用SF-36量表评价慢性病患者的生命质量

目的　用 SF- 36量表分析慢性疾病对生命质量的影响。方法　在四川省某城乡用 SF- 36量表对438名慢性疾病患者进行调查 ,并按照 ICD- 9进行疾病分类 ,对不同系统疾病患者的生命质量进行分析。结果　不同系统疾病患者的生命质量在 SF- 36量表所测的不同领域均低于一般人群 (≥ 40岁 )。不同系统疾病患者在躯体活动功能、社会功能、活力和心理功能四个领域均有差别。影响生命质量的主要疾病有精神疾患、血液及造血器官疾病、传染病和寄生虫病。结论　慢性病降低了患者的生命质量 ,不同系统疾病对生命质量的影响程度不同。SF- 36量表适用于评价慢性病患者的生命质量。在慢性疾病的预防控制中 ,生命质量应作为健康评价指标。     

用SF—36量表评价慢性病患者的生命质量

目的 用SF－36量表分析慢性疾病对生命质量的影响。方法 在四川省某城乡用SP－36量表对438名慢性疾病患者进行调查,并按照ICD－8进行疾病分类,对不同系统疾病患者的生命质量进行分析。结果 不同系统疾病患者的生命质量在SF－36量表所测的不同领域均低于一般人群（≥40岁）,不同系统疾病患者在躯体活动性能、社会功能、活力和心理功能四个领域均有差别。影响生命质量的主要疾病有精神疾患、血液及造血器官疾病,传染病和寄生虫病。结论 慢性病降低了患者的生命质量。不同系统疾病对生命质量的影响程度不同,SF－36量表适用于评价慢性病患者的生命质量。在慢性疾病的预防控制中,生命质量应作为健康评价指标。     

终末期肾脏疾病患者生活质量研究近况

随着生物—心理—社会健康观的确立，终末期肾脏疾病(ESRD)的治疗目的不再局限于生命的维持和症状的缓解，生活质量逐渐成为新的临床评价终点。ESRD患者生活质量测评需普适性量表和疾病特异性量表联合使用。     

2型糖尿病患者与社区人群自测健康对照分析

随着社会的进步和疾病谱的变化 ,糖尿病的发病率正在迅速攀升 ,严重影响着人们的生活质量。糖尿病人患病后如何看待或评价自己的身体健康状况 ?如何看待或评价自己的心理健康与社会适应状况 ?这关系到他们的生活质量 ,治疗效果和全面康复等。本文基于生理 心理 社会医学的健康模式 ,利用自测健康这一新兴的健康评价方式 ,对住院的 2型糖尿病患者的自测健康状况与社区人群对照研究进行对照分析 ,了解患者的自评健康情况并探讨影响因素。对象与方法一、研究对象 :本研究应用自测健康量表 (SRHMS) [1] 对住院 2型糖尿病患者的健康情况进行评…     

SF-36量表在骨质疏松症患者生命质量评价中的应用研究

36条目简明量表（SF-36）是普适性生命质量量表，主要用于一般人群调查、不同状况下的健康比较、卫生政策制定、临床试验、卫生服务研究和监测个体患者。本研究运用SF-36量表，从躯体活动功能及其对角色功能的影响、疼痛、健康总体自评、活动、社会功能、情绪对角色功能的影响、心理功能等8个领域对骨质疏松症患者的生命质量进行评价。结果显示骨质疏松症患者的生命质量低于一般人群。     

老年人社交支持情况与生命质量关系的研究

目的；分析和探讨老年人社会支持情况对美国简明健康测量量表SF－36中文版和中国老年人生活质量调查表两个量表测出的生命质量的不同影响关系。方法：采用SSRS量表、SF－36中文版量表和中国老年人生活质量调查表对苏州市167名离退休人员进行自评调查。结果：SF－36中文版量表测得的中国老年人生命质量中的活力和精神健康与其社会支持情况的主观支持相关，其余方面均与社会支持情况不相关。而中国老年人生活质量调查表测得的中国老年人生命质量与其社会支持情况有显著性相关，尤其是在主观支持方面。结论：对于中国老年人，他们的社会支持情况是共生命质量密切相关的因素，中国老年人生活质量调查表在社会支持方面较SF－36中文版量表更敏感、更明显。     

简体中文版MOS-HIV量表对HIV/AIDS患者生存质量测评与社会歧视的相关性分析

目的 了解HIV/AIDS生存质量的相关影响因素及与社会歧视的相关性,为减少社会对HIV感染者/AIDS患者的歧视,提高其生命质量提供科学依据.方法 利用自行设计的相关影响因素问卷了解该地区目标人群的一般人口学特征;应用简体中文版MOS-HIV量表对目标人群的生活质量现状进行评价,调查可能影响生活质量的人口学特征和与HIV/AIDS相关特征的11个维度的测评;同时探索HIV/AIDS人群生活质量及社会歧视影响因素.统计学处理采用t检验进行显著性检验及用Logistic回归进行典型相关分析.结果 MOS-HIV量表得分总体情况与国内研究基本一致,不同HIV传播途径影响研究对象的总体健康、认知功能和生命质量(P＜0.01),不同的收入人群社会歧视态度不同,在不同歧视态度人群中Logistic回归分析发现,主要影响因素是躯体功能、认知功能、社会功能、性别与职业,P＜0.01.结论 对HIV感染者/AIDS患者社会歧视越高,总体健康、认知功能和生活质量越低,应减少社会歧视,提高生存质量.     

汉族多囊卵巢综合征(PCOS)患者生命质量状况及影响因素

目的 评价汉族多囊卵巢综合征患者生命质量并探讨其影响因素.方法 采用方便抽样的方法,在云南省三级甲等医院妇科门诊及体检中心,选取163名汉族PCOS患者和194名健康女性作为研究对象.采用一般社会人口学和临床特征问卷、WHOQOL-BREF量表进行调查,以进行汉族PCOS患者生命质量现状及影响因素分析.结果 PCOS患者和健康女性生命质量的生理领域和心理领域比较,PCOS组低于健康对照组,差异有统计学意义(P<0.05);PCOS患者生命质量得分为5.50～23.25(14.82±2.84)分.各维度得分由低到高依次是心理领域、环境领域、社会关系、生理领域;PCOS患者生命质量及各维度进行多元线性回归显示,PCOS患者生命质量及各维度受不同因素的影响,其中负性生活事件是影响生命质量及生理领域、心理领域的重要影响因素(P<0.05).结论 PCOS患者生命质量降低,主要表现在心理健康状况降低,应关注PCOS患者的心理健康.为了提高PCOS患者生命质量,应重视患者的心理健康,注意对不同社会人口学和临床表现特征的患者采取个性化、有针对性的干预措施.     

汉族多囊卵巢综合征(PCOS)患者生命质量状况及影响因素

目的 评价汉族多囊卵巢综合征患者生命质量并探讨其影响因素.方法 采用方便抽样的方法,在云南省三级甲等医院妇科门诊及体检中心,选取163名汉族PCOS患者和194名健康女性作为研究对象.采用一般社会人口学和临床特征问卷、WHOQOL-BREF量表进行调查,以进行汉族PCOS患者生命质量现状及影响因素分析.结果 PCOS患者和健康女性生命质量的生理领域和心理领域比较,PCOS组低于健康对照组,差异有统计学意义(P<0.05);PCOS患者生命质量得分为5.50～23.25(14.82±2.84)分.各维度得分由低到高依次是心理领域、环境领域、社会关系、生理领域;PCOS患者生命质量及各维度进行多元线性回归显示,PCOS患者生命质量及各维度受不同因素的影响,其中负性生活事件是影响生命质量及生理领域、心理领域的重要影响因素(P<0.05).结论 PCOS患者生命质量降低,主要表现在心理健康状况降低,应关注PCOS患者的心理健康.为了提高PCOS患者生命质量,应重视患者的心理健康,注意对不同社会人口学和临床表现特征的患者采取个性化、有针对性的干预措施.     

HIV/AIDS患者在进行抗病毒治疗中的生命质量研究

目的 评价抗病毒治疗过程中HIV/AIDS生命质量的现状.方法 应用简体中文版MOS-HIV量表对云南省开远市及省关爱中心抗病毒治疗过程中253名HIV/AIDS患者的生命质量进行测评,调查可能影响生命质量的人口学特征.结果 用简体中文版MOS-HIV量表测量研究地点HIV感染者/AIDS病人的生命质量得分,总体健康为(61.28±8.23)分,生理健康(31.94±7.20)分,统计结果显示不同婚姻状况的人群总体健康、健康转移有统计学差异(P＜0.05);HIV和AIDS生命质量的1 1个维度中仅社会功能方面没有统计学差异(P＞0.05);不同感染途径的人群在总体健康、健康压力、生命质量、健康转移方面有统计学差异(P＜0.05).结论 已婚的HIV/AIDS患者在总体健康、健康转移方面的得分高于非婚的HIV/AIDS患者;性感染途径的HIV/AIDS患者在总体健康、生活质量、健康转移比共用针具途径以及其他途径的HIV/AIDS病人降低,在健康压力方面却是增加;HIV生命质量的11个维度中除社会功能方面和AIDS患者没有差异外,其他维度的得分都高于AIDS患者.要提高HIV/AIDS的生命质量,应针对其生命质量的不同方面进行相应的健康教育、心理咨询、社会救助、物质支持.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.