Short- and long-term skeletal relapse after mandibular advancement surgery

This study analyzes short- and long-term skeletal relapse after mandibular advancement surgery and determines its contributing factors. Thirty-two consecutive patients were treated for skeletal Class II malocclusion during the period between 1986 and 1989. They all had combined orthodontic and surgical treatment with BSSO and rigid fixation excluding other surgery. Of these, 15 patients (47%) were available for a long-term cephalography in 2000. The measurement was performed based on the serial cephalograms taken preoperatively; 1 week, 6 months and 14 months postoperatively; and at the final evaluation after an average of 12 years. Mean mandibular advancement was 4.1 mm at B-point and 4.9 mm at pogonion. Representing surgical mandibular ramus displacement, gonion moved downwards 2 mm immediately after surgery. During the short-term postoperative period, mandibular corpus length decreased only 0.5 mm, indicating that there was no osteotomy slippage. After the first year of observation, skeletal relapse was 1.3 mm at B-point and pogonion. The relapse continued, reaching a total of 2.3 mm after 12 years, corresponding to 50% of the mandibular advancement. Mandibular ramus length continuously decreased 1 mm during the same observation period, indicating progressive condylar resorption. No significant relationship between the amount of initial surgical advancement and skeletal relapse was found. Preoperative high mandibulo-nasal plane (ML-NL) angle appears to be associated with long-term skeletal relapse.     

Skeletal relapse after mandibular advancement and setback in single-jaw surgery

PURPOSE: The aim of this study was to identify contributing factors to skeletal relapse by analyzing cephalometric changes after bilateral sagittal split ramus osteotomy. PATIENTS AND METHODS: This study included 60 consecutive patients who underwent either mandibular advancement (30 patients) or setback surgery (30 patients). There were 36 women and 24 men (mean age, 23 years). The radiographs of these patients taken immediately before operation, at 1 week, and 14 months postoperatively were studied. To analyze the influence of hyper- and hypodivergent facial patterns on the surgical outcome, the patients were divided into 3 groups according to the mandibulo-nasal plane angle. The position of the maxilla was also taken into account. RESULTS: Measured at B-point, skeletal relapse was 1.3 mm (30%) after mean advancement of 4.4 mm and 0.8 mm (12%) after setback of 6.0 mm. The magnitude of the surgical movement correlated with skeletal relapse. However, the correlation was not linear. Advancement of greater than 7 mm is associated with an increased tendency to relapse (r=0.52), but setback of more than 12 mm with a decreased tendency (r=-0.95). The retrognathic patients with a high mandibulo-nasal plane angle (hyperdivergence) had 30% higher relapse rate. Patients with hypodivergent facial patterns had less relapse in both advancement and setback surgery. CONCLUSION: Skeletal relapse was affected by magnitude of surgical movement and different facial patterns according to the mandibulo-nasal plane angle; however, influences of both factors were different between mandibular advancement and setback.     

Relapse patterns of two-jaw surgical correction in patients with skeletal Class III malocclusion and different vertical facial types

The aim of this study was to evaluate postoperative relapse after the surgical correction of skeletal Class III deformities of various facial patterns as a guide to surgical planning. A retrospective cohort study of 90 consecutive patients with skeletal Class III malocclusion who underwent bimaxillary surgery was performed. The surgical outcomes and postoperative stability were compared. The primary predictor variable was vertical facial type, which was classified into three groups according to the Frankfort mandibular plane angle (FMA). The primary outcome of angular and linear measurements was obtained using serial cone beam computed tomography scans obtained at time points of preoperative, 1 week after surgery, and orthodontic debonding. No significant difference in skeletal relapse was observed in patients with the different vertical facial types. The mandible displayed a forward and upward relapse in all three groups postoperatively. The patients with a low FMA exhibited a more consistent mandibular relapse pattern than those with a normal or high FMA. These findings suggest that bimaxillary surgery is clinically stable for mandibular prognathism regardless of the vertical facial pattern. However, 1–1.5 mm of overcorrection in the mandible setback should be considered in patients with a low FMA, because of the greater facial depth and consistent forward and upward mandibular relapse pattern.     

Distraction osteogenesis versus bilateral sagittal split osteotomy for advancement of the retrognathic mandible: a review of the literature

Bilateral sagittal split osteotomy (BSSO) and distraction osteogenesis (DO) are the most common techniques currently applied to surgically correct mandibular retrognathia. It is the responsibility of the maxillofacial surgeon to determine the optimal treatment option in each individual case. The aim of this study was to review the literature on BSSO and mandibular DO with emphasis on the influence of age and post-surgical growth, damage to the inferior alveolar nerve, and post-surgical stability and relapse. Although randomized clinical trials are lacking, some support was found in the literature for DO having advantages over BSSO in the surgical treatment of low and normal mandibular plane angle patients needing greater advancement (>7 mm). In all other mandibular retrognathia patients the treatment outcomes of DO and BSSO seemed to be comparable. DO is accompanied by greater patient discomfort than BSSO during and shortly after treatment, but it is unclear whether this has any consequences in the long term. There is a need for randomized clinical trials comparing the two techniques in all types of mandibular retrognathia, in order to provide evidence-based guidelines for selecting which retrognathia cases are preferably treated by BSSO or DO, both from the surgeon's and the patient's perspective.     

Bilateral sagittal split osteotomy for correction of mandibular prognathism: long-term results.

PURPOSE: To identify the long-term maxillomandibular changes after surgical correction of mandibular prognathism using bilateral sagittal split osteotomy (BSSO). PATIENTS AND METHODS: Twenty patients who underwent BSSO to setback the mandible and had cephalometric radiographs taken preoperatively and postoperatively at 6 weeks, 1 year, and long-term follow-up (mean, 28 months). The cephalograms were traced and measured to determine the operative and postoperative changes. Correlation analyses were performed to see the relationship between the magnitude of setback and the amount of long-term postsurgical change at B point and pogonion. RESULTS: The mean surgical setback was 8.2 mm at B point and 8.8 mm at pogonion. The mean long-term horizontal relapse was 2.3 mm (28.0%) at B point and 3.0 mm (34.1%) at pogonion. Out of 20 patients, 12 (60.0%) relapsed horizontally greater than 2 mm at B point and 13 (65.0%) at pogonion. The mean vertical surgical changes showed downward displacement of B point (2.3 mm) and pogonion (2.0 mm). The mean long-term vertical relapse was 1.6 mm (69.6%) at B point and 1.7 mm (85.0%) at pogonion. CONCLUSION: There was no correlation between the magnitude of setback and the amount of relapse at B point and pogonion. However, there was significant correlation between the magnitude of vertical, downward surgical displacement and the amount of vertical relapse at B point and pogonion. The majority of the maxillofacial changes occurred within 1 year postoperatively.     

Long-term stability of mandibular setback surgery: a follow-up of 80 bilateral sagittal split osteotomy patients

The objective of this cephalometric study was to evaluate skeletal stability and time course of postoperative changes in 80 consecutive mandibular prognathism patients operated with bilateral sagittal split osteotomy (BSSO) and rigid fixation. Lateral cephalograms were taken on 6 occasions: immediately preoperative, immediately postoperative, 2 and 6 months postoperative, and 1 and 3 years postoperative. The results indicate that BSSO with rigid fixation for mandibular setback is a fairly stable clinical procedure. Three years after surgery, mean relapse at pogonion represented 26% of the surgical setback (19% at point B). Most of the relapse (72%) took place during the first 6 months after surgery. Clockwise rotation of the ascending ramus at surgery with lengthening of the elevator muscles, though evident in this study and apparently responsible for the early horizontal postoperative changes, does not seem to be associated with marked relapse. Changes occurring in some of the younger patients between 1 and 3 years postoperatively are likely to be manifestations of late mandibular growth.     

Asymmetric mandibular prognathism: Outcome,stability and patient satisfaction after BSSO surgery. A retrospective study

PurposeTo investigate surgical outcome, long-term stability, the time course of relapse, neurosensory disturbances, and patient satisfaction after BSSO for correction of mandibular asymmetry. Another objective was to examine whether osteotomies for transverse rotation of the distal segment represent an increased risk for nerve injury.Subjects and methodsIn a retrospective study lateral and postero-anterior cephalograms, information from patient files and questionnaires were analysed for 38 patients having more than 4 mm asymmetry at the chin pre-treatment (mean 8.4 mm). The radiographs were analysed preoperatively, postoperatively, after 6 months and 3 years.ResultsAsymmetry of the chin to the facial midline improved on average by 56%. Skeletal relapse was about the same for transverse and antero-posterior surgical changes (10–15%). 58% of the patients had asymmetry of more than 3 mm at menton 3 years post-surgery. Discrepancy between upper and lower dental midlines improved on average 80%. Normal or near normal sensation to the lower lip/chin was reported by 44% of the patients which is similar to sensory disturbances after BSSO straight set-back performed by the same surgical team. A difference in the incidence of neurosensory disturbance between the two osteotomy sides was observed. Satisfaction with the treatment result was reported by all patients except for two.ConclusionCorrection of mandibular asymmetry by BSSO is fairly stable. Although the risk for sensory impairment for the individual patient was similar to impairment in a sample having straight setback, rotation of the distal segment during surgery may represent an increased risk for sensory impairment on the deviating side (P = 0.06). Three years after surgery patients were generally satisfied with the result even if more than 3 mm of asymmetry at the chin remained for 58%. The findings have implications for treatment planning and the decision to elect one-jaw, bimaxillary surgery and/or additional genioplasty.     

Stabilisation of sagittal split advancement osteotomies with miniplates: a prospective, multicentre study with two-year follow-up. Part II. Radiographic parameters

This prospective study implied a two-year follow-up on a group of patients that underwent a Bilateral Sagittal Split Osteotomy (BSSO) for advancement (n=222) of the mandible that were treated in seven institutions following the same treatment protocol. The aim of Part II of this study was to correlate the clinical findings on stability and relapse as reported in Part I (clinical parameters) of this series of articles with the cephalometric findings. The mean skeletal relapse at pogonion of the whole group after two years was 0.9 mm. The clinically stable group, however, had only 0.4 mm relapse, whereas the clinical relapse group showed a mean relapse of 3.3 mm. The findings underline a relationship between the amount of advancement and relapse. The tendency for both, horizontal and vertical movement is the same, i.e., the larger the surgery effect, the larger the relapse. The angle post plane/mandibular plane showed the highest explained variance 9%. Patients with a high mandibular plane angle may be more prone to relapse. The explained variance of all considered prognostic factors together, however, is small (13%). The findings of this study express that patients with a clinical stable occlusion after a BSSO advancement, stabilised with miniplates, have a minimal to no skeletal relapse as measured on the cephalometric radiograms. The clinically non-stable group, however, appeared to have considerable skeletal relapse.     

Stability of mandibular advancement procedures: bilateral sagittal split osteotomy versus distraction osteogenesis

The aim of this study was to compare the postoperative stability of the mandible after a bilateral lengthening procedure, either by bilateral sagittal split osteotomy (BSSO) or distraction osteogenesis (DOG). All patients who underwent mandibular advancement surgery between March 2001 and June 2004 were evaluated; 26 patients in the BSSO group and 27 patients in the DOG group were included. The decision to use the intraoral distraction or BSSO for mandibular advancement primarily depended on the patient's choice. In both groups, standardized cephalometric radiographs were taken preoperatively, postoperatively (BSSO group) or directly post-distraction (DOG group) and during the last study measurement in May 2005. The cephalometric analysis was performed using the following measurements: Sella/Nasion-Mandibular point B and Sella/Nasion-Mandibular Plane. Point B was used to estimate relapse. This study showed no significant difference in relapse between the BSSO and the DOG group measured 10-49 months after advancement of the mandible (p>0.05). There is no postoperative difference in the stability between BSSO and DOG after mandibular advancement after 1 year.     

Stability after rigid fixation of simultaneous maxillary impaction and mandibular advancement osteotomies

The purpose of this study was to investigate the short- and long-term stability of bimaxillary surgery following LeFort I (LF-1) impaction with simultaneous bilateral sagittal split ramus osteotomy (BSSO) and mandibular advancement using the technique of rigid internal fixation (RIF). In order to assess the postoperative maxillary and mandibular movement pattern in 26 patients with vertical maxillary excess and mandibular deficiency, cephalograms were taken immediately preoperatively, and 1 week, 2 months, and 1 year after surgery. With paired t-test showing no statistically significant postoperative change for the point A of the maxilla from immediate postsurgery to longest follow-up (P> 0.05), the used technique of "RIF LF-I impaction and RIF BSSO advancement" tended to render excellent postsurgical stability in the horizontal (0.1+/-0.8mm mean posterior movement) and vertical (0.1+/-0.5mm mean inferior movement) direction. There was no instance of maxillary relapse of >2mm. Regarding mandibular BSSO advancement, the point B showed a significant vertical upward movement (1.6+/-1.2mm) (P< 0.001) and a slight horizontal forward movement (0.3+/-2.0mm) (P> 0.05) at 1-year follow-up. The incidence of posterior relapse of >2mm accounted for 11.5%. The data confirm the concept that the bimaxillary approach of "LF-I impaction and BSSO advancement" using the described technique of RIF is a stable procedure in the treatment of open bite patients classified as vertical maxillary excess in combination with mandibular deficiency.     

Long term stability of mandibular advancement procedures: bilateral sagittal split osteotomy versus distraction osteogenesis

The aim of this study was to compare the postoperative stability of the mandible after a bilateral lengthening procedure, either by bilateral sagittal split osteotomy (BSSO) or distraction osteogenesis (DO). All patients who underwent mandibular advancement surgery between March 2001 and June 2004 were evaluated. There were 17 patients in the BSSO group and 18 patients in the DO group. The decision to use intra-oral distraction or BSSO for mandibular advancement primarily depended on the choice of the patient and their parents. In both groups, standardized cephalometric radiographs were taken preoperatively, postoperatively (BSSO group) or directly post-distraction (DO group) and during the last study measurement in May 2008. Cephalometric analysis was performed using the following measurements: sella/nasion-mandibular point B and sella/nasion-mandibular plane. Point B was used to estimate relapse. This study showed no significant difference in relapse between the BSSO and the DO groups measured 46-95 months after advancement of the mandible (P>.05). It can be concluded from this study that there is no postoperative difference in the stability between BSSO and DO after mandibular advancement after 4 years.     

Changes in condylar long axis and skeletal stability after bilateral sagittal split ramus osteotomy with poly-L-lactic acid or titanium plate fixation

This study was designed to assess skeletal stability after bilateral sagittal split ramus osteotomy (BSSO) and fixation with a poly-l-lactic acid (PLLA) plate, as compared to that after BSSO and fixation with a titanium plate, and to analyze the change in the condylar long axis after these procedures. The study group comprised 40 patients who had mandibular prognathism (20, titanium group; 20, PLLA group). The groups were randomized to show similar distributions of preoperative SNB. All patients underwent BSSO setback by the Obwegeser method. Fixation was done with bent titanium plates or bent PLLA plates, applied in a similar manner. Lateral, frontal, and submental-vertical cephalograms were analyzed preoperatively and postoperatively. The maximum mouth opening range and the incidence of temporomandibular disorders were also evaluated. There was no significant difference in the right condylar angle or width between the two groups, but the left condylar angle and width, gonial angle, and ramus inclination differed significantly between them (P<0.05). SNA, SNB, and ANB were similar in both groups. There was no significant difference between the groups in maximum mouth opening range or temporomandibular disorders. We conclude that the change in condylar angle after BSSO and fixation with a titanium plate is greater than that after BSSO and fixation with a PLLA plate, but skeletal stability related to the occlusion is similar for the two procedures.     

Static and dynamic loading of mandibular condyles and their positional changes after bilateral sagittal split advancement osteotomies

This study analysed the effects of change of direction of masseter (MAS) and medial pterygoid muscles (MPM) and changes of moment arms of MAS, MPM and bite force on static and dynamic loading of the condyles after surgical mandibular advancement. Rotations of the condyles were assessed on axial MRIs. 16 adult patients with mandibular hypoplasia were studied. The mandibular plane angle (MPA) was <39° in Group I (n=8) and >39° in Group II (n=8). All mandibles were advanced with a bilateral sagittal split osteotomy (BSSO). In Group II, BSSO was combined with Le Fort I osteotomy. Pre and postoperative moment arms of MAS, MPM and bite force were used in a two-dimensional model to assess static loading of the condyles. Pre and postoperative data on muscle cross-sectional area, volume and direction were introduced in three-dimensional dynamic models of the masticatory system to assess the loading of the condyles during opening and closing. Postsurgically, small increases of static condylar loading were calculated. Dynamic loading decreased slightly. Minor rotations of the condyles were observed. The results do not support the idea that increased postoperative condylar loading is a serious cause for condylar resorption or relapse.     

Density of the mandibular ramus (cancellous:cortical bone volume ratio) as a predictor of the lingual fracture pattern in bilateral sagittal split osteotomy

The aim of this retrospective cohort study was to evaluate the relative amount of cancellous bone in the mandibular ramus as a predictor of lingual fracture patterns after bilateral sagittal split osteotomy (BSSO). The study including 78 consecutive patients (156 osteotomy sites). In preoperative cone-beam computed tomographic (CT) scans, the volumes of cancellous and cortical bone in the BSSO surgical field were estimated. Patients were divided into two groups based on the cancellous:cortical bone ratio. We studied postoperative cone-beam CT scans for lingual fracture lines and subcategorised them according to the lingual split scale (LSS). Generalised linear mixed models (GLMM) were estimated to evaluate the association between the cancellous:cortical bone ratio and the lingual fracture pattern. There was a significant association between the cancellous:cortical bone ratio of the mandibular angle and the lingual fracture pattern after BSSO. Mandibular angles with a relatively small amount of cancellous bone showed significantly more LSS3 fracture lines (OR = 1.990, 95%CI 1.043 to 3.796, p = 0.043). These mandibular angles also showed more unfavourable fractures (LSS4), although this was not significant (OR = 2.352, 95%CI 0.748 to 7.392, p = 0.143). The relative amount of cancellous bone in the mandibular angle is significantly associated with the lingual fracture line after BSSO.     

Skeletal stability after mandibular advancement in bilateral sagittal split osteotomies during adolescence

Bilateral sagittal split osteotomy (BSSO) is the most frequently performed surgery for correcting mandibular retrognathia. Few studies have reported the use of BSSO in young patients, as growth may cause relapse. The aim of the present study was to determine the amount of relapse after performing BSSO in patients aged less than 18 years. Patients who had a mandibular advancement by BSSO surgery between January 2003 and June 2008 were evaluated. Eighteen patients were treated before the age of 18 years and compared with patients treated at 20–24 years of age. Cephalometric radiographs were used to determine the amount of relapse. For patients aged less than 18 years, the mean horizontal relapse after 1 year was 0.5 mm, (10.9% of perioperative advancement). For patients aged 20–24 years, the mean relapse was 0.9 mm, (16.4% of perioperative advancement). There were no significant differences between the age groups (p > 0.05). In conclusion, the BSSO procedure is a relatively stable procedure, even during adolescence.     

Positional changes of the masseter and medial pterygoid muscles after surgical mandibular advancement procedures: an MRI study

This study evaluated whether surgical mandibular advancement procedures induced a change in the direction and the moment arms of the masseter (MAS) and medial pterygoid (MPM) muscles. Sixteen adults participated in this study. The sample was divided in two groups: Group I (n=8) with a mandibular plane angle (mpa) <39° and Group II (n=8) with an mpa >39°. Group I patients were treated with a bilateral sagittal split osteotomy (BSSO). Those in Group II were treated with a BSSO combined with a Le Fort I osteotomy. Pre- and postoperative direction and moment arms of MAS and MPM were compared in these groups. Postsurgically, MAS and MPM in Group II showed a significantly more vertical direction in the sagittal plane. Changes of direction in the frontal plane and changes of moment arms were insignificant in both groups. This study demonstrated that bimaxillary surgery in patients with an mpa >39° leads to a significant change of direction of MAS and MPM in the sagittal plane.     

Alloplastic augmentation of the mandibular angle

This article describes the use of a large-pore polyethylene implant for mandibular angle augmentation. Patients with severe facial deformities who had previously undergone multiple surgical procedures and were now seeking esthetic improvement were included in this series. Their deficient mandibular angles and reduced ramus height were corrected with polyethylene implants appropriately sculptured and fixed to the mandible through extraoral incisions that preexisted in most patients. The surgical technique is described, and four representative cases are presented that illustrate the changes in facial contour and esthetics. Postoperative appearance was considered very satisfactory, and the patients' esthetic expectations were met to a great extent. The mandibular angle was well outlined, and facial contour and proportions were enhanced. This surgical procedure is recommended for mandibular angle augmentation when proper indications are strictly observed and surgical steps are accurately followed.     

Clinical and radiographic evaluation of a computer-generated guiding device in bilateral sagittal split osteotomies

The bilateral sagittal split osteotomy (BSSO) is one of the main orthognathic surgery procedures used for managing skeletal mandibular excess, deficiency or asymmetry. It is known to be a technique-sensitive procedure with high reported incidences of inferior alveolar nerve injury, bad splits and post-surgical relapse. With the increasing use of computer-assisted techniques in orthognathic surgery, the accurate transfer of the virtual plan to the operating room is currently a subject of research. This study evaluated the efficacy of computer-generated device at maintaining the planned condylar position and minimizing inferior alveolar nerve injury during BSSO. The device was used in 6 patients who required isolated mandibular surgery for correction of their skeletal deformities. Clinical evaluation showed good recovery of the maximal incisal opening and a reproducible occlusion in 5 of the 6 patients. Radiographic evaluation showed better control of the condyle position in both the vertical and anteroposterior directions than in the mediolateral direction. The degree of accuracy between the planned and achieved screw positions were judged as good to excellent in all cases. Within the limitations of this study and the small sample size, the proposed device design allowed for good transfer of the virtual surgical plan to the operating room.     

Stabilisation of sagittal split advancement osteotomies with miniplates: a prospective, multicentre study with two-year follow-up. Part III--condylar remodelling and resorption

This prospective study implied a two-year follow-up in a group of patients that underwent a Bilateral Sagittal Split Osteotomy (BSSO) for advancement of the mandible that were treated in seven institutions following the same treatment protocol (using two miniplates). The aim of Part III of this study was to define a Condylar Morphology Scale (CMS) and to analyse radiological changes in the TMJ after BSSO in relation to postoperative relapse and to determine the incidence of morphologic changes and its risk factors. It was concluded that the used 3-point CMS served its purpose well. In eight patients (4%) resorption of the condyle developed postoperatively. The value of preoperative cephalograms to predict condylar alterations appeared to be limited (12% explained variance). Patients treated at a relative low age (< or = 14 years) appeared to be at risk for the occurrence of condylar alterations including resorption. A steep mandibular plane angle and the low facial height ratio (post:ant) were also significantly related to the occurrence of condylar alteration, but the multi variance regression showed that these parameters had only limited value. The occurrence of pain and TMJ sounds in the first few months postoperatively are highly suspicious for condylar changes to occur in the next months.     

Risk factors of nerve injury during mandibular sagittal split osteotomy

There is little objective data about whether surgical technique or mandibular anatomy are a risk for inferior alveolar nerve (IAN) injury during bilateral sagittal split osteotomy (BSSO). Orthodromic sensory nerve action potentials (SNAPs) of the IAN were continuously recorded on both sides in 20 patients with mandibular retrognathia during BSSO operation. Changes in latency, amplitude, and sensory nerve conduction velocity (SNCV) at baseline and at different stages of the operation were analyzed. The SNAP latencies prolonged, the amplitudes diminished, and the SNCVs slowed down during BSSO (P = 0.0000 for all parameters). The most obvious changes occurred during surgical procedures on the medial side of the mandibular ramus. There was a clear tendency towards more disturbed IAN conduction with longer duration of these procedures (right side R = -0.529. P = 0.02; left side R = -0.605, P = 0.006). Exposure or manipulation of the IAN usually had no effect on nerve function, but the IAN conduction tended to be more disturbed in cases with nerve laceration. Low corpus height (R = 0.802, P = 0.001) and the location of the mandibular canal near the inferior border of the mandible (R = 0.52, P = 0.02) may increase the risk of IAN injury. There was no correlation between the age of the patients and the electrophysiological grade of nerve damage.