背阔肌皮瓣的血管和神经供给

解剖了50具成年尸体,对背阔肌皮瓣的形态、大小、血管和神经进行了观察和测量。肩胛下动脉的长度为23.8±1.2mm,外径为3.7±0.2mm。胸背动脉的长度为92.2±1.9mm,外径为2.3±0.1mm。胸背神经的干长为75.9±1.9mm,外径为2.0±0.1mm。主要神经血管门约位于腋后襞下方10cm,背阔肌前缘后方2cm,相当于肩胛骨下角平面处。整个背阔肌表面的皮肤,除了肩胛骨下角平面稍上方的皮肤外,均可作为肌皮瓣提取。对背阔肌皮瓣、肌骨皮瓣和反转的岛状感觉肌皮瓣的临床应用作了讨论。     

肱三头肌外侧头神经肌支和血供的应用解剖

目的 :为肱三头肌外侧头的神经肌支移位和游离肌皮瓣移植提供解剖学基础。方法 :在 3 0侧成人上肢标本上对肱三头肌外侧头的神经肌支和血管进行详细解剖观测。结果 :外侧头肌支数 2～ 4支 ,一般为 3支。入肌部位位于大圆肌腱下缘 ( 5 .3 1± 2 .0 1)、( 6.0 6± 1.2 1)、( 5 .96± 1.0 )cm ,横径分别为( 1.4± 0 .5 )、( 1.2± 0 .2 )、( 1.9± 0 .9)mm。肌皮神经肱二头肌平均 2个肌支 ,入肌部位分别在大圆肌下缘以下 ( 4 .2 1± 1.66)和 ( 4 .5 8± 1.3 2 )cm ,横径为 ( 1.4± 0 .6)和 ( 1.2± 0 .8)mm。腋神经入肌部位在大圆肌下缘以上发出。肱三头肌外侧头血供来源于肱深、旋肱后及部分近侧肌支 ,且均与肱深血管有关。结论 :肱三头肌外侧头肌支有足够长度和横径 ,在肌门处可无张力移位至肌皮神经肱二头肌支及部分腋神经肌支。以肱深血管为蒂的肱三头肌外侧头游离肌皮瓣是修复前臂肌肉皮肤缺损的良好供体     

带腓肠外侧皮神经及其营养血管筋膜皮瓣的应用解剖

<正> 为带腓肠外侧皮神经及其营养血管筋膜皮瓣的临床应用提供解剖学基础.在32侧成人下肢标本上,对腓肠外侧皮神经及其营养血管进行解剖观测.结果:腓肠外侧皮神经在腓骨头平面上方(7.l±2.4)cm处起于腓总神经,横径为(2.6±1.0)mm,沿腘窝及小腿后外侧面下行,腓骨头平面的横径为(3.0±0.9)mm,发出1-3个终支,分布于小腿后外侧上半或上2/3的皮肤.其营养动脉主要为:①腓肠外侧皮动脉;起自腘动脉外侧壁,在排骨头平面上方(5.0±1.5)cm处浅出,外径为(0.9±0.3)mm,穿出前长度为(3.11.2)cm,伴腓肠外侧皮神经及其主要分支下行;②肌间隔筋膜皮支:起自胫后动脉(占54.5%)和腓动脉(占45.5%),向后外行,自小腿三头肌与腓骨长、短肌之间的肌间隔穿出,穿出点分别在腓骨头平面下方(9.2±3.8)cm和(15.8±3.8)cm,外径为(0.7±0.3)mm和(0.9±0.4)mm,穿出前长度分别为(3.6±1.1)cm和(3.6±1.4)cm.该营养动脉除在腓肠外侧皮神经主干及其分支旁或其内呈相互吻合,形成纵行的动脉丛(网)外,沿途还发出分支至周围的筋膜皮肤,并借吻合支     

背阔肌的神经解剖及其临床意义

目的:为背阔肌亚部肌移植的临床应用提供神经解剖学资料。方法:观察60侧背阔肌的胸背神经分支类型并定位神经入肌点。结果:(1)91.67%的胸背神经分出两支(一级分支),即内上支和外下支,其中内上支分出2~3支(二级分支),外下支分出3~5支(二级分支),外下支的分支多见集中型或羽状型。(2)胸背神经内上支与外下支的入肌点距肩胛骨下角下缘的直线距离分别为(5.38±0.36)cm、(6.70±0.41)cm。两神经入肌点之间的距离为(2.17±0.32)cm。结论:背阔肌有较恒定的神经分支分布及入肌点定位,对背阔肌的临床应用具有一定的参考价值。     

胸内、外侧神经与肌皮神经吻接的应用解剖

在专供研究用的18具(男9,女9)成人尸体上解剖,观察了36侧胸内、外侧神经和肌皮神经。胸内、外侧神经主干长度分别为42.81±4.18mm和40、55±3.12mm,主干入肌处的宽度分别为1.29±0.09mm和1.57±0.09mm,厚度分别为0.63±0.04mm和0.68±0.05mm。胸内侧神经中有28侧(77.8%)发出1-3支分支入肌,其上支长度为30.69±2.61mm;胸外侧神经中有26侧(72.2%)发出1-3支分支入肌,其上支长度为35.97±3.22mm。肌皮神经的自然长度为43.87±3.41mm,无损伤分离出的长度为22.94±2.17mm,起始处的宽、厚度分别为2.90±0.11mm和1.76±0.07mm。肌皮神经起点与胸内、外侧神经起点之间的距离分别为43.14±3.81mm和50.57±3.71mm。     

背阔肌作动力性心肌成形术的应用解剖学

<正> 在25具成人尸体上,对左侧背阔肌的形态、血管、神经进行了观测,对以背阔肌作动力性心肌成形术的有关应用解剖学进行了研究。我们设计了以胸背动脉外侧支为蒂的背阔肌瓣,该瓣长374.32±32.08mm,肌瓣包卷心室表面的部份(心脏部)接近梯形,面积约为(260+24)×120÷2mm~2。该肌     

季肋—腹部皮瓣的应用解剖学

在68侧成人尸体上,对腹上外侧部T_(10)T_(11)T_(12)神经血管的外侧皮支的前支进行了解剖学研究。以肋间后血管外侧皮支的前支为蒂,可以构成一个新的皮瓣供区。第十肋间动脉外侧皮支的前支在背阔肌前缘外径0.9±0.3mm,第十一肋间后动脉外侧皮支的前支为0.9±0.3mm,肋下动脉的外侧皮支的前支为0.8±0.3mm。     

胸背神经移位与肱二头肌肌支吻接重建屈肘功能的应用解剖

目的 :为胸背神经移位与肱二头肌肌支吻接重建屈肘功能提供应用解剖学基础。方法 :取 15具 ( 3 0侧 )成人尸体 ,对肌皮神经肱二头肌肌支和胸背神经及其伴行动脉进行解剖 ,观测其走行、可应用长度、横径及分支情况 ,并取神经标本经石蜡切片、HE染色 ,对有髓神经纤维进行计数。在 2具 ( 4侧 )新鲜尸体上模拟设计手术入路。结果 :( 1)定上肢外展 60°时胸锁关节与喙突间连线中外 1/3交界处锁骨下缘为测量点。肌皮神经肱二头肌肌支发出点距测量点距离平均为 13 .1cm ,强行分离长度平均为 5 .0cm。胸背神经 1～ 3肌支距测量点平均距离分别为 :9.2、11.1、12 .3cm。 ( 2 )肱二头肌肌支发出点与胸背神经各肌支发出点的横径、束数和有髓纤维数等数值相仿。 ( 3 )在新鲜尸体上设计上肢外展 60°锁骨中点下缘至上臂上段内侧正中切口与背阔肌前缘斜行切口 ,操作简易 ,创伤较小。结论 :应用带血供的胸背神经移位与肱二头肌肌支吻接重建屈肘功能具有可行性     

人背阔肌肌内神经分布和肌构筑特征及其临床意义

目的:为背阔肌亚部肌移植的临床应用提供形态学基础。方法:改良Sihler’s肌内神经染色法和肌构筑法。结果:(1)支配背阔肌的胸背神经发出2～3支一级神经支入肌,入肌后发出呈树枝状分支分布到该肌,在肌中部构成网格状的神经分支密集区。(2)背阔肌内上部肌重(58.91±10.29)g、肌长(18.76±1.67)cm、生理横切面积(3.39±0.65)cm2,外下部肌重(119.60±20.89)g、肌长(29.33±1.70)cm、生理横切面积(4.69±0.92)cm2。结论:(1)背阔肌有恒定的肌内神经分支分布,可分为两个亚部:内上部和外下部。(2)背阔肌内上部在肢体运动中更多的维持肩关节的稳定;而背阔肌外下部则更多参与肢体的速度运动。     

胫骨后肌神经血管蒂的应用解剖

目的 :探讨胫骨后肌神经血管蒂为肌瓣移植提供解剖学资料。方法 :在 30侧人下肢标本上进行了显微解剖并观察了胫骨后肌神经、血管的关系。结果 :胫骨后肌神经起自胫神经 ,始部横径左侧 1.30± 0 .0 5( 1.0 2～ 1.68)mm;右侧 1.36± 0 .0 7( 1.0 2～ 1.98) mm。蒂长左侧 3.2 1± 0 .33( 1.82～ 5.60 ) cm;右侧 3.0 5± 0 .19( 1.80～ 4 .16)cm。伴行动脉外径左侧 1.36± 0 .12 ( 1.0 2～ 2 .38) mm;右侧 1.50± 0 .10 ( 1.0 2～ 2 .36) mm。结论 :选用以神经肌支和伴行血管为蒂的胫骨后肌神经血管蒂可转位修复因腓浅神经或腓深神经损伤引起的小腿外侧群、前群肌瘫痪     

Schizophrenia in a North Swedish geographical isolate, 1900–1977. Epidemiology, genetics and biochemistry

Over 200 schizophrenic patients belonging to three major and interrelated pedigree complexes have been investigated over the past 30 years in a North Swedish geographically isolated population, presently numbering about 6,000. An intensive investigation of a number of biochemical correlates and genetic markers in a few selected families belonging to one of the major pedigrees has indicated new strategies for the current research program.
Schizophrenia, as defined operationally, is significantly associated with decreased activities of two enzymes (1) blood platelet monoamine oxidase, (2) plasma dopamine-β-hydroxylase, and (3) with the genetic marker Gc² (group specific antigen). Both enzymes are subject to genetic variation. A positive score for linkage between schizophrenia and low plasma DBH activity has been calculated, but, so far, available data are insufficient for discrimination between linkage and partial contribution of genetically controlled low plasma DBH to the pathogenesis of the disease. Alternatively, both mechanisms could be involved.
As a model for continued research, schizophrenia is explained as based on a double dominant-recessive genotype (Aabb), representing a vulnerability which in about 50 % of cases develops into clinical schizophrenia. It is suggested that the dominant mutation (A) operates on or affects MAO activity, and that the recessive genotype (bb) is instrumental in low variates of DBH activity and very likely such variates within the normal range of physiological variation. Moreover, it is suggested that the combined effects of MAO- and DBH-reduced efficiency on the metabolism of e.g. dopamine could be an essential pathogenic mechanism for the schizophrenic illness which is segregating in this population.     

Renal dysplasia and asplenia in two sibs

A family is reported in which two sibs, one male and the other female, both died within 24 hours of birth with enlarged polycystic kidneys. Postmortem histology in the second child showed gross renal dysplasia. In both children the pancreas was enlarged, nodular and cystic but the liver appeared macroscopically normal. In the second child, histological examination confirmed pancreatic fibrosis with cystic dilation of ducts, but showed portal fibrosis with bile duct proliferation in the liver.
This combination of findings is very reminiscent of those in a girl and her brother reported by Ivemark et al. (1959). The children reported here also showed absence or hypoplasia of the spleen, cardiac anomalies and other features of the Ivemark syndrome (Ivemark 1955), a quite different, usually sporadic, congenital disorder. It is suggested that the children described here have a distinct lethal congenital disorder, probably inherited in an autosomal recessive manner.     

The dominant diseases of modernized societies as omega-3 essential fatty acid deficiency syndrome: Substrate beriberi

About 1900, modern food selection and processing caused widespread $\text{epidemics}$ of the B vitamin deficiency diseases of beriberi and pellagra which, for genetic reasons, often expressed as different diseases ranging from bowel and heart disease to dermatoses and psychoses. But the B vitamins merely help convert essential fatty acids (EFA) into the prostaglandin (PG) tissue regulators and it now turns out that, through hydrogenation, milling and selection of w3-poor southern foods, we have also been systematically depleting, by as much as 90%, a newly discovered trace Nordic EFA (w3) of special importance to primates and sole precursor of the PG3(4) series, even as a concurrent fiber deficiency increases body demand for EFA. Since substrate EFA is processed by many B vitamin catalysts, an EFA deficiency will mimic a $\text{panh}$ypovitaminosis B, i.e., a mixture of $\text{substrate}$ beriberi and $\text{substrate}$ pellagra resembling vitamin beriberi and pellagra but exhibiting as even more diverse $\text{endemic}$ disease. This would consitute a second stage of the Modern Malnutrition and explain why some workers now hold the dominant diseases of modermized societies to be new, nutritionally based, pellagraform yet lipid-related and to range, once again, from heart disease to psychosis. It is an assumption that our dominant diseases are unrelated to each other or are merely revealed by our diagnostic acumen and therapeutic success; and that hydrogenating millions of tons of food oils annually, to destroy the rancidity producing w3-EFA, is safe for $\text{primates}$. Extensive beriberiform disease is reported here in 32 typical cases taken from medical practice which responds strikingly to linseed oil supplements (60% w3-EFA) in confirmation of identical results in Capuchins.     

'Very sore nights and days': the child's experience of illness in early modern England, c.1580-1720

Sick children were ubiquitous in early modern England, and yet they have received very little attention from historians. Taking the elusive perspective of the child, this article explores the physical, emotional, and spiritual experience of illness in England between approximately 1580 and 1720. What was it like being ill and suffering pain? How did the young respond emotionally to the anticipation of death? It is argued that children’s experiences were characterised by profound ambivalence: illness could be terrifying and distressing, but also a source of emotional and spiritual fulfilment and joy. This interpretation challenges the common assumption amongst medical historians that the experiences of early modern patients were utterly miserable. It also sheds light on children’s emotional feelings for their parents, a subject often overlooked in the historiography of childhood. The primary sources used in this article include diaries, autobiographies, letters, the biographies of pious children, printed possession cases, doctors’ casebooks, and theological treatises concerning the afterlife.     

Guidelines for the Validation and Use of Immunoassays for Determination of Introduced Proteins in Biotechnology Enhanced Crops and Derived Food Ingredients

Recent advancements in agricultural biotechnology have created a need for analytical techniques to determine introduced proteins in crops enhanced through modern biotechnology techniques. These proteins are expressed in plant tissues and may be present in food ingredients. Immunoassays are ideally suited for protein detection and may be used as both quantitative and threshold methods. Microplate ELISA and lateral flow devices are two of the most commonly used immunoassay formats for agricultural biotechnology applications. This paper provides general background information and a discussion of criteria for the validation and application of immunochemical methods to the analysis of proteins introduced into plants and food ingredients using biotechnology methods. It is the result of a collaborative effort of members of the Analytical Environmental Immunochemical Consortium. This collaborative effort represents the combined expertise of several organizations to reach consensus on establishing guidelines for the validation and use of immunoassays. Further, the paper offers developers and users a consistent approach to adopting the technology as well as aid in producing accurate and meaningful results.     

HLA in North Colombia Chimila Amerindians

HLA-A,-B,-C,-DRB1 and -DQB1 alleles have been studied in Chimila Amerindians from Sabana de San Angel (North Colombian Coast) by using high resolution molecular typing. A frequent extended haplotype was found:HLA-A*24:02-B*51:10-C*15:02-BRB1*04:07-DQB1*03:02 (28.7%) which has also been described in Amerinndian Mayos Mexican population (Mexico, California Gulf, Pacific Ocean). Other haplotypes had already been found in Amerindians from Mexico (Pacific and Atlantic Coast), Peru (highlands and Amazon Basin), Bolivia and North USA. A geographic pattern according to HLA allele or haplotype frequencies is lacking in Amerindians, as already known. Also, five new extended haplotypes were found in Chimila Amerindians. Their HLA-A*24:02 high frequencies characteristic is shared with aboriginal populations of Taiwan; also, HLA-C*01:02 high frequencies are found in New Zealand Maoris, New Caledonians and Kimberly Aborigines from Australia. Finally, this study may show a model of evolutionary factors acting and rising one HLA allele frequency (-A*24:02), but not in others that belong to the same or different HLA loci.     

Ultracryotomy: development and application (with examples from the yeast cytology) (author's transl)

The preparation steps usually necessary for obtaining ultrathin frozen sections of biological material (chemical prefixation, enclosing, cryoprotective treatment, freezing, sectioning, and post-staining the sections for transmission electron microscopy) are submitted to a critical analysis. The application of cryo-ultramicrotomy, in particularly for cytochemical purposes, is reviewed. Fundamental considerations of chemical prefixation and poststaining are supported by examples from yeast cytology. Furthermore, the efficiency of the cryo-ultramicrotomy (electron optical resolution of ultrastructural details) is demonstrated on yeast cells and protoplasts.     

The universal muscular chamber. A basic unit of the genitourinary, cardiovascular, gastro-intestinal, skeletal, cutaneous, respiratory and other systems, endocameral hypertension; and spasm, the key to their idiopathic diseases and arthropathies

Starting with the integument, we see many organs are contractile sacs or multiples thereof, which tubes or bags constitute the major part of the entire body. Recognition of this basic unit and its characteristics sheds new light, individually and collectively, on many disorders previously considered unrelated. Muscular tears and perforations develop in the walls of these chambers, being no way peculiar to those organs, wherein, hydrochloric acid occurs. So, it is not necessary to explain the absence of excessive acid from patients who exhibit holes in the gastric, uterine, aortic, duodenal, rectal, pulmonary, retina, and other walls. Muscle, not acid is the great common factor relating idiopathic disorders in the gastrointestinal tract to each other and to similar diseases in other systems. When the units are linked together, the lesions tend to appear as arthropathies, i.e. at the joints. Rephrasing common-place observations, frees us from conventional, conceptual cul-de-sacs. An observation is only as good as its interpretation, so all possibilities must be considered, otherwise, we will remain blinded by our misconceptions.     

Der Einfluß von Nahrungsmitteln und Rauchen auf die klinisch-chemische Diagnostik von Phäochromozytom,Neuroblastom und Karzinoid-Syndrom

Zusammenfassung Der Einfluß von verschiedenen Nahrungsmitteln auf Methoden zur Bestimmung von Adrenalin (AD), Noradrenalin (NA), Vanillinmandelsäure (VMS), Metanephrinen (MN), Homovanillinsäure (HVS) und 5-Hydroxyindolessigsäure (5-HIE) im 24 h-Harn zur Diagnose des Phäochromozytoms bzw. Karzinoid-Syndroms wurde untersucht. Die in die Untersuchung einbezogenen Nahrungsmittel waren: Tee, Kaffee, Mandeln, Ananas, Käse, Walnüsse, Vanillepudding, Bananen, Tomaten und Milchschokolade. Außerdem wurde der Einfluß des Zigarettenrauchens auf die Bestimmung von AD, NA, VMS und MN untersucht.Walnüsse führten zu einer starken Erhöhung der 5-HIE-Ausscheidung. Bananen erhöhten die Ausscheidung von AD, NA, VMS, MN und 5-HIE. Kaffee und Ananas bewirkten eine geringe Zunahme der MN-Werte. Rauchen von 20–30 Zigaretten/Tag beeinflußte keine der vier Variablen.Wenn die beschriebenen Methoden benutzt werden, sollte lediglich auf den Verzehr von Bananen und Walnüssen vor und während der Harnsammelperioden verzichtet werden, da die oberen Normgrenzen im Harn überschritten werden könnten. Ein Verzicht auf Kaffee und Ananas in normalen Mengen ist nicht erforderlich. Es besteht kein Anlaß, weiterhin die bisherigen umfangreichen Restriktionen der übrigen Nahrungsmittel beizubehalten.