管静脉窦内弹簧圈或/和明胶海绵植入致脑静脉窦急性栓塞动物模型的建立方法,评价其有效性、可行性、优缺点。方法:采用经静脉插管的介入方法将弹簧圈和/或明胶海绵放置在实验小型猪脑静脉窦的不同位置达到静脉窦完全或不完全栓塞的效果。结果:9例实验动物均成功的完全或不完全栓塞上矢状窦、直窦、乙状窦。右侧乙状窦栓塞1例,上矢状窦中后1/3 Rolandic静脉前1~2cm处1例,Rolandic静脉处栓塞3例,Rolandic静脉后1~2cm处栓塞2例,直窦栓塞1例,窦汇和直窦栓塞1例。结论:经皮穿刺静脉插管脑静脉窦内弹簧圈、明胶海绵植入致脑静脉窦急性栓塞动物模型的实验方法有效可行,此方法不开颅,脑组织无人为损伤,更加接近实际发病状况。